{"id":"https://openalex.org/W2135588164","doi":"https://doi.org/10.1186/1471-2105-12-268","title":"New words in human mutagenesis","display_name":"New words in human mutagenesis","publication_year":2011,"publication_date":"2011-06-30","ids":{"openalex":"https://openalex.org/W2135588164","doi":"https://doi.org/10.1186/1471-2105-12-268","mag":"2135588164","pmid":"https://pubmed.ncbi.nlm.nih.gov/21718472"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-268","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-268","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-268","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-268","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038592787","display_name":"Alexander Y. Panchin","orcid":"https://orcid.org/0000-0002-3422-6564"},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210107660","display_name":"Institute for Information Transmission Problems","ror":"https://ror.org/013w2d378","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210107660"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alexander Y Panchin","raw_affiliation_strings":["Department of Bioengineering and Bioinformatics, Moscow State University, Vorbyevy Gory 1-73, Moscow, 119992, Russian Federation. alexpanchin@yahoo.com","Department of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russian Federation","Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Bioinformatics, Moscow State University, Vorbyevy Gory 1-73, Moscow, 119992, Russian Federation. alexpanchin@yahoo.com","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Department of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russian Federation","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210107660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083946667","display_name":"Sergey I. Mitrofanov","orcid":"https://orcid.org/0000-0003-0358-0568"},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergey I Mitrofanov","raw_affiliation_strings":["Department of Bioengineering and Bioinformatics, Moscow State University, Vorbyevy Gory 1-73, Moscow, 119992, Russian Federation","Department of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Bioinformatics, Moscow State University, Vorbyevy Gory 1-73, Moscow, 119992, Russian Federation","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Department of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russian Federation","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056758947","display_name":"Andrei V. Alexeevski","orcid":"https://orcid.org/0000-0001-7939-9939"},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210121062","display_name":"Research Institute for System Studies","ror":"https://ror.org/02smvmz76","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121062"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Andrei V Alexeevski","raw_affiliation_strings":["Department of Mathematical Methods in Biology, Belozersky Institute, Moscow State University, Vorbyevy Gory 1-40, Moscow, 119991, Russian Federation","Department of Mathematics, Scientific-Research Institute for System Studies, Russian Academy of Sciences, Nakhimovskii prospekt 36-1, Moscow, 117218, Russian Federation","Department of Mathematical Methods in Biology, Belozersky Institute, Moscow State University, Moscow, Russian Federation","Department of Mathematics, Scientific-Research Institute for System Studies, Russian Academy of Sciences, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Methods in Biology, Belozersky Institute, Moscow State University, Vorbyevy Gory 1-40, Moscow, 119991, Russian Federation","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Department of Mathematics, Scientific-Research Institute for System Studies, Russian Academy of Sciences, Nakhimovskii prospekt 36-1, Moscow, 117218, Russian Federation","institution_ids":["https://openalex.org/I4210121062"]},{"raw_affiliation_string":"Department of Mathematical Methods in Biology, Belozersky Institute, Moscow State University, Moscow, Russian Federation","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Department of Mathematics, Scientific-Research Institute for System Studies, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076136987","display_name":"Sergey Spirin","orcid":"https://orcid.org/0000-0002-8041-1808"},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210121062","display_name":"Research Institute for System Studies","ror":"https://ror.org/02smvmz76","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121062"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergey A Spirin","raw_affiliation_strings":["Department of Mathematical Methods in Biology, Belozersky Institute, Moscow State University, Vorbyevy Gory 1-40, Moscow, 119991, Russian Federation","Department of Mathematics, Scientific-Research Institute for System Studies, Russian Academy of Sciences, Nakhimovskii prospekt 36-1, Moscow, 117218, Russian Federation","Department of Mathematical Methods in Biology, Belozersky Institute, Moscow State University, Moscow, Russian Federation","Department of Mathematics, Scientific-Research Institute for System Studies, Russian Academy of Sciences, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Methods in Biology, Belozersky Institute, Moscow State University, Vorbyevy Gory 1-40, Moscow, 119991, Russian Federation","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Department