{"id":"https://openalex.org/W2162675057","doi":"https://doi.org/10.1186/1471-2105-11-s4-p2","title":"Identifying potential drugs that induce QT prolongation using electronic medical records","display_name":"Identifying potential drugs that induce QT prolongation using electronic medical records","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2162675057","doi":"https://doi.org/10.1186/1471-2105-11-s4-p2","mag":"2162675057"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-11-s4-p2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-s4-p2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-S4-P2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-S4-P2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100347924","display_name":"Mei Liu","orcid":"https://orcid.org/0000-0002-4960-0096"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mei Liu","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, 37232, USA","Department of Biomedical Informatics, Vanderbilt University, Nashville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University, Nashville, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070908224","display_name":"Joshua C. Denny","orcid":"https://orcid.org/0000-0002-3049-7332"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua C Denny","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, 37232, USA","Department of Biomedical Informatics, Vanderbilt University, Nashville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University, Nashville, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035264371","display_name":"Subramani Mani","orcid":null},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subramani Mani","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, 37232, USA","Department of Biomedical Informatics, Vanderbilt University, Nashville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University, Nashville, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101672477","display_name":"Yukun Chen","orcid":"https://orcid.org/0000-0002-3639-5847"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yukun Chen","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, 37232, USA","Department of Biomedical Informatics, Vanderbilt University, Nashville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University, Nashville, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086685216","display_name":"Yong Hu","orcid":"https://orcid.org/0000-0002-3837-1750"},"institutions":[{"id":"https://openalex.org/I186272606","display_name":"Guangdong University of Foreign Studies","ror":"https://ror.org/00fhc9y79","country_code":"CN","type":"education","lineage":["https://openalex.org/I186272606"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Hu","raw_affiliation_strings":["Department of E-commerce, Guangdong University of Foreign Studies, Guangzhou, Guangdong, 510000, China","Department of E-commerce, Guangdong University of Foreign Studies, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Department of E-commerce, Guangdong University of Foreign Studies, Guangzhou, Guangdong, 510000, China","institution_ids":["https://openalex.org/I186272606"]},{"raw_affiliation_string":"Department of E-commerce, Guangdong University of Foreign Studies, Guangzhou, China","institution_ids":["https://openalex.org/I186272606"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101973930","display_name":"Hua Xu","orcid":"https://orcid.org/0000-0001-9730-7276"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hua Xu","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, 37232, USA","Department of Biomedical Informatics, Vanderbilt University, Nashville, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University, Nashville, USA","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5101973930"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.22721453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"11","issue":"S4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.9484999775886536,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.940500020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prolongation","display_name":"Prolongation","score":0.7035266160964966},{"id":"https://openalex.org/keywords/qt-interval","display_name":"QT interval","score":0.6506986021995544},{"id":"https://openalex.org/keywords/long-qt-syndrome","display_name":"Long QT syndrome","score":0.525787353515625},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.48219290375709534},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.39391449093818665},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3747766315937042},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.23973780870437622},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23230469226837158}],"concepts":[{"id":"https://openalex.org/C2777672339","wikidata":"https://www.wikidata.org/wiki/Q7249641","display_name":"Prolongation","level":2,"score":0.7035266160964966},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.6506986021995544},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.525787353515625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48219290375709534},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39391449093818665},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3747766315937042},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23973780870437622},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23230469226837158}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/1471-2105-11-s4-p2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-s4-p2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-S4-P2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3290073","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3290073","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-11-s4-p2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-s4-p2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-S4-P2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G3428628828","display_name":null,"funder_award_id":"T15LM007450","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4838924695","display_name":null,"funder_award_id":"NCI R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8962343269","display_name":null,"funder_award_id":"LM007450","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2162675057.pdf","grobid_xml":"https://content.openalex.org/works/W2162675057.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2074911837","https://openalex.org/W2131308754"],"related_works":["https://openalex.org/W3094909023","https://openalex.org/W2090924548","https://openalex.org/W2361932603","https://openalex.org/W1541396481","https://openalex.org/W2783367047","https://openalex.org/W4291786306","https://openalex.org/W2093586813","https://openalex.org/W409827524","https://openalex.org/W2308296687","https://openalex.org/W3217580492"],"abstract_inverted_index":{"Table":[0],"1":[1],"Potential":[2],"drugs":[3],"that":[4],"prolong":[5],"QT":[6,29],"interval":[7],"with":[8,27],"significance":[9],"level":[10],"of":[11],"0.001":[12],"Drug":[13],"Chi-square":[14],"Evidence":[15],"Amiodarone":[16],"39.21":[17],"Known":[18,37,41],"reaction":[19,38,42],"Potassium":[20],"supplements":[21],"24.78":[22],"Treatmenttypically":[23],"given":[24],"to":[25,31],"people":[26],"long":[28],"intervals":[30],"keep":[32],"it":[33],"normal":[34],"Procainamide":[35],"22.11":[36],"Sotalol":[39],"21.62":[40],"Warfarin":[43],"18.42":[44],"No":[45,50,55,60],"evidence":[46,51,56,61],"found":[47,52,57,62],"Meperidine":[48],"18.13":[49],"Oxycodone":[53],"17.08":[54],"Promethazine":[58],"12.90":[59]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}