{"id":"https://openalex.org/W2116642156","doi":"https://doi.org/10.1186/1471-2105-11-27","title":"Biomarker discovery in heterogeneous tissue samples -taking the in-silico deconfounding approach","display_name":"Biomarker discovery in heterogeneous tissue samples -taking the in-silico deconfounding approach","publication_year":2010,"publication_date":"2010-01-14","ids":{"openalex":"https://openalex.org/W2116642156","doi":"https://doi.org/10.1186/1471-2105-11-27","mag":"2116642156","pmid":"https://pubmed.ncbi.nlm.nih.gov/20070912"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-11-27","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-27","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-27","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-27","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065327075","display_name":"Dirk Repsilber","orcid":"https://orcid.org/0000-0002-7173-5579"},"institutions":[{"id":"https://openalex.org/I4210099379","display_name":"Zimmer Biomet (Germany)","ror":"https://ror.org/016731f38","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099379","https://openalex.org/I4210115238"]},{"id":"https://openalex.org/I4210119682","display_name":"Research Institute for Farm Animal Biology (FBN)","ror":"https://ror.org/02n5r1g44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210119682"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Dirk Repsilber","raw_affiliation_strings":["Department of Genetics and Biometry, Research Institute for Biology of Farm Animals, Wilhelm-Stahl Allee 2, D 18196 Dummerstorf, Germany. repsilber@fbn-dummerstorf.de","Department of Genetics and Biometry, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Genetics and Biometry, Research Institute for Biology of Farm Animals, Wilhelm-Stahl Allee 2, D 18196 Dummerstorf, Germany. repsilber@fbn-dummerstorf.de","institution_ids":["https://openalex.org/I4210119682"]},{"raw_affiliation_string":"Department of Genetics and Biometry, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany","institution_ids":["https://openalex.org/I4210119682","https://openalex.org/I4210099379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110508035","display_name":"Sabine Kern","orcid":null},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Kern","raw_affiliation_strings":["Bioinformatics Chair, Institute for Biochemistry and Biology at the University of Potsdam, Karl-Liebknecht-Str. 24-25, D 14476, Potsdam-Golm, Germany","Bioinformatics Chair, Institute for Biochemistry and Biology at the University of Potsdam, Potsdam-Golm, Germany"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Chair, Institute for Biochemistry and Biology at the University of Potsdam, Karl-Liebknecht-Str. 24-25, D 14476, Potsdam-Golm, Germany","institution_ids":["https://openalex.org/I176453806"]},{"raw_affiliation_string":"Bioinformatics Chair, Institute for Biochemistry and Biology at the University of Potsdam, Potsdam-Golm, Germany","institution_ids":["https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046866452","display_name":"Anna Telaar","orcid":null},"institutions":[{"id":"https://openalex.org/I4210099379","display_name":"Zimmer Biomet (Germany)","ror":"https://ror.org/016731f38","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099379","https://openalex.org/I4210115238"]},{"id":"https://openalex.org/I4210119682","display_name":"Research Institute for Farm Animal Biology (FBN)","ror":"https://ror.org/02n5r1g44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210119682"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna Telaar","raw_affiliation_strings":["Department of Genetics and Biometry, Research Institute for the Biology of Farm Animals, Wilhelm-Stahl Allee 2, D 18196, Dummerstorf, Germany","Department of Genetics and Biometry, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Genetics and Biometry, Research Institute for the Biology of Farm Animals, Wilhelm-Stahl Allee 2, D 18196, Dummerstorf, Germany","institution_ids":["https://openalex.org/I4210119682"]},{"raw_affiliation_string":"Department of Genetics and Biometry, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany","institution_ids":["https://openalex.org/I4210119682","https://openalex.org/I4210099379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022897595","display_name":"Gerhard Walzl","orcid":"https://orcid.org/0000-0003-2487-125X"},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gerhard Walzl","raw_affiliation_strings":["Molecular Biology and Human Genetics, University of Stellenbosch, Tygerberg, Cape Town, 7505, South Africa","Molecular Biology and Human Genetics, University of Stellenbosch, Tygerberg, South Africa"],"affiliations":[{"raw_affiliation_string":"Molecular Biology and Human Genetics, University of Stellenbosch, Tygerberg, Cape Town, 7505, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Molecular Biology and Human Genetics, University of Stellenbosch, Tygerberg, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026222310","display_name":"Gillian F. Black","orcid":"https://orcid.org/0000-0002-5081-274X"},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gillian F Black","raw_affiliation_strings":["Molecular Biology and Human Genetics, University of Stellenbosch, Tygerberg, Cape Town, 7505, South Africa","Molecular Biology and Human Genetics, University of Stellenbosch, Tygerberg, South Africa"],"affiliations":[{"raw_affiliation_string":"Molecular Biology and Human Genetics, University of Stellenbosch, Tygerberg, Cape Town, 7505, South Africa","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Molecular Biology and Human Genetics, University of Stellenbosch, Tygerberg, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034181383","display_name":"Joachim