{"id":"https://openalex.org/W2104330120","doi":"https://doi.org/10.1186/1471-2105-12-62","title":"Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas","display_name":"Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas","publication_year":2011,"publication_date":"2011-02-25","ids":{"openalex":"https://openalex.org/W2104330120","doi":"https://doi.org/10.1186/1471-2105-12-62","mag":"2104330120","pmid":"https://pubmed.ncbi.nlm.nih.gov/21352540"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-62","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-62","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-62","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-62","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065367138","display_name":"Jonathon T. Hill","orcid":"https://orcid.org/0000-0003-1190-6302"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathon T Hill","raw_affiliation_strings":["Department of Genetics and Development, Columbia University, New York, NY 10032, USA","Department of Genetics and Development,  Columbia University, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Development, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Genetics and Development,  Columbia University, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043931801","display_name":"Keith R. Anderson","orcid":"https://orcid.org/0000-0001-8713-4965"},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith R Anderson","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, University of Colorado at Denver and Health Sciences Center, Aurora, CO, 80045, USA","Department of Biochemistry and Molecular Genetics, University of Colorado at Denver and Health Sciences Center, Aurora, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Colorado at Denver and Health Sciences Center, Aurora, CO, 80045, USA","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Colorado at Denver and Health Sciences Center, Aurora, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063732167","display_name":"Teresa L. Mastracci","orcid":"https://orcid.org/0000-0003-1956-1951"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa L Mastracci","raw_affiliation_strings":["Department of Genetics and Development, Columbia University, New York, NY, 10032, USA","Department of Genetics and Development,  Columbia University, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Development, Columbia University, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Genetics and Development,  Columbia University, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012746992","display_name":"Klaus H. Kaestner","orcid":"https://orcid.org/0000-0002-1228-021X"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Klaus H Kaestner","raw_affiliation_strings":["Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA, 19104, USA","Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074669984","display_name":"Lori Sussel","orcid":"https://orcid.org/0000-0003-4672-7304"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lori Sussel","raw_affiliation_strings":["Department of Genetics and Development, Columbia University, New York, NY, 10032, USA","Department of Genetics and Development,  Columbia University, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Development, Columbia University, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Genetics and Development,  Columbia University, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5074669984"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.7791,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.85120637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":"1","first_page":"62","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9222999811172485,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9222999811172485,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.7146223783493042},{"id":"https://openalex.org/keywords/dna-binding-site","display_name":"DNA binding site","score":0.6743602752685547},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6733914017677307},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.6351186037063599},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5544261932373047},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5507104992866516},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.5093077421188354},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4783996343612671},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4639344811439514},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3802372217178345},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.18578311800956726}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7146223783493042},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.6743602752685547},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6733914017677307},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.6351186037063599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5544261932373047},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5507104992866516},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5093077421188354},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4783996343612671},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4639344811439514},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3802372217178345},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18578311800956726}],"mesh":[{"descriptor_ui":"D000090322","descriptor_name":"Homeobox Protein Nkx-2.2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090322","descriptor_name":"Homeobox Protein Nkx-2.2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090322","descriptor_name":"Homeobox Protein