{"id":"https://openalex.org/W2142856425","doi":"https://doi.org/10.1186/1471-2105-12-s1-s36","title":"Integrated metabolome and transcriptome analysis of the NCI60 dataset","display_name":"Integrated metabolome and transcriptome analysis of the NCI60 dataset","publication_year":2011,"publication_date":"2011-02-15","ids":{"openalex":"https://openalex.org/W2142856425","doi":"https://doi.org/10.1186/1471-2105-12-s1-s36","mag":"2142856425","pmid":"https://pubmed.ncbi.nlm.nih.gov/21342567"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-s1-s36","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s1-s36","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S1-S36","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S1-S36","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105527581","display_name":"Gang Su","orcid":null},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gang Su","raw_affiliation_strings":["Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA. sugang@umich.edu","Bioinformatics Program, University of Michigan, Ann Arbor, MI, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA. sugang@umich.edu","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Bioinformatics Program, University of Michigan, Ann Arbor, MI, 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054894697","display_name":"Charles Burant","orcid":"https://orcid.org/0000-0001-9189-5003"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles F Burant","raw_affiliation_strings":["University of Michigan Medical School, University of Michigan, Ann Arbor, MI, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical School, University of Michigan, Ann Arbor, MI, 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001180013","display_name":"Chris Beecher","orcid":"https://orcid.org/0000-0003-4934-7278"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher W Beecher","raw_affiliation_strings":["Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brian D Athey","orcid":null},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian D Athey","raw_affiliation_strings":["National Center for Integrative Biomedical Informatics, University of Michigan, Ann Arbor, MI, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Integrative Biomedical Informatics, University of Michigan, Ann Arbor, MI, 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108018249","display_name":"Fan Meng","orcid":"https://orcid.org/0000-0001-8002-0615"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Meng","raw_affiliation_strings":["National Center for Integrative Biomedical Informatics, University of Michigan, Ann Arbor, MI 48109, USA","National Center for Integrative Biomedical Informatics, University of Michigan, Ann Arbor, MI, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Integrative Biomedical Informatics, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"National Center for Integrative Biomedical Informatics, University of Michigan, Ann Arbor, MI, 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5105527581"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.9732,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.74344567,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"S1","first_page":"S36","last_page":"S36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.855400025844574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.855400025844574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolome","display_name":"Metabolome","score":0.9803573489189148},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.861258864402771},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.708620548248291},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6793995499610901},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.619377076625824},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.5443333387374878},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4365711510181427},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.41532906889915466},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.41103723645210266},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3799787759780884},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33236202597618103},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30636370182037354},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.23579800128936768},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.13641566038131714},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06255882978439331}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.9803573489189148},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.861258864402771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.708620548248291},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6793995499610901},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.619377076625824},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5443333387374878},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4365711510181427},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.41532906889915466},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.41103723645210266},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3799787759780884},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33236202597618103},