{"id":"https://openalex.org/W2107583716","doi":"https://doi.org/10.1186/1471-2105-12-s1-s12","title":"An efficient algorithmic approach for mass spectrometry-based disulfide connectivity determination using multi-ion analysis","display_name":"An efficient algorithmic approach for mass spectrometry-based disulfide connectivity determination using multi-ion analysis","publication_year":2011,"publication_date":"2011-02-15","ids":{"openalex":"https://openalex.org/W2107583716","doi":"https://doi.org/10.1186/1471-2105-12-s1-s12","mag":"2107583716"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-s1-s12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s1-s12","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S1-S12","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S1-S12","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113567737","display_name":"William Murad","orcid":null},"institutions":[{"id":"https://openalex.org/I71838634","display_name":"San Francisco State University","ror":"https://ror.org/05ykr0121","country_code":"US","type":"education","lineage":["https://openalex.org/I71838634"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William Murad","raw_affiliation_strings":["Department of Computer Science, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA, 94132, USA","Department of Computer Science, San Francisco State University, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA, 94132, USA","institution_ids":["https://openalex.org/I71838634"]},{"raw_affiliation_string":"Department of Computer Science, San Francisco State University, San Francisco, USA","institution_ids":["https://openalex.org/I71838634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073550054","display_name":"Rahul Singh","orcid":"https://orcid.org/0000-0003-3900-4298"},"institutions":[{"id":"https://openalex.org/I71838634","display_name":"San Francisco State University","ror":"https://ror.org/05ykr0121","country_code":"US","type":"education","lineage":["https://openalex.org/I71838634"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahul Singh","raw_affiliation_strings":["Department of Computer Science, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA, 94132, USA","Department of Computer Science, San Francisco State University, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA, 94132, USA","institution_ids":["https://openalex.org/I71838634"]},{"raw_affiliation_string":"Department of Computer Science, San Francisco State University, San Francisco, USA","institution_ids":["https://openalex.org/I71838634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111901700","display_name":"Ten\u2010Yang Yen","orcid":null},"institutions":[{"id":"https://openalex.org/I71838634","display_name":"San Francisco State University","ror":"https://ror.org/05ykr0121","country_code":"US","type":"education","lineage":["https://openalex.org/I71838634"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ten-Yang Yen","raw_affiliation_strings":["Department of Chemistry and Biochemistry, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA, 94132, USA","Department of Chemistry and Biochemistry, San Francisco State University,San Francisco,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA, 94132, USA","institution_ids":["https://openalex.org/I71838634"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, San Francisco State University,San Francisco,USA","institution_ids":["https://openalex.org/I71838634"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113567737"],"corresponding_institution_ids":["https://openalex.org/I71838634"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.7747,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8327096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"12","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.628817081451416},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5600190758705139},{"id":"https://openalex.org/keywords/dissociation","display_name":"Dissociation (chemistry)","score":0.5526137351989746},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.5348179936408997},{"id":"https://openalex.org/keywords/collision-induced-dissociation","display_name":"Collision-induced dissociation","score":0.5166687965393066},{"id":"https://openalex.org/keywords/ion","display_name":"Ion","score":0.48736315965652466},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.44399189949035645},{"id":"https://openalex.org/keywords/matching","display_name":"Matching (statistics)","score":0.4425967335700989},{"id":"https://openalex.org/keywords/disulfide-bond","display_name":"Disulfide bond","score":0.43948984146118164},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.43565133213996887},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.4262147843837738},{"id":"https://openalex.org/keywords/fragmentation","display_name":"Fragmentation (computing)","score":0.4180065393447876},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"Tandem mass spectrometry","score":0.3588913679122925},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3535201847553253},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3221731185913086},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2867963910102844},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.17266690731048584},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1282787024974823},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10642349720001221},{"id":"https://openalex.org/keywords/physical-chemistry","display_name":"Physical chemistry","score":0.10373371839523315}],"concepts":[{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.628817081451416},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5600190758705139},{"id":"https://openalex.org/C102931765","wikidata":"https://www.wikidata.org/wiki/Q189673","display_name":"Dissociation (chemistry)","level":2,"score":0.5526137351989746},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5348179936408997},{"id":"https://openalex.org/C176107965","wikidata":"https://www.wikidata.org/wiki/Q3710336","display_name":"Collision-induced dissociation","level":4,"score":0.5166687965393066},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.48736315965652466},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.44399189949035645},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.4425967335700989},{"id":"https://openalex.org/C27256138","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide bond","level":2,"score":0.43948984146118164},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43565133213996887},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.4262147843837738},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.4180065393447876},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.3588913679122925},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3535201847553253},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3221731185913086},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2867963910102844},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.17266690731048584},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1282787024974823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10642349720001221},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.10373371839523315},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2105-12-s1-s12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s1-s12","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S1-S12","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:7b022e2787134b9bb39a3f9d8fc2f4fe","is_oa":false,"landing_page_url":"https://doaj.org/article/7b022e2787134b9bb39a3f9d8fc2f4fe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 12, Iss Suppl 1, p S12 (2011)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3044266","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3044266","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-s1-s12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-s1-s12","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-S1-S12","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2065233809","display_name":"CAREER: Designing Systems for Molecular Query-Retrieval and Molecular Informatics","funder_award_id":"0644418","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3704327303","display_name":null,"funder_award_id":"CHE-0619163","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G5686502598","display_name":"MRI:  Acquisition of an Liquid Chromatograph Mass Spectrometer to Enhance Research and Research Training Opportunities at San Francisco State University","funder_award_id":"0619163","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5986892838","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7392132443","display_name":null,"funder_award_id":"IIS-0644418","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107583716.pdf","grobid_xml":"https://content.openalex.org/works/W2107583716.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1498748326","https://openalex.org/W1533668030","https://openalex.org/W1841168618","https://openalex.org/W1999008391","https://openalex.org/W2020275421","https://openalex.org/W2027469236","https://openalex.org/W2045985536","https://openalex.org/W2072708496","https://openalex.org/W2073035613","https://openalex.org/W2074859966","https://openalex.org/W2078288344","https://openalex.org/W2079464577","https://openalex.org/W2080418501","https://openalex.org/W2090168101","https://openalex.org/W2091375086","https://openalex.org/W2097150498","https://openalex.org/W2112078820","https://openalex.org/W2120409251","https://openalex.org/W2159128192","https://openalex.org/W2163526800","https://openalex.org/W2167463986","https://openalex.org/W2323912248","https://openalex.org/W2470330810