{"id":"https://openalex.org/W2124688822","doi":"https://doi.org/10.1186/1471-2105-12-386","title":"Cross-validated stepwise regression for identification of novel non-nucleoside reverse transcriptase inhibitor resistance associated mutations","display_name":"Cross-validated stepwise regression for identification of novel non-nucleoside reverse transcriptase inhibitor resistance associated mutations","publication_year":2011,"publication_date":"2011-10-03","ids":{"openalex":"https://openalex.org/W2124688822","doi":"https://doi.org/10.1186/1471-2105-12-386","mag":"2124688822","pmid":"https://pubmed.ncbi.nlm.nih.gov/21966893"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-386","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-386","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-386","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-386","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108111797","display_name":"Koen Van der Borght","orcid":null},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Koen Van der Borght","raw_affiliation_strings":["Tibotec-Virco, Beerse, Belgium. kvdborgh@its.jnj.com","Tibotec-Virco, Beerse, Belgium","I-Biostat, Katholieke Universiteit Leuven and Universiteit Hasselt, , Belgium"],"affiliations":[{"raw_affiliation_string":"Tibotec-Virco, Beerse, Belgium. kvdborgh@its.jnj.com","institution_ids":[]},{"raw_affiliation_string":"Tibotec-Virco, Beerse, Belgium","institution_ids":[]},{"raw_affiliation_string":"I-Biostat, Katholieke Universiteit Leuven and Universiteit Hasselt, , Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075594468","display_name":"Elke Van Craenenbroeck","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elke Van Craenenbroeck","raw_affiliation_strings":["Tibotec-Virco, Beerse, Belgium"],"affiliations":[{"raw_affiliation_string":"Tibotec-Virco, Beerse, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003672837","display_name":"Pierre Lecocq","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Lecocq","raw_affiliation_strings":["Tibotec-Virco, Beerse, Belgium"],"affiliations":[{"raw_affiliation_string":"Tibotec-Virco, Beerse, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112027462","display_name":"Margriet Van Houtte","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margriet Van Houtte","raw_affiliation_strings":["Tibotec-Virco, Beerse, Belgium"],"affiliations":[{"raw_affiliation_string":"Tibotec-Virco, Beerse, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001511313","display_name":"Barbara Van Kerckhove","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Van Kerckhove","raw_affiliation_strings":["Tibotec-Virco, Beerse, Belgium"],"affiliations":[{"raw_affiliation_string":"Tibotec-Virco, Beerse, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078740089","display_name":"Lee T. Bacheler","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lee Bacheler","raw_affiliation_strings":["VircoLab Inc, Chapel Hill, NC, USA","VircoLab Inc, Chapel Hill, USA"],"affiliations":[{"raw_affiliation_string":"VircoLab Inc, Chapel Hill, NC, USA","institution_ids":[]},{"raw_affiliation_string":"VircoLab Inc, Chapel Hill, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012712033","display_name":"Geert Verbeke","orcid":"https://orcid.org/0000-0001-8430-7576"},"institutions":[{"id":"https://openalex.org/I878454856","display_name":"Hasselt University","ror":"https://ror.org/04nbhqj75","country_code":"BE","type":"education","lineage":["https://openalex.org/I878454856"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Geert Verbeke","raw_affiliation_strings":["I-Biostat, Katholieke Universiteit Leuven and Universiteit Hasselt, Belgium","I-Biostat; Katholieke Universiteit Leuven and Universiteit Hasselt; Belgium"],"affiliations":[{"raw_affiliation_string":"I-Biostat, Katholieke Universiteit Leuven and Universiteit Hasselt, Belgium","institution_ids":["https://openalex.org/I878454856","https://openalex.org/I99464096"]},{"raw_affiliation_string":"I-Biostat; Katholieke Universiteit Leuven and Universiteit Hasselt; Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015253529","display_name":"Herman van Vlijmen","orcid":"https://orcid.org/0000-0002-1915-3141"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herman van Vlijmen","raw_affiliation_strings":["Tibotec-Virco, Beerse, Belgium"],"affiliations":[{"raw_affiliation_string":"Tibotec-Virco, Beerse, Belgium","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5108111797"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.6298,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.67750887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"386","last_page":"386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitor","display_name":"Nucleoside Reverse Transcriptase Inhibitor","score":0.6433216333389282},{"id":"https://openalex.org/keywords/reverse-transcriptase","display_name":"Reverse transcriptase","score":0.618628978729248},{"id":"https://openalex.org/keywords/reverse-transcriptase-inhibitor","display_name":"Reverse-transcriptase inhibitor","score":0.551862895488739},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.5384089946746826},{"id":"https://openalex.org/keywords/etravirine","display_name":"Etravirine","score":0.526447594165802},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.5208442807197571},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47482213377952576},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44161728024482727},{"id":"https://openalex.org/keywords/linear-regression","display_name":"Linear regression","score":0.43480274081230164},{"id":"https://openalex.org/keywords/hiv-drug-resistance","display_name":"HIV drug