{"id":"https://openalex.org/W2072097575","doi":"https://doi.org/10.1186/1471-2105-13-121","title":"Detection of identity by descent using next-generation whole genome sequencing data","display_name":"Detection of identity by descent using next-generation whole genome sequencing data","publication_year":2012,"publication_date":"2012-06-06","ids":{"openalex":"https://openalex.org/W2072097575","doi":"https://doi.org/10.1186/1471-2105-13-121","mag":"2072097575","pmid":"https://pubmed.ncbi.nlm.nih.gov/22672699"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-13-121","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-121","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-121","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050227199","display_name":"Shu-Yi Su","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210157818","display_name":"Ernest Gallo Clinic and Research Center","ror":"https://ror.org/04g7y4303","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157818"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shu-Yi Su","raw_affiliation_strings":["Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton St., Suite 200, Emeryville, CA 94608, USA. shuyisu@gallo.ucsf.edu","Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton St., Suite 200, Emeryville, CA 94608, USA. shuyisu@gallo.ucsf.edu","institution_ids":["https://openalex.org/I4210157818"]},{"raw_affiliation_string":"Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, USA","institution_ids":["https://openalex.org/I4210157818","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076190720","display_name":"Jay Kasberger","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210157818","display_name":"Ernest Gallo Clinic and Research Center","ror":"https://ror.org/04g7y4303","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157818"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay Kasberger","raw_affiliation_strings":["Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA, 94608, USA","Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA, 94608, USA","institution_ids":["https://openalex.org/I4210157818","https://openalex.org/I180670191"]},{"raw_affiliation_string":"Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, USA","institution_ids":["https://openalex.org/I4210157818","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014721690","display_name":"Sergio E. Baranzini","orcid":"https://orcid.org/0000-0003-0067-194X"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio Baranzini","raw_affiliation_strings":["Department of Neurology, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA, 94608, USA","Department of Neurology, University of California San Francisco, Emeryville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA, 94608, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Neurology, University of California San Francisco, Emeryville, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029134292","display_name":"William Byerley","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Byerley","raw_affiliation_strings":["Department of Psychiatry, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA 94608, USA","Department of Psychiatry, University of California San Francisco, Emeryville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA 94608, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Psychiatry, University of California San Francisco, Emeryville, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103505462","display_name":"Wilson Liao","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wilson Liao","raw_affiliation_strings":["Department of Dermatology, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA, 94608, USA","Department of Dermatology, University of California San Francisco, Emeryville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA, 94608, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Dermatology, University of California San Francisco, Emeryville, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088568312","display_name":"Jorge R. Oksenberg","orcid":"https://orcid.org/0000-0002-3613-9544"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Oksenberg","raw_affiliation_strings":["Department of Neurology, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA, 94608, USA","Department of Neurology, University of California San Francisco, Emeryville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA, 94608, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Neurology, University of California San Francisco, Emeryville, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078694313","display_name":"Elliott H. Sherr","orcid":"https://orcid.org/0000-0002-4118-5385"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliott Sherr","raw_affiliation_strings":["Department of Neurology, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA, 94608, USA","Department of Neurology, University of California San Francisco, Emeryville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA, 94608, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Neurology, University of California San Francisco, Emeryville, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046031453","display_name":"Eric Jorgenson","orcid":"https://orcid.org/0000-0002-5829-8191"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210157818","display_name":"Ernest Gallo Clinic and Research