{"id":"https://openalex.org/W2074456530","doi":"https://doi.org/10.1186/1471-2105-12-s13-s8","title":"Comprehensive evaluation of matrix factorization methods for the analysis of DNA microarray gene expression data","display_name":"Comprehensive evaluation of matrix factorization methods for the analysis of DNA microarray gene expression data","publication_year":2011,"publication_date":"2011-11-30","ids":{"openalex":"https://openalex.org/W2074456530","doi":"https://doi.org/10.1186/1471-2105-12-s13-s8","mag":"2074456530","pmid":"https://pubmed.ncbi.nlm.nih.gov/22373334"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-s13-s8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s13-s8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S13-S8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S13-S8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010410951","display_name":"Mi Hyeon Kim","orcid":"https://orcid.org/0000-0002-9232-0401"},"institutions":[{"id":"https://openalex.org/I2802457231","display_name":"New Generation University College","ror":"https://ror.org/015aem925","country_code":"ET","type":"education","lineage":["https://openalex.org/I2802457231"]},{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["ET","KR"],"is_corresponding":true,"raw_author_name":"Mi Hyeon Kim","raw_affiliation_strings":["Seoul National University Biomedical Informatics, Systems Biomedical Informatics Research Center, and Interdisciplinary Program of Medical Informatics Div. of Biomedical Informatics, Seoul National University College of Medicine, Seoul 110799, Korea","Seoul National University Biomedical Informatics (SNUBI), Systems Biomedical Informatics Research Center, and Interdisciplinary Program of Medical Informatics Div. of Biomedical Informatics, Seoul National University College of Medicine, Seoul, 110799, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Biomedical Informatics, Systems Biomedical Informatics Research Center, and Interdisciplinary Program of Medical Informatics Div. of Biomedical Informatics, Seoul National University College of Medicine, Seoul 110799, Korea","institution_ids":["https://openalex.org/I2802457231"]},{"raw_affiliation_string":"Seoul National University Biomedical Informatics (SNUBI), Systems Biomedical Informatics Research Center, and Interdisciplinary Program of Medical Informatics Div. of Biomedical Informatics, Seoul National University College of Medicine, Seoul, 110799, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037021023","display_name":"Hwa Jeong Seo","orcid":"https://orcid.org/0000-0002-6050-2104"},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hwa Jeong Seo","raw_affiliation_strings":["Medical Informatics, Graduate School of Public Health, Gachon University of Medicine and Science, Incheon, 40576, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Informatics, Graduate School of Public Health, Gachon University of Medicine and Science, Incheon, 40576, Korea","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060488559","display_name":"Je\u2010Gun Joung","orcid":"https://orcid.org/0000-0003-2859-1036"},"institutions":[{"id":"https://openalex.org/I2802457231","display_name":"New Generation University College","ror":"https://ror.org/015aem925","country_code":"ET","type":"education","lineage":["https://openalex.org/I2802457231"]},{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["ET","KR"],"is_corresponding":false,"raw_author_name":"Je-Gun Joung","raw_affiliation_strings":["Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, 110799, Korea","Seoul National University Biomedical Informatics (SNUBI), Systems Biomedical Informatics Research Center, and Interdisciplinary Program of Medical Informatics Div. of Biomedical Informatics, Seoul National University College of Medicine, Seoul, 110799, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, 110799, Korea","institution_ids":["https://openalex.org/I2802457231"]},{"raw_affiliation_string":"Seoul National University Biomedical Informatics (SNUBI), Systems Biomedical Informatics Research Center, and Interdisciplinary Program of Medical Informatics Div. of Biomedical Informatics, Seoul National University College of Medicine, Seoul, 110799, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101730979","display_name":"Ju Han Kim","orcid":"https://orcid.org/0000-0003-1522-9038"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju Han Kim","raw_affiliation_strings":["Seoul National University Biomedical Informatics (SNUBI), Systems Biomedical Informatics Research Center, and Interdisciplinary Program of Medical Informatics Div. of Biomedical Informatics, Seoul National University College of Medicine, Seoul, 110799, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Biomedical Informatics (SNUBI), Systems Biomedical Informatics Research Center, and Interdisciplinary Program of Medical Informatics Div. of Biomedical Informatics, Seoul National