of Mathematics, Scientific-Research Institute for System Studies, Russian Academy of Sciences, Nakhimovskii prospekt 36-1, Moscow, 117218, Russian Federation","institution_ids":["https://openalex.org/I4210121062"]},{"raw_affiliation_string":"Department of Mathematical Methods in Biology, Belozersky Institute, Moscow State University, Moscow, Russian Federation","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Department of Mathematics, Scientific-Research Institute for System Studies, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074005874","display_name":"Yuri V. Panchin","orcid":"https://orcid.org/0000-0002-8006-2839"},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210107660","display_name":"Institute for Information Transmission Problems","ror":"https://ror.org/013w2d378","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210107660"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yuri V Panchin","raw_affiliation_strings":["Department of Mathematical Methods in Biology, Belozersky Institute, Moscow State University, Vorbyevy Gory 1-40, Moscow, 119991, Russian Federation","Institute for Information Transmission Problems, Russian Academy of Sciences, Bolshoi Karetny pereulok 19-1, Moscow, 127994, Russian Federation","Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russian Federation","Department of Mathematical Methods in Biology, Belozersky Institute, Moscow State University, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Methods in Biology, Belozersky Institute, Moscow State University, Vorbyevy Gory 1-40, Moscow, 119991, Russian Federation","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Institute for Information Transmission Problems, Russian Academy of Sciences, Bolshoi Karetny pereulok 19-1, Moscow, 127994, Russian Federation","institution_ids":["https://openalex.org/I4210107660"]},{"raw_affiliation_string":"Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210107660"]},{"raw_affiliation_string":"Department of Mathematical Methods in Biology, Belozersky Institute, Moscow State University, Moscow, Russian Federation","institution_ids":["https://openalex.org/I19880235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5038592787"],"corresponding_institution_ids":["https://openalex.org/I19880235","https://openalex.org/I4210107660"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.1883,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.80969419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"268","last_page":"268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.20010000467300415,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.20010000467300415,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.12449999898672104,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.06840000301599503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.7645769119262695},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6942973732948303},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5965818762779236},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.5941619873046875},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.5604671239852905},{"id":"https://openalex.org/keywords/point-mutation","display_name":"Point mutation","score":0.5133237242698669},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.43989068269729614},{"id":"https://openalex.org/keywords/intergenic-region","display_name":"Intergenic region","score":0.4368411600589752},{"id":"https://openalex.org/keywords/indel","display_name":"Indel","score":0.4127136766910553},{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.4104993939399719},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.40937045216560364},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.37833482027053833},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.361722469329834},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.15146532654762268},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.08570718765258789}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7645769119262695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6942973732948303},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5965818762779236},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.5941619873046875},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5604671239852905},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.5133237242698669},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.43989068269729614},{"id":"https://openalex.org/C195139083","wikidata":"https://www.wikidata.org/wiki/Q3463539","display_name":"Intergenic region","level":4,"score":0.4368411600589752},{"id":"https://openalex.org/C119054055","wikidata":"https://www.wikidata.org/wiki/Q1576681","display_name":"Indel","level":5,"score":0.4127136766910553},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.4104993939399719},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.40937045216560364},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37833482027053833},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.361722469329834},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.15146532654762268},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08570718765258789},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057079","descriptor_name":"Pongo","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057079","descriptor_name":"Pongo","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057079","descriptor_name":"Pongo","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-12-268","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-268","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-268","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21718472","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21718472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:9a241946dd9b40aa934c42f1ed918458","is_oa":true,"landing_page_url":"https://doaj.org/article/9a241946dd9b40aa934c42f1ed918458","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 