{"id":"https://openalex.org/W2170522361","doi":"https://doi.org/10.1186/1471-2105-12-123","title":"Discovering time-lagged rules from microarray data using gene profile classifiers","display_name":"Discovering time-lagged rules from microarray data using gene profile classifiers","publication_year":2011,"publication_date":"2011-04-27","ids":{"openalex":"https://openalex.org/W2170522361","doi":"https://doi.org/10.1186/1471-2105-12-123","mag":"2170522361","pmid":"https://pubmed.ncbi.nlm.nih.gov/21524308"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-12-123","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-123","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-123","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-123","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061229419","display_name":"C.A. Gallo","orcid":"https://orcid.org/0000-0001-9339-1802"},"institutions":[{"id":"https://openalex.org/I56858762","display_name":"Universidad Nacional del Sur","ror":"https://ror.org/028crwz56","country_code":"AR","type":"education","lineage":["https://openalex.org/I56858762"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Cristian A Gallo","raw_affiliation_strings":["Laboratorio de Investigaci\u00f3n y Desarrollo en Computaci\u00f3n Cient\u00edfica (LIDeCC), Departamento de Ciencias e Ingenier\u00eda de la Computaci\u00f3n, Universidad Nacional del Sur, Av, Alem 1253, 8000, Bah\u00eda Blanca, Argentina","Laboratorio de Investigaci\u00f3n y Desarrollo en Computaci\u00f3n Cient\u00edfica (LIDeCC), Departamento de Ciencias e Ingenier\u00eda de la Computaci\u00f3n, Universidad Nacional del Sur, Av. Alem 1253, 8000, Bah\u00eda Blanca, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n y Desarrollo en Computaci\u00f3n Cient\u00edfica (LIDeCC), Departamento de Ciencias e Ingenier\u00eda de la Computaci\u00f3n, Universidad Nacional del Sur, Av, Alem 1253, 8000, Bah\u00eda Blanca, Argentina","institution_ids":["https://openalex.org/I56858762"]},{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n y Desarrollo en Computaci\u00f3n Cient\u00edfica (LIDeCC), Departamento de Ciencias e Ingenier\u00eda de la Computaci\u00f3n, Universidad Nacional del Sur, Av. Alem 1253, 8000, Bah\u00eda Blanca, Argentina","institution_ids":["https://openalex.org/I56858762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063101145","display_name":"Jessica Andrea Carballido","orcid":"https://orcid.org/0000-0001-6284-1049"},"institutions":[{"id":"https://openalex.org/I56858762","display_name":"Universidad Nacional del Sur","ror":"https://ror.org/028crwz56","country_code":"AR","type":"education","lineage":["https://openalex.org/I56858762"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Jessica A Carballido","raw_affiliation_strings":["Laboratorio de Investigaci\u00f3n y Desarrollo en Computaci\u00f3n Cient\u00edfica (LIDeCC), Departamento de Ciencias e Ingenier\u00eda de la Computaci\u00f3n, Universidad Nacional del Sur, Av. Alem 1253, 8000, Bah\u00eda Blanca, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n y Desarrollo en Computaci\u00f3n Cient\u00edfica (LIDeCC), Departamento de Ciencias e Ingenier\u00eda de la Computaci\u00f3n, Universidad Nacional del Sur, Av. Alem 1253, 8000, Bah\u00eda Blanca, Argentina","institution_ids":["https://openalex.org/I56858762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008182880","display_name":"Ignacio Ponzoni","orcid":"https://orcid.org/0000-0002-6923-9592"},"institutions":[{"id":"https://openalex.org/I4210097725","display_name":"Planta Piloto de Ingenier\u00eda Qu\u00edmica","ror":"https://ror.org/00xpayr72","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210097725","https://openalex.org/I4210123736","https://openalex.org/I4210125789","https://openalex.org/I4387155568","https://openalex.org/I56858762"]},{"id":"https://openalex.org/I56858762","display_name":"Universidad Nacional del Sur","ror":"https://ror.org/028crwz56","country_code":"AR","type":"education","lineage":["https://openalex.org/I56858762"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Ignacio Ponzoni","raw_affiliation_strings":["Laboratorio de Investigaci\u00f3n y Desarrollo en Computaci\u00f3n Cient\u00edfica (LIDeCC), Departamento de Ciencias e Ingenier\u00eda de la Computaci\u00f3n, Universidad Nacional del Sur, Av. Alem 1253, 8000, Bah\u00eda Blanca, Argentina","Planta Piloto de Ingenier\u00eda Qu\u00edmica (PLAPIQUI) - UNS - CONICET, Complejo CRIBABB, Co., La Carrindanga km.7, CC 717, Bah\u00eda Blanca, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n y Desarrollo en Computaci\u00f3n Cient\u00edfica (LIDeCC), Departamento de Ciencias e Ingenier\u00eda de la Computaci\u00f3n, Universidad Nacional del Sur, Av. Alem 1253, 8000, Bah\u00eda Blanca, Argentina","institution_ids":["https://openalex.org/I56858762"]},{"raw_affiliation_string":"Planta Piloto de Ingenier\u00eda Qu\u00edmica (PLAPIQUI) - UNS - CONICET, Complejo CRIBABB, Co., La Carrindanga km.7, CC 717, Bah\u00eda