{"id":"https://openalex.org/W2127087491","doi":"https://doi.org/10.1186/1471-2105-12-s13-s20","title":"Construction and analysis of the protein-protein interaction networks for schizophrenia, bipolar disorder, and major depression","display_name":"Construction and analysis of the protein-protein interaction networks for schizophrenia, bipolar disorder, and major depression","publication_year":2011,"publication_date":"2011-11-30","ids":{"openalex":"https://openalex.org/W2127087491","doi":"https://doi.org/10.1186/1471-2105-12-s13-s20","mag":"2127087491","pmid":"https://pubmed.ncbi.nlm.nih.gov/22373040"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-s13-s20","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s13-s20","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S13-S20","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S13-S20","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024600786","display_name":"Sheng\u2010An Lee","orcid":"https://orcid.org/0009-0008-7953-7877"},"institutions":[{"id":"https://openalex.org/I174748290","display_name":"Kainan University","ror":"https://ror.org/018p1hd91","country_code":"TW","type":"education","lineage":["https://openalex.org/I174748290"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Sheng-An Lee","raw_affiliation_strings":["Department of Information Management, Kainan University, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Management, Kainan University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I174748290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109228035","display_name":"Theresa Tsun-Hui Tsao","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Theresa Tsun-Hui Tsao","raw_affiliation_strings":["Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan","Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078669016","display_name":"Ko-Chun Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ko-Chun Yang","raw_affiliation_strings":["Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101549959","display_name":"Han Lin","orcid":"https://orcid.org/0000-0002-3446-5098"},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Han Lin","raw_affiliation_strings":["Graduate Institute of Electronics Engineering, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Electronics Engineering, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102686456","display_name":"Yu-Lun Kuo","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Lun Kuo","raw_affiliation_strings":["Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059673073","display_name":"Chien-Hsiang Hsu","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chien-Hsiang Hsu","raw_affiliation_strings":["Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006632762","display_name":"Wen-Kuei Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I4210097658","display_name":"Tri-Service General Hospital Beitou Branch","ror":"https://ror.org/00dc6rr74","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210097658"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Kuei Lee","raw_affiliation_strings":["Department of Psychiatry, Armed Forces Beitou Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Armed Forces Beitou Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210097658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111638509","display_name":"Kuo-Chuan Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210097658","display_name":"Tri-Service General Hospital Beitou Branch","ror":"https://ror.org/00dc6rr74","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210097658"]},{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuo-Chuan Huang","raw_affiliation_strings":["Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan","Department of Psychiatry, Armed Forces Beitou Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Department of Psychiatry, Armed Forces Beitou Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210097658"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102154466","display_name":"Cheng\u2010Yan Kao","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Yan Kao","raw_affiliation_strings":["Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan","Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5024600786"],"corresponding_institution_ids":["https://openalex.org/I174748290"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.3255,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.92979734,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"12","issue":"S13","first_page":"S20","last_page":"S20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.9376000165939331,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.9376000165939331,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"Bipolar disorder","score":0.7319563627243042},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"Schizophrenia (object-oriented