{"id":"https://openalex.org/W2116568613","doi":"https://doi.org/10.1186/1471-2105-11-s9-s11","title":"Stromal microenvironment processes unveiled by biological component analysis of gene expression in xenograft tumor models","display_name":"Stromal microenvironment processes unveiled by biological component analysis of gene expression in xenograft tumor models","publication_year":2010,"publication_date":"2010-10-01","ids":{"openalex":"https://openalex.org/W2116568613","doi":"https://doi.org/10.1186/1471-2105-11-s9-s11","mag":"2116568613","pmid":"https://pubmed.ncbi.nlm.nih.gov/21044358"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-11-s9-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-s9-s11","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-S9-S11","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-S9-S11","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079231875","display_name":"Xinan Yang","orcid":"https://orcid.org/0000-0001-8061-8692"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinan Yang","raw_affiliation_strings":["Section of Genetic Medicine, Dept, of Medicine, University of Chicago, IL, USA. xyang2@uchicago.edu","Section of Genetic Medicine, Dept. of Medicine, University of Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Genetic Medicine, Dept, of Medicine, University of Chicago, IL, USA. xyang2@uchicago.edu","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Section of Genetic Medicine, Dept. of Medicine, University of Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100778649","display_name":"Younghee Lee","orcid":"https://orcid.org/0000-0002-6850-0082"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Younghee Lee","raw_affiliation_strings":["Section of Genetic Medicine, Dept. of Medicine, University of Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Genetic Medicine, Dept. of Medicine, University of Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044514129","display_name":"Yong Huang","orcid":"https://orcid.org/0009-0001-1989-8223"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Huang","raw_affiliation_strings":["Section of Genetic Medicine, Dept. of Medicine, University of Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Genetic Medicine, Dept. of Medicine, University of Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037373285","display_name":"James L. Chen","orcid":"https://orcid.org/0000-0002-4095-5202"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James L Chen","raw_affiliation_strings":["Sect. of Hematology/Oncology, Dept. of Medicine, University of Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sect. of Hematology/Oncology, Dept. of Medicine, University of Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027597143","display_name":"Rosie Xing","orcid":null},"institutions":[{"id":"https://openalex.org/I196064397","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05923xh51","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["BE","US"],"is_corresponding":true,"raw_author_name":"Rosie H Xing","raw_affiliation_strings":["Dept. of Pathology and of Radiation and Cellular Oncology, University of Chicago, IL, USA","UC Comprehensive Cancer Centre; Ludwig Centre for Metastasis Research, University of Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pathology and of Radiation and Cellular Oncology, University of Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"UC Comprehensive Cancer Centre; Ludwig Centre for Metastasis Research, University of Chicago, IL, USA","institution_ids":["https://openalex.org/I196064397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074706648","display_name":"Yves A. Lussier","orcid":"https://orcid.org/0000-0001-9854-1005"},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I196064397","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05923xh51","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Yves A Lussier","raw_affiliation_strings":["Institute of Genomics and Systems Biology, Institute for Translational Medicine; Computational Institute, University of Chicago, IL, USA","Section of Genetic Medicine, Dept. of Medicine, University of Chicago, IL, USA","UC Comprehensive Cancer Centre; Ludwig Centre for Metastasis Research, University of Chicago, IL, USA","UC Comprehensive Cancer Centre","Ludwig Centre for Metastasis Research, University of Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genomics and Systems Biology, Institute for Translational Medicine; Computational Institute, University of Chicago, IL, USA","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Section of Genetic Medicine, Dept. of Medicine, University of Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"UC Comprehensive Cancer Centre; Ludwig Centre for Metastasis Research, University of Chicago, IL, USA","institution_ids":["https://openalex.org/I196064397"]},{"raw_affiliation_string":"UC Comprehensive Cancer Centre","institution_ids":[]},{"raw_affiliation_string":"Ludwig Centre for Metastasis Research, University of Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027597143"],"corresponding_institution_ids":["https://openalex.org/I196064397","https://openalex.org/I40347166"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.4027,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.63362978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"11","issue":"S9","first_page":"S11","last_page":"S11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.25270000100135803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.25270000100135803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.09759999811649323,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.06340000033378601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stromal-cell","display_name":"Stromal cell","score":0.7865496873855591},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6176049709320068},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.5637391805648804},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5570806860923767},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5531972050666809},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5355515480041504},{"id":"https://openalex.org/keywords/component","display_name":"Component (thermodynamics)","score":0.5347996950149536},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.45454877614974976},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4299900531768799},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.40602266788482666},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22159767150878906},{"id":"https://openalex.org/keywords/tumor-cells","display_name":"Tumor cells","score":0.2158994972705841}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7865496873855591},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6176049709320068},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5637391805648804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5570806860923767},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5531972050666809},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5355515480041504},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.5347996950149536},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45454877614974976},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4299900531768799},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40602266788482666},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22159767150878906},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2158994972705841},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-11-s9-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-s9-s11","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-S9-S11","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21044358","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21044358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:f375e052cfa0433fa3b792ce13e61e6e","is_oa":false,"landing_page_url":"https://doaj.org/article/f375e052cfa0433fa3b792ce13e61e6e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 11, Iss Suppl 9, p S11 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2967741","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2967741","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-11-s9-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-s9-s11","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-S9-S11","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6673663299","display_name":null,"funder_award_id":"UL1 RR024999-03","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7583224788","display_name":null,"funder_award_id":"1U54CA121852","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7972181056","display_name":null,"funder_award_id":"K22 LM008308","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G8543961968","display_name":null,"funder_award_id":"K22 LM008308-04","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2116568613.pdf","grobid_xml":"https://content.openalex.org/works/W2116568613.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1497663772","https://openalex.org/W2002810210","https://openalex.org/W2020541351","https://openalex.org/W2032980774","https://openalex.org/W2041944280","https://openalex.org/W2055043387","https://openalex.org/W2060667827","https://openalex.org/W2062265555","https://openalex.org/W2089097320","https://openalex.org/W2099020540","https://openalex.org/W2100095805","https://openalex.org/W2101595316","https://openalex.org/W2105981681","https://openalex.org/W2120004030","https://openalex.org/W2120314156","https://openalex.org/W2138255346","https://openalex.org/W2146991492","https://openalex.org/W2154453972","https://openalex.org/W2161744213","https://openalex.org/W2166623085","https://openalex.org/W2169401431"],"related_works":["https://openalex.org/W2069695727","https://openalex.org/W1996185163","https://openalex.org/W2084813257","https://openalex.org/W2045929470","https://openalex.org/W2081127504","https://openalex.org/W2122223946","https://openalex.org/W4233500668","https://openalex.org/W1974145978","https://openalex.org/W1977867163","https://openalex.org/W2393426762"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mouse":[1],"xenograft":[2,62,139],"models,":[3],"in":[4,11,39,61,117,130],"which":[5],"human":[6,53,80],"cancer":[7],"cells":[8,112],"are":[9,156],"implanted":[10],"immune-suppressed":[12],"mice,":[13],"have":[14],"been":[15],"popular":[16],"for":[17,78],"studying":[18],"the":[19,35,79,106,118,144],"mechanisms":[20],"of":[21,110,120],"novel":[22],"therapeutic":[23],"targets,":[24],"tumor":[25,63,114,145],"progression":[26],"and":[27,74,89,153],"metastasis.":[28],"We":[29],"hypothesized":[30],"that":[31],"we":[32],"could":[33],"exploit":[34],"interspecies":[36],"genetic":[37],"differences":[38],"these":[40,100],"experiments.":[41],"Our":[42],"purpose":[43],"is":[44],"to":[45,132,141],"elucidate":[46],"stromal":[47,84,111,123],"microenvironment":[48,146],"signals":[49],"from":[50,71,96,113],"probes":[51,70,152],"on":[52],"arrays":[54],"unintentionally":[55],"cross-hybridizing":[56],"with":[57,102],"mouse":[58],"homologous":[59],"genes":[60,85],"models.":[64],"RESULTS:":[65],"By":[66],"identifying":[67],"cross-species":[68,75],"hybridizing":[69],"sequence":[72],"alignment":[73],"hybridization":[76],"experiment":[77],"whole-genome":[81],"arrays,":[82],"deregulated":[83],"can":[86,137],"be":[87],"identified":[88],"then":[90],"their":[91,133],"biological":[92,124],"significance":[93],"were":[94],"predicted":[95],"enrichment":[97],"studies.":[98],"Comparing":[99],"results":[101],"those":[103],"found":[104],"by":[105],"laser":[107],"capture":[108],"microdissection":[109],"specimens":[115],"resulted":[116],"discovery":[119],"significantly":[121],"enriched":[122],"processes.":[125],"CONCLUSIONS:":[126],"Using":[127],"this":[128],"method,":[129],"addition":[131],"primary":[134],"endpoints,":[135],"researchers":[136],"leverage":[138],"experiments":[140],"better":[142],"characterize":[143],"without":[147],"additional":[148],"costs.":[149],"The":[150],"Xhyb":[151],"R":[154],"script":[155],"available":[157],"at":[158],"http://www.lussierlab.org/publications/Stroma.":[159]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
