{"id":"https://openalex.org/W2055668535","doi":"https://doi.org/10.1186/1471-2105-11-234","title":"A semi-parametric Bayesian model for unsupervised differential co-expression analysis","display_name":"A semi-parametric Bayesian model for unsupervised differential co-expression analysis","publication_year":2010,"publication_date":"2010-05-07","ids":{"openalex":"https://openalex.org/W2055668535","doi":"https://doi.org/10.1186/1471-2105-11-234","mag":"2055668535","pmid":"https://pubmed.ncbi.nlm.nih.gov/20459663"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-11-234","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-234","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-234","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-234","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022233425","display_name":"Johannes Freudenberg","orcid":"https://orcid.org/0000-0002-5327-4414"},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Johannes M Freudenberg","raw_affiliation_strings":["Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati OH 45267-0056, USA","Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati OH 45267-0056, USA","institution_ids":["https://openalex.org/I92156820","https://openalex.org/I63135867"]},{"raw_affiliation_string":"Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, USA","institution_ids":["https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002224386","display_name":"Siva Sivaganesan","orcid":null},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siva Sivaganesan","raw_affiliation_strings":["Mathematical Sciences Department, University of Cincinnati, Cincinnati, OH, 45221, USA","Mathematical Sciences Department, University of Cincinnati, Cincinnati, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematical Sciences Department, University of Cincinnati, Cincinnati, OH, 45221, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Mathematical Sciences Department, University of Cincinnati, Cincinnati, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034994947","display_name":"Michael Wagner","orcid":"https://orcid.org/0000-0003-3421-4763"},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Wagner","raw_affiliation_strings":["Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, USA","Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057856712","display_name":"Mario Medvedovic","orcid":"https://orcid.org/0000-0003-4510-3102"},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario Medvedovic","raw_affiliation_strings":["Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Ave. ML 56, Cincinnati, OH, 45267-0056, USA","Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Ave. ML 56, Cincinnati, OH, 45267-0056, USA","institution_ids":["https://openalex.org/I92156820"]},{"raw_affiliation_string":"Laboratory for Statistical Genomics and Systems Biology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, USA","institution_ids":["https://openalex.org/I92156820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5022233425"],"corresponding_institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.0888,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.76095647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"234","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7996000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7996000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.13850000500679016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7277710437774658},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5799964070320129},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5631215572357178},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.52760249376297},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5059344172477722},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.46431872248649597},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.46214473247528076},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4558696448802948},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4274216890335083},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4242200255393982},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.41801488399505615},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3737095296382904},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3625611662864685},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.33861982822418213},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.31485915184020996}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7277710437774658},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5799964070320129},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5631215572357178},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.52760249376297},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5059344172477722},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46431872248649597},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.46214473247528076},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4558696448802948},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4274216890335083},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4242200255393982},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41801488399505615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3737095296382904},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3625611662864685},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33861982822418213},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31485915184020996},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-11-234","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-234","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-234","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20459663","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20459663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:2f12b86a5b40413a9bfe1778d6131468","is_oa":false,"landing_page_url":"https://doaj.org/article/2f12b86a5b40413a9bfe1778d6131468","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 11, Iss 1, p 234 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2876132","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2876132","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-11-234","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-234","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-234","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6499999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2055668535.pdf","grobid_xml":"https://content.openalex.org/works/W2055668535.