{"id":"https://openalex.org/W2081172987","doi":"https://doi.org/10.1186/1471-2105-12-370","title":"Toponomics method for the automated quantification of membrane protein translocation","display_name":"Toponomics method for the automated quantification of membrane protein translocation","publication_year":2011,"publication_date":"2011-09-19","ids":{"openalex":"https://openalex.org/W2081172987","doi":"https://doi.org/10.1186/1471-2105-12-370","mag":"2081172987","pmid":"https://pubmed.ncbi.nlm.nih.gov/21929784"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-370","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-370","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-370","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-370","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031898606","display_name":"Olga Domanova","orcid":null},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]},{"id":"https://openalex.org/I4210164149","display_name":"Bonn Aachen International Center for Information Technology","ror":"https://ror.org/054zhq066","country_code":"DE","type":"facility","lineage":["https://openalex.org/I135140700","https://openalex.org/I155417937","https://openalex.org/I4210164149","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I4210110507","display_name":"Fraunhofer Institute for Applied Information Technology","ror":"https://ror.org/01ak24c12","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210110507","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Olga Domanova","raw_affiliation_strings":["Fraunhofer Institute for Applied Information Technology FIT, Schloss Birlinghoven, Sankt Augustin, Germany. olga.domanova@gmail.com","RWTH Aachen University, Information Systems Group (Informatik 5), Aachen, Germany","Fraunhofer Institute for Applied Information Technology FIT, Schloss Birlinghoven, Sankt Augustin, Germany","Bonn-Aachen International Center for Information Technology B-IT, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Applied Information Technology FIT, Schloss Birlinghoven, Sankt Augustin, Germany. olga.domanova@gmail.com","institution_ids":["https://openalex.org/I4210110507"]},{"raw_affiliation_string":"RWTH Aachen University, Information Systems Group (Informatik 5), Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Fraunhofer Institute for Applied Information Technology FIT, Schloss Birlinghoven, Sankt Augustin, Germany","institution_ids":["https://openalex.org/I4210110507"]},{"raw_affiliation_string":"Bonn-Aachen International Center for Information Technology B-IT, Bonn, Germany","institution_ids":["https://openalex.org/I4210164149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011575502","display_name":"Stefan Borbe","orcid":null},"institutions":[{"id":"https://openalex.org/I4210110507","display_name":"Fraunhofer Institute for Applied Information Technology","ror":"https://ror.org/01ak24c12","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210110507","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Borbe","raw_affiliation_strings":["Fraunhofer Institute for Applied Information Technology FIT, Schloss Birlinghoven, Sankt Augustin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Applied Information Technology FIT, Schloss Birlinghoven, Sankt Augustin, Germany","institution_ids":["https://openalex.org/I4210110507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032896434","display_name":"Stefanie M\u00fchlfeld","orcid":null},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie M\u00fchlfeld","raw_affiliation_strings":["Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, Moorenstr. 5, D\u00fcsseldorf, Germany","Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, Moorenstr. 5, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038989124","display_name":"Martin Becker","orcid":"https://orcid.org/0000-0002-1751-1056"},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Becker","raw_affiliation_strings":["Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, Moorenstr. 5, D\u00fcsseldorf, Germany","Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, Moorenstr. 5, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032077120","display_name":"Ralf Kubitz","orcid":null},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Kubitz","raw_affiliation_strings":["Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, Moorenstr. 5, D\u00fcsseldorf, Germany","Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, Moorenstr. 5, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008452332","display_name":"Dieter H\u00e4ussinger","orcid":"https://orcid.org/0000-0002-5936-682X"},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter H\u00e4ussinger","raw_affiliation_strings":["Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, Moorenstr. 5, D\u00fcsseldorf, Germany","Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, Moorenstr. 5, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Heinrich-Heine University of D\u00fcsseldorf, Medical Faculty, Department of Gastroenterology, Hepatology and Infectiology, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062530306","display_name":"Thomas Berlage","orcid":null},"institutions":[{"id":"https://openalex.org/I4210164149","display_name":"Bonn Aachen International Center for Information Technology","ror":"https://ror.org/054zhq066","country_code":"DE","type":"facility","lineage":["https://openalex.org/I135140700","https://openalex.org/I155417937","https://openalex.org/I4210164149","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I4210110507","display_name":"Fraunhofer Institute for Applied Information Technology","ror":"https://ror.org/01ak24c12","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210110507","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Berlage","raw_affiliation_strings":["Bonn-Aachen International Center for Information Technology B-IT, Dahlmannstra\u00dfe 2, Bonn, Germany","Fraunhofer Institute for Applied Information Technology FIT, Schloss Birlinghoven, Sankt Augustin, Germany","RWTH Aachen University, Information Systems Group (Informatik 5), Ahornstra\u00dfe 55, Aachen, Germany","Bonn-Aachen International Center for Information Technology B-IT, Bonn, Germany","RWTH Aachen University, Information Systems Group (Informatik 5), Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bonn-Aachen International Center for Information Technology B-IT, Dahlmannstra\u00dfe 2, Bonn, Germany","institution_ids":["https://openalex.org/I4210164149"]},{"raw_affiliation_string":"Fraunhofer Institute for Applied Information Technology FIT, Schloss Birlinghoven, Sankt Augustin, Germany","institution_ids":["https://openalex.org/I4210110507"]},{"raw_affiliation_string":"RWTH Aachen University, Information Systems Group (Informatik 5), Ahornstra\u00dfe 55, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Bonn-Aachen International Center for Information Technology B-IT, Bonn, Germany","institution_ids":["https://openalex.org/I4210164149"]},{"raw_affiliation_string":"RWTH Aachen University, Information Systems Group (Informatik 5), Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5031898606"],"corresponding_institution_ids":["https://openalex.org/I4210110507","https://openalex.org/I4210164149","https://openalex.org/I887968799"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.3991,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.62832149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"12","issue":"1","first_page":"370","last_page":"370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.883400022983551,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.883400022983551,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5956257581710815},{"id":"https://openalex.org/keywords/automated-method","display_name":"Automated method","score":0.54462730884552},{"id":"https://openalex.org/keywords/reproducibility","display_name":"Reproducibility","score":0.4891114830970764},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47476673126220703},{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.42164134979248047},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.38792628049850464},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.37532898783683777},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3260413110256195},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3037438988685608},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2544657588005066},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.22576266527175903},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12655171751976013}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5956257581710815},{"id":"https://openalex.org/C3019060180","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automated method","level":2,"score":0.54462730884552},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.4891114830970764},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47476673126220703},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.42164134979248047},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38792628049850464},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.37532898783683777},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3260413110256195},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3037438988685608},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2544657588005066},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.22576266527175903},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12655171751976013},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003720","descriptor_name":"Densitometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003720","descriptor_name":"Densitometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003720","descriptor_name":"Densitometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-12-370","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-370","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-370","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21929784","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21929784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:ac088a53fd8d4423bed9afde9eed502e","is_oa":false,"landing_page_url":"https://doaj.org/article/ac088a53fd8d4423bed9afde9eed502e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 12, Iss 1, p 370 