{"id":"https://openalex.org/W1596845942","doi":"https://doi.org/10.1186/1471-2105-11-202","title":"Systematic calibration of a cell signaling network model","display_name":"Systematic calibration of a cell signaling network model","publication_year":2010,"publication_date":"2010-04-23","ids":{"openalex":"https://openalex.org/W1596845942","doi":"https://doi.org/10.1186/1471-2105-11-202","mag":"1596845942","pmid":"https://pubmed.ncbi.nlm.nih.gov/20416044"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-11-202","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-202","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-202","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-202","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028893132","display_name":"Kyoung A.E. Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kyoung Ae Kim","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon, 305-701, Republic of Korea","Department of Chemical and Biomolecular Engineering(BK21 Program) and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, Yuseong-gu, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon, 305-701, Republic of Korea","institution_ids":[]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering(BK21 Program) and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, Yuseong-gu, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000042681","display_name":"Sabrina L. Spencer","orcid":"https://orcid.org/0000-0002-5798-3007"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabrina L Spencer","raw_affiliation_strings":["Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA","Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA","Department of Systems Biology, Harvard Medical School, Boston, USA","Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA"],"affiliations":[{"raw_affiliation_string":"Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052109946","display_name":"John G. Albeck","orcid":"https://orcid.org/0000-0003-2688-8653"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John G Albeck","raw_affiliation_strings":["Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA","Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA","Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA","Department of Systems Biology, Harvard Medical School, Boston, USA"],"affiliations":[{"raw_affiliation_string":"Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002748007","display_name":"John M. Burke","orcid":"https://orcid.org/0000-0002-1412-5539"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M Burke","raw_affiliation_strings":["Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA","Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA","Department of Systems Biology, Harvard Medical School, Boston, USA","Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA"],"affiliations":[{"raw_affiliation_string":"Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063426870","display_name":"Peter K. Sorger","orcid":"https://orcid.org/0000-0002-3364-1838"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter K Sorger","raw_affiliation_strings":["Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA","Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA","Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA","Department of Systems Biology, Harvard Medical School, Boston, USA"],"affiliations":[{"raw_affiliation_string":"Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089810766","display_name":"Suzanne Gaudet","orcid":"https://orcid.org/0000-0002-5701-2825"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Gaudet","raw_affiliation_strings":["Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA","Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA","Department of Systems Biology, Harvard Medical School, Boston, USA","Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA"],"affiliations":[{"raw_affiliation_string":"Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Center for Cell Decision Process, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100336711","display_name":"Do Hyun Kim","orcid":"https://orcid.org/0000-0001-8631-2790"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Do Hyun Kim","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering(BK21 Program) and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, 335 Gwahak-, Yuseong-gu, Daejeon, 305-701, Republic of Korea","Department of Chemical and Biomolecular Engineering(BK21 Program) and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, Yuseong-gu, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering(BK21 Program) and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, 335 Gwahak-, Yuseong-gu, Daejeon, 305-701, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering(BK21 Program) and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, Yuseong-gu, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5028893132"],"corresponding_institution_ids":["https://openalex.org/I157485424"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.3448,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.5904503,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"11","issue":"1","first_page":"202","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9562000036239624,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9451000094413757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calibration","display_name":"Calibration","score":0.6121391654014587},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5766634941101074},{"id":"https://openalex.org/keywords/limiting","display_name":"Limiting","score":0.5399070382118225},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.5236178040504456},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.32715797424316406},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.32156798243522644},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.18457907438278198},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16035780310630798},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.10687950253486633}],"concepts":[{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.6121391654014587},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5766634941101074},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.5399070382118225},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5236178040504456},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.32715797424316406},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.32156798243522644},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.18457907438278198},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16035780310630798},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10687950253486633},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-11-202","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-202","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-202","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20416044","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20416044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:dspace.mit.edu:1721.1/58679","is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/58679","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioMed Central Ltd","raw_type":"http://purl.org/eprint/type/JournalArticle"},{"id":"pmh:oai:koasas.kaist.ac.kr:10203/25195","is_oa":false,"landing_page_url":"http://hdl.handle.net/10203/25195","pdf_url":null,"source":{"id":"https://openalex.org/S4306402435","display_name":"KAIST Institutional Repository (KAIST)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157485424","host_organization_name":"Korea Advanced Institute of Science and Technology","host_organization_lineage":["https://openalex.org/I157485424"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2880028","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2880028","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"mag:1596845942","is_oa":false,"landing_page_url":"https://dspace.mit.edu/handle/1721.1/58679","pdf_url":null,"source":{"id":"https://openalex.org/S4306504412","display_name":"BioMed Central Ltd","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"BioMed Central Ltd","raw_type":null}],"best_oa_location":{"id":"doi:10.1186/1471-2105-11-202","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-202","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-202","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1596845942.pdf","grobid_xml":"https://content.openalex.org/works/W1596845942.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1553833389","https://openalex.org/W1557686543","https://openalex.org/W1964037688","https://openalex.org/W1982258483","https://openalex.org/W1985911638","https://openalex.org/W1996861281","https://openalex.org/W1997774242","https://openalex.org/W2039793587","https://openalex.org/W2054286320","https://openalex.org/W2096337402","https://openalex.org/W2101589741","https://openalex.org/W2106362845","https://openalex.org/W2111510713","https://openalex.org/W2124630954","https://openalex.org/W2138766682","https://openalex.org/W2149286020","https://openalex.org/W2151339633","https://openalex.org/W2165603655","https://openalex.org/W2166565152","https://openalex.org/W4241793634","https://openalex.org/W4247680473"],"related_works":["https://openalex.org/W2092077482","https://openalex.org/W2340194604","https://openalex.org/W2767424954","https://openalex.org/W2102434872","https://openalex.org/W2949890765","https://openalex.org/W2311379758","https://openalex.org/W2953160040","https://openalex.org/W2096369764","https://openalex.org/W2084162120","https://openalex.org/W3007078092","https://openalex.org/W2748151855","https://openalex.org/W2146432559","https://openalex.org/W2253963043","https://openalex.org/W2951100694","https://openalex.org/W1496074117","https://openalex.org/W2793570956","https://openalex.org/W3090947236","https://openalex.org/W2245948944","https://openalex.org/W2088383307","https://openalex.org/W2510729796"],"abstract_inverted_index":{"Our":[0],"proposed":[1],"framework":[2],"covers":[3],"the":[4,27],"entire":[5],"process":[6],"from":[7],"validating":[8],"a":[9,13,23],"proto-model":[10],"to":[11],"establishing":[12],"realistic":[14],"model":[15],"for":[16,26],"in":[17],"silico":[18],"experiments":[19],"and":[20],"thereby":[21],"provides":[22],"generalized":[24],"workflow":[25],"construction":[28],"of":[29,32],"predictive":[30],"models":[31],"complex":[33],"network":[34],"systems.":[35]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}