Center","ror":"https://ror.org/04g7y4303","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157818"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Jorgenson","raw_affiliation_strings":["Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA, 94608, USA","Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton St. Suite 200, Emeryville, CA, 94608, USA","institution_ids":["https://openalex.org/I4210157818","https://openalex.org/I180670191"]},{"raw_affiliation_string":"Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, USA","institution_ids":["https://openalex.org/I4210157818","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5050227199"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210157818"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.2487,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.88271985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"121","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9764999747276306,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9764999747276306,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/international-hapmap-project","display_name":"International HapMap Project","score":0.7315253615379333},{"id":"https://openalex.org/keywords/1000-genomes-project","display_name":"1000 Genomes Project","score":0.6768732070922852},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6161532402038574},{"id":"https://openalex.org/keywords/identity-by-descent","display_name":"Identity by descent","score":0.6125099658966064},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.5077953934669495},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5015296936035156},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.49545204639434814},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48532834649086},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.4573286771774292},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.43145036697387695},{"id":"https://openalex.org/keywords/cancer-genome-sequencing","display_name":"Cancer genome sequencing","score":0.4123288691043854},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.41081446409225464},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.38250336050987244},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.3505364656448364},{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.13661444187164307},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1119515597820282},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.1119326651096344},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07849934697151184}],"concepts":[{"id":"https://openalex.org/C177580304","wikidata":"https://www.wikidata.org/wiki/Q1147298","display_name":"International HapMap Project","level":5,"score":0.7315253615379333},{"id":"https://openalex.org/C97425143","wikidata":"https://www.wikidata.org/wiki/Q164786","display_name":"1000 Genomes Project","level":5,"score":0.6768732070922852},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6161532402038574},{"id":"https://openalex.org/C178221405","wikidata":"https://www.wikidata.org/wiki/Q5988338","display_name":"Identity by descent","level":5,"score":0.6125099658966064},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5077953934669495},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5015296936035156},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49545204639434814},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48532834649086},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4573286771774292},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.43145036697387695},{"id":"https://openalex.org/C205270622","wikidata":"https://www.wikidata.org/wiki/Q17082639","display_name":"Cancer genome sequencing","level":5,"score":0.4123288691043854},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.41081446409225464},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.38250336050987244},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.3505364656448364},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.13661444187164307},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1119515597820282},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1119326651096344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07849934697151184},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060148","descriptor_name":"HapMap Project","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060148","descriptor_name":"HapMap Project","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060148","descriptor_name":"HapMap Project","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060148","descriptor_name":"HapMap Project","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/1471-2105-13-121","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-121","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-121","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22672699","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22672699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:ark:/13030/qt14q0x2hx","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:6fcf6560a73d48f48f9925f1cf6ed45a","is_oa":false,"landing_page_url":"https://doaj.org/article/6fcf6560a73d48f48f9925f1cf6ed45a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 13, Iss 1, p 121 (2012)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt1q38w9qx","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/1q38w9qx","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt14q0x2hx","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/14q0x2hx","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:europepmc.org:2406732","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3403908","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:qt1q38w9qx","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/1q38w9qx","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Baranzini, Sergio; Su, SY; Kasberger, J; Byerley, W; Liao, W; Oksenberg, J; \u00c2\u00a0et al.