{"id":"https://openalex.org/W2109520948","doi":"https://doi.org/10.1186/1471-2105-11-s1-s49","title":"Comparative analysis of thermophilic and mesophilic proteins using Protein Energy Networks","display_name":"Comparative analysis of thermophilic and mesophilic proteins using Protein Energy Networks","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2109520948","doi":"https://doi.org/10.1186/1471-2105-11-s1-s49","mag":"2109520948","pmid":"https://pubmed.ncbi.nlm.nih.gov/20122223"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-11-s1-s49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-s1-s49","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-S1-S49","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-S1-S49","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016171735","display_name":"M. S. Vijayabaskar","orcid":"https://orcid.org/0000-0002-5559-9394"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"MS Vijayabaskar","raw_affiliation_strings":["Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India","Molecular Biophysics Unit, Indian Institute of Science Bangalore India"],"affiliations":[{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science Bangalore India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031607667","display_name":"Saraswathi Vishveshwara","orcid":"https://orcid.org/0000-0002-5035-7433"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saraswathi Vishveshwara","raw_affiliation_strings":["Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India","Molecular Biophysics Unit, Indian Institute of Science Bangalore India"],"affiliations":[{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science, Bangalore, 560012, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science Bangalore India","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016171735"],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.4909,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.81582372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"S1","first_page":"S49","last_page":"S49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermophile","display_name":"Thermophile","score":0.971815824508667},{"id":"https://openalex.org/keywords/mesophile","display_name":"Mesophile","score":0.7147412300109863},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.6186283230781555},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5378358364105225},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44731175899505615},{"id":"https://openalex.org/keywords/community-structure","display_name":"Community structure","score":0.43019434809684753},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.41922807693481445},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.35878580808639526},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.33307135105133057},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.28718119859695435},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.27898499369621277},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2370191514492035},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.167690247297287},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.16459211707115173},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.10000535845756531},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.08918485045433044}],"concepts":[{"id":"https://openalex.org/C27911776","wikidata":"https://www.wikidata.org/wiki/Q834023","display_name":"Thermophile","level":3,"score":0.971815824508667},{"id":"https://openalex.org/C63223902","wikidata":"https://www.wikidata.org/wiki/Q669652","display_name":"Mesophile","level":3,"score":0.7147412300109863},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.6186283230781555},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5378358364105225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44731175899505615},{"id":"https://openalex.org/C133079900","wikidata":"https://www.wikidata.org/wiki/Q5155065","display_name":"Community structure","level":2,"score":0.43019434809684753},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.41922807693481445},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.35878580808639526},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.33307135105133057},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28718119859695435},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27898499369621277},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2370191514492035},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.167690247297287},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.16459211707115173},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.10000535845756531},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08918485045433044},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-11-s1-s49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-s1-s49","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-S1-S49","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20122223","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20122223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:c23382415b87464e8df36a0523d1f36b","is_oa":true,"landing_page_url":"https://doaj.org/article/c23382415b87464e8df36a0523d1f36b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 11, Iss Suppl 1, p S49 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3009521","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3009521","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-11-s1-s49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-s1-s49","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-S1-S49","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.7400000095367432}],"awards":[{"id":"https://openalex.org/G4018744250","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2109520948.pdf","grobid_xml":"https://content.openalex.org/works/W2109520948.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1987958688","https://openalex.org/W1998041471","https://openalex.org/W2013888408","https://openalex.org/W2031328428","https://openalex.org/W2067411283","https://openalex.org/W2075422720","https://openalex.org/W2087293973","https://openalex.org/W2101414808","https://openalex.org/W2141179031","https://openalex.org/W2143163389","https://openalex.org/W2153195964","https://openalex.org/W2158543301","https://openalex.org/W2163407325","https://openalex.org/W2163480486","https://openalex.org/W2165533101","https://openalex.org/W2170090899","https://openalex.org/W2171268876","https://openalex.org/W2899278297"],"related_works":["https://openalex.org/W2439525197","https://openalex.org/W2123989420","https://openalex.org/W3046261807","https://openalex.org/W2522404978","https://openalex.org/W4235509827","https://openalex.org/W2063860220","https://openalex.org/W2203541977","https://openalex.org/W2069629445","https://openalex.org/W2007616346","https://openalex.org/W1970617146"],"abstract_inverted_index":{"In":[0],"this":[1],"study":[2],"we":[3],"were":[4,27],"able":[5,28],"to":[6,13,29],"take":[7],"an":[8],"energy":[9],"based":[10],"network":[11],"approach,":[12],"identify":[14],"the":[15,33,37],"factors":[16],"responsible":[17],"for":[18],"enhanced":[19],"stability":[20,56],"of":[21],"thermophiles,":[22,53],"by":[23],"comparative":[24],"analysis.":[25],"We":[26,48],"point":[30],"out":[31],"that":[32],"sub-graph":[34],"parameters":[35],"are":[36],"prominent":[38],"contributing":[39],"factors.":[40],"The":[41],"thermophiles":[42],"have":[43,49],"a":[44,64],"better-packed":[45],"hydrophobic":[46],"core.":[47],"also":[50],"discussed":[51],"how":[52],"although":[54],"increasing":[55],"through":[57],"higher":[58],"connectivity":[59],"retains":[60],"conformational":[61],"flexibility,":[62],"from":[63],"cliques":[65],"and":[66],"communities":[67],"perspective.":[68]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2016-06-24T00:00:00"}