12, Iss 1, p 268 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2159804","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3152918","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-268","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-268","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-268","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4099999964237213}],"awards":[{"id":"https://openalex.org/G1897214537","display_name":null,"funder_award_id":"11-04-01511","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G4183918515","display_name":null,"funder_award_id":"08-04-00478","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G6756932160","display_name":null,"funder_award_id":"14.740.11.1202","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G6893159799","display_name":null,"funder_award_id":"11-04-91340","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"}],"funders":[{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2135588164.pdf","grobid_xml":"https://content.openalex.org/works/W2135588164.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W71597126","https://openalex.org/W131810194","https://openalex.org/W1976608804","https://openalex.org/W1984104678","https://openalex.org/W1998646180","https://openalex.org/W2001085484","https://openalex.org/W2007890023","https://openalex.org/W2023697086","https://openalex.org/W2024848067","https://openalex.org/W2027882785","https://openalex.org/W2033998937","https://openalex.org/W2034105248","https://openalex.org/W2052058909","https://openalex.org/W2063235239","https://openalex.org/W2069902477","https://openalex.org/W2075651743","https://openalex.org/W2081551908","https://openalex.org/W2083033591","https://openalex.org/W2085384621","https://openalex.org/W2088073190","https://openalex.org/W2111538766","https://openalex.org/W2123472832","https://openalex.org/W2127640118","https://openalex.org/W2158630016","https://openalex.org/W2160799235","https://openalex.org/W2167754834","https://openalex.org/W2167888624","https://openalex.org/W2168487231","https://openalex.org/W2168947776","https://openalex.org/W2918025614"],"related_works":["https://openalex.org/W2381780980","https://openalex.org/W2160515792","https://openalex.org/W3114716990","https://openalex.org/W2291958186","https://openalex.org/W2156272823","https://openalex.org/W2087700126","https://openalex.org/W2154243124","https://openalex.org/W2138849310","https://openalex.org/W1594294324","https://openalex.org/W3124953809"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,15,38,54],"substitution":[2,65],"rates":[3,66,84],"within":[4],"different":[5],"nucleotide":[6,58,91,100],"contexts":[7,59,92,179],"are":[8,44,74,159,186],"subject":[9],"to":[10,28,198],"varying":[11],"levels":[12],"of":[13,20,26,56,71,85,97,121,130,140,149,166,208],"bias.":[14],"most":[16],"well":[17,187],"known":[18],"example":[19],"such":[21],"bias":[22,43],"is":[23],"the":[24,127,146,150,156,163,174,200,205],"excess":[25,139,165],"C":[27,124,143,167],"T":[29,122,169],"(C":[30],">":[31,123,142,168],"T)":[32],"mutations":[33,73,87,125,144,170],"in":[34,47,88,126,145,171],"CpG":[35],"(CG)":[36],"dinucleotides.":[37],"molecular":[39],"mechanisms":[40,202],"underlying":[41,201],"this":[42],"important":[45],"factors":[46],"human":[48,98],"genome":[49],"evolution":[50],"and":[51,76,107,118,132,136],"cancer":[52],"development.":[53],"discovery":[55],"other":[57,191],"that":[60],"have":[61],"profound":[62],"effects":[63],"on":[64],"can":[67],"improve":[68],"our":[69],"understanding":[70],"how":[72],"acquired,":[75],"why":[77],"mutation":[78,178,192],"hotspots":[79],"exist.":[80],"RESULTS:":[81],"We":[82,115],"compared":[83],"inherited":[86],"1-4":[89],"bp":[90,177],"using":[93],"reconstructed":[94],"ancestral":[95],"states":[96],"single":[99],"polymorphisms":[101],"(SNPs)":[102],"from":[103,189],"intergenic":[104],"regions.":[105],"Chimp":[106],"orangutan":[108],"genomic":[109],"sequences":[110],"were":[111],"used":[112],"as":[113],"outgroups.":[114],"uncovered":[116],"3.5":[117],"3.3-fold":[119],"excesses":[120,207],"second":[128],"position":[129,148],"ATTG":[131],"ATAG":[133],"words,":[134],"respectively,":[135],"a":[137,196],"3.4-fold":[138],"A":[141],"first":[147],"ACAA":[151],"word.":[152],"CONCLUSIONS:":[153],"Although":[154],"all":[155,190],"observed":[157,206],"biases":[158],"less":[160],"pronounced":[161],"than":[162],"5.1-fold":[164],"CG":[172],"dinucleotides,":[173],"three":[175],"4":[176],"mentioned":[180],"above":[181],"(and":[182],"their":[183],"complementary":[184],"contexts)":[185],"distinguished":[188],"contexts.":[193],"This":[194],"provides":[195],"challenge":[197],"discover":[199],"responsible":[203],"for":[204],"mutations.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}