(2012). Detection of identity by descent using next-generation whole genome sequencing data. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1q38w9qx","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-13-121","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-121","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-121","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals","score":0.4399999976158142}],"awards":[{"id":"https://openalex.org/G1791619246","display_name":null,"funder_award_id":"K08 AR057763","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072097575.pdf","grobid_xml":"https://content.openalex.org/works/W2072097575.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1490046998","https://openalex.org/W1973950074","https://openalex.org/W1980792369","https://openalex.org/W1985515653","https://openalex.org/W1991944680","https://openalex.org/W2007991486","https://openalex.org/W2020937422","https://openalex.org/W2026323344","https://openalex.org/W2033243230","https://openalex.org/W2055485782","https://openalex.org/W2062864613","https://openalex.org/W2065035179","https://openalex.org/W2107010473","https://openalex.org/W2115038037","https://openalex.org/W2115335486","https://openalex.org/W2118379383","https://openalex.org/W2130542470","https://openalex.org/W2151880726","https://openalex.org/W2161633633","https://openalex.org/W2168933019"],"related_works":["https://openalex.org/W2017753262","https://openalex.org/W2122946544","https://openalex.org/W2609071159","https://openalex.org/W1989743336","https://openalex.org/W2115511842","https://openalex.org/W2474139959","https://openalex.org/W2206749611","https://openalex.org/W2227014354","https://openalex.org/W2098149062","https://openalex.org/W2500479701"],"abstract_inverted_index":{"BACKGROUND:":[0],"Identity":[1],"by":[2],"descent":[3],"(IBD)":[4],"has":[5,232,247],"played":[6],"a":[7,248],"fundamental":[8],"role":[9],"in":[10,42,54,65,139,207,300],"the":[11,55,66,87,115,146,160,167,175,258,269,283],"discovery":[12],"of":[13,32,90,117,136,197,218,260,285],"genetic":[14,43,127,265],"loci":[15,120],"underlying":[16],"human":[17],"diseases.":[18],"Both":[19],"pedigree-based":[20],"and":[21,30,60,141,179,205,303],"population-based":[22],"linkage":[23],"analyses":[24],"rely":[25],"on":[26,264,268],"estimating":[27],"recent":[28],"IBD,":[29,50,293],"evidence":[31],"ancient":[33],"IBD":[34,106,150,240,273,278],"can":[35,151,194],"be":[36,152],"used":[37],"to":[38,104,212,215,271],"detect":[39,105,195,216],"population":[40,71],"structure":[41],"association":[44,296,298],"studies.":[45,306],"Various":[46],"methods":[47],"for":[48,238],"detecting":[49,239],"including":[51,294],"those":[52],"implemented":[53],"soft-":[56],"ware":[57],"programs":[58],"fastIBD":[59,204,237],"GERMLINE,":[61],"have":[62],"been":[63],"developed":[64],"past":[67],"several":[68],"years":[69],"using":[70,203,242],"genotype":[72,143,157,164,226],"data":[73,81,99,144,158,165,173,184],"from":[74,159,166,174,185],"microarray":[75,142,156,225],"platforms.":[76],"Now,":[77],"next-generation":[78],"DNA":[79],"sequencing":[80,98,140,172,208,243,289],"is":[82],"becoming":[83],"increasingly":[84],"available,":[85],"enabling":[86,114],"comprehensive":[88],"analysis":[89],"genomes,":[91],"in-":[92],"cluding":[93],"identifying":[94],"rare":[95],"variants.":[96],"These":[97,275],"may":[100,280],"provide":[101],"an":[102],"opportunity":[103],"with":[107,125,224],"higher":[108,223,234,250],"resolution":[109,147,279],"than":[110,236],"previously":[111,123],"possible,":[112],"potentially":[113],"detection":[116],"disease":[118],"causing":[119],"that":[121,230,291],"were":[122],"undetectable":[124],"sparser":[126],"data.":[128,209,227],"RESULTS:":[129],"Here,":[130],"we":[131,193],"investigate":[132],"how":[133],"different":[134],"levels":[135],"variant":[137,261],"coverage":[138,171,181],"influences":[145],"at":[148],"which":[149],"detected.":[153],"This":[154,210],"includes":[155],"WTCCC":[161],"study,":[162],"denser":[163],"HapMap":[168],"Project,":[169,178],"low":[170],"1000":[176],"Genomes":[177],"deep":[180],"complete":[182],"genome":[183],"our":[186],"own":[187],"projects.":[188],"With":[189],"high":[190],"power":[191,214,235,270],"(78%),":[192],"segments":[196,217,241],"length":[198,219],"0.4":[199],"cM":[200,221],"or":[201,222],"larger":[202],"GERMLINE":[206,231],"compares":[211],"similar":[213],"1.0":[220],"We":[228,255],"find":[229],"slightly":[233],"data,":[244],"but":[245],"also":[246],"much":[249],"false":[251],"positive":[252],"rate.":[253],"CONCLUSION:":[254],"further":[256],"quantify":[257],"effect":[259],"density,":[262],"conditional":[263],"map":[266],"length,":[267],"resolve":[272],"segments.":[274],"investigations":[276],"into":[277],"help":[281],"guide":[282],"design":[284],"future":[286],"next":[287],"generation":[288],"studies":[290,299],"utilize":[292],"family-based":[295],"studies,":[297],"admixed":[301],"populations,":[302],"homozygosity":[304],"mapping":[305]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}