programming)","score":0.6522541642189026},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5825963020324707},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5331425070762634},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4919090270996094},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4828660786151886},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.4647004008293152},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.45391303300857544},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.43118909001350403},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38155123591423035},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3379855751991272},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2105371654033661},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.19956287741661072},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.1699467897415161},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.11853307485580444},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.09191176295280457}],"concepts":[{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.7319563627243042},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.6522541642189026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5825963020324707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5331425070762634},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4919090270996094},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4828660786151886},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4647004008293152},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.45391303300857544},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.43118909001350403},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38155123591423035},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3379855751991272},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2105371654033661},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19956287741661072},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1699467897415161},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11853307485580444},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.09191176295280457},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Depressive Disorder, Major","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-12-s13-s20","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s13-s20","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S13-S20","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22373040","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22373040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:772114d781c74bb2bb278a3d7eba7156","is_oa":false,"landing_page_url":"https://doaj.org/article/772114d781c74bb2bb278a3d7eba7156","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 12, Iss Suppl 13, p S20 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2286245","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3278837","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-s13-s20","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s13-s20","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S13-S20","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320323900","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127087491.pdf","grobid_xml":"https://content.openalex.org/works/W2127087491.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W86924499","https://openalex.org/W144758851","https://openalex.org/W150037852","https://openalex.org/W207208649","https://openalex.org/W1525318654","https://openalex.org/W1525985997","https://openalex.org/W1964209173","https://openalex.org/W1965252360","https://openalex.org/W1966581051","https://openalex.org/W1966841828","https://openalex.org/W1968545758","https://openalex.org/W1969300914","https://openalex.org/W1973125755","https://openalex.org/W1978177843","https://openalex.org/W1978370477","https://openalex.org/W1979008433","https://openalex.org/W1979056373","https://openalex.org/W1981637710","https://openalex.org/W1984092261","https://openalex.org/W1984120803","https://openalex.org/W1988237294","https://openalex.org/W1988764534","https://openalex.org/W1988917445","https://openalex.org/W1989598267","https://openalex.org/W1989897446","https://openalex.org/W1996926758","https://openalex.org/W1997881288","https://openalex.org/W1998177934","https://openalex.org/W1998641585","https://openalex.org/W1999762980","https://openalex.org/W1999945084","https://openalex.org/W2000551557","https://openalex.org/W2002732312","https://openalex.org/W2006883575","https://openalex.org/W2013318867","https://openalex.org/W2013390729","https://openalex.org/W2016086434","https://openalex.org/W2019465651","https://openalex.org/W2020977183","https://openalex.org/W2022809747","https://openalex.org/W2024901841","https://openalex.org/W2028992001","https://openalex.org/W2030866126","https://openalex.org/W2037248339","https://openalex.org/W2038692754","https://openalex.org/W2042024605","https://openalex.org/W2044008059","https://openalex.org/W2050552296","https://openalex.org/W2052692422","https://openalex.org/W2056641564","https://openalex.org/W2059644034","https://openalex.org/W2062076979","https://openalex.org/W2064656118","https://openalex.org/W2065505208","https://openalex.org/W2066855153","https://openalex.org/W2069125243","https://openalex.org/W2069896738","https://openalex.org/W2072691099","https://openalex.org/W2074443723","https://openalex.org/W2075650547","https://openalex.org/W2076241970","https://openalex.org/W2083217982","https://