Selbig","orcid":null},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Selbig","raw_affiliation_strings":["Bioinformatics Chair, Institute for Biochemistry and Biology at the University of Potsdam, Karl-Liebknecht-Str. 24-25, D 14476, Potsdam-Golm, Germany","Bioinformatics Chair, Institute for Biochemistry and Biology at the University of Potsdam, Potsdam-Golm, Germany"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Chair, Institute for Biochemistry and Biology at the University of Potsdam, Karl-Liebknecht-Str. 24-25, D 14476, Potsdam-Golm, Germany","institution_ids":["https://openalex.org/I176453806"]},{"raw_affiliation_string":"Bioinformatics Chair, Institute for Biochemistry and Biology at the University of Potsdam, Potsdam-Golm, Germany","institution_ids":["https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076984957","display_name":"Shreemanta K. Parida","orcid":"https://orcid.org/0000-0003-2129-6691"},"institutions":[{"id":"https://openalex.org/I4210087223","display_name":"Max Planck Institute for Infection Biology","ror":"https://ror.org/0046gcs23","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210087223"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Shreemanta K Parida","raw_affiliation_strings":["Department of Immunology, Max-Planck-Institute for Infection Biology, Charit\u00e9platz 1, D 10117, Berlin, Germany","Dept. of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Immunology, Max-Planck-Institute for Infection Biology, Charit\u00e9platz 1, D 10117, Berlin, Germany","institution_ids":["https://openalex.org/I4210087223","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Dept. of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany","institution_ids":["https://openalex.org/I4210087223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007001229","display_name":"Stefan H. E. Kaufmann","orcid":"https://orcid.org/0000-0001-9866-8268"},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]},{"id":"https://openalex.org/I4210087223","display_name":"Max Planck Institute for Infection Biology","ror":"https://ror.org/0046gcs23","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210087223"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan HE Kaufmann","raw_affiliation_strings":["Department of Immunology, Max-Planck-Institute for Infection Biology, Charit\u00e9platz 1, D 10117, Berlin, Germany","Dept. of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Immunology, Max-Planck-Institute for Infection Biology, Charit\u00e9platz 1, D 10117, Berlin, Germany","institution_ids":["https://openalex.org/I4210087223","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Dept. of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany","institution_ids":["https://openalex.org/I4210087223"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018648114","display_name":"Marc Jacobsen","orcid":"https://orcid.org/0000-0002-4703-5652"},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]},{"id":"https://openalex.org/I4210087223","display_name":"Max Planck Institute for Infection Biology","ror":"https://ror.org/0046gcs23","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210087223"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc Jacobsen","raw_affiliation_strings":["Department of Immunology, Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, D 20359, Hamburg, Germany","Department of Immunology, Max-Planck-Institute for Infection Biology, Charit\u00e9platz 1, D 10117, Berlin, Germany","Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, Germany","Department of Immunology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Immunology, Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, D 20359, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]},{"raw_affiliation_string":"Department of Immunology, Max-Planck-Institute for Infection Biology, Charit\u00e9platz 1, D 10117, Berlin, Germany","institution_ids":["https://openalex.org/I4210087223","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, Germany","institution_ids":["https://openalex.org/I4210087223"]},{"raw_affiliation_string":"Department of Immunology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5065327075"],"corresponding_institution_ids":["https://openalex.org/I4210099379","https://openalex.org/I4210119682"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.3885,"has_fulltext":true,"cited_by_count":129,"citation_normalized_percentile":{"value":0.92885752,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"27","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12535","display_name":"Machine Learning and Data Classification","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.9837999939918518,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.6717450618743896},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5753892660140991},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5529478192329407},{"id":"https://openalex.org/keywords/quantile","display_name":"Quantile","score":0.506445050239563},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4948987364768982},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.43987423181533813},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.43986037373542786},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.40605419874191284},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.40397369861602783},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.397169828414917},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3457852005958557},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3079755902290344},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.29322439432144165},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2176993489265442},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18494799733161926},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