{"id":"https://openalex.org/W2097917417","doi":"https://doi.org/10.1186/1471-2105-11-48","title":"Power and sample size estimation in microarray studies","display_name":"Power and sample size estimation in microarray studies","publication_year":2010,"publication_date":"2010-01-25","ids":{"openalex":"https://openalex.org/W2097917417","doi":"https://doi.org/10.1186/1471-2105-11-48","mag":"2097917417","pmid":"https://pubmed.ncbi.nlm.nih.gov/20100337"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-11-48","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-48","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-48","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-48","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101852345","display_name":"Wei\u2010Jiun Lin","orcid":"https://orcid.org/0009-0000-6944-5874"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei-Jiun Lin","raw_affiliation_strings":["Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA","Division of Personalized Nutrition and Medicine, National Center for Toxicological Research/FDA, Jefferson, USA"],"affiliations":[{"raw_affiliation_string":"Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA","institution_ids":["https://openalex.org/I1304557061"]},{"raw_affiliation_string":"Division of Personalized Nutrition and Medicine, National Center for Toxicological Research/FDA, Jefferson, USA","institution_ids":["https://openalex.org/I1304557061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049314583","display_name":"Huey\u2010Miin Hsueh","orcid":"https://orcid.org/0000-0003-0536-9440"},"institutions":[{"id":"https://openalex.org/I87354575","display_name":"National Chengchi University","ror":"https://ror.org/03rqk8h36","country_code":"TW","type":"education","lineage":["https://openalex.org/I87354575"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Huey-Miin Hsueh","raw_affiliation_strings":["Department of Statistics, National Chengchi University, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, National Chengchi University, Taipei, Taiwan","institution_ids":["https://openalex.org/I87354575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051461953","display_name":"James J. Chen","orcid":"https://orcid.org/0000-0001-6967-6349"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"James J Chen","raw_affiliation_strings":["Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, FDA, Jefferson, AR, 72079, USA","Graduate Institute of Biostatistics and Biostatistics Center, China Medical University, Taichung, Taiwan","Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, FDA, Jefferson, USA"],"affiliations":[{"raw_affiliation_string":"Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, FDA, Jefferson, AR, 72079, USA","institution_ids":["https://openalex.org/I1304557061"]},{"raw_affiliation_string":"Graduate Institute of Biostatistics and Biostatistics Center, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, FDA, Jefferson, USA","institution_ids":["https://openalex.org/I1304557061"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101852345"],"corresponding_institution_ids":["https://openalex.org/I1304557061"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.9304,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.94326061,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"48","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9764999747276306,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.8777816295623779},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.6635972261428833},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.6420860290527344},{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.6076383590698242},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.5381698608398438},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.5321822166442871},{"id":"https://openalex.org/keywords/statistical-power","display_name":"Statistical power","score":0.5315083265304565},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43996870517730713},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.43886247277259827},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.4127744734287262},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.37281960248947144},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15186670422554016},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1121094822883606},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.10707294940948486},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.0976940393447876},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09488639235496521}],"concepts":[{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.8777816295623779},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.6635972261428833},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.6420860290527344},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.6076383590698242},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.5381698608398438},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.5321822166442871},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.5315083265304565},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43996870517730713},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.43886247277259827},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.4127744734287262},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37281960248947144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15186670422554016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1121094822883606},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.10707294940948486},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0976940393447876},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09488639235496521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-11-48","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-48","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-48","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20100337","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20100337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:7f1a1c060a784ffcb8b2f158e3b4d280","is_oa":true,"landing_page_url":"https://doaj.org/article/7f1a1c060a784ffcb8b2f158e3b4d280","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 11, Iss 1, p 48 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2837028","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2837028","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-11-48","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-48","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-48","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2097917417.pdf","grobid_xml":"https://content.openalex.org/works/W2097917417.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1802936766","https://openalex.org/W1985062374","https://openalex.org/W1999649023","https://openalex.org/W2022903980","https://openalex.org/W2087684630","https://openalex.org/W2105381419","https://openalex.org/W2106962250","https://openalex.org/W2110065044","https://openalex.org/W2112071941","https://openalex.org/W2126421206","https://openalex.org/W2129571249","https://openalex.org/W2132804140","https://openalex.org/W2145229405","https://openalex.org/W2156178399","https://openalex.org/W2159741108"],"related_works":["https://openalex.org/W2922240306","https://openalex.org/W1989415248","https://openalex.org/W2055552685","https://openalex.org/W977438452","https://openalex.org/W3041891053","https://openalex.org/W2318436337","https://openalex.org/W139386289","https://openalex.org/W2901452957","https://openalex.org/W2107645900","https://openalex.org/W2156178399"],"abstract_inverted_index":{"We":[0],"recommend":[1],"that":[2],"the":[3,26,40],"sample":[4],"size":[5,45],"problem":[6],"should":[7],"be":[8],"formulated":[9],"to":[10],"detect":[11],"a":[12,54],"specified":[13],"proportion":[14,28],"of":[15,29],"differentially":[16],"expressed":[17],"genes":[18],"with":[19,32],"95%":[20],"probability.":[21,34],"This":[22],"formulation":[23],"ensures":[24],"finding":[25],"desired":[27],"true":[30],"positives":[31],"high":[33],"The":[35],"proposed":[36],"permutation":[37],"method":[38],"takes":[39],"correlation":[41],"structure":[42],"and":[43,49],"effect":[44],"heterogeneity":[46],"into":[47],"consideration":[48],"works":[50],"well":[51],"using":[52],"only":[53],"small":[55],"pilot":[56],"dataset.":[57]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":8}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}