{"id":"https://openalex.org/W2122208633","doi":"https://doi.org/10.1186/1471-2105-12-314","title":"Open-target sparse sensing of biological agents using DNA microarray","display_name":"Open-target sparse sensing of biological agents using DNA microarray","publication_year":2011,"publication_date":"2011-07-29","ids":{"openalex":"https://openalex.org/W2122208633","doi":"https://doi.org/10.1186/1471-2105-12-314","mag":"2122208633","pmid":"https://pubmed.ncbi.nlm.nih.gov/21801424"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-314","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-314","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-314","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-314","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033322567","display_name":"Mojdeh Mohtashemi","orcid":null},"institutions":[{"id":"https://openalex.org/I44896327","display_name":"Mitre (United States)","ror":"https://ror.org/03ks2a131","country_code":"US","type":"company","lineage":["https://openalex.org/I44896327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mojdeh Mohtashemi","raw_affiliation_strings":["Emerging & Disruptive Technologies, The MITRE Corporation, McLean, Virginia, USA. mojdeh@mitre.org","MIT CSAIL, Cambridge, USA","Emerging & Disruptive Technologies, The MITRE Corporation, McLean, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emerging & Disruptive Technologies, The MITRE Corporation, McLean, Virginia, USA. mojdeh@mitre.org","institution_ids":["https://openalex.org/I44896327"]},{"raw_affiliation_string":"MIT CSAIL, Cambridge, USA","institution_ids":[]},{"raw_affiliation_string":"Emerging & Disruptive Technologies, The MITRE Corporation, McLean, USA","institution_ids":["https://openalex.org/I44896327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073185004","display_name":"David K. Walburger","orcid":null},"institutions":[{"id":"https://openalex.org/I44896327","display_name":"Mitre (United States)","ror":"https://ror.org/03ks2a131","country_code":"US","type":"company","lineage":["https://openalex.org/I44896327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David K Walburger","raw_affiliation_strings":["Emerging & Disruptive Technologies, The MITRE Corporation, McLean, Virginia, USA","Emerging & Disruptive Technologies, The MITRE Corporation, McLean, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emerging & Disruptive Technologies, The MITRE Corporation, McLean, Virginia, USA","institution_ids":["https://openalex.org/I44896327"]},{"raw_affiliation_string":"Emerging & Disruptive Technologies, The MITRE Corporation, McLean, USA","institution_ids":["https://openalex.org/I44896327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086629705","display_name":"Matthew Peterson","orcid":"https://orcid.org/0000-0003-4422-4463"},"institutions":[{"id":"https://openalex.org/I44896327","display_name":"Mitre (United States)","ror":"https://ror.org/03ks2a131","country_code":"US","type":"company","lineage":["https://openalex.org/I44896327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew W Peterson","raw_affiliation_strings":["Emerging & Disruptive Technologies, The MITRE Corporation, McLean, Virginia, USA","Emerging & Disruptive Technologies, The MITRE Corporation, McLean, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emerging & Disruptive Technologies, The MITRE Corporation, McLean, Virginia, USA","institution_ids":["https://openalex.org/I44896327"]},{"raw_affiliation_string":"Emerging & Disruptive Technologies, The MITRE Corporation, McLean, USA","institution_ids":["https://openalex.org/I44896327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025010356","display_name":"Felicia N. Sutton","orcid":null},"institutions":[{"id":"https://openalex.org/I44896327","display_name":"Mitre (United States)","ror":"https://ror.org/03ks2a131","country_code":"US","type":"company","lineage":["https://openalex.org/I44896327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Felicia N Sutton","raw_affiliation_strings":["Emerging & Disruptive Technologies, The MITRE Corporation, McLean, Virginia, USA","Emerging & Disruptive Technologies, The MITRE Corporation, McLean, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emerging & Disruptive Technologies, The MITRE Corporation, McLean, Virginia, USA","institution_ids":["https://openalex.org/I44896327"]},{"raw_affiliation_string":"Emerging & Disruptive Technologies, The MITRE Corporation, McLean, USA","institution_ids":["https://openalex.org/I44896327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027315920","display_name":"Haley B. Skaer","orcid":null},"institutions":[{"id":"https://openalex.org/I44896327","display_name":"Mitre (United States)","ror":"https://ror.org/03ks2a131","country_code":"US","type":"company","lineage":["https://openalex.org/I44896327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haley B Skaer","raw_affiliation_strings":["Emerging & Disruptive Technologies, The MITRE Corporation, McLean, Virginia, USA","Emerging & Disruptive Technologies, The MITRE