Blanca, Argentina","institution_ids":["https://openalex.org/I4210097725"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008182880"],"corresponding_institution_ids":["https://openalex.org/I4210097725","https://openalex.org/I56858762"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.3722,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.61386478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"123","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.6931999921798706,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.6931999921798706,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.10740000009536743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12205","display_name":"Time Series Analysis and Forecasting","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/1711","display_name":"Signal Processing"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6689807772636414},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6296267509460449},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6164448261260986},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5536693334579468},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.5459928512573242},{"id":"https://openalex.org/keywords/time-series","display_name":"Time series","score":0.5239365696907043},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5131877064704895},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.45349419116973877},{"id":"https://openalex.org/keywords/series","display_name":"Series (stratigraphy)","score":0.4509144425392151},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4446820616722107},{"id":"https://openalex.org/keywords/soundness","display_name":"Soundness","score":0.43656080961227417},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3748215436935425},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.37196969985961914},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35036104917526245},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2964712381362915},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23059001564979553},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1581471562385559},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12054938077926636}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6689807772636414},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6296267509460449},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6164448261260986},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5536693334579468},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.5459928512573242},{"id":"https://openalex.org/C151406439","wikidata":"https://www.wikidata.org/wiki/Q186588","display_name":"Time series","level":2,"score":0.5239365696907043},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5131877064704895},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.45349419116973877},{"id":"https://openalex.org/C143724316","wikidata":"https://www.wikidata.org/wiki/Q312468","display_name":"Series (stratigraphy)","level":2,"score":0.4509144425392151},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4446820616722107},{"id":"https://openalex.org/C39920170","wikidata":"https://www.wikidata.org/wiki/Q693083","display_name":"Soundness","level":2,"score":0.43656080961227417},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3748215436935425},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37196969985961914},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35036104917526245},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2964712381362915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23059001564979553},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1581471562385559},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12054938077926636},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-12-123","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-123","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-123","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21524308","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21524308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3111372","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3111372","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:americanae.aecid.es:3889395","is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3889395","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:85368d3fae434aedb0e19eeab8b78be5","is_oa":true,"landing_page_url":"https://doaj.org/article/85368d3fae434aedb0e19eeab8b78be5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 12, Iss 1, p 123 (2011)","raw_type":"article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/55446","is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/55446","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-12-123","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-12-123","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-12-123","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3520918852","display_name":null,"funder_award_id":"PGI 24","funder_id":"https://openalex.org/F4320323402","funder_display_name":"Universidad Nacional del Sur"},{"id":"https://openalex.org/G4359570771","display_name":null,"funder_award_id":"PIP 112","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"}],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320323402","display_name":"Universidad Nacional del Sur","ror":"https://ror.org/028crwz56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170522361.pdf","grobid_xml":"https://content.openalex.org/works/W2170522361.