{"id":"https://openalex.org/W2017757915","doi":"https://doi.org/10.1186/1471-2105-12-349","title":"Statistical methods for analyzing immunosignatures","display_name":"Statistical methods for analyzing immunosignatures","publication_year":2011,"publication_date":"2011-08-19","ids":{"openalex":"https://openalex.org/W2017757915","doi":"https://doi.org/10.1186/1471-2105-12-349","mag":"2017757915","pmid":"https://pubmed.ncbi.nlm.nih.gov/21854615"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-349","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-349","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-349","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-349","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018136532","display_name":"Justin R. Brown","orcid":"https://orcid.org/0000-0001-6351-3231"},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Justin R Brown","raw_affiliation_strings":["Department of Biomedical Informatics, Arizona State University, Mayo Clinic - Samuel C, Johnson Research Bldg, 13212 East Shea Boulevard, Scottsdale, AZ 85259, USA. jrbrown2@asu.edu","Department of Biomedical Informatics, Arizona State University, Mayo Clinic, Samuel C. Johnson Research Bldg., Scottsdale, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Arizona State University, Mayo Clinic - Samuel C, Johnson Research Bldg, 13212 East Shea Boulevard, Scottsdale, AZ 85259, USA. jrbrown2@asu.edu","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Arizona State University, Mayo Clinic, Samuel C. Johnson Research Bldg., Scottsdale, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073415783","display_name":"Phillip Stafford","orcid":"https://orcid.org/0000-0001-7989-9036"},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]},{"id":"https://openalex.org/I4210138309","display_name":"Center for Innovation","ror":"https://ror.org/04c1v2b17","country_code":"US","type":"facility","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089489","https://openalex.org/I4210138309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip Stafford","raw_affiliation_strings":["Arizona State University - Center for Innovations in Medicine, Biodesign Institute and School of Life Sciences, 727 E. Tyler St, Tempe, AZ, 85287, USA","Arizona State University - Center for Innovations in Medicine, Biodesign Institute and School of Life Sciences, Tempe, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University - Center for Innovations in Medicine, Biodesign Institute and School of Life Sciences, 727 E. Tyler St, Tempe, AZ, 85287, USA","institution_ids":["https://openalex.org/I4210138309","https://openalex.org/I55732556"]},{"raw_affiliation_string":"Arizona State University - Center for Innovations in Medicine, Biodesign Institute and School of Life Sciences, Tempe, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110954361","display_name":"Stephen Albert Johnston","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138309","display_name":"Center for Innovation","ror":"https://ror.org/04c1v2b17","country_code":"US","type":"facility","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210089489","https://openalex.org/I4210138309"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen A Johnston","raw_affiliation_strings":["Arizona State University - Center for Innovations in Medicine, Biodesign Institute and School of Life Sciences, 727 E. Tyler St, Tempe, AZ, 85287, USA","Arizona State University - Center for Innovations in Medicine, Biodesign Institute and School of Life Sciences, Tempe, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona State University - Center for Innovations in Medicine, Biodesign Institute and School of Life Sciences, 727 E. Tyler St, Tempe, AZ, 85287, USA","institution_ids":["https://openalex.org/I4210138309","https://openalex.org/I55732556"]},{"raw_affiliation_string":"Arizona State University - Center for Innovations in Medicine, Biodesign Institute and School of Life Sciences, Tempe, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027625472","display_name":"Valentin Dinu","orcid":"https://orcid.org/0000-0001-6192-7836"},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valentin Dinu","raw_affiliation_strings":["Department of Biomedical Informatics, Arizona State University, Mayo Clinic - Samuel C. Johnson Research Bldg, 13212 East Shea Boulevard, Scottsdale, AZ, 85259, USA","Department of Biomedical Informatics, Arizona State University, Mayo Clinic, Samuel C. Johnson Research Bldg., Scottsdale, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Arizona State University, Mayo Clinic - Samuel C. Johnson Research Bldg, 13212 East Shea Boulevard, Scottsdale, AZ, 85259, USA","institution_ids":["https://openalex.org/I4210125099","https://openalex.org/I55732556"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Arizona State University, Mayo Clinic, Samuel C. Johnson Research Bldg., Scottsdale, USA","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018136532"],"corresponding_institution_ids":["https://openalex.org/I4210125099","https://openalex.org/I55732556"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.5274,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.89502931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"349","last_page":"349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9725000262260437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9725000262260437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.6072285771369934},{"id":"https://openalex.org/keywords/structural-equation-modeling","display_name":"Structural equation modeling","score":0.5546765923500061},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5469515323638916},{"id":"https://openalex.org/keywords/latent-variable","display_name":"Latent variable","score":0.5448543429374695},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.5343598127365112},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.4722822606563568},{"id":"https://openalex.org/keywords/confirmatory-factor-analysis","display_name":"Confirmatory factor