Corporation, McLean, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emerging & Disruptive Technologies, The MITRE Corporation, McLean, Virginia, USA","institution_ids":["https://openalex.org/I44896327"]},{"raw_affiliation_string":"Emerging & Disruptive Technologies, The MITRE Corporation, McLean, USA","institution_ids":["https://openalex.org/I44896327"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026946614","display_name":"James Diggans","orcid":"https://orcid.org/0000-0003-3871-2380"},"institutions":[{"id":"https://openalex.org/I44896327","display_name":"Mitre (United States)","ror":"https://ror.org/03ks2a131","country_code":"US","type":"company","lineage":["https://openalex.org/I44896327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C Diggans","raw_affiliation_strings":["Emerging & Disruptive Technologies, The MITRE Corporation, McLean, Virginia, USA","Emerging & Disruptive Technologies, The MITRE Corporation, McLean, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emerging & Disruptive Technologies, The MITRE Corporation, McLean, Virginia, USA","institution_ids":["https://openalex.org/I44896327"]},{"raw_affiliation_string":"Emerging & Disruptive Technologies, The MITRE Corporation, McLean, USA","institution_ids":["https://openalex.org/I44896327"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.12787725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"12","issue":"1","first_page":"314","last_page":"314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7278000116348267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7278000116348267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.15240000188350677,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.7336980104446411},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6244087219238281},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5124831199645996},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5057823657989502},{"id":"https://openalex.org/keywords/oligonucleotide","display_name":"Oligonucleotide","score":0.4646358788013458},{"id":"https://openalex.org/keywords/partial-least-squares-regression","display_name":"Partial least squares regression","score":0.4582686722278595},{"id":"https://openalex.org/keywords/false-positive-rate","display_name":"False positive rate","score":0.44215330481529236},{"id":"https://openalex.org/keywords/replicate","display_name":"Replicate","score":0.41701897978782654},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3279784917831421},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.31615149974823},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.25048285722732544},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1898956596851349},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.14576229453086853},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10890725255012512},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.09751477837562561},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.08450064063072205}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.7336980104446411},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6244087219238281},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5124831199645996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5057823657989502},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.4646358788013458},{"id":"https://openalex.org/C22354355","wikidata":"https://www.wikidata.org/wiki/Q422009","display_name":"Partial least squares regression","level":2,"score":0.4582686722278595},{"id":"https://openalex.org/C95922358","wikidata":"https://www.wikidata.org/wiki/Q5432725","display_name":"False positive rate","level":2,"score":0.44215330481529236},{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.41701897978782654},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3279784917831421},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.31615149974823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25048285722732544},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1898956596851349},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14576229453086853},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10890725255012512},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.09751477837562561},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.08450064063072205},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-12-314","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-314","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-314","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21801424","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21801424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:a363a4ce9a914f9680af06ca8b5abadb","is_oa":false,"landing_page_url":"https://doaj.org/article/a363a4ce9a914f9680af06ca8b5abadb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 12, Iss 1, p 314 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2165556","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3161048","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-314","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-314","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-314","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2122208633.pdf","grobid_xml":"https://content.openalex.org/works/W2122208633.