{"id":"https://openalex.org/W2133640207","doi":"https://doi.org/10.1186/1471-2105-12-s1-s17","title":"A genetic algorithm-based boolean delay model of intracellular signal transduction in inflammation","display_name":"A genetic algorithm-based boolean delay model of intracellular signal transduction in inflammation","publication_year":2011,"publication_date":"2011-02-15","ids":{"openalex":"https://openalex.org/W2133640207","doi":"https://doi.org/10.1186/1471-2105-12-s1-s17","mag":"2133640207","pmid":"https://pubmed.ncbi.nlm.nih.gov/21342546"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-s1-s17","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s1-s17","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S1-S17","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S1-S17","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111937780","display_name":"Chu Chun Kang","orcid":null},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chu Chun Kang","raw_affiliation_strings":["Department of Computer Science, National Tsing Hua University, Hsinchu, 30013 Taiwan, ROC. g9662584@oz.nthu.edu.tw","Department of Computer Science, National Tsing Hua University, Hsinchu, ROC#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, National Tsing Hua University, Hsinchu, 30013 Taiwan, ROC. g9662584@oz.nthu.edu.tw","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Department of Computer Science, National Tsing Hua University, Hsinchu, ROC#TAB#","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052901007","display_name":"Yung\u2010Jen Chuang","orcid":"https://orcid.org/0000-0002-6022-0107"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yung Jen Chuang","raw_affiliation_strings":["Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC","Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, ROC","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048065639","display_name":"Kai Che Tung","orcid":null},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kai Che Tung","raw_affiliation_strings":["Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC","Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, ROC","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076642115","display_name":"Chun\u2010Cheih Chao","orcid":"https://orcid.org/0000-0003-4108-2658"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chun Cheih Chao","raw_affiliation_strings":["Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC","Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, ROC","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101474162","display_name":"Chuan Yi Tang","orcid":"https://orcid.org/0000-0003-0729-1624"},"institutions":[{"id":"https://openalex.org/I177918364","display_name":"Providence University","ror":"https://ror.org/03fcpsq87","country_code":"TW","type":"education","lineage":["https://openalex.org/I177918364"]},{"id":"https://openalex.org/I196272386","display_name":"Providence College","ror":"https://ror.org/00rxpqe74","country_code":"US","type":"education","lineage":["https://openalex.org/I196272386"]},{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Chuan Yi Tang","raw_affiliation_strings":["Department of Computer Science and Information Engineering, Providence University, Taichung, 43301, Taiwan, ROC","Department of Computer Science, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC","Department of Computer Science and Information Engineering, Providence University, Taichung, ROC","Department of Computer Science, National Tsing Hua University, Hsinchu, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Information Engineering, Providence University, Taichung, 43301, Taiwan, ROC","institution_ids":["https://openalex.org/I177918364"]},{"raw_affiliation_string":"Department of Computer Science, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Department of Computer Science and Information Engineering, Providence University, Taichung, ROC","institution_ids":["https://openalex.org/I196272386"]},{"raw_affiliation_string":"Department of Computer Science, National Tsing Hua University, Hsinchu, ROC","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111937781","display_name":"Shih Chi Peng","orcid":null},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shih Chi Peng","raw_affiliation_strings":["Department of Computer Science, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC","Department of Computer Science, National Tsing Hua University, Hsinchu, ROC#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Department of Computer Science, National Tsing Hua University, Hsinchu, ROC#TAB#","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046832315","display_name":"David Shan\u2010Hill Wong","orcid":"https://orcid.org/0000-0001-8574-8234"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"David Shan Hill Wong","raw_affiliation_strings":["Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC","Department of Chemical Engineering, National Tsing-Hua University,Hsinchu,ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 30013, Taiwan, ROC","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"Department of Chemical Engineering, National Tsing-Hua University,Hsinchu,ROC","institution_ids":["https://openalex.org/I25846049"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5046832315","https://openalex.org/A5111937781"],"corresponding_institution_ids":["https://openalex.org/I25846049"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.3478,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.6762907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":"S1","first_page":"S17","last_page":"S17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.7389000058174133,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.7389000058174133,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.706389844417572},{"id":"https://openalex.org/keywords/boolean-network","display_name":"Boolean network","score":0.5601347088813782},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5104886293411255},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4918067753314972},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4613407254219055},{"id":"https://openalex.org/keywords/transduction","display_name":"Transduction (biophysics)","score":0.4190743863582611},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4125567376613617},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4071163237094879},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3786657452583313},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.29535913467407227},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.28850293159484863},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.25104403495788574},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.24473387002944946},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.19859090447425842},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14259925484657288},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.10695973038673401},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09102898836135864}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.706389844417572},{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.5601347088813782},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5104886293411255},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4918067753314972},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4613407254219055},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.4190743863582611},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4125567376613617},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4071163237094879},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3786657452583313},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.29535913467407227},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28850293159484863},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25104403495788574},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.24473387002944946},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19859090447425842},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14259925484657288},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.10695973038673401},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09102898836135864},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020239","descriptor_name":"Receptor Cross-Talk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020239","descriptor_name":"Receptor Cross-Talk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020239","descriptor_name":"Receptor Cross-Talk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2105-12-s1-s17","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s1-s17","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S1-S17","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21342546","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21342546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3044271","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3044271","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-s1-s17","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s1-s17","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S1-S17","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2133640207.pdf","grobid_xml":"https://content.openalex.org/works/W2133640207.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W9608450","https://openalex.org/W135888752","https://openalex.org/W1965913972","https://openalex.org/W1968461883","https://openalex.org/W1968519358","https://openalex.org/W1971224531","https://openalex.org/W2015761685","https://openalex.org/W2015789031","https://openalex.org/W2026932044","https://openalex.org/W2028569720","https://openalex.org/W2046282447","https://openalex.org/W2052549489","https://openalex.org/W2068878490","https://openalex.org/W2073136141","https://openalex.org/W2074097004","https://openalex.org/W2079829409","https://openalex.org/W2092755129","https://openalex.org/W2140053284","https://openalex.org/W2140540053","https://openalex.org/W2142601830","https://openalex.org/W2157565327","https://openalex.org/W2167334954","https://openalex.org/W2171835071"],"related_works":["https://openalex.org/W2890433954","https://openalex.org/W2053366384","https://openalex.org/W2167472940","https://openalex.org/W2622826586","https://openalex.org/W4246428841","https://openalex.org/W2369434682","https://openalex.org/W4280525841","https://openalex.org/W1981686597","https://openalex.org/W2966233672","https://openalex.org/W2332505650"],"abstract_inverted_index":{"BACKGROUND:":[0],"Signal":[1],"transduction":[2],"is":[3,36,62],"the":[4,30,56,94,104,117],"major":[5,38],"mechanism":[6],"through":[7],"which":[8],"cells":[9],"transmit":[10],"external":[11,21],"stimuli":[12,22,61],"to":[13,47,54,75,83,89,115],"evoke":[14],"intracellular":[15],"biochemical":[16],"responses.":[17,134],"Understanding":[18],"relationship":[19],"between":[20],"and":[23,51,86,96,128,147],"corresponding":[24],"cellular":[25,145],"responses,":[26],"as":[27,29],"well":[28],"subsequent":[31],"effects":[32],"on":[33,93,132,144],"downstream":[34],"genes,":[35],"a":[37,44,70],"challenge":[39],"in":[40],"systems":[41],"biology.":[42],"Thus,":[43],"systematic":[45],"approach":[46,136],"integrate":[48],"experimental":[49,130],"data":[50,131],"qualitative":[52],"knowledge":[53,124],"identify":[55],"physiological":[57],"consequences":[58],"of":[59,119],"environmental":[60],"needed.":[63],"RESULTS:":[64],"In":[65],"present":[66],"study,":[67],"we":[68],"employed":[69],"genetic":[71],"algorithm-based":[72],"Boolean":[73],"model":[74],"represent":[76],"NF-\u03baB":[77],"signaling":[78],"pathway.":[79],"We":[80,110],"were":[81,107],"able":[82],"capture":[84],"feedback":[85],"crosstalk":[87],"characteristics":[88],"enhance":[90],"our":[91],"understanding":[92],"acute":[95],"chronic":[97],"inflammatory":[98],"response.":[99],"Key":[100],"network":[101,126],"components":[102],"affecting":[103],"response":[105,121],"dynamics":[106],"identified.":[108],"CONCLUSIONS:":[109],"designed":[111],"an":[112],"effective":[113],"algorithm":[114],"elucidate":[116],"process":[118],"immune":[120],"using":[122],"comprehensive":[123],"about":[125],"structure":[127],"limited":[129],"dynamic":[133],"This":[135],"can":[137],"potentially":[138],"be":[139],"implemented":[140],"for":[141],"large-scale":[142],"analysis":[143],"processes":[146],"organism":[148],"behaviors.":[149]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-06-19T17:40:00.097472","created_date":"2025-10-10T00:00:00"}