{"id":"https://openalex.org/W2118179630","doi":"https://doi.org/10.1186/1471-2105-12-s10-s10","title":"A CoD-based stationary control policy for intervening in large gene regulatory networks","display_name":"A CoD-based stationary control policy for intervening in large gene regulatory networks","publication_year":2011,"publication_date":"2011-10-18","ids":{"openalex":"https://openalex.org/W2118179630","doi":"https://doi.org/10.1186/1471-2105-12-s10-s10","mag":"2118179630","pmid":"https://pubmed.ncbi.nlm.nih.gov/22165980"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-s10-s10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s10-s10","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S10-S10","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S10-S10","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088517574","display_name":"Noushin Ghaffari","orcid":"https://orcid.org/0000-0001-5354-5643"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Noushin Ghaffari","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843 USA. nghaffari@tamu.edu","Department of Electrical and Computer Engineering, Texas A&M University,College Station,USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843 USA. nghaffari@tamu.edu","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&M University,College Station,USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079620688","display_name":"Ivan Ivanov","orcid":"https://orcid.org/0000-0002-5323-8325"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Ivanov","raw_affiliation_strings":["Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77843, USA","Dept. of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, USA"],"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77843, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Dept. of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073946580","display_name":"Xiaoning Qian","orcid":"https://orcid.org/0000-0002-4347-2476"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoning Qian","raw_affiliation_strings":["Department of Computer Science and Engineering, University of South Florida, 4202 E Fowler Ave., ENB 118, Tampa, FL, 33620, USA","Department of Computer Science & Engineering, University of South Florida, Tampa, USA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of South Florida, 4202 E Fowler Ave., ENB 118, Tampa, FL, 33620, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Computer Science & Engineering, University of South Florida, Tampa, USA#TAB#","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112221423","display_name":"Edward R. Dougherty","orcid":null},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]},{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward R Dougherty","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, USA","Translational Genomics Research Institute (TGEN), 400 North Fifth Street, Suite 1600, Phoenix, AZ, 85004, USA","Translational Genomics Research Institute (TGEN), Phoenix, USA","Department of Electrical and Computer Engineering, Texas A&M University, College Station, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Translational Genomics Research Institute (TGEN), 400 North Fifth Street, Suite 1600, Phoenix, AZ, 85004, USA","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Translational Genomics Research Institute (TGEN), Phoenix, USA","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Texas A&M University, College Station, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088517574"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.5336,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.6658596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"S10","first_page":"S10","last_page":"S10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6262770891189575},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5658029913902283},{"id":"https://openalex.org/keywords/greedy-algorithm","display_name":"Greedy algorithm","score":0.5055348873138428},{"id":"https://openalex.org/keywords/stationary-distribution","display_name":"Stationary distribution","score":0.48816877603530884},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.4484538733959198},{"id":"https://openalex.org/keywords/reduction","display_name":"Reduction (mathematics)","score":0.4161393642425537},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20078089833259583},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.1777125895023346},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.15521970391273499},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14168882369995117},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09469062089920044}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6262770891189575},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5658029913902283},{"id":"https://openalex.org/C51823790","wikidata":"https://www.wikidata.org/wiki/Q504353","display_name":"Greedy algorithm","level":2,"score":0.5055348873138428},{"id":"https://openalex.org/C98951983","wikidata":"https://www.wikidata.org/wiki/Q7604341","display_name":"Stationary distribution","level":3,"score":0.48816877603530884},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.4484538733959198},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.4161393642425537},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20078089833259583},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.1777125895023346},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.15521970391273499},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14168882369995117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09469062089920044},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-12-s10-s10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s10-s10","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S10-S10","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22165980","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22165980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/180234","is_oa":false,"landing_page_url":"https://hdl.handle.net/1969.1/180234","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:pubmedcentral.nih.gov:3236832","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3236832","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-s10-s10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s10-s10","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S10-S10","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118179630.pdf","grobid_xml":"https://content.openalex.org/works/W2118179630.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W51833465","https://openalex.org/W1680219837","https://openalex.org/W1980138510","https://openalex.org/W2030387392","https://openalex.org/W2031100365","https://openalex.org/W2077895748","https://openalex.org/W2086150890","https://openalex.org/W2098432798","https://openalex.org/W2098669780","https://openalex.org/W2104862630","https://openalex.org/W2106034845","https://openalex.org/W2107040525","https://openalex.org/W2108020239","https://openalex.org/W2113305236","https://openalex.org/W2115350121","https://openalex.org/W2121782762","https://openalex.org/W2129842602","https://openalex.org/W2132775962","https://openalex.org/W2133851381","https://openalex.org/W2137324353","https://openalex.org/W2138888747","https://openalex.org/W2159638256","https://openalex.org/W2160220288","https://openalex.org/W2160533336","https://openalex.org/W2160904474","https://openalex.org/W2165350808","https://openalex.org/W2169765391","https://openalex.org/W2752885492","https://openalex.org/W3145128584","https://openalex.org/W4242024146","https://openalex.org/W4388252848"],"related_works":["https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W1531601525","https://openalex.org/W2380602987","https://openalex.org/W2389640906","https://openalex.org/W4312077400"],"abstract_inverted_index":{"The":[0],"newly":[1],"proposed":[2],"CoD-CP":[3],"provides":[4],"an":[5,24],"attractive":[6],"alternative":[7],"for":[8],"intervening":[9],"large":[10],"networks":[11],"where":[12],"other":[13],"available":[14],"greedy":[15],"methods":[16],"require":[17],"size":[18],"reduction":[19],"on":[20],"the":[21],"network":[22],"and":[23],"extra":[25],"induction":[26],"step":[27],"before":[28],"designing":[29],"a":[30],"control":[31],"policy.":[32]},"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}