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1499500424","https://openalex.org/W1529531571","https://openalex.org/W1533335653","https://openalex.org/W1546952499","https://openalex.org/W1576737979","https://openalex.org/W1920924307","https://openalex.org/W1966673696","https://openalex.org/W1970926544","https://openalex.org/W1971402995","https://openalex.org/W1976251851","https://openalex.org/W1990937720","https://openalex.org/W2011485152","https://openalex.org/W2029401821","https://openalex.org/W2034780522","https://openalex.org/W2073722866","https://openalex.org/W2075715210","https://openalex.org/W2082967074","https://openalex.org/W2091065275","https://openalex.org/W2104342875","https://openalex.org/W2119346362","https://openalex.org/W2119667497","https://openalex.org/W2122082071","https://openalex.org/W2122548617","https://openalex.org/W2123138987","https://openalex.org/W2145096794","https://openalex.org/W2148101811","https://openalex.org/W2155152726","https://openalex.org/W2162075284","https://openalex.org/W2164452299","https://openalex.org/W2296616510","https://openalex.org/W2400250419","https://openalex.org/W3148116038","https://openalex.org/W3211343847","https://openalex.org/W4241876622","https://openalex.org/W4247187964","https://openalex.org/W4250955649"],"related_works":["https://openalex.org/W2041540252","https://openalex.org/W2138580185","https://openalex.org/W2415545834","https://openalex.org/W3203113381","https://openalex.org/W2366558827","https://openalex.org/W170658859","https://openalex.org/W4232333928","https://openalex.org/W1594655861","https://openalex.org/W2089975163","https://openalex.org/W4233699124"],"abstract_inverted_index":{"BACKGROUND:":[0],"Current":[1],"biosensors":[2],"are":[3,30],"designed":[4],"to":[5,9,35,117,166,179,228,258,274,297],"target":[6],"and":[7,41,230,262,288],"react":[8],"specific":[10],"nucleic":[11],"acid":[12],"sequences":[13,91],"or":[14],"structural":[15],"epitopes.":[16],"These":[17],"'target-specific'":[18],"platforms":[19],"require":[20],"creation":[21],"of":[22,50,68,74,82,98,121,140,176,184,194,199,242,246,265,278,303],"new":[23,28,295],"physical":[24],"capture":[25,55,180,266,275],"reagents":[26],"when":[27],"organisms":[29,75,88,124,143,203,248],"targeted.":[31],"An":[32],"'open-target'":[33,226],"approach":[34,227,296],"DNA":[36,90,238],"microarray":[37,48,100,239,270],"biosensing":[38,298],"is":[39,240],"proposed":[40],"substantiated":[42],"using":[43,78,208],"laboratory":[44,259],"generated":[45,260],"data.":[46],"The":[47,188],"consisted":[49],"12,900":[51,130],"25":[52],"bp":[53],"oligonucleotide":[54],"probes":[56,131,177,211],"derived":[57],"from":[58],"a":[59,79,155,173,233,254],"statistical":[60],"model":[61,106,135,191,256],"trained":[62],"on":[63,108],"randomly":[64],"selected":[65],"genomic":[66],"segments":[67],"pathogenic":[69],"prokaryotic":[70],"organisms.":[71,187],"Open-target":[72],"detection":[73,190],"was":[76,115,163,192,272,291],"accomplished":[77],"reference":[80],"library":[81],"hybridization":[83,182],"patterns":[84],"for":[85,172],"three":[86,122,141,201],"test":[87,123,142,186,202],"whose":[89],"were":[92,132],"not":[93],"included":[94],"in":[95,125,144,204,249,281],"the":[96,99,109,119,134,138,169,181,185,197,200,244,268,276,301],"design":[97],"probes.":[101],"RESULTS:":[102],"A":[103,160],"multivariate":[104],"mathematical":[105,255],"based":[107],"partial":[110],"least":[111],"squares":[112],"regression":[113],"(PLSR)":[114],"developed":[116,165],"detect":[118],"presence":[120,198,245],"mixed":[126,146,206,250,283],"samples.":[127,251],"When":[128],"all":[129,145,205,282],"used,":[133],"correctly":[136,195],"detected":[137],"signature":[139,277],"samples":[147,207,284],"(mean(R\u00b2))":[148,212],"=":[149,152,213,216],"0.76,":[150],"CI":[151,215],"0.95),":[153],"with":[154,218,253,285],"6%":[156],"false":[157],"positive":[158],"rate.":[159],"sampling":[161,264],"algorithm":[162],"then":[164],"sparsely":[167],"sample":[168],"probe":[170],"space":[171],"minimal":[174],"number":[175],"required":[178],"imprints":[183],"PLSR":[189],"capable":[193,241],"identifying":[196,243],"only":[209],"47":[210],"0.77,":[214],"0.95)":[217],"nearly":[219],"100%":[220],"specificity.":[221,289],"CONCLUSIONS:":[222],"We":[223],"conceived":[224],"an":[225],"biosensing,":[229],"hypothesized":[231],"that":[232,293],"relatively":[234],"small,":[235],"non-specifically":[236],"designed,":[237],"multiple":[247],"Coupled":[252],"applied":[257],"data,":[261],"sparse":[263,304],"probes,":[267],"prototype":[269],"platform":[271],"able":[273],"each":[279],"organism":[280],"high":[286],"sensitivity":[287],"It":[290],"demonstrated":[292],"this":[294],"closely":[299],"follows":[300],"principles":[302],"sensing.":[305]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}