1688709855079651}],"concepts":[{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.6717450618743896},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5753892660140991},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5529478192329407},{"id":"https://openalex.org/C118671147","wikidata":"https://www.wikidata.org/wiki/Q578714","display_name":"Quantile","level":2,"score":0.506445050239563},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4948987364768982},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.43987423181533813},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.43986037373542786},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.40605419874191284},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.40397369861602783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.397169828414917},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3457852005958557},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3079755902290344},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.29322439432144165},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2176993489265442},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18494799733161926},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1688709855079651},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2105-11-27","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-27","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-27","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20070912","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20070912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:0d6d65dc13bd473587f63195b2001608","is_oa":true,"landing_page_url":"https://doaj.org/article/0d6d65dc13bd473587f63195b2001608","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 11, Iss 1, p 27 (2010)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:534718","is_oa":true,"landing_page_url":"http://edoc.mpg.de/534718","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, v.11 (2010)","raw_type":"Article"},{"id":"pmh:oai:frl.publisso.de:frl:6406288","is_oa":true,"landing_page_url":"https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-11-27#Declarations","pdf_url":null,"source":{"id":"https://openalex.org/S4377196269","display_name":"PUBLISSO (German National Library of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC bioinformatics, 11: 27","raw_type":"Zeitschriftenartikel"},{"id":"pmh:oai:pubmedcentral.nih.gov:3098067","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3098067","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:pure.mpg.de:item_1686789","is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-000E-C032-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-11-27","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-27","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-27","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1128133788","display_name":null,"funder_award_id":"Gates","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G1301755124","display_name":null,"funder_award_id":"37772","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320322480","display_name":"Universit\u00e4t Potsdam","ror":"https://ror.org/03bnmw459"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2116642156.pdf","grobid_xml":"https://content.openalex.org/works/W2116642156.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W1533335653","https://openalex.org/W1546952499","https://openalex.org/W1562464101","https://openalex.org/W1773728303","https://openalex.org/W1878998981","https://openalex.org/W1947136876","https://openalex.org/W1968881502","https://openalex.org/W2007615926","https://openalex.org/W2013444425","https://openalex.org/W2020859582","https://openalex.org/W2032980774","https://openalex.org/W2051853325","https://openalex.org/W2075665712","https://openalex.org/W2085602902","https://openalex.org/W2100668965","https://openalex.org/W2103431543","https://openalex.org/W2106096333","https://openalex.org/W2109847775","https://openalex.org/W2129271267","https://openalex.org/W2137605677","https://openalex.org/W2145347221","https://openalex.org/W2147730364","https://openalex.org/W2161027523","https://openalex.org/W2164216268","https://openalex.org/W2333836441","https://openalex.org/W2764941563","https://openalex.org/W2911964244","https://openalex.org/W4248966074"],"related_works":["https://openalex.org/W2096302356","https://openalex.org/W2069695727","https://openalex.org/W1996185163","https://openalex.org/W2084813257","https://openalex.org/W2043690326","https://openalex.org/W2045929470","https://openalex.org/W4233500668","https://openalex.org/W2081127504","https://openalex.org/W1974145978","https://openalex.org/W1977867163"],"abstract_inverted_index":{"The":[0],"deconfounding":[1,39],"algorithm":[2],"without":[3],"decorrelation":[4],"using":[5],"quantile":[6],"normalization":[7],"on":[8],"non-log":[9],"data":[10],"is":[11,31],"proposed":[12],"for":[13,21,61],"biomarkers":[14,60],"that":[15],"are":[16],"difficult":[17],"to":[18,57],"detect,":[19],"and":[20,64,72],"cases":[22],"where":[23],"confounding":[24],"by":[25],"varying":[26],"proportions":[27],"of":[28],"cell":[29],"types":[30],"the":[32],"suspected":[33],"reason.":[34],"In":[35],"this":[36],"case,":[37],"a":[38,46],"ranking":[40],"approach":[41],"can":[42],"be":[43],"used":[44],"as":[45],"powerful":[47],"alternative":[48],"to,":[49],"or":[50],"complement":[51],"of,":[52],"other":[53],"statistical":[54],"learning":[55],"approaches":[56],"define":[58],"candidate":[59],"molecular":[62],"diagnosis":[63],"prediction":[65],"in":[66,68],"biomedicine,":[67],"realistically":[69],"noisy":[70],"conditions":[71],"with":[73],"moderate":[74],"sample":[75],"sizes.":[76]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}