University College of Medicine, Seoul, 110799, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010410951"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802457231"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.5321,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.66052685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"S13","first_page":"S8","last_page":"S8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.8385573625564575},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5980201363563538},{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"Non-negative matrix factorization","score":0.5269224047660828},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5158978700637817},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4887375831604004},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.47351884841918945},{"id":"https://openalex.org/keywords/gene-chip-analysis","display_name":"Gene chip analysis","score":0.45265501737594604},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4348493814468384},{"id":"https://openalex.org/keywords/biclustering","display_name":"Biclustering","score":0.42755964398384094},{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.4240581691265106},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.41758155822753906},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4047291576862335},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4006875455379486},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34458860754966736},{"id":"https://openalex.org/keywords/fuzzy-clustering","display_name":"Fuzzy clustering","score":0.33649009466171265},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3304939866065979},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2895817756652832},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2846162021160126},{"id":"https://openalex.org/keywords/cure-data-clustering-algorithm","display_name":"CURE data clustering algorithm","score":0.22596591711044312},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13760867714881897}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.8385573625564575},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5980201363563538},{"id":"https://openalex.org/C152671427","wikidata":"https://www.wikidata.org/wiki/Q10843505","display_name":"Non-negative matrix factorization","level":4,"score":0.5269224047660828},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5158978700637817},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4887375831604004},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.47351884841918945},{"id":"https://openalex.org/C24361400","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Gene chip analysis","level":5,"score":0.45265501737594604},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4348493814468384},{"id":"https://openalex.org/C144817290","wikidata":"https://www.wikidata.org/wiki/Q2976575","display_name":"Biclustering","level":5,"score":0.42755964398384094},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.4240581691265106},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.41758155822753906},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4047291576862335},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4006875455379486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34458860754966736},{"id":"https://openalex.org/C17212007","wikidata":"https://www.wikidata.org/wiki/Q5511111","display_name":"Fuzzy clustering","level":3,"score":0.33649009466171265},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3304939866065979},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2895817756652832},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2846162021160126},{"id":"https://openalex.org/C33704608","wikidata":"https://www.wikidata.org/wiki/Q5014717","display_name":"CURE data clustering algorithm","level":4,"score":0.22596591711044312},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13760867714881897},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-12-s13-s8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s13-s8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S13-S8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22373334","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22373334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:d60218227d454ae395e3cfd98617869c","is_oa":true,"landing_page_url":"https://doaj.org/article/d60218227d454ae395e3cfd98617869c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 12, Iss Suppl 13, p S8 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2286369","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3278848","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-s13-s8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s13-s8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S13-S8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6306468299","display_name":null,"funder_award_id":"A070001","funder_id":"https://openalex.org/F4320322349","funder_display_name":"Ministry