{"id":"https://openalex.org/W2061453990","doi":"https://doi.org/10.1186/1471-2105-11-2","title":"Predicting gene function using hierarchical multi-label decision tree ensembles","display_name":"Predicting gene function using hierarchical multi-label decision tree ensembles","publication_year":2010,"publication_date":"2010-01-02","ids":{"openalex":"https://openalex.org/W2061453990","doi":"https://doi.org/10.1186/1471-2105-11-2","mag":"2061453990","pmid":"https://pubmed.ncbi.nlm.nih.gov/20044933"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-11-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056559240","display_name":"Leander Schietgat","orcid":"https://orcid.org/0000-0002-2097-0974"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Leander Schietgat","raw_affiliation_strings":["Department of Computer Science, Katholieke Universiteit Leuven, Celestijnenlaan 200A, 3001 Leuven, Belgium. leander.schietgat@cs.kuleuven.be","Department of Computer Science , Katholieke Universiteit Leuven , Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Katholieke Universiteit Leuven, Celestijnenlaan 200A, 3001 Leuven, Belgium. leander.schietgat@cs.kuleuven.be","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Computer Science , Katholieke Universiteit Leuven , Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044903173","display_name":"Celine Vens","orcid":"https://orcid.org/0000-0003-0983-256X"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Celine Vens","raw_affiliation_strings":["Department of Computer Science, Katholieke Universiteit Leuven, Celestijnenlaan 200A, 3001, Leuven, Belgium","Department of Computer Science , Katholieke Universiteit Leuven , Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Katholieke Universiteit Leuven, Celestijnenlaan 200A, 3001, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Computer Science , Katholieke Universiteit Leuven , Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068600618","display_name":"Jan Struyf","orcid":null},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Struyf","raw_affiliation_strings":["Department of Computer Science, Katholieke Universiteit Leuven, Celestijnenlaan 200A, 3001, Leuven, Belgium","Department of Computer Science , Katholieke Universiteit Leuven , Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Katholieke Universiteit Leuven, Celestijnenlaan 200A, 3001, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Computer Science , Katholieke Universiteit Leuven , Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086906175","display_name":"Hendrik Blockeel","orcid":"https://orcid.org/0000-0003-0378-3699"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hendrik Blockeel","raw_affiliation_strings":["Department of Computer Science, Katholieke Universiteit Leuven, Celestijnenlaan 200A, 3001, Leuven, Belgium","Department of Computer Science , Katholieke Universiteit Leuven , Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Katholieke Universiteit Leuven, Celestijnenlaan 200A, 3001, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Computer Science , Katholieke Universiteit Leuven , Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004076545","display_name":"Dragi Kocev","orcid":"https://orcid.org/0000-0003-0687-0878"},"institutions":[{"id":"https://openalex.org/I3006985408","display_name":"Jo\u017eef Stefan Institute","ror":"https://ror.org/05060sz93","country_code":"SI","type":"facility","lineage":["https://openalex.org/I3006985408"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Dragi Kocev","raw_affiliation_strings":["Department of Knowledge Technologies, Jo\u017eef Stefan Institute, Jamova cesta 39, 1000, Ljubljana, Slovenia","Department of Knowledge Technologies, Jo\u017eef Stefan Institute Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Knowledge Technologies, Jo\u017eef Stefan Institute, Jamova cesta 39, 1000, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3006985408"]},{"raw_affiliation_string":"Department of Knowledge Technologies, Jo\u017eef Stefan Institute Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3006985408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064609702","display_name":"Sa\u0161o D\u017eeroski","orcid":"https://orcid.org/0000-0003-2363-712X"},"institutions":[{"id":"https://openalex.org/I3006985408","display_name":"Jo\u017eef Stefan Institute","ror":"https://ror.org/05060sz93","country_code":"SI","type":"facility","lineage":["https://openalex.org/I3006985408"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Sa\u0161o D\u017eeroski","raw_affiliation_strings":["Department of Knowledge Technologies, Jo\u017eef Stefan Institute, Jamova cesta 39, 1000, Ljubljana, Slovenia","Department of Knowledge Technologies, Jo\u017eef Stefan Institute Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Knowledge Technologies, Jo\u017eef Stefan Institute, Jamova cesta 39, 1000, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3006985408"]},{"raw_affiliation_string":"Department of Knowledge Technologies, Jo\u017eef Stefan