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30636370182037354},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23579800128936768},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.13641566038131714},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06255882978439331}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-12-s1-s36","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s1-s36","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S1-S36","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21342567","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21342567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/112946","is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/112946","pdf_url":"https://hdl.handle.net/2027.42/112946","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3044292","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3044292","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-s1-s36","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s1-s36","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S1-S36","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2142856425.pdf","grobid_xml":"https://content.openalex.org/works/W2142856425.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1578104218","https://openalex.org/W1844182321","https://openalex.org/W1968747399","https://openalex.org/W2075283200","https://openalex.org/W2092741708","https://openalex.org/W2094658693","https://openalex.org/W2102006623","https://openalex.org/W2122683221","https://openalex.org/W2125697820","https://openalex.org/W2135827569","https://openalex.org/W2145829756","https://openalex.org/W2153056550","https://openalex.org/W2163841023","https://openalex.org/W2169487163"],"related_works":["https://openalex.org/W1996644818","https://openalex.org/W1965468642","https://openalex.org/W2093500216","https://openalex.org/W2053588008","https://openalex.org/W2916376502","https://openalex.org/W2260452057","https://openalex.org/W3101161779","https://openalex.org/W423371831","https://openalex.org/W2777729175","https://openalex.org/W4295779760"],"abstract_inverted_index":{"BACKGROUND:":[0],"Metabolite":[1],"profiles":[2,72],"can":[3,201],"be":[4,202],"used":[5],"for":[6,46,73,232],"identifying":[7,82],"molecular":[8,59,91,157,234,269],"signatures":[9],"and":[10,25,69,85,88,127,135,151,209,225],"mechanisms":[11],"underlying":[12,61,236,271],"diseases":[13],"since":[14],"they":[15],"reflect":[16],"the":[17,48,58,74,79,107,165,214,242,250,256,266],"outcome":[18],"of":[19,30,50,67,81,103,244,258,268],"complex":[20],"upstream":[21],"genomic,":[22],"transcriptomic,":[23],"proteomic":[24],"environmental":[26],"events.":[27],"The":[28,65],"scarcity":[29],"publicly":[31],"accessible":[32],"large":[33,245],"scale":[34,246],"metabolome":[35,84,134,167,224,247],"datasets":[36],"related":[37,93],"to":[38,94,111,154,205],"human":[39],"disease":[40],"has":[41],"been":[42],"a":[43,101,229],"major":[44],"obstacle":[45],"assessing":[47],"potential":[49],"metabolites":[51],"as":[52,54,56,147,149],"biomarkers":[53],"well":[55,148],"understanding":[57,233,267],"events":[60],"disease-related":[62],"metabolic":[63,113,144],"changes.":[64],"availability":[66,243],"metabolite":[68],"gene":[70,207],"expression":[71],"NCI-60":[75,166],"cell":[76,118,130,216],"lines":[77,119,131],"offers":[78],"possibility":[80],"significant":[83],"transcriptome":[86,136,175,226],"features":[87,114],"discovering":[89],"unique":[90],"processes":[92],"different":[95,121],"cancer":[96,117],"types.":[97],"METHODS:":[98],"We":[99,184,240],"utilized":[100],"combination":[102],"analytical":[104],"methods":[105],"in":[106,213,249,263],"R":[108],"statistical":[109],"package":[110],"evaluate":[112],"associated":[115,156],"with":[116,143,173],"from":[120],"tissue":[122,180],"origins,":[123],"identify":[124],"metabolite-gene":[125],"correlations":[126],"detect":[128],"outliers":[129],"based":[132],"on":[133],"data.":[137],"Statistical":[138],"analysis":[139,161,227],"results":[140,220],"are":[141],"integrated":[142],"pathway":[145],"annotations":[146],"COSMIC":[150],"Tumorscape":[152],"databases":[153],"explore":[155],"mechanisms.":[158],"RESULTS:":[159],"Our":[160,219],"reveals":[162],"that":[163,222],"although":[164],"dataset":[168],"is":[169,228],"quite":[170],"noisy":[171],"comparing":[172],"microarray-based":[174],"data,":[176],"it":[177],"does":[178],"contain":[179],"origin":[181],"specific":[182],"signatures.":[183],"also":[185],"identified":[186,197],"biologically":[187],"meaningful":[188],"gene-metabolite":[189,195],"associations.":[190],"Most":[191],"remarkably,":[192],"several":[193],"abnormal":[194],"relationships":[196],"by":[198],"our":[199],"approach":[200],"directly":[203],"linked":[204],"known":[206],"mutations":[208],"copy":[210],"number":[211],"variations":[212],"corresponding":[215],"lines.":[217],"CONCLUSIONS:":[218],"suggest":[221],"integrative":[223],"powerful":[230],"method":[231],"machinery":[235],"various":[237],"pathophysiological":[238],"processes.":[239],"expect":[241],"data":[248],"coming":[251],"years":[252],"will":[253,262],"significantly":[254],"promote":[255],"discovery":[257],"novel":[259],"biomarkers,":[260],"which":[261],"turn":[264],"improve":[265],"mechanism":[270],"diseases.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}