{"id":"https://openalex.org/W1995723821","doi":"https://doi.org/10.1186/1471-2105-12-140","title":"Biomarker Discovery and Redundancy Reduction towards Classification using a Multi-factorial MALDI-TOF MS T2DM Mouse Model Dataset","display_name":"Biomarker Discovery and Redundancy Reduction towards Classification using a Multi-factorial MALDI-TOF MS T2DM Mouse Model Dataset","publication_year":2011,"publication_date":"2011-05-09","ids":{"openalex":"https://openalex.org/W1995723821","doi":"https://doi.org/10.1186/1471-2105-12-140","mag":"1995723821","pmid":"https://pubmed.ncbi.nlm.nih.gov/21554713"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-140","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-140","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-140","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-140","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088005032","display_name":"Chris Bauer","orcid":null},"institutions":[{"id":"https://openalex.org/I4210121740","display_name":"MicroDiscovery (Germany)","ror":"https://ror.org/02y7tka90","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210121740"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Chris Bauer","raw_affiliation_strings":["MicroDiscovery GmbH, Marienburger Str, 1, 10405 Berlin, Germany. chris.bauer@microdiscovery.de","MicroDiscovery GmbH, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MicroDiscovery GmbH, Marienburger Str, 1, 10405 Berlin, Germany. chris.bauer@microdiscovery.de","institution_ids":["https://openalex.org/I4210121740"]},{"raw_affiliation_string":"MicroDiscovery GmbH, Berlin, Germany","institution_ids":["https://openalex.org/I4210121740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027745611","display_name":"Frank Kleinjung","orcid":"https://orcid.org/0000-0002-2486-1759"},"institutions":[{"id":"https://openalex.org/I4210121740","display_name":"MicroDiscovery (Germany)","ror":"https://ror.org/02y7tka90","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210121740"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Kleinjung","raw_affiliation_strings":["MicroDiscovery GmbH, Marienburger Str. 1, 10405, Berlin, Germany","MicroDiscovery GmbH, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MicroDiscovery GmbH, Marienburger Str. 1, 10405, Berlin, Germany","institution_ids":["https://openalex.org/I4210121740"]},{"raw_affiliation_string":"MicroDiscovery GmbH, Berlin, Germany","institution_ids":["https://openalex.org/I4210121740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079089462","display_name":"Celia Smith","orcid":null},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Celia J Smith","raw_affiliation_strings":["Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, RG6 6AS, UK","Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, RG6 6AS, UK","institution_ids":["https://openalex.org/I71052956"]},{"raw_affiliation_string":"Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, UK","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048429407","display_name":"Mark Towers","orcid":"https://orcid.org/0000-0002-6302-219X"},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark W Towers","raw_affiliation_strings":["Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, RG6 6AS, UK","Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, RG6 6AS, UK","institution_ids":["https://openalex.org/I71052956"]},{"raw_affiliation_string":"Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, UK","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048705942","display_name":"Ali Tiss","orcid":"https://orcid.org/0000-0002-3024-5370"},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ali Tiss","raw_affiliation_strings":["Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, RG6 6AS, UK","Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, RG6 6AS, UK","institution_ids":["https://openalex.org/I71052956"]},{"raw_affiliation_string":"Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, UK","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043699942","display_name":"Alexandra Chadt","orcid":"https://orcid.org/0000-0003-3873-1477"},"institutions":[{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexandra Chadt","raw_affiliation_strings":["Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany","Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]},{"raw_affiliation_string":"Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057582308","display_name":"Tanja Dreja","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tanja Dreja","raw_affiliation_strings":["Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany","Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]},{"raw_affiliation_string":"Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064391109","display_name":"Dieter Beule","orcid":"https://orcid.org/0000-0002-3284-0632"},"institutions":[{"id":"https://openalex.org/I4210121740","display_name":"MicroDiscovery (Germany)","ror":"https://ror.org/02y7tka90","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210121740"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter Beule","raw_affiliation_strings":["MicroDiscovery GmbH, Marienburger Str. 1, 10405, Berlin, Germany","MicroDiscovery GmbH, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MicroDiscovery GmbH, Marienburger Str. 1, 10405, Berlin, Germany","institution_ids":["https://openalex.org/I4210121740"]},{"raw_affiliation_string":"MicroDiscovery GmbH, Berlin, Germany","institution_ids":["https://openalex.org/I4210121740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064733533","display_name":"Hadi Al\u2010Hasani","orcid":"https://orcid.org/0000-0003-2543-0130"},"institutions":[{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hadi