{"id":"https://openalex.org/W2092182190","doi":"https://doi.org/10.1186/1471-2105-12-43","title":"DoBo: Protein domain boundary prediction by integrating evolutionary signals and machine learning","display_name":"DoBo: Protein domain boundary prediction by integrating evolutionary signals and machine learning","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W2092182190","doi":"https://doi.org/10.1186/1471-2105-12-43","mag":"2092182190","pmid":"https://pubmed.ncbi.nlm.nih.gov/21284866"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-43","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-43","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-43","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-43","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033383597","display_name":"Jesse Eickholt","orcid":"https://orcid.org/0000-0002-1764-1838"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse Eickholt","raw_affiliation_strings":["Department of Computer Science, University of Missouri, Columbia, MO 65211, USA","Department of Computer Science , University of Missouri, Columbia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Missouri, Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Computer Science , University of Missouri, Columbia, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650157","display_name":"Xin Deng","orcid":"https://orcid.org/0000-0003-1257-694X"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Deng","raw_affiliation_strings":["Department of Computer Science, University of Missouri, Columbia, MO, 65211, USA","Department of Computer Science , University of Missouri, Columbia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Missouri, Columbia, MO, 65211, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Computer Science , University of Missouri, Columbia, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044354277","display_name":"Jianlin Cheng","orcid":"https://orcid.org/0000-0003-0305-2853"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jianlin Cheng","raw_affiliation_strings":["C. Bond Life Science Center, University of Missouri, Columbia, MO, 65211, USA","Department of Computer Science, University of Missouri, Columbia, MO, 65211, USA","Informatics Institute, University of Missouri, Columbia, MO, 65211, USA","Informatics Institute, University of Missouri, Columbia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. Bond Life Science Center, University of Missouri, Columbia, MO, 65211, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Computer Science, University of Missouri, Columbia, MO, 65211, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Informatics Institute, University of Missouri, Columbia, MO, 65211, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Informatics Institute, University of Missouri, Columbia, USA","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5044354277"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.7299,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.84149525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"43","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9287999868392944,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9287999868392944,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.7678447961807251},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.6786324977874756},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6516032218933105},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.6491429805755615},{"id":"https://openalex.org/keywords/precision-and-recall","display_name":"Precision and recall","score":0.6311421394348145},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6012739539146423},{"id":"https://openalex.org/keywords/boundary","display_name":"Boundary (topology)","score":0.57591712474823},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5666965842247009},{"id":"https://openalex.org/keywords/decision-boundary","display_name":"Decision boundary","score":0.5512814521789551},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5356786847114563},{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.4785652458667755},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.467048317193985},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.42419230937957764},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.39073213934898376},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18376260995864868},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18252113461494446},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13663551211357117}],"concepts":[{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.7678447961807251},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.6786324977874756},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6516032218933105},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.6491429805755615},{"id":"https://openalex.org/C81669768","wikidata":"https://www.wikidata.org/wiki/Q2359161","display_name":"Precision and recall","level":2,"score":0.6311421394348145},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6012739539146423},{"id":"https://openalex.org/C62354387","wikidata":"https://www.wikidata.org/wiki/Q875399","display_name":"Boundary (topology)","level":2,"score":0.57591712474823},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5666965842247009},{"id":"https://openalex.org/C42023084","wikidata":"https://www.wikidata.org/wiki/Q5249231","display_name":"Decision