Institute Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3006985408"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044903173","https://openalex.org/A5056559240"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":5.6004,"has_fulltext":true,"cited_by_count":197,"citation_normalized_percentile":{"value":0.96927689,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"2","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.8284000158309937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.8284000158309937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.060600001364946365,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11550","display_name":"Text and Document Classification Technologies","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orfs","display_name":"ORFS","score":0.7343374490737915},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6790063977241516},{"id":"https://openalex.org/keywords/decision-tree","display_name":"Decision tree","score":0.6751112341880798},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.6611263751983643},{"id":"https://openalex.org/keywords/tree","display_name":"Tree (set theory)","score":0.6381824016571045},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6179099082946777},{"id":"https://openalex.org/keywords/protein-function-prediction","display_name":"Protein function prediction","score":0.5080976486206055},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.48337501287460327},{"id":"https://openalex.org/keywords/usability","display_name":"Usability","score":0.42683690786361694},{"id":"https://openalex.org/keywords/hierarchy","display_name":"Hierarchy","score":0.4172733426094055},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3840159475803375},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3793550431728363},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.28312647342681885},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20598509907722473},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16062021255493164},{"id":"https://openalex.org/keywords/protein-function","display_name":"Protein function","score":0.1493123471736908},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14206182956695557},{"id":"https://openalex.org/keywords/open-reading-frame","display_name":"Open reading frame","score":0.13037225604057312}],"concepts":[{"id":"https://openalex.org/C2780530800","wikidata":"https://www.wikidata.org/wiki/Q7072921","display_name":"ORFS","level":5,"score":0.7343374490737915},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6790063977241516},{"id":"https://openalex.org/C84525736","wikidata":"https://www.wikidata.org/wiki/Q831366","display_name":"Decision tree","level":2,"score":0.6751112341880798},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6611263751983643},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.6381824016571045},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6179099082946777},{"id":"https://openalex.org/C207060522","wikidata":"https://www.wikidata.org/wiki/Q7251473","display_name":"Protein function prediction","level":4,"score":0.5080976486206055},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.48337501287460327},{"id":"https://openalex.org/C170130773","wikidata":"https://www.wikidata.org/wiki/Q216378","display_name":"Usability","level":2,"score":0.42683690786361694},{"id":"https://openalex.org/C31170391","wikidata":"https://www.wikidata.org/wiki/Q188619","display_name":"Hierarchy","level":2,"score":0.4172733426094055},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3840159475803375},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3793550431728363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28312647342681885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20598509907722473},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16062021255493164},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.1493123471736908},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14206182956695557},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.13037225604057312},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.0},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C34447519","wikidata":"https://www.wikidata.org/wiki/Q179522","display_name":"Market economy","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2105-11-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20044933","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20044933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/261164","is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/261164","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"BMC Bioinformatics, vol. 11 (2), Art.No. ARTN 2","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:5a9f4a5f3b0446cda695404f1f3b8415","is_oa":false,"landing_page_url":"https://doaj.org/article/5a9f4a5f3b0446cda695404f1f3b8415","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 11, Iss 1, p 2 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2824675","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2824675","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2863290","is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/59676","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC bioinformatics","raw_type":"Article / Letter to editor"},{"id":"pmh:ul:oai:scholarlypublications.universiteitleiden.nl:item_2863290","is_oa":true,"landing_page_url":"https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-11-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC bioinformatics, 11, 2","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-11-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions","score":0.7200000286102295}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2061453990.pdf","grobid_xml":"https://content.openalex.org/works/W2061453990.