{"id":"https://openalex.org/W2083449189","doi":"https://doi.org/10.1186/1471-2105-11-162","title":"Knowledge-guided gene ranking by coordinative component analysis","display_name":"Knowledge-guided gene ranking by coordinative component analysis","publication_year":2010,"publication_date":"2010-03-30","ids":{"openalex":"https://openalex.org/W2083449189","doi":"https://doi.org/10.1186/1471-2105-11-162","mag":"2083449189","pmid":"https://pubmed.ncbi.nlm.nih.gov/20353603"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-11-162","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-162","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-162","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-162","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100337669","display_name":"Chen Wang","orcid":"https://orcid.org/0000-0003-2638-3081"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Wang","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA","Department of Electrical & Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Department of Electrical & Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101536121","display_name":"Jianhua Xuan","orcid":"https://orcid.org/0000-0001-7256-1374"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhua Xuan","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA","Virginia Polytechnic Institute And State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Virginia Polytechnic Institute And State University","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074947237","display_name":"Huai Li","orcid":"https://orcid.org/0000-0001-7129-6660"},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huai Li","raw_affiliation_strings":["Bioinformatics Unit, Research Resources Branch, National Institute on Aging, NIH, Baltimore, MD, USA","Bioinformatics Unit, Research Resources Branch, National Institute on Aging, NIH, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Unit, Research Resources Branch, National Institute on Aging, NIH, Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Bioinformatics Unit, Research Resources Branch, National Institute on Aging, NIH, Baltimore, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100646913","display_name":"Yue Wang","orcid":"https://orcid.org/0000-0001-6698-6210"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Wang","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA","Virginia Polytechnic Institute And State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Virginia Polytechnic Institute And State University","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028221595","display_name":"Ming Zhan","orcid":"https://orcid.org/0000-0002-4668-727X"},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Zhan","raw_affiliation_strings":["Bioinformatics Unit, Research Resources Branch, National Institute on Aging, NIH, Baltimore, MD, USA","Bioinformatics Unit, Research Resources Branch, National Institute on Aging, NIH, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Unit, Research Resources Branch, National Institute on Aging, NIH, Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Bioinformatics Unit, Research Resources Branch, National Institute on Aging, NIH, Baltimore, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086088688","display_name":"Eric P. Hoffman","orcid":"https://orcid.org/0000-0001-6470-5139"},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric P Hoffman","raw_affiliation_strings":["Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, USA","Research Center for Genetic Medicine, Children\u2019s National Medical Center, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"Research Center for Genetic Medicine, Children\u2019s National Medical Center, Washington, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011322600","display_name":"Robert Clarke","orcid":"https://orcid.org/0000-0002-9278-0854"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Clarke","raw_affiliation_strings":["Departments of Oncology and Physiology & Biophysics, Georgetown University School of Medicine, Washington, DC, USA","Departments of Oncology and Physiology & Biophysics, Georgetown University School of Medicine, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncology and Physiology & Biophysics, Georgetown University School of Medicine, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"Departments of Oncology and Physiology & Biophysics, Georgetown University School of Medicine, Washington, USA","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.0891,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.76361541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"162","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8144000172615051,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8144000172615051,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.14890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5903537273406982},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5354623198509216},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.4790550470352173},{"id":"https://openalex.org/keywords/bootstrapping","display_name":"Bootstrapping (finance)","score":0.4767609238624573},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4747752845287323},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.46945804357528687},{"id":"https://openalex.org/keywords/coca","display_name":"Coca","score":0.46885213255882263},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.44914111495018005},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4464963674545288},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.44069749116897583},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.44003331661224365},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.435601145029068},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.42901909351348877},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.42389416694641113},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3925780951976776},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.330214262008667},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2838703691959381},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2544018626213074},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.19399654865264893},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1643349826335907},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10635235905647278}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5903537273406982},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5354623198509216},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.4790550470352173},{"id":"https://openalex.org/C207609745","wikidata":"https://www.wikidata.org/wiki/Q4944086","display_name":"Bootstrapping (finance)","level":2,"score":0.4767609238624573},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4747752845287323},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46945804357528687},{"id":"https://openalex.org/C2781313679","wikidata":"https://www.wikidata.org/wiki/Q66793593","display_name":"Coca","level":2,"score":0.46885213255882263},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.44914111495018005},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4464963674545288},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.44069749116897583},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.44003331661224365},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.435601145029068},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.42901909351348877},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.42389416694641113},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3925780951976776},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.330214262008667},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2838703691959381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2544018626213074},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19399654865264893},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1643349826335907},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10635235905647278},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051188","descriptor_name":"Knowledge