Al-Hasani","raw_affiliation_strings":["Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany","Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]},{"raw_affiliation_string":"Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078948324","display_name":"Knut Reinert","orcid":"https://orcid.org/0000-0003-3078-8129"},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Knut Reinert","raw_affiliation_strings":["Department Computer Science and Mathematics, Free University of Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Computer Science and Mathematics, Free University of Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035832306","display_name":"Johannes Schuchhardt","orcid":"https://orcid.org/0009-0008-8896-4328"},"institutions":[{"id":"https://openalex.org/I4210121740","display_name":"MicroDiscovery (Germany)","ror":"https://ror.org/02y7tka90","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210121740"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Schuchhardt","raw_affiliation_strings":["MicroDiscovery GmbH, Marienburger Str. 1, 10405, Berlin, Germany","MicroDiscovery GmbH, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MicroDiscovery GmbH, Marienburger Str. 1, 10405, Berlin, Germany","institution_ids":["https://openalex.org/I4210121740"]},{"raw_affiliation_string":"MicroDiscovery GmbH, Berlin, Germany","institution_ids":["https://openalex.org/I4210121740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016772331","display_name":"Rainer Cramer","orcid":"https://orcid.org/0000-0002-8037-2511"},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rainer Cramer","raw_affiliation_strings":["Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, RG6 6AS, UK","Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, RG6 6AS, UK","institution_ids":["https://openalex.org/I71052956"]},{"raw_affiliation_string":"Department of Chemistry and The BioCentre, The University of Reading, Whiteknights, Reading, UK","institution_ids":["https://openalex.org/I71052956"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5088005032"],"corresponding_institution_ids":["https://openalex.org/I4210121740"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.3226,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57981129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"1","first_page":"140","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.7120000123977661,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.7120000123977661,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.031700000166893005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/redundancy","display_name":"Redundancy (engineering)","score":0.632280170917511},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.6253080368041992},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5578304529190063},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5066167116165161},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4476619064807892},{"id":"https://openalex.org/keywords/fractional-factorial-design","display_name":"Fractional factorial design","score":0.43161648511886597},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.3478652536869049},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3237435221672058},{"id":"https://openalex.org/keywords/factorial-experiment","display_name":"Factorial experiment","score":0.2346557378768921},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.18360576033592224},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16473734378814697},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.06793999671936035}],"concepts":[{"id":"https://openalex.org/C152124472","wikidata":"https://www.wikidata.org/wiki/Q1204361","display_name":"Redundancy (engineering)","level":2,"score":0.632280170917511},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.6253080368041992},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5578304529190063},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5066167116165161},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4476619064807892},{"id":"https://openalex.org/C16469947","wikidata":"https://www.wikidata.org/wiki/Q2400745","display_name":"Fractional factorial design","level":3,"score":0.43161648511886597},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.3478652536869049},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3237435221672058},{"id":"https://openalex.org/C169222746","wikidata":"https://www.wikidata.org/wiki/Q4116558","display_name":"Factorial experiment","level":2,"score":0.2346557378768921},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.18360576033592224},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16473734378814697},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06793999671936035},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-12-140","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-140","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-140","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21554713","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21554713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:centaur.reading.ac.uk:22025","is_oa":false,"landing_page_url":"https://centaur.reading.ac.uk/view/creators/90003936.html>,","pdf_url":null,"source":{"id":"https://openalex.org/S4306402273","display_name":"CentAUR (University of Reading)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I71052956","host_organization_name":"University of Reading","host_organization_lineage":["https://openalex.org/I71052956"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:doaj.org/article:39027ace414d41d7a498a3012cec2f1a","is_oa":true,"landing_page_url":"https://doaj.org/article/39027ace414d41d7a498a3012cec2f1a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 12, Iss 1, p 140 (2011)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3116487","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3116487","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-140","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-140","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-140","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995723821.pdf","grobid_xml":"https://content.openalex.org/works/W1995723821.