","https://openalex.org/W3145128584","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2034217269","https://openalex.org/W79082427","https://openalex.org/W2058796268","https://openalex.org/W3143930805","https://openalex.org/W2513843752","https://openalex.org/W1990469447","https://openalex.org/W1978384787","https://openalex.org/W1786732003","https://openalex.org/W1994248318","https://openalex.org/W4386116490"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Determining":[2],"the":[3,58,73,93,107,124,208,212,235,241,259,293,312,324,340,349,356],"disulfide":[4,221,237,272,345],"(S-S)":[5],"bond":[6,245,346],"pattern":[7,232],"in":[8,106,228,254,343,366],"a":[9,148,217,229,249],"protein":[10,35],"is":[11,57,246,329,355],"often":[12],"crucial":[13],"for":[14],"understanding":[15],"its":[16],"structure":[17],"and":[18,41,101,169,172,256,292,301,376],"function.":[19],"In":[20],"recent":[21],"research,":[22],"mass":[23],"spectrometry":[24],"(MS)":[25],"based":[26],"analysis":[27],"has":[28],"been":[29],"applied":[30],"to":[31,50,72,134,233,282,317],"this":[32,45,83,120,135,354,367],"problem":[33,136,368],"following":[34],"digestion":[36],"under":[37],"both":[38],"partial":[39],"reduction":[40],"non-reduction":[42],"conditions.":[43],"However,":[44],"paradigm":[46],"still":[47],"awaits":[48],"solutions":[49],"certain":[51,96],"algorithmic":[52,132,358],"problems":[53],"fundamental":[54],"amongst":[55],"which":[56,252],"efficient":[59],"matching":[60],"of":[61,66,76,95,126,207,240,258,275,290,295,339,351,379],"an":[62,131,191],"exponentially":[63],"growing":[64],"set":[65],"putative":[67],"S-S":[68],"bonded":[69],"structural":[70],"alternatives":[71],"large":[74],"amounts":[75],"experimental":[77],"spectrometric":[78],"data.":[79],"Current":[80],"methods":[81],"circumvent":[82],"challenge":[84],"primarily":[85],"through":[86],"simplifications,":[87],"such":[88,112,178],"as":[89,113,179,319],"by":[90,285],"assuming":[91],"only":[92,204],"occurrence":[94],"ion-types":[97],"(":[98,116,147],"b":[99,150,152,155],"-ions":[100],"y":[102,163,166],"-ions)":[103],"that":[104,137,360],"predominate":[105],"more":[108,183],"popular":[109],"dissociation":[110,115],"methods,":[111],"collision-induced":[114],"CID":[117],").":[118],"Unfortunately,":[119],"can":[121,361],"adversely":[122],"impact":[123],"quality":[125],"results.":[127,260,380],"Method":[128],"We":[129],"present":[130],"approach":[133,189],"can,":[138],"with":[139,174,196,216,248,308],"high":[140,218,286,377],"computational":[141],"efficiency,":[142],"analyze":[143],"multiple":[144,363],"ions":[145],"types":[146,365],",":[149,151,154,157,159,161,165,168],"o":[153,164],"*":[156,167],"c":[158],"x":[160],"y,":[162],"z":[170],")":[171],"deal":[173],"complex":[175],"bonding":[176,181,238,273],"topologies,":[177],"inter/intra":[180],"involving":[182],"than":[184,323],"two":[185],"peptides.":[186],"The":[187,262,303],"proposed":[188],"combines":[190],"approximation":[192],"algorithm-based":[193],"search":[194,209,296],"formulation":[195,202],"data":[197],"driven":[198],"parameter":[199],"estimation.":[200],"This":[201,335],"considers":[203],"those":[205],"regions":[206],"space":[210,297],"where":[211],"correct":[213],"solution":[214],"resides":[215],"likelihood.":[219],"Putative":[220],"bonds":[222],"thus":[223],"obtained":[224],"are":[225],"finally":[226],"combined":[227],"globally":[230],"consistent":[231],"yield":[234],"overall":[236],"topology":[239],"molecule.":[242],"Additionally,":[243],"each":[244],"associated":[247],"confidence":[250],"score,":[251],"aids":[253],"interpretation":[255],"assimilation":[257],"Results":[261],"method":[263,304],"was":[264,280,305,315],"tested":[265],"on":[266],"nine":[267],"different":[268],"eukaryotic":[269],"Glycosyltransferases":[270],"possessing":[271],"topologies":[274],"varying":[276],"complexity.":[277],"Its":[278],"performance":[279],"found":[281,316],"be":[283],"characterized":[284],"efficiency":[287],"(in":[288],"terms":[289],"time":[291,374],"fraction":[294],"considered),":[298],"sensitivity,":[299],"specificity,":[300],"accuracy.":[302],"also":[306],"compared":[307],"other":[309],"techniques":[310],"at":[311],"state-of-the-art.":[313],"It":[314],"perform":[318],"well":[320],"or":[321],"better":[322],"competing":[325],"techniques.":[326],"An":[327],"implementation":[328],"available":[330],"at:":[331],"http://tintin.sfsu.edu/~whemurad/disulfidebond":[332],".":[333],"Conclusions":[334],"research":[336],"addresses":[337],"some":[338],"significant":[341],"challenges":[342],"MS-based":[344],"determination.":[347],"To":[348],"best":[350],"our":[352],"knowledge,":[353],"first":[357],"work":[359],"consider":[362],"ion":[364],"setting":[369],"while":[370],"simultaneously":[371],"ensuring":[372],"polynomial":[373],"complexity":[375],"accuracy":[378]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2016-06-24T00:00:00"}