resistance","score":0.4119383692741394},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3720186948776245},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.2022354006767273},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19766971468925476},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.16954305768013},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"Antiretroviral therapy","score":0.13273799419403076},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.1312292218208313},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.128233402967453},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.10892289876937866}],"concepts":[{"id":"https://openalex.org/C2909970146","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Nucleoside Reverse Transcriptase Inhibitor","level":5,"score":0.6433216333389282},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.618628978729248},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.551862895488739},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.5384089946746826},{"id":"https://openalex.org/C2780345285","wikidata":"https://www.wikidata.org/wiki/Q414762","display_name":"Etravirine","level":5,"score":0.526447594165802},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5208442807197571},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47482213377952576},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44161728024482727},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.43480274081230164},{"id":"https://openalex.org/C2778451633","wikidata":"https://www.wikidata.org/wiki/Q5629934","display_name":"HIV drug resistance","level":5,"score":0.4119383692741394},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3720186948776245},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2022354006767273},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19766971468925476},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16954305768013},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.13273799419403076},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.1312292218208313},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.128233402967453},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.10892289876937866}],"mesh":[{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-12-386","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-386","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-386","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21966893","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21966893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:e120d6aa42ff443ea34dfe65615bc603","is_oa":true,"landing_page_url":"https://doaj.org/article/e120d6aa42ff443ea34dfe65615bc603","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 12, Iss 1, p 386 (2011)","raw_type":"article"},{"id":"pmh:oai:documentserver.uhasselt.be:1942/12330","is_oa":true,"landing_page_url":"http://hdl.handle.net/1942/12330","pdf_url":null,"source":{"id":"https://openalex.org/S4306401926","display_name":"Document Server@UHasselt (UHasselt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I878454856","host_organization_name":"Hasselt University","host_organization_lineage":["https://openalex.org/I878454856"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3223907","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3223907","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-386","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-386","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-386","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124688822.pdf","grobid_xml":"https://content.openalex.org/works/W2124688822.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W55384331","https://openalex.org/W1480376833","https://openalex.org/W1491468287","https://openalex.org/W1496518737","https://openalex.org/W1565138467","https://openalex.org/W1978954330","https://openalex.org/W1989692384","https://openalex.org/W1994753827","https://openalex.org/W1995945562","https://openalex.org/W2016568689","https://openalex.org/W2033694908","https://openalex.org/W2033872649","https://openalex.org/W2053570554","https://openalex.org/W2074877586","https://openalex.org/W2082744016","https://openalex.org/W2087730348","https://openalex.org/W2120830682","https://openalex.org/W2128685318","https://openalex.org/W2132365525","https://openalex.org/W2134713579","https://openalex.org/W2142635246","https://openalex.org/W2143684265","https://openalex.org/W2158325103","https://openalex.org/W2162041430","https://openalex.org/W2168175751","https://openalex.org/W2170181617","https://openalex.org/W2797563284","https://openalex.org/W2911949936","https://openalex.org/W2912934387","https://openalex.org/W3146425672","https://openalex.org/W3149745985","https://openalex.org/W4291114417","https://openalex.org/W4400191782"],"related_works":["https://openalex.org/W1807651963","https://openalex.org/W4239744013","https://openalex.org/W2388389329","https://openalex.org/W1659667976","https://openalex.org/W1969043670","https://openalex.org/W2051938714","https://openalex.org/W4318070645","https://openalex.org/W1976163006","https://openalex.org/W178069510","https://openalex.org/W2018114381"],"abstract_inverted_index":{"We":[0],"successfully":[1],"identified":[2],"and":[3,37],"validated":[4],"novel":[5],"NNRTI":[6],"resistance":[7,13],"associated":[8],"mutations":[9],"by":[10],"developing":[11],"parsimonious":[12],"prediction":[14],"models":[15],"in":[16],"which":[17],"repeated":[18],"cross-validation":[19],"within":[20],"the":[21,42],"stepwise":[22],"regression":[23],"was":[24],"applied.":[25],"Our":[26],"model":[27],"selection":[28],"technique":[29],"is":[30],"computationally":[31],"feasible":[32],"for":[33],"large":[34],"data":[35],"sets":[36],"provides":[38],"an":[39],"approach":[40],"to":[41],"continued":[43],"identification":[44],"of":[45],"resistance-causing":[46],"mutations.":[47]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}