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1251130462","https://openalex.org/W1481919380","https://openalex.org/W1484413656","https://openalex.org/W1504694836","https://openalex.org/W1524141331","https://openalex.org/W1557900165","https://openalex.org/W1559547793","https://openalex.org/W1562345870","https://openalex.org/W1592292819","https://openalex.org/W1607097986","https://openalex.org/W1851004085","https://openalex.org/W1872619067","https://openalex.org/W1923453853","https://openalex.org/W1978217568","https://openalex.org/W1981933378","https://openalex.org/W1982657570","https://openalex.org/W1996993801","https://openalex.org/W2030132106","https://openalex.org/W2046618236","https://openalex.org/W2047614415","https://openalex.org/W2048671957","https://openalex.org/W2058221907","https://openalex.org/W2060393046","https://openalex.org/W2062029454","https://openalex.org/W2062319807","https://openalex.org/W2064153193","https://openalex.org/W2072252885","https://openalex.org/W2073188230","https://openalex.org/W2074755764","https://openalex.org/W2076683000","https://openalex.org/W2079829409","https://openalex.org/W2097973787","https://openalex.org/W2099807710","https://openalex.org/W2103014023","https://openalex.org/W2103453943","https://openalex.org/W2104854813","https://openalex.org/W2112821758","https://openalex.org/W2117720828","https://openalex.org/W2125055259","https://openalex.org/W2128150566","https://openalex.org/W2133376865","https://openalex.org/W2133401281","https://openalex.org/W2134651489","https://openalex.org/W2136988691","https://openalex.org/W2139083403","https://openalex.org/W2139084975","https://openalex.org/W2141012957","https://openalex.org/W2144544802","https://openalex.org/W2158583828","https://openalex.org/W2159203162","https://openalex.org/W2162601372","https://openalex.org/W2164495402","https://openalex.org/W2167190345","https://openalex.org/W2171118759","https://openalex.org/W2413268848","https://openalex.org/W2611370172","https://openalex.org/W2738858705","https://openalex.org/W2903883712"],"related_works":["https://openalex.org/W1986892844","https://openalex.org/W170658859","https://openalex.org/W2490137852","https://openalex.org/W4310366902","https://openalex.org/W3023720143","https://openalex.org/W3141198878","https://openalex.org/W1982897783","https://openalex.org/W2056932428","https://openalex.org/W2412120523","https://openalex.org/W1483316219"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gene":[1],"regulatory":[2,35,52,219],"networks":[3,36,53,220],"have":[4,153,244],"an":[5],"essential":[6],"role":[7],"in":[8,161,228],"every":[9],"process":[10],"of":[11,18,41,83,92,100,108,130,163,201,255,264],"life.":[12],"In":[13,61,190],"this":[14,62,191,229],"regard,":[15],"the":[16,28,32,39,84,139,143,158,164,169,193,197,202,247,262],"amount":[17],"genome-wide":[19,56,179,222],"time":[20,58,109,114,126,185,223],"series":[21,59,115,127,186,224],"data":[22,128,187,240],"is":[23,79,98,226],"becoming":[24],"increasingly":[25],"available,":[26],"providing":[27],"opportunity":[29],"to":[30,125],"discover":[31],"time-delayed":[33,217],"gene":[34,51,93,209,218,265],"that":[37,134,155,168,246],"govern":[38],"majority":[40],"these":[42],"molecular":[43],"processes.":[44],"RESULTS:":[45],"This":[46],"paper":[47],"aims":[48],"at":[49],"reconstructing":[50],"from":[54,112,221],"multiple":[55,182],"microarray":[57],"datasets.":[60],"sense,":[63],"a":[64,80,178,250],"new":[65,203],"model-free":[66,252],"algorithm":[67,122,248],"called":[68],"GRNCOP2":[69,156],"(Gene":[70],"Regulatory":[71],"Network":[72],"inference":[73],"by":[74],"Combinatorial":[75],"OPtimization":[76],"2),":[77],"which":[78,205],"significant":[81],"evolution":[82],"GRNCOP":[85],"algorithm,":[86],"was":[87,123,188,233],"developed":[88],"using":[89],"combinatorial":[90],"optimization":[91],"profile":[94],"classifiers.":[95],"The":[96,120,151,231,242],"method":[97,204,214,232],"capable":[99,254],"inferring":[101,216],"potential":[102],"time-delay":[103],"relationships":[104,258],"with":[105,173,236],"any":[106],"span":[107],"between":[110,259],"genes":[111,133],"various":[113],"datasets":[116,225],"given":[117],"as":[118],"input.":[119],"proposed":[121,165,227],"applied":[124],"composed":[129],"twenty":[131],"yeast":[132],"are":[135,171],"highly":[136],"relevant":[137],"for":[138,215],"cell-cycle":[140],"study,":[141],"and":[142,167,199],"results":[144,170,243],"were":[145],"compared":[146],"against":[147],"several":[148,237],"related":[149],"approaches.":[150],"outcomes":[152],"shown":[154],"outperforms":[157],"contrasted":[159],"methods":[160],"terms":[162],"metrics,":[166],"consistent":[172],"previous":[174],"biological":[175],"knowledge.":[176],"Additionally,":[177],"study":[180],"on":[181],"publicly":[183,238],"available":[184,239],"performed.":[189],"case,":[192],"experimentation":[194],"has":[195],"exhibited":[196],"soundness":[198],"scalability":[200],"inferred":[206],"highly-related":[207],"statistically-significant":[208],"associations.":[210],"CONCLUSIONS:":[211],"A":[212],"novel":[213],"paper.":[230],"carefully":[234],"validated":[235],"sets.":[241],"demonstrated":[245],"constitutes":[249],"usable":[251],"approach":[253],"predicting":[256],"meaningful":[257],"genes,":[260],"revealing":[261],"time-trends":[263],"regulation.":[266]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-08-23T07:36:19.812096","created_date":"2025-10-10T00:00:00"}