{"id":"https://openalex.org/W1967162333","doi":"https://doi.org/10.1186/1471-2105-10-s6-s9","title":"Functional assessment of time course microarray data","display_name":"Functional assessment of time course microarray data","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W1967162333","doi":"https://doi.org/10.1186/1471-2105-10-s6-s9","mag":"1967162333","pmid":"https://pubmed.ncbi.nlm.nih.gov/19534758"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-s6-s9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s6-s9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S6-S9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S6-S9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007029827","display_name":"Mar\u00eda Jos\u00e9 Nueda","orcid":"https://orcid.org/0000-0002-1666-4771"},"institutions":[{"id":"https://openalex.org/I130194489","display_name":"University of Alicante","ror":"https://ror.org/05t8bcz72","country_code":"ES","type":"education","lineage":["https://openalex.org/I130194489"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Jos\u00e9 Nueda","raw_affiliation_strings":["Department of Statistics and Operation Research, University of Alicante, Ctra, San Vicente del Raspeig, S/N 03690 Alicante, Spain. mj.nueda@ua.es","Department of Statistics and Operation Research, University of Alicante, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics and Operation Research, University of Alicante, Ctra, San Vicente del Raspeig, S/N 03690 Alicante, Spain. mj.nueda@ua.es","institution_ids":["https://openalex.org/I130194489"]},{"raw_affiliation_string":"Department of Statistics and Operation Research, University of Alicante, Alicante, Spain","institution_ids":["https://openalex.org/I130194489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079179603","display_name":"Patricia Sebasti\u00e1n-Le\u00f3n","orcid":"https://orcid.org/0000-0001-7299-3660"},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Patricia Sebasti\u00e1n","raw_affiliation_strings":["Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Avda. Autopista Saler 16, 46012, Valencia, Spain","Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Avda. Autopista Saler 16, 46012, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]},{"raw_affiliation_string":"Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091413224","display_name":"Sonia Tarazona","orcid":"https://orcid.org/0000-0001-5346-1407"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sonia Tarazona","raw_affiliation_strings":["Department of Applied Statistics and Operations Research, Universidad Polit\u00e9cnica of Valencia, Cno. vera s/n, Edifico 7A, 46022, Valencia, Spain","Department of Applied Statistics and Operations Research, Universidad Polit\u00e9cnica of Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Statistics and Operations Research, Universidad Polit\u00e9cnica of Valencia, Cno. vera s/n, Edifico 7A, 46022, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]},{"raw_affiliation_string":"Department of Applied Statistics and Operations Research, Universidad Polit\u00e9cnica of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050320389","display_name":"Francisco Garcia\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0001-8354-5636"},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Garc\u00eda-Garc\u00eda","raw_affiliation_strings":["Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Avda. Autopista Saler 16, 46012, Valencia, Spain","Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Avda. Autopista Saler 16, 46012, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]},{"raw_affiliation_string":"Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074140420","display_name":"Joaqu\u0131\u0301n Dopazo","orcid":"https://orcid.org/0000-0003-3318-120X"},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210161579","display_name":"Instituto de Investigaci\u00f3n de Enfermedades Raras","ror":"https://ror.org/05mwdqq98","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210161579","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joaqu\u00edn Dopazo","raw_affiliation_strings":["Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Avda. Autopista Saler 16, 46012, Valencia, Spain","CIBER de Enfermedades Raras (CIBERER), ISCIII, Spain","Functional Genomics Node (INB), Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF), Valencia, Spain","Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Avda. Autopista Saler 16, 46012, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]},{"raw_affiliation_string":"CIBER de Enfermedades Raras (CIBERER), ISCIII, Spain","institution_ids":["https://openalex.org/I4210161579","https://openalex.org/I4210111366","https://openalex.org/I2801357902"]},{"raw_affiliation_string":"Functional Genomics Node (INB), Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF), Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]},{"raw_affiliation_string":"Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038963177","display_name":"Alberto Ferrer","orcid":"https://orcid.org/0000-0001-7244-5947"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alberto Ferrer","raw_affiliation_strings":["Department of Applied Statistics and Operations Research, Universidad Polit\u00e9cnica of Valencia, Cno. vera s/n, Edifico 7A, 46022, Valencia, Spain","Department of Applied Statistics and Operations Research, Universidad Polit\u00e9cnica of Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Statistics and Operations Research, Universidad Polit\u00e9cnica of Valencia, Cno. vera s/n, Edifico 7A, 46022, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]},{"raw_affiliation_string":"Department of Applied Statistics and Operations Research, Universidad Polit\u00e9cnica of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002377126","display_name":"Ana Conesa","orcid":"https://orcid.org/0000-0001-9597-311X"},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Ana Conesa","raw_affiliation_strings":["Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Avda. Autopista Saler 16, 46012, Valencia, Spain","Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Avda. Autopista Saler 16, 46012, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]},{"raw_affiliation_string":"Bioinformatics and Genomics Department, Centro de Investigaciones Pr\u00edncipe Felipe, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5002377126"],"corresponding_institution_ids":["https://openalex.org/I4210165109"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.3687,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.79279211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"S6","first_page":"S9","last_page":"S9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9193000197410583,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9193000197410583,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/functional-data-analysis","display_name":"Functional data