Nkx-2.2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-12-62","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-62","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-62","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21352540","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21352540","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:370b6ddc998f41fc812dfd4eff7cdade","is_oa":true,"landing_page_url":"https://doaj.org/article/370b6ddc998f41fc812dfd4eff7cdade","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 12, Iss 1, p 62 (2011)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3050729","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3050729","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-62","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-62","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-62","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1719859641","display_name":null,"funder_award_id":"U01 DK072504","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2439435313","display_name":null,"funder_award_id":"DK07328","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3007523300","display_name":null,"funder_award_id":"T32 DK07328","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4939517961","display_name":null,"funder_award_id":"R01 DK082590","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6937056040","display_name":null,"funder_award_id":"R01 DK082590","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8288036582","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2104330120.pdf","grobid_xml":"https://content.openalex.org/works/W2104330120.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1536291417","https://openalex.org/W1980253661","https://openalex.org/W1982942261","https://openalex.org/W1987536328","https://openalex.org/W1994122295","https://openalex.org/W2006735433","https://openalex.org/W2012455440","https://openalex.org/W2013449615","https://openalex.org/W2015396348","https://openalex.org/W2041422237","https://openalex.org/W2042392223","https://openalex.org/W2061057966","https://openalex.org/W2062494105","https://openalex.org/W2070194051","https://openalex.org/W2070630477","https://openalex.org/W2071753700","https://openalex.org/W2080152736","https://openalex.org/W2093489239","https://openalex.org/W2105355645","https://openalex.org/W2107134966","https://openalex.org/W2112019511","https://openalex.org/W2112717966","https://openalex.org/W2119437780","https://openalex.org/W2125182057","https://openalex.org/W2125810118","https://openalex.org/W2127593441","https://openalex.org/W2128345282","https://openalex.org/W2129795133","https://openalex.org/W2137914783","https://openalex.org/W2141354959","https://openalex.org/W2141408320","https://openalex.org/W2146393977","https://openalex.org/W2149769193","https://openalex.org/W2154056136","https://openalex.org/W2159883877","https://openalex.org/W2161849959","https://openalex.org/W2164814636","https://openalex.org/W2171019508"],"related_works":["https://openalex.org/W2036927633","https://openalex.org/W2146517458","https://openalex.org/W2153561273","https://openalex.org/W2152664145","https://openalex.org/W2079197459","https://openalex.org/W2379997263","https://openalex.org/W2165899269","https://openalex.org/W2236968607","https://openalex.org/W4233525429","https://openalex.org/W2131580913"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"creation":[2,226],"of":[3,8,38,94,121,171,227,230],"a":[4,65,91],"complete":[5],"genome-wide":[6,228],"map":[7],"transcription":[9,34,69,111,231],"factor":[10,35,70,112,232],"binding":[11,47,71,83,104,138,166,201,217,233],"sites":[12,72,105,124,167,202,218],"is":[13,210],"essential":[14,108],"for":[15,67,106,203,214,224],"understanding":[16],"gene":[17],"regulatory":[18],"networks":[19],"in":[20,73,114,168],"vivo.":[21],"However,":[22],"current":[23],"prediction":[24,40,58],"methods":[25,41],"generally":[26],"rely":[27,52],"on":[28,45,53],"statistical":[29],"models":[30,55],"that":[31,42,161,181,192],"imperfectly":[32],"model":[33],"binding.":[36],"Generation":[37],"new":[39],"are":[43],"based":[44,142],"protein":[46,82],"data,":[48],"but":[49],"do":[50],"not":[51,183],"these":[54],"may":[56,220],"improve":[57],"sensitivity":[59],"and":[60,89,118,127,179,219],"specificity.":[61],"RESULTS:":[62],"We":[63,144],"propose":[64],"method":[66,133,163,213],"predicting":[68,215],"the":[74,87,107,115,122,154,169,193,204,225],"genome":[75,88,117],"by":[76,125,153,185],"directly":[77],"mapping":[78],"data":[79],"generated":[80,130],"from":[81,131],"microarrays":[84],"(PBM)":[85],"to":[86,199],"calculating":[90],"moving":[92],"average":[93],"several":[95],"overlapping":[96],"octamers.":[97],"Using":[98],"this":[99,132,162],"unique":[100],"algorithm,":[101],"we":[102,158,189],"predicted":[103,136,184],"pancreatic":[109,174],"islet":[110,175],"Nkx2.2":[113,155,216],"mouse":[116],"confirmed":[119],">90%":[120],"tested":[123],"EMSA":[126],"ChIP.":[128],"Scores":[129],"more":[134],"accurately":[135],"relative":[137],"affinity":[139],"than":[140],"PWM":[141],"methods.":[143,187],"have":[145,159],"also":[146,196],"identified":[147,165],"an":[148,211],"alternative":[149],"core":[150],"sequence":[151],"recognized":[152],"homeodomain.":[156],"Furthermore,":[157],"shown":[160],"correctly":[164],"promoters":[170],"two":[172],"critical":[173],"\u03b2-cell":[176],"genes,":[177],"NeuroD1":[178],"insulin2,":[180],"were":[182],"traditional":[186],"Finally,":[188],"show":[190],"evidence":[191],"algorithm":[194],"can":[195],"be":[197,221],"applied":[198],"predict":[200],"nuclear":[205],"receptor":[206],"Hnf4\u03b1.":[207],"CONCLUSIONS:":[208],"PBM-mapping":[209],"accurate":[212],"widely":[222],"applicable":[223],"maps":[229],"sites.":[234]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}