Bases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-11-162","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-162","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-162","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20353603","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20353603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:f7e561e04324465f9c1978f72a6deca8","is_oa":true,"landing_page_url":"https://doaj.org/article/f7e561e04324465f9c1978f72a6deca8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 11, Iss 1, p 162 (2010)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1919049","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2865494","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/18755","is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/18755","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-11-162","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-11-162","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-11-162","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1144149631","display_name":null,"funder_award_id":"BC030280","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1507878677","display_name":null,"funder_award_id":"NS29525-13A","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2974495216","display_name":null,"funder_award_id":"CA109872","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3283202979","display_name":null,"funder_award_id":"EB000830","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4951317011","display_name":null,"funder_award_id":"CA139246","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2083449189.pdf","grobid_xml":"https://content.openalex.org/works/W2083449189.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1497450746","https://openalex.org/W1814100322","https://openalex.org/W1975391983","https://openalex.org/W1976948369","https://openalex.org/W1979678061","https://openalex.org/W1995945562","https://openalex.org/W1997921822","https://openalex.org/W2010637767","https://openalex.org/W2012708732","https://openalex.org/W2012881624","https://openalex.org/W2013449615","https://openalex.org/W2014073178","https://openalex.org/W2014596061","https://openalex.org/W2016926978","https://openalex.org/W2023282380","https://openalex.org/W2029735349","https://openalex.org/W2037562549","https://openalex.org/W2042673292","https://openalex.org/W2045660925","https://openalex.org/W2051262326","https://openalex.org/W2053193370","https://openalex.org/W2056022475","https://openalex.org/W2068000365","https://openalex.org/W2069645361","https://openalex.org/W2072569268","https://openalex.org/W2076889248","https://openalex.org/W2096410350","https://openalex.org/W2103453943","https://openalex.org/W2105282404","https://openalex.org/W2107208924","https://openalex.org/W2111840226","https://openalex.org/W2125512776","https://openalex.org/W2127337868","https://openalex.org/W2130410032","https://openalex.org/W2132692097","https://openalex.org/W2143516113","https://openalex.org/W2149566602","https://openalex.org/W2157795344","https://openalex.org/W2157875785","https://openalex.org/W2158217645","https://openalex.org/W2158384363","https://openalex.org/W2161653775","https://openalex.org/W2168466769","https://openalex.org/W2474105888","https://openalex.org/W2797563284","https://openalex.org/W2912934387","https://openalex.org/W2913668833","https://openalex.org/W4244086115","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2155492529","https://openalex.org/W4252504573","https://openalex.org/W4385510321","https://openalex.org/W15348386","https://openalex.org/W2314128295","https://openalex.org/W1509942269","https://openalex.org/W4287026692","https://openalex.org/W2077895977","https://openalex.org/W2130939068","https://openalex.org/W2131550814"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"cancer,":[2],"gene":[3,54,76,83,179,249,291],"networks":[4],"and":[5,64,75,145,175,245,264],"pathways":[6],"often":[7,39,62],"exhibit":[8],"dynamic":[9],"behavior,":[10],"particularly":[11],"during":[12],"the":[13,30,69,125,134,148,166,195,216,228,267],"process":[14],"of":[15,32,165],"carcinogenesis.":[16],"Thus,":[17],"it":[18],"is":[19,129,159],"important":[20],"to":[21,41,49,66,111,123,131,151,161,183,190,201,205,241,259,270,274],"prioritize":[22],"those":[23,101],"genes":[24,102,144,149,209,255,268],"that":[25,108,223,283],"are":[26,38,61,109],"strongly":[27],"associated":[28],"with":[29,293],"functionality":[31],"a":[33,87,104,115,139,214,237,257,275,285],"network.":[34],"Traditional":[35],"statistical":[36,163,192],"methods":[37],"inept":[40],"identify":[42,206],"biologically":[43,207],"relevant":[44,208],"member":[45,299],"genes,":[46],"motivating":[47],"researchers":[48],"incorporate":[50,67],"biological":[51,73,106,243],"knowledge":[52,74,143,244,254],"into":[53,227],"ranking":[55,292],"methods.":[56,193],"However,":[57],"current":[58],"integration":[59],"strategies":[60],"heuristic":[63],"fail":[65],"fully":[68],"true":[70],"interplay":[71],"between":[72],"expression":[77,180],"data.":[78],"RESULTS:":[79],"To":[80],"improve":[81,162],"knowledge-guided":[82,286],"ranking,":[84],"we":[85],"propose":[86],"novel":[88,220],"method":[89,252],"called":[90],"coordinative":[91,116,126,135,262],"component":[92],"analysis":[93],"(COCA)":[94],"in":[95,114,210,231,297],"this":[96],"paper.":[97],"COCA":[98,128,168,196,217],"explicitly":[99],"captures":[100],"within":[103],"specific":[105],"context":[107],"likely":[110],"be":[112],"expressed":[113],"manner.":[117],"Formulated":[118],"as":[119,188],"an":[120,294],"optimization":[121],"problem":[122],"maximize":[124],"effort,":[127],"designed":[130],"first":[132,260],"extract":[133,261],"components":[136],"based":[137],"on":[138,172,177],"partial":[140],"guidance":[141,258],"from":[142],"then":[146,176,265],"rank":[147,266],"according":[150,269],"their":[152,271],"participation":[153],"strengths.":[154],"An":[155],"embedded":[156],"bootstrapping":[157],"procedure":[158],"implemented":[160],"robustness":[164],"solutions.":[167],"was":[169],"initially":[170],"tested":[171],"simulation":[173],"data":[174,182,204,247],"published":[178],"microarray":[181,246],"demonstrate":[184],"its":[185],"improved":[186,295],"performance":[187,296],"compared":[189],"traditional":[191],"Finally,":[194],"approach":[197,218],"has":[198],"been":[199],"applied":[200],"stem":[202],"cell":[203],"signaling":[211],"pathways.":[212],"As":[213],"result,":[215],"uncovers":[219],"pathway":[221,229,298],"members":[222],"may":[224],"shed":[225],"light":[226],"deregulation":[230],"cancers.":[232],"CONCLUSION:":[233],"We":[234],"have":[235],"developed":[236],"new":[238],"integrative":[239],"strategy":[240,287],"combine":[242],"for":[248,256],"ranking.":[250],"The":[251,279],"utilizes":[253],"components,":[263],"contribution":[272],"related":[273],"network":[276],"or":[277],"pathway.":[278],"experimental":[280],"results":[281],"show":[282],"such":[284],"can":[288],"provide":[289],"context-specific":[290],"identification.":[300]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