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W13366983","https://openalex.org/W1493217831","https://openalex.org/W1513861746","https://openalex.org/W1546709038","https://openalex.org/W1607267312","https://openalex.org/W2003124695","https://openalex.org/W2016493165","https://openalex.org/W2021129827","https://openalex.org/W2028236537","https://openalex.org/W2035037267","https://openalex.org/W2053126761","https://openalex.org/W2055842970","https://openalex.org/W2057682468","https://openalex.org/W2058451329","https://openalex.org/W2069429561","https://openalex.org/W2071047821","https://openalex.org/W2080972498","https://openalex.org/W2083875149","https://openalex.org/W2087684630","https://openalex.org/W2088160256","https://openalex.org/W2096079397","https://openalex.org/W2096261772","https://openalex.org/W2097255042","https://openalex.org/W2098216772","https://openalex.org/W2105877777","https://openalex.org/W2105883975","https://openalex.org/W2107273620","https://openalex.org/W2111627808","https://openalex.org/W2114954827","https://openalex.org/W2118413367","https://openalex.org/W2118460019","https://openalex.org/W2120865735","https://openalex.org/W2121158863","https://openalex.org/W2121195642","https://openalex.org/W2128985829","https://openalex.org/W2129296674","https://openalex.org/W2130095365","https://openalex.org/W2131994307","https://openalex.org/W2134092271","https://openalex.org/W2134891969","https://openalex.org/W2135827569","https://openalex.org/W2136107412","https://openalex.org/W2139329624","https://openalex.org/W2139522545","https://openalex.org/W2139807849","https://openalex.org/W2150473224","https://openalex.org/W2150671673","https://openalex.org/W2150698576","https://openalex.org/W2157840751","https://openalex.org/W2161732139","https://openalex.org/W2165133998","https://openalex.org/W2165816035","https://openalex.org/W2167190345","https://openalex.org/W2168546553","https://openalex.org/W2169318796","https://openalex.org/W4237780050"],"related_works":["https://openalex.org/W2069695727","https://openalex.org/W1996185163","https://openalex.org/W2084813257","https://openalex.org/W2045929470","https://openalex.org/W2081127504","https://openalex.org/W2122223946","https://openalex.org/W4233500668","https://openalex.org/W1974145978","https://openalex.org/W1977867163","https://openalex.org/W2393426762"],"abstract_inverted_index":{"BACKGROUND:":[0],"Differential":[1],"co-expression":[2,60,68,160,184],"analysis":[3,25,161,238],"is":[4,93,139,151],"an":[5],"emerging":[6],"strategy":[7],"for":[8,50,89,157],"characterizing":[9],"disease":[10,201],"related":[11],"dysregulation":[12],"of":[13,21,41,56,64,99,109,137,147,170,174,182,199,205,216,227,239],"gene":[14,110,241],"expression":[15,111,122,188,242,248],"regulatory":[16,219,249],"networks.":[17,250],"Given":[18],"pre-defined":[19],"sets":[20],"biological":[22,91,117],"samples,":[23],"such":[24,71],"aims":[26],"at":[27],"identifying":[28,171],"genes":[29,65,100,138,208],"that":[30,224],"are":[31],"co-expressed":[32,207],"in":[33,37,85,127,162,235],"one,":[34],"but":[35],"not":[36,105],"the":[38,81,96,128,134,145,152,168,200,213,217,225,228,232,236],"other":[39],"set":[40],"samples.":[42,143],"RESULTS:":[43],"We":[44,222],"developed":[45],"a":[46],"novel":[47],"probabilistic":[48],"framework":[49],"jointly":[51],"uncovering":[52],"contexts":[53],"(i.e.":[54],"groups":[55,63],"samples)":[57],"with":[58,66,119],"specific":[59],"patterns,":[61],"and":[62,78,104],"different":[67],"patterns":[69,123,181,195,204],"across":[70,185],"contexts.":[72],"In":[73],"contrast":[74],"to":[75,155,167],"current":[76],"clustering":[77,97],"bi-clustering":[79],"procedures,":[80],"implicit":[82],"similarity":[83,233],"measure":[84,234],"this":[86,115,150,163],"model":[87],"used":[88],"grouping":[90],"samples":[92,118],"based":[94],"on":[95,106],"structure":[98,136,230],"within":[101,141],"each":[102],"sample":[103,240],"traditional":[107],"measures":[108],"level":[112],"similarities.":[113],"Within":[114],"framework,":[116],"widely":[120],"discordant":[121],"can":[124],"be":[125],"placed":[126],"same":[129],"context":[130],"as":[131,133,231],"long":[132],"co-clustering":[135,229],"concordant":[140],"these":[142,194],"To":[144],"best":[146],"our":[148,177],"knowledge,":[149],"first":[153],"method":[154,178],"date":[156],"unsupervised":[158,237],"differential":[159,183],"generality.":[164],"When":[165],"applied":[166],"problem":[169],"molecular":[172],"subtypes":[173],"breast":[175],"cancer,":[176],"identified":[179],"reproducible":[180],"several":[186],"independent":[187],"datasets.":[189],"Sample":[190],"groupings":[191],"induced":[192],"by":[193],"were":[196],"highly":[197],"informative":[198],"outcome.":[202],"Expression":[203],"differentially":[206],"provided":[209],"new":[210],"insights":[211],"into":[212],"complex":[214],"nature":[215],"ERalpha":[218],"network.":[220],"CONCLUSIONS:":[221],"demonstrated":[223],"use":[226],"profiles":[243],"provides":[244],"valuable":[245],"information":[246],"about":[247]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}