openalex.org/W2085361495","https://openalex.org/W2089752613","https://openalex.org/W2091017864","https://openalex.org/W2098597355","https://openalex.org/W2105097410","https://openalex.org/W2108491719","https://openalex.org/W2108610913","https://openalex.org/W2110921107","https://openalex.org/W2113602915","https://openalex.org/W2116840690","https://openalex.org/W2116983458","https://openalex.org/W2117446594","https://openalex.org/W2122683221","https://openalex.org/W2122863289","https://openalex.org/W2127303484","https://openalex.org/W2129386492","https://openalex.org/W2130790725","https://openalex.org/W2131273916","https://openalex.org/W2132692850","https://openalex.org/W2134893852","https://openalex.org/W2136476530","https://openalex.org/W2136869363","https://openalex.org/W2137920275","https://openalex.org/W2140628921","https://openalex.org/W2142706148","https://openalex.org/W2143473358","https://openalex.org/W2148043260","https://openalex.org/W2152495216","https://openalex.org/W2153847003","https://openalex.org/W2157891062","https://openalex.org/W2158116492","https://openalex.org/W2158270257","https://openalex.org/W2162821981","https://openalex.org/W2162871532","https://openalex.org/W2163524909","https://openalex.org/W2163784272","https://openalex.org/W2164683872","https://openalex.org/W2166417505","https://openalex.org/W2170696995","https://openalex.org/W2172222726","https://openalex.org/W2409647512"],"related_works":["https://openalex.org/W1488408180","https://openalex.org/W2360290178","https://openalex.org/W2335257745","https://openalex.org/W3005464483","https://openalex.org/W415785311","https://openalex.org/W2956125676","https://openalex.org/W2070581548","https://openalex.org/W3145527116","https://openalex.org/W2350543355","https://openalex.org/W2391388634"],"abstract_inverted_index":{"BACKGROUND:":[0],"Schizophrenia,":[1],"bipolar":[2,90],"disorder,":[3,91],"and":[4,19,35,59,70,92,120,135,147,156,188,205,215,225,234,264,279],"major":[5,93],"depression":[6,94],"are":[7,37,49,266],"devastating":[8],"mental":[9],"diseases,":[10],"each":[11],"with":[12,39],"distinctive":[13],"yet":[14],"overlapping":[15],"epidemiologic":[16],"characteristics.":[17],"Microarray":[18],"proteomics":[20],"data":[21],"have":[22],"revealed":[23],"genes":[24,58,83,112,124,199,214,246],"which":[25,179],"expressed":[26,82,110,173,201],"abnormally":[27,81,172],"in":[28,84,127,137,150,166,202],"patients.":[29,95],"Several":[30,209],"single":[31],"nucleotide":[32],"polymorphisms":[33],"(SNPs)":[34],"mutations":[36],"associated":[38],"one":[40],"or":[41,149,170,243],"more":[42],"of":[43,80,88,105,181,186,237,252],"the":[44,53,56,65,77,106,118,167,238,249,253,257],"three":[45],"diseases.":[46,255],"Nevertheless,":[47],"there":[48],"few":[50],"studies":[51],"on":[52,232],"interactions":[54],"among":[55],"disease-associated":[57],"proteins.":[60],"RESULTS:":[61],"This":[62],"study,":[63],"for":[64,271],"first":[66],"time,":[67],"incorporated":[68],"microarray":[69],"protein-protein":[71],"interaction":[72],"(PPI)":[73],"databases":[74],"to":[75,276],"construct":[76],"PPI":[78,168,239],"network":[79,169],"postmortem":[85],"brain":[86,138],"samples":[87,97],"schizophrenia,":[89],"The":[96,241],"were":[98,113,125,160,195,229],"collected":[99],"from":[100],"Brodmann":[101],"area":[102],"(BA)":[103],"10":[104],"prefrontal":[107],"cortex.":[108],"Abnormally":[109],"disease":[111,119,204,212],"selected":[114],"by":[115,197],"t-tests":[116],"comparing":[117],"control":[121,206],"samples.":[122,207],"These":[123,193],"involved":[126],"housekeeping":[128],"functions":[129,140],"(e.g.":[130,141,153],"translation,":[131],"transcription,":[132],"energy":[133],"conversion,":[134],"metabolism),":[136],"specific":[139],"signal":[142],"transduction,":[143],"neuron":[144],"cell":[145],"differentiation,":[146],"cytoskeleton),":[148],"stress":[151],"responses":[152],"heat":[154],"shocks":[155],"biotic":[157],"stress).The":[158],"diseases":[159],"interconnected":[161],"through":[162],"several":[163],"\"switchboard\"-like":[164],"nodes":[165],"shared":[171,242,250],"genes.":[174],"A":[175],"\"core\"":[176],"functional":[177,278],"module":[178],"consisted":[180],"a":[182],"tightly":[183],"knitted":[184],"sub-network":[185],"clique-5":[187],"-4s":[189],"was":[190],"also":[191],"observed.":[192],"cliques":[194],"formed":[196],"12":[198],"highly":[200],"both":[203],"CONCLUSIONS:":[208],"previously":[210],"unidentified":[211],"marker":[213,245],"drug":[216],"targets,":[217],"such":[218,260],"as":[219,261,268],"SBNO2":[220],"(schizophrenia),":[221],"SEC24C":[222],"(bipolar":[223],"disorder),":[224],"SRRT":[226],"(major":[227],"depression),":[228],"identified":[230],"based":[231],"statistical":[233],"topological":[235,280],"analyses":[236],"network.":[240],"interconnecting":[244],"may":[247],"explain":[248],"symptoms":[251],"studied":[254],"Furthermore,":[256],"\"switchboard\"":[258],"genes,":[259],"APP,":[262],"UBC,":[263],"YWHAZ,":[265],"proposed":[267],"potential":[269],"targets":[270],"developing":[272],"new":[273],"treatments":[274],"due":[275],"their":[277],"significance.":[281]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-08T15:41:06.802602","created_date":"2025-10-10T00:00:00"}