boundary","level":3,"score":0.5512814521789551},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5356786847114563},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.4785652458667755},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.467048317193985},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.42419230937957764},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.39073213934898376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18376260995864868},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18252113461494446},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13663551211357117},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-12-43","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-43","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-43","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21284866","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21284866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:d3dfbd4474bc40d8ab58e2f9a8238eae","is_oa":true,"landing_page_url":"https://doaj.org/article/d3dfbd4474bc40d8ab58e2f9a8238eae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 12, Iss 1, p 43 (2011)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3036623","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3036623","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-43","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-43","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-43","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.6700000166893005}],"awards":[{"id":"https://openalex.org/G4400813460","display_name":null,"funder_award_id":"1R01GM093123","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7060844078","display_name":null,"funder_award_id":"1R01GM093123","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2092182190.pdf","grobid_xml":"https://content.openalex.org/works/W2092182190.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W353011834","https://openalex.org/W1574862351","https://openalex.org/W1604938182","https://openalex.org/W1968035630","https://openalex.org/W1973491891","https://openalex.org/W1978012062","https://openalex.org/W1979602468","https://openalex.org/W1987468852","https://openalex.org/W2002990906","https://openalex.org/W2027446338","https://openalex.org/W2031903428","https://openalex.org/W2035278976","https://openalex.org/W2041589571","https://openalex.org/W2049690299","https://openalex.org/W2054629535","https://openalex.org/W2055118532","https://openalex.org/W2055193239","https://openalex.org/W2056536050","https://openalex.org/W2062233253","https://openalex.org/W2073785345","https://openalex.org/W2077515504","https://openalex.org/W2085277871","https://openalex.org/W2096495474","https://openalex.org/W2097932035","https://openalex.org/W2102588875","https://openalex.org/W2108067237","https://openalex.org/W2110949039","https://openalex.org/W2116160060","https://openalex.org/W2116827999","https://openalex.org/W2122300808","https://openalex.org/W2125501682","https://openalex.org/W2128899444","https://openalex.org/W2129834345","https://openalex.org/W2130792460","https://openalex.org/W2133828198","https://openalex.org/W2134353698","https://openalex.org/W2135385301","https://openalex.org/W2138953240","https://openalex.org/W2140628140","https://openalex.org/W2141885858","https://openalex.org/W2149548330","https://openalex.org/W2155144535","https://openalex.org/W2155479906","https://openalex.org/W2156909104","https://openalex.org/W2158714788","https://openalex.org/W2159596810","https://openalex.org/W2160649303","https://openalex.org/W2162381238","https://openalex.org/W4210400672","https://openalex.org/W6611933094"],"related_works":["https://openalex.org/W2378211422","https://openalex.org/W4321353415","https://openalex.org/W2745001401","https://openalex.org/W2130974462","https://openalex.org/W2028665553","https://openalex.org/W2086519370","https://openalex.org/W184442817","https://openalex.org/W2009611918","https://openalex.org/W2814966788","https://openalex.org/W1983643426"],"abstract_inverted_index":{"BACKGROUND:":[0],"Accurate":[1],"identification":[2],"of":[3,41,123,133,173],"protein":[4,10,17,49,55,191],"domain":[5,18,56,64,116,125,156,175],"boundaries":[6,19,126],"is":[7,23,198],"useful":[8,188],"for":[9,190],"structure":[11,192],"determination":[12,193],"and":[13,27,76,85,107,121,140,170,181,194],"prediction.":[14,58],"However,":[15],"predicting":[16],"from":[20,67],"a":[21,33,68,73,115,131,187],"sequence":[22,70,75,98],"still":[24],"very":[25],"challenging":[26],"largely":[28],"unsolved.":[29],"RESULTS:":[30],"We":[31],"developed":[32],"new":[34],"method":[35,60,111,186,197],"to":[36,53,146],"integrate":[37],"the":[38,105,138,155,161,171],"classification":[39],"power":[40],"machine":[42],"learning":[43],"with":[44,93],"evolutionary":[45],"signals":[46,66],"embedded":[47],"in":[48,51,91],"families":[50],"order":[52],"improve":[54],"boundary":[57,65,157,176],"The":[59,79,110,135,166,196],"first":[61],"extracts":[62],"putative":[63,80],"multiple":[69],"alignment":[71],"between":[72,137],"query":[74],"its":[77],"homologs.":[78],"sites":[81,106,177],"are":[82],"then":[83],"classified":[84],"scored":[86],"by":[87,118,149,160],"support":[88,162],"vector":[89,163],"machines":[90],"conjunction":[92],"input":[94],"features":[95],"such":[96],"as":[97],"profiles,":[99],"secondary":[100],"structures,":[101],"solvent":[102],"accessibilities":[103],"around":[104],"their":[108],"positions.":[109],"was":[112],"evaluated":[113],"on":[114,154],"benchmark":[117],"10-fold":[119],"cross-validation":[120],"60%":[122],"true":[124],"can":[127,142],"be":[128,143],"recalled":[129],"at":[130,178,200],"precision":[132,139,180],"60%.":[134],"trade-off":[136],"recall":[141,182],"adjusted":[144],"according":[145],"specific":[147],"needs":[148],"using":[150],"different":[151,179],"decision":[152],"thresholds":[153],"scores":[158],"assigned":[159],"machines.":[164],"CONCLUSIONS:":[165],"good":[167],"prediction":[168],"accuracy":[169],"flexibility":[172],"selecting":[174],"values":[183],"make":[184],"our":[185],"tool":[189],"modelling.":[195],"available":[199],"http://sysbio.rnet.missouri.edu/dobo/.":[201]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}