analysis","score":0.4466113746166229},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.40902644395828247},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3988122344017029},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3328491449356079},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2011914849281311},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.195692241191864}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6072285771369934},{"id":"https://openalex.org/C71104824","wikidata":"https://www.wikidata.org/wiki/Q1476639","display_name":"Structural equation modeling","level":2,"score":0.5546765923500061},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5469515323638916},{"id":"https://openalex.org/C51167844","wikidata":"https://www.wikidata.org/wiki/Q4422623","display_name":"Latent variable","level":2,"score":0.5448543429374695},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5343598127365112},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.4722822606563568},{"id":"https://openalex.org/C40722632","wikidata":"https://www.wikidata.org/wiki/Q5160137","display_name":"Confirmatory factor analysis","level":3,"score":0.4466113746166229},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.40902644395828247},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3988122344017029},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3328491449356079},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2011914849281311},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.195692241191864},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-12-349","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-349","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-349","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21854615","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21854615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:item:41918","is_oa":true,"landing_page_url":"http://hdl.handle.net/2286/R.I.41918","pdf_url":null,"source":{"id":"https://openalex.org/S4306400254","display_name":"Arizona State University Library Digital Repository (Arizona State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I55732556","host_organization_name":"Arizona State University","host_organization_lineage":["https://openalex.org/I55732556"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8107f279ed4e4e06adb5d33b8328da0c","is_oa":false,"landing_page_url":"https://doaj.org/article/8107f279ed4e4e06adb5d33b8328da0c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 12, Iss 1, p 349 (2011)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3175483","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3175483","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-349","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-349","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-349","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.47999998927116394,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309808","display_name":"Science Foundation Arizona","ror":"https://ror.org/05kjhj835"},{"id":"https://openalex.org/F4320332688","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771"},{"id":"https://openalex.org/F4320337890","display_name":"School of Medicine, University of California, Irvine","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017757915.pdf","grobid_xml":"https://content.openalex.org/works/W2017757915.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1554825545","https://openalex.org/W2013074264","https://openalex.org/W2020559219","https://openalex.org/W2034108143","https://openalex.org/W2059334100","https://openalex.org/W2125297253","https://openalex.org/W2133097426","https://openalex.org/W2160025866","https://openalex.org/W2163988453","https://openalex.org/W2494904642","https://openalex.org/W4298091299","https://openalex.org/W4299927410"],"related_works":["https://openalex.org/W2013493105","https://openalex.org/W4285213959","https://openalex.org/W2385721021","https://openalex.org/W126662069","https://openalex.org/W2904003081","https://openalex.org/W1965085721","https://openalex.org/W2110740376","https://openalex.org/W2509729113","https://openalex.org/W2734236000","https://openalex.org/W1973995187"],"abstract_inverted_index":{"BACKGROUND:":[0],"Immunosignaturing":[1],"is":[2,116],"a":[3,55,66,117,154,158,182],"new":[4,16,25],"peptide":[5],"microarray":[6],"based":[7,36,108],"technology":[8,120],"for":[9,121,149,161,185],"profiling":[10],"of":[11,58,65,68,83,126,190],"humoral":[12],"immune":[13],"responses.":[14],"Despite":[15],"challenges,":[17],"immunosignaturing":[18,115],"gives":[19],"us":[20],"the":[21,40,63],"opportunity":[22],"to":[23,33,51,71,105,133],"explore":[24],"and":[26,43,75,88,97,112,123,137,151,187],"fundamentally":[27],"different":[28],"research":[29],"questions.":[30],"In":[31,128],"addition":[32],"classifying":[34],"samples":[35,107],"on":[37,109,166],"disease":[38,110,150,191],"status,":[39],"complex":[41,135],"patterns":[42,136],"latent":[44,138,143],"factors":[45,139,144],"underlying":[46,140],"immunosignatures,":[47],"which":[48],"we":[49,130,169],"attempt":[50],"model,":[52],"may":[53,145,152,178],"have":[54],"diverse":[56],"range":[57],"applications.":[59],"METHODS:":[60],"We":[61,101],"investigate":[62],"utility":[64],"number":[67],"statistical":[69],"methods":[70,85],"determine":[72],"model":[73,134],"performance":[74],"address":[76],"challenges":[77],"inherent":[78],"in":[79,157],"analyzing":[80],"immunosignatures.":[81,141],"Some":[82],"these":[84],"include":[86],"exploratory":[87],"confirmatory":[89],"factor":[90],"analyses,":[91],"classical":[92],"significance":[93],"testing,":[94],"structural":[95],"equation":[96],"mixture":[98],"modeling.":[99],"RESULTS:":[100],"demonstrate":[102],"an":[103,172],"ability":[104],"classify":[106],"status":[111],"show":[113],"that":[114],"very":[118],"promising":[119],"screening":[122,125,186,189],"presymptomatic":[124,188],"disease.":[127],"addition,":[129],"are":[131],"able":[132],"These":[142],"serve":[146],"as":[147,181,192,194],"biomarkers":[148],"play":[153],"key":[155],"role":[156],"bioinformatic":[159],"method":[160,184],"antibody":[162,195],"discovery.":[163,196],"CONCLUSION:":[164],"Based":[165],"this":[167],"research,":[168],"lay":[170],"out":[171],"analytic":[173],"framework":[174],"illustrating":[175],"how":[176],"immunosignatures":[177],"be":[179],"useful":[180],"general":[183],"well":[193]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
