{"id":"https://openalex.org/W2004044531","doi":"https://doi.org/10.1186/1471-2105-13-120","title":"On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies","display_name":"On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies","publication_year":2012,"publication_date":"2012-06-06","ids":{"openalex":"https://openalex.org/W2004044531","doi":"https://doi.org/10.1186/1471-2105-13-120","mag":"2004044531","pmid":"https://pubmed.ncbi.nlm.nih.gov/22672667"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-13-120","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-120","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-120","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110556004","display_name":"Ann-Kristin Petersen","orcid":null},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ann-Kristin Petersen","raw_affiliation_strings":["Institute of Genetic Epidemiology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Genetic Epidemiology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023342647","display_name":"Jan Krumsiek","orcid":"https://orcid.org/0000-0003-4734-3791"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210100097","display_name":"Institute of Bioinformatics and Systems Biology","ror":"https://ror.org/0127fwn18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4210100097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Krumsiek","raw_affiliation_strings":["Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210100097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001478917","display_name":"Brigitte W\u00e4gele","orcid":null},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4210100097","display_name":"Institute of Bioinformatics and Systems Biology","ror":"https://ror.org/0127fwn18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4210100097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Brigitte W\u00e4gele","raw_affiliation_strings":["Department of Genome-oriented Bioinformatics, Life and Food Science Center Weihenstephan, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany","Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Genome-oriented Bioinformatics, Life and Food Science Center Weihenstephan, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210100097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083128670","display_name":"Fabian J. Theis","orcid":"https://orcid.org/0000-0002-2419-1943"},"institutions":[{"id":"https://openalex.org/I4210100097","display_name":"Institute of Bioinformatics and Systems Biology","ror":"https://ror.org/0127fwn18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4210100097"]},{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian J Theis","raw_affiliation_strings":["Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210100097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110132157","display_name":"H.\u2010Erich Wichmann","orcid":null},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H-Erich Wichmann","raw_affiliation_strings":["Institute of Epidemiology I, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany","Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universit\u00e4t, M\u00fcnchen, Germany","Klinikum Grosshadern, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Epidemiology I, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universit\u00e4t, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Klinikum Grosshadern, Munich, Germany","institution_ids":["https://openalex.org/I3018771216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085407328","display_name":"Christian Gieger","orcid":"https://orcid.org/0000-0001-6986-9554"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Gieger","raw_affiliation_strings":["Institute of Genetic Epidemiology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Genetic Epidemiology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034424670","display_name":"Karsten Suhre","orcid":"https://orcid.org/0000-0001-9638-3912"},"institutions":[{"id":"https://openalex.org/I4210100097","display_name":"Institute of Bioinformatics and Systems Biology","ror":"https://ror.org/0127fwn18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4210100097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]}],"countries":["DE","QA"],"is_corresponding":false,"raw_author_name":"Karsten Suhre","raw_affiliation_strings":["Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City - Qatar Foundation, Doha, Qatar","Faculty of Biology, Ludwig-Maximilians-Universit\u00e4t, Planegg, Martinsried, Germany","Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City - Qatar Foundation, Doha, Qatar","institution_ids":["https://openalex.org/I4210152471"]},{"raw_affiliation_string":"Faculty of Biology, Ludwig-Maximilians-Universit\u00e4t, Planegg, Martinsried, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210100097"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5110556004"],"corresponding_institution_ids":["https://openalex.org/I3018134672"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.4163,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.88833082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"120","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolome","display_name":"Metabolome","score":0.8757991790771484},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.7727919816970825},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.7545861005783081},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.634171724319458},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6168046593666077},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5949461460113525},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5165082812309265},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.4555772840976715},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.452159583568573},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.38572779297828674},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.3477358818054199},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16570106148719788},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.10815295577049255},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.10660549998283386}