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W98862427","https://openalex.org/W392423658","https://openalex.org/W1483118642","https://openalex.org/W1485485495","https://openalex.org/W1549710828","https://openalex.org/W1550629956","https://openalex.org/W1554219991","https://openalex.org/W1571836963","https://openalex.org/W1576520375","https://openalex.org/W1583837637","https://openalex.org/W1584659901","https://openalex.org/W1594031697","https://openalex.org/W1604938182","https://openalex.org/W1967542092","https://openalex.org/W1976526581","https://openalex.org/W1977224551","https://openalex.org/W1999154602","https://openalex.org/W2013502943","https://openalex.org/W2022366078","https://openalex.org/W2042210880","https://openalex.org/W2053621743","https://openalex.org/W2089306171","https://openalex.org/W2099946731","https://openalex.org/W2100857059","https://openalex.org/W2103017472","https://openalex.org/W2107710781","https://openalex.org/W2119043225","https://openalex.org/W2121526711","https://openalex.org/W2121893605","https://openalex.org/W2124649441","https://openalex.org/W2125055259","https://openalex.org/W2134206588","https://openalex.org/W2135140174","https://openalex.org/W2137810087","https://openalex.org/W2140611547","https://openalex.org/W2144482798","https://openalex.org/W2147461734","https://openalex.org/W2148851475","https://openalex.org/W2152871646","https://openalex.org/W2155440340","https://openalex.org/W2156386646","https://openalex.org/W2158714788","https://openalex.org/W2170913656","https://openalex.org/W2526526357","https://openalex.org/W2911731670","https://openalex.org/W2911964244","https://openalex.org/W2912934387","https://openalex.org/W2913340405","https://openalex.org/W2913529121","https://openalex.org/W2913965489","https://openalex.org/W2914218031","https://openalex.org/W3085162807","https://openalex.org/W3199143553","https://openalex.org/W4246925013","https://openalex.org/W4252684946"],"related_works":["https://openalex.org/W2100847587","https://openalex.org/W2039410154","https://openalex.org/W2140948740","https://openalex.org/W2552089663","https://openalex.org/W1976390578","https://openalex.org/W2360726289","https://openalex.org/W1980765857","https://openalex.org/W2055792485","https://openalex.org/W1991032667","https://openalex.org/W2020342284"],"abstract_inverted_index":{"BACKGROUND:":[0],"S.":[1],"cerevisiae,":[2],"A.":[3],"thaliana":[4],"and":[5,13,70,182,189,200,217],"M.":[6],"musculus":[7],"are":[8,176,183,213],"well-studied":[9],"organisms":[10],"in":[11,40,64],"biology":[12],"the":[14,38,75,84,105,133,144,152,194],"sequencing":[15],"of":[16,66,77,87,107,115,155,162,173],"their":[17],"genomes":[18,42],"was":[19],"completed":[20],"many":[21],"years":[22],"ago.":[23],"It":[24],"is":[25,60,158,197],"still":[26],"a":[27,112,214],"challenge,":[28],"however,":[29],"to":[30,37,51,61,202,220],"develop":[31],"methods":[32,47,212],"that":[33,132,161,171,208],"assign":[34],"biological":[35],"functions":[36,86,106,117],"ORFs":[39],"these":[41],"automatically.":[43],"Different":[44],"machine":[45],"learning":[46,95,167,188],"have":[48],"been":[49],"proposed":[50,165],"this":[52,129],"end,":[53],"but":[54],"it":[55,137],"remains":[56],"unclear":[57],"which":[58],"method":[59,196],"be":[62],"preferred":[63],"terms":[65],"predictive":[67,141,153],"performance,":[68],"efficiency":[69],"usability.":[71],"RESULTS:":[72],"We":[73,123,169],"study":[74],"use":[76],"decision":[78,98,209],"tree":[79,210],"based":[80,211],"models":[81],"for":[82,94],"predicting":[83],"multiple":[85],"ORFs.":[88],"First,":[89],"we":[90],"describe":[91],"an":[92,108],"algorithm":[93],"hierarchical":[96],"multi-label":[97],"trees.":[99],"These":[100],"can":[101],"simultaneously":[102],"predict":[103],"all":[104],"ORF,":[109],"while":[110],"respecting":[111],"given":[113],"hierarchy":[114],"gene":[116],"(such":[118],"as":[119],"FunCat":[120],"or":[121],"GO).":[122],"present":[124],"new":[125],"results":[126,206],"obtained":[127],"with":[128,185],"algorithm,":[130],"showing":[131],"trees":[134,145,157,175,181],"found":[135,146],"by":[136,147],"exhibit":[138],"clearly":[139],"better":[140],"performance":[142,154],"than":[143,160,179],"previously":[148],"described":[149],"methods.":[150,168,192],"Nevertheless,":[151],"individual":[156],"lower":[159],"some":[163],"recently":[164],"statistical":[166,187],"show":[170],"ensembles":[172],"such":[174],"more":[177],"accurate":[178],"single":[180],"competitive":[184],"state-of-the-art":[186],"functional":[190],"linkage":[191],"Moreover,":[193],"ensemble":[195],"computationally":[198],"efficient":[199,216],"easy":[201],"use.":[203],"CONCLUSIONS:":[204],"Our":[205],"suggest":[207],"state-of-the-art,":[215],"easy-to-use":[218],"approach":[219],"ORF":[221],"function":[222],"prediction.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":13}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}