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2240117","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3230911","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:publica.fraunhofer.de:publica/226726","is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/226726","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:publications.rwth-aachen.de:192299","is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/record/192299","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC bioinformatics 12, 370 (2011). doi:10.1186/1471-2105-12-370","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-370","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-370","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-370","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.699999988079071,"id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G5467488073","display_name":null,"funder_award_id":"KFO 217","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2081172987.pdf","grobid_xml":"https://content.openalex.org/works/W2081172987.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W138651633","https://openalex.org/W633766847","https://openalex.org/W1561442812","https://openalex.org/W1570448133","https://openalex.org/W1969420116","https://openalex.org/W1989068154","https://openalex.org/W1991652499","https://openalex.org/W1992739395","https://openalex.org/W1994191775","https://openalex.org/W2003535921","https://openalex.org/W2008392372","https://openalex.org/W2010588449","https://openalex.org/W2028013465","https://openalex.org/W2044465660","https://openalex.org/W2047834789","https://openalex.org/W2051242307","https://openalex.org/W2059432853","https://openalex.org/W2061569374","https://openalex.org/W2070347161","https://openalex.org/W2073476191","https://openalex.org/W2076435408","https://openalex.org/W2078846638","https://openalex.org/W2086210233","https://openalex.org/W2091888562","https://openalex.org/W2112684736","https://openalex.org/W2121011070","https://openalex.org/W2126777639","https://openalex.org/W2130513366","https://openalex.org/W2131075172","https://openalex.org/W2137783427","https://openalex.org/W2169982896","https://openalex.org/W2475506025","https://openalex.org/W2505399031","https://openalex.org/W2826711317","https://openalex.org/W2914094842","https://openalex.org/W4241239920","https://openalex.org/W4243154030","https://openalex.org/W4249037079"],"related_works":["https://openalex.org/W2413717610","https://openalex.org/W1973270181","https://openalex.org/W2417696084","https://openalex.org/W2368782778","https://openalex.org/W2087830269","https://openalex.org/W3106281778","https://openalex.org/W2003643616","https://openalex.org/W638612878","https://openalex.org/W4324138256","https://openalex.org/W2156260160"],"abstract_inverted_index":{"BACKGROUND:":[0],"Intra-cellular":[1],"and":[2,24,33,91,142,159,176,182,224],"inter-cellular":[3],"protein":[4,154],"translocation":[5,56,87,212],"can":[6,218],"be":[7,197,219],"observed":[8],"by":[9,221],"microscopic":[10],"imaging":[11],"of":[12,57,88,102],"tissue":[13,51],"sections":[14,52],"prepared":[15],"immunohistochemically.":[16],"A":[17,168],"manual":[18,39,98,216],"densitometric":[19,113,140],"analysis":[20],"is":[21,29],"time-consuming,":[22],"subjective":[23],"error-prone.":[25],"An":[26,78],"automated":[27,42,79,170,226],"quantification":[28,80],"faster,":[30],"more":[31,198,201],"reproducible,":[32],"should":[34],"yield":[35],"results":[36],"comparable":[37],"to":[38,53,72,84,95,119,129,151,196],"evaluation.":[40],"The":[41,214],"method":[43,81],"presented":[44],"here":[45],"was":[46,70,82],"developed":[47,83,181],"on":[48],"rat":[49],"liver":[50,68],"study":[54],"the":[55,66,73,86,123,126,139,152,173,190,211,222],"bile":[58],"salt":[59],"transport":[60,153],"proteins":[61,90],"in":[62,93,108,206],"hepatocytes.":[63],"For":[64],"validation,":[65],"cholestatic":[67],"state":[69],"compared":[71,144],"normal":[74],"biological":[75],"state.":[76],"RESULTS:":[77],"analyze":[85],"membrane":[89,120,128],"evaluated":[92],"comparison":[94],"an":[96],"established":[97],"method.":[99,227],"Firstly,":[100],"regions":[101],"interest":[103],"(membrane":[104],"fragments)":[105],"are":[106,116],"identified":[107],"confocal":[109],"microscopy":[110],"images.":[111],"Further,":[112],"intensity":[114,191],"profiles":[115,141,193],"extracted":[117],"orthogonally":[118],"fragments,":[121],"following":[122],"direction":[124],"from":[125,138],"plasma":[127],"cytoplasm.":[130],"Finally,":[131],"several":[132,164],"different":[133],"quantitative":[134],"descriptors":[135,188],"were":[136,143,161,194],"derived":[137],"regarding":[145],"their":[146],"statistical":[147,177],"significance":[148],"with":[149],"respect":[150],"distribution.":[155],"Stable":[156],"performance,":[157],"robustness":[158],"reproducibility":[160],"tested":[162],"using":[163],"independent":[165],"experimental":[166],"datasets.":[167],"fully":[169],"workflow":[171],"for":[172,189,210],"information":[174],"extraction":[175],"evaluation":[178],"has":[179],"been":[180],"produces":[183],"robust":[184],"results.":[185],"CONCLUSIONS:":[186],"New":[187],"distribution":[192],"found":[195],"discriminative,":[199],"i.e.":[200],"significant,":[202],"than":[203],"those":[204],"used":[205],"previous":[207],"research":[208],"publications":[209],"quantification.":[213],"slow":[215],"calculation":[217],"substituted":[220],"fast":[223],"unbiased":[225]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