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.8757991790771484},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7727919816970825},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7545861005783081},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.634171724319458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6168046593666077},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5949461460113525},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5165082812309265},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4555772840976715},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.452159583568573},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38572779297828674},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.3477358818054199},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16570106148719788},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.10815295577049255},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.10660549998283386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-13-120","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-120","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-120","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22672667","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22672667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:d0c16b36d93d4da2874ee40f65a7b214","is_oa":true,"landing_page_url":"https://doaj.org/article/d0c16b36d93d4da2874ee40f65a7b214","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 13, Iss 1, p 120 (2012)","raw_type":"article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:23487","is_oa":false,"landing_page_url":"https://epub.ub.uni-muenchen.de/23487/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"doc-type:article"},{"id":"pmh:oai:europepmc.org:2543870","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3537592","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:10478","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=10478","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics 13:120 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-13-120","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-13-120","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-120","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2734144814","display_name":null,"funder_award_id":"Munich","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G3241005160","display_name":"Verbundprojekt Molekulare Mechanismen der Adipositas - Gen Validierung in epidemiologischen Kohorten und Fall-Kontrollstudien (WB2-A) und Funktionelle Studien von adipositasrelevanten Genen (WB3-A)","funder_award_id":"01GS0823","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G352791218","display_name":null,"funder_award_id":"(BMBF)","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G3973266048","display_name":"Verbundprojekt: Netzwerk Mitochondriale Erkrankungen (mitoNET); TP CU, C1, D2: Koordination, Register, Biobank Muskelgewebe","funder_award_id":"01GM0862","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G4423549963","display_name":null,"funder_award_id":"SysMBo 0315494A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G4783010297","display_name":null,"funder_award_id":"German Center for Diabetes Research (DZD e.V.)","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G6091700672","display_name":null,"funder_award_id":"mitoNET","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G6605204835","display_name":"Verbundprojekt: Atherogenomics - Teilprojekt; A3, E2: Genomik und funktionelle Analysen subklinischer Ph\u00e4notypen der Arteriosklerose, Evaluation eines SNP-Chips bez\u00fcglich koronarer Herzkrankheit und Diabetes","funder_award_id":"01GS0834","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G7929977276","display_name":null,"funder_award_id":"0315494A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320309815","display_name":"Qatar Foundation","ror":"https://ror.org/01cawbq05"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320322572","display_name":"Studienstiftung des Deutschen Volkes","ror":"https://ror.org/05xwwfy96"},{"id":"https://openalex.org/F4320325530","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02"},{"id":"https://openalex.org/F4320336371","display_name":"M\u00fcnchner Zentrum f\u00fcr Gesundheitswissenschaften","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004044531.pdf","grobid_xml":"https://content.openalex.org/works/W2004044531.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1834081490","https://openalex.org/W1911601650","https://openalex.org/W1973529232","https://openalex.org/W1980270094","https://openalex.org/W1999409172","https://openalex.org/W2006141598","https://openalex.org/W2007806275","https://openalex.org/W2018263125","https://openalex.org/W2021426287","https://openalex.org/W2044572863","https://openalex.org/W2065691650","https://openalex.org/W2065877459","https://openalex.org/W2078186961","https://openalex.org/W2078489012","https://openalex.org/W2087246553","https://openalex.org/W2124850376","https://openalex.org/W2134296519","https://openalex.org/W2151329891","https://openalex.org/W2164339823","https://openalex.org/W2166711199","https://openalex.org/W2582743722"],"related_works":["https://openalex.org/W1996644818","https://openalex.org/W1965468642","https://openalex.org/W2093500216","https://openalex.org/W2053588008","https://openalex.org/W2916376502","https://openalex.org/W3101161779","https://openalex.org/W423371831","https://openalex.org/W2777729175","https://openalex.org/W2260452057","https://openalex.org/W4295779760"],"abstract_inverted_index":{"We":[0],"show":[1],"that":[2,10],"the":[3,30],"p-gain":[4,31],"is":[5],"a":[6,25],"well":[7],"defined":[8],"measure":[9],"can":[11],"be":[12],"used":[13],"to":[14],"identify":[15],"statistically":[16],"significant":[17],"metabolite":[18],"ratios":[19],"in":[20,34],"association":[21,36],"studies":[22,37],"and":[23],"provide":[24],"conservative":[26],"significance":[27],"cut-off":[28],"for":[29,32],"use":[33],"future":[35],"with":[38],"metabolic":[39],"traits.":[40]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-03-28T08:17:26.163206","created_date":"2025-10-10T00:00:00"}