of Education, Science and Technology"},{"id":"https://openalex.org/G6459009094","display_name":null,"funder_award_id":"2011-0018257","funder_id":"https://openalex.org/F4320322349","funder_display_name":"Ministry of Education, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2074456530.pdf"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W156555589","https://openalex.org/W206759535","https://openalex.org/W1548802052","https://openalex.org/W1570285922","https://openalex.org/W1902027874","https://openalex.org/W1987971958","https://openalex.org/W1991680649","https://openalex.org/W1996716987","https://openalex.org/W2001619934","https://openalex.org/W2013029404","https://openalex.org/W2029064186","https://openalex.org/W2033403400","https://openalex.org/W2050667238","https://openalex.org/W2051224630","https://openalex.org/W2059745395","https://openalex.org/W2071949631","https://openalex.org/W2080823347","https://openalex.org/W2088851040","https://openalex.org/W2092423825","https://openalex.org/W2104608541","https://openalex.org/W2109174028","https://openalex.org/W2109363337","https://openalex.org/W2109970232","https://openalex.org/W2116216716","https://openalex.org/W2118718620","https://openalex.org/W2127117261","https://openalex.org/W2127284416","https://openalex.org/W2128040385","https://openalex.org/W2129066856","https://openalex.org/W2131456395","https://openalex.org/W2132206153","https://openalex.org/W2136171036","https://openalex.org/W2136787567","https://openalex.org/W2156336405","https://openalex.org/W2170968232","https://openalex.org/W2171975443","https://openalex.org/W2325346015","https://openalex.org/W2612166593","https://openalex.org/W2797177778","https://openalex.org/W2911468636","https://openalex.org/W3138771162","https://openalex.org/W4205778870","https://openalex.org/W4230702621","https://openalex.org/W4235169531","https://openalex.org/W4236155230","https://openalex.org/W4285719527","https://openalex.org/W4298420982"],"related_works":["https://openalex.org/W2127243424","https://openalex.org/W4390394189","https://openalex.org/W2037504162","https://openalex.org/W2539013788","https://openalex.org/W2792706544","https://openalex.org/W1568451138","https://openalex.org/W2156699640","https://openalex.org/W2045265907","https://openalex.org/W2972997031","https://openalex.org/W34555840"],"abstract_inverted_index":{"BACKGROUND:":[0],"Clustering-based":[1],"methods":[2,49],"on":[3,116],"gene-expression":[4],"analysis":[5],"have":[6,50,203],"been":[7,51,63],"shown":[8],"to":[9,131],"be":[10],"useful":[11],"in":[12,86,153,164],"biomedical":[13],"applications":[14],"such":[15],"as":[16,36,141,143],"cancer":[17],"subtype":[18],"discovery.":[19],"Among":[20],"them,":[21],"Matrix":[22,108],"factorization":[23],"(MF)":[24],"is":[25],"advantageous":[26],"for":[27,53,84,95,190,211],"clustering":[28,54,71,180,191,212],"gene":[29,43,55,88],"expression":[30,44,56,89],"patterns":[31],"from":[32],"DNA":[33],"microarray":[34,192,213],"experiments,":[35],"it":[37],"efficiently":[38],"reduces":[39],"the":[40,70,165,179],"dimension":[41],"of":[42,73,81,182],"data.":[45,214],"Although":[46],"several":[47],"MF":[48,102],"proposed":[52],"patterns,":[57],"a":[58,79,100,120,144],"systematic":[59],"evaluation":[60],"has":[61],"not":[62],"reported":[64],"yet.":[65],"RESULTS:":[66],"Here":[67],"we":[68,98],"evaluated":[69,189],"performance":[72,85,152,163,181,205],"orthogonal":[74,139,183,207],"and":[75,91,125,135,173,184,209],"non-orthogonal":[76,101,185,201],"MFs":[77,129,140,157,186,202,208],"by":[78,194],"total":[80],"nine":[82],"measurements":[83],"four":[87],"datasets":[90],"one":[92],"well-known":[93],"dataset":[94],"clustering.":[96],"Specifically,":[97],"employed":[99],"algorithm,":[103],"BSNMF":[104,149,159],"(Bi-directional":[105],"Sparse":[106],"Non-negative":[107],"Factorization),":[109],"that":[110,200],"applies":[111],"bi-directional":[112],"sparseness":[113],"constraints":[114],"superimposed":[115],"non-negative":[117],"constraints,":[118],"comprising":[119],"few":[121],"dominantly":[122],"co-expressed":[123],"genes":[124],"samples":[126],"together.":[127],"Non-orthogonal":[128,156],"tended":[130],"show":[132],"better":[133,204],"clustering-quality":[134],"prediction-accuracy":[136],"indices":[137],"than":[138,206],"well":[142],"traditional":[145],"method,":[146],"K-means.":[147],"Moreover,":[148],"showed":[150,160,199],"improved":[151],"these":[154],"measurements.":[155,196],"including":[158],"also":[161],"good":[162],"functional":[166],"enrichment":[167],"test":[168],"using":[169],"Gene":[170],"Ontology":[171],"terms":[172],"biological":[174],"pathways.":[175],"CONCLUSIONS:":[176],"In":[177],"conclusion,":[178],"was":[187],"appropriately":[188],"data":[193],"comprehensive":[195],"This":[197],"study":[198],"K-means":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}