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W52410658","https://openalex.org/W111509594","https://openalex.org/W1479823809","https://openalex.org/W1480376833","https://openalex.org/W1533335653","https://openalex.org/W1592785605","https://openalex.org/W1922017469","https://openalex.org/W1964126817","https://openalex.org/W1965291023","https://openalex.org/W1984971566","https://openalex.org/W1985291814","https://openalex.org/W1987057619","https://openalex.org/W1995434974","https://openalex.org/W1998546517","https://openalex.org/W2002260514","https://openalex.org/W2023096047","https://openalex.org/W2027257553","https://openalex.org/W2038856295","https://openalex.org/W2051702381","https://openalex.org/W2052388444","https://openalex.org/W2058312749","https://openalex.org/W2061474362","https://openalex.org/W2061637917","https://openalex.org/W2063483916","https://openalex.org/W2064096746","https://openalex.org/W2077191503","https://openalex.org/W2078155356","https://openalex.org/W2086986126","https://openalex.org/W2096459935","https://openalex.org/W2098924836","https://openalex.org/W2101508556","https://openalex.org/W2102427034","https://openalex.org/W2106835969","https://openalex.org/W2107941094","https://openalex.org/W2113952909","https://openalex.org/W2114101303","https://openalex.org/W2118142823","https://openalex.org/W2123989476","https://openalex.org/W2126297361","https://openalex.org/W2128589733","https://openalex.org/W2129321896","https://openalex.org/W2130559534","https://openalex.org/W2136487516","https://openalex.org/W2136970782","https://openalex.org/W2141204169","https://openalex.org/W2142372384","https://openalex.org/W2142415307","https://openalex.org/W2142594023","https://openalex.org/W2147141017","https://openalex.org/W2160697532","https://openalex.org/W2163137121","https://openalex.org/W2163905612","https://openalex.org/W2165134694","https://openalex.org/W2168130065","https://openalex.org/W2171109114","https://openalex.org/W2187321354","https://openalex.org/W2255892451","https://openalex.org/W2297395784","https://openalex.org/W2787894218","https://openalex.org/W2911964244","https://openalex.org/W4205699531","https://openalex.org/W4213192890","https://openalex.org/W4236706032"],"related_works":["https://openalex.org/W112583468","https://openalex.org/W96119380","https://openalex.org/W4298030740","https://openalex.org/W3023706879","https://openalex.org/W4246773350","https://openalex.org/W1539981706","https://openalex.org/W1485011350","https://openalex.org/W2108949684","https://openalex.org/W1965976436","https://openalex.org/W2012655824"],"abstract_inverted_index":{"BACKGROUND:":[0],"Diabetes":[1],"like":[2],"many":[3],"diseases":[4],"and":[5,61,105,140,151,161,188,217,233],"biological":[6],"processes":[7],"is":[8,229],"not":[9],"mono-causal.":[10],"On":[11,27],"the":[12,28,31,108,112,134,146,166,234,240],"one":[13],"hand":[14],"multi-factorial":[15,84],"studies":[16,35,202],"with":[17,57,128,203,224],"complex":[18,79,179,204],"experimental":[19,99,205],"design":[20],"are":[21,47,236],"required":[22],"for":[23,68,77,120,133,159,192],"its":[24],"comprehensive":[25,74],"analysis.":[26],"other":[29],"hand,":[30],"data":[32,64,80,82],"from":[33,83],"these":[34],"often":[36],"include":[37],"a":[38,51,66,73,95,137,153,215],"substantial":[39],"amount":[40],"of":[41,53,98,114,136,143,148,156,186,194],"redundancy":[42,144,189],"such":[43],"as":[44],"proteins":[45],"that":[46],"typically":[48],"represented":[49],"by":[50,94,238],"multitude":[52],"peptides.":[54],"Coping":[55],"simultaneously":[56],"both":[58],"complexities":[59],"(experimental":[60],"technological)":[62],"makes":[63],"analysis":[65,113],"challenge":[67],"Bioinformatics.":[69],"RESULTS:":[70],"We":[71],"present":[72],"work-flow":[75,110],"tailored":[76],"analyzing":[78],"including":[81],"studies.":[85],"The":[86,184,227],"developed":[87,109],"approach":[88,171],"aims":[89],"at":[90],"revealing":[91],"effects":[92],"caused":[93],"distinct":[96],"combination":[97,135,185],"factors,":[100],"in":[101,197,231],"our":[102,170,212],"case":[103],"genotype":[104],"diet.":[106,141],"Applying":[107],"to":[111,174,209,220],"an":[115],"established":[116],"polygenic":[117],"mouse":[118],"model":[119],"diet-induced":[121],"type":[122],"2":[123],"diabetes,":[124],"we":[125],"found":[126],"peptides":[127],"significant":[129],"fold":[130],"changes":[131],"exclusively":[132],"particular":[138],"strain":[139],"Exploitation":[142],"enables":[145],"visualization":[147],"peptide":[149],"correlation":[150],"provides":[152,214],"natural":[154],"way":[155],"feature":[157,180,210],"selection":[158,181,211],"classification":[160],"prediction.":[162],"Classification":[163],"based":[164,176],"on":[165,177],"features":[167],"selected":[168],"using":[169],"performs":[172],"similar":[173],"classifications":[175],"more":[178],"methods.":[182],"CONCLUSIONS:":[183],"ANOVA":[187],"exploitation":[190],"allows":[191],"identification":[193],"biomarker":[195],"candidates":[196],"multi-dimensional":[198],"MALDI-TOF":[199],"MS":[200],"profiling":[201],"design.":[206],"With":[207],"respect":[208],"method":[213,228],"fast":[216],"intuitive":[218],"alternative":[219],"global":[221],"optimization":[222],"strategies":[223],"comparable":[225],"performance.":[226],"implemented":[230],"R":[232],"scripts":[235],"available":[237],"contacting":[239],"corresponding":[241],"author.":[242]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}