analysis","score":0.6047545671463013},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5789827108383179},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.5636390447616577},{"id":"https://openalex.org/keywords/functional-principal-component-analysis","display_name":"Functional principal component analysis","score":0.5605209469795227},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.5545430183410645},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5182209610939026},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.49431896209716797},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45704537630081177},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.42827659845352173},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4282619059085846},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.41597557067871094},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.41475579142570496},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3756941556930542},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.34200775623321533},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3328150510787964},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33141952753067017},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.28688865900039673},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2830624580383301},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.27386903762817383},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18438085913658142},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.16051366925239563},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1433948278427124},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.11169224977493286},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.10291939973831177}],"concepts":[{"id":"https://openalex.org/C51820054","wikidata":"https://www.wikidata.org/wiki/Q5508814","display_name":"Functional data analysis","level":2,"score":0.6047545671463013},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5789827108383179},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.5636390447616577},{"id":"https://openalex.org/C71176878","wikidata":"https://www.wikidata.org/wiki/Q17014987","display_name":"Functional principal component analysis","level":3,"score":0.5605209469795227},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.5545430183410645},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5182209610939026},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.49431896209716797},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45704537630081177},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.42827659845352173},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4282619059085846},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.41597557067871094},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.41475579142570496},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3756941556930542},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.34200775623321533},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3328150510787964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33141952753067017},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28688865900039673},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2830624580383301},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27386903762817383},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18438085913658142},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.16051366925239563},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1433948278427124},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.11169224977493286},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.10291939973831177},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-10-s6-s9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s6-s9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S6-S9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19534758","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19534758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:924e3f477b2b47ee8832b93c2ff9a707","is_oa":false,"landing_page_url":"https://doaj.org/article/924e3f477b2b47ee8832b93c2ff9a707","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss Suppl 6, p S9 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2697656","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2697656","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-s6-s9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s6-s9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S6-S9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1967162333.pdf","grobid_xml":"https://content.openalex.org/works/W1967162333.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1618121403","https://openalex.org/W1853153349","https://openalex.org/W1981572786","https://openalex.org/W1982335518","https://openalex.org/W1984225101","https://openalex.org/W1985035274","https://openalex.org/W2029485495","https://openalex.org/W2049527386","https://openalex.org/W2054959400","https://openalex.org/W2055053285","https://openalex.org/W2069119097","https://openalex.org/W2081098333","https://openalex.org/W2085443789","https://openalex.org/W2093775273","https://openalex.org/W2095557641","https://openalex.org/W2098562143","https://openalex.org/W2098687325","https://openalex.org/W2101142880","https://openalex.org/W2101934336","https://openalex.org/W2103017472","https://openalex.org/W2105022693","https://openalex.org/W2105559737","https://openalex.org/W2108401170","https://openalex.org/W2112047656","https://openalex.org/W2116343015","https://openalex.org/W2118069309","https://openalex.org/W2120391288","https://openalex.org/W2121111814","https://openalex.org/W2122863959","https://openalex.org/W2122915349","https://openalex.org/W2123106337","https://openalex.org/W2128083889","https://openalex.org/W2130410032","https://openalex.org/W2142237411","https://openalex.org/W2142890842","https://openalex.org/W2144113827","https://openalex.org/W2146646206","https://openalex.org/W2149566602","https://openalex.org/W2159578516","https://openalex.org/W2160091849","https://openalex.org/W2161175828","https://openalex.org/W2162681898","https://openalex.org/W2163856173","https://openalex.org/W2164154943","https://openalex.org/W2231238316","https://openalex.org/W3104024536"],"related_works":["https://openalex.org/W2605967135","https://openalex.org/W2963184067","https://openalex.org/W3124114881","https://openalex.org/W2122223946","https://openalex.org/W1994852842","https://openalex.org/W2039699813","https://openalex.org/W2095233242","https://openalex.org/W2008565169","https://openalex.org/W2183420549","https://openalex.org/W1995735659"],"abstract_inverted_index":{"MOTIVATION:":[0],"Time-course":[1],"microarray":[2,80],"experiments":[3],"study":[4,191],"the":[5,24,27,42,50,56,60,75,86,161,208,218,243,252],"progress":[6],"of":[7,31,41,45,52,59,78,111,133,143,217],"gene":[8],"expression":[9,29,95,137,144,174],"along":[10],"time":[11,173],"across":[12,102],"one":[13],"or":[14,26],"several":[15],"experimental":[16,188,204],"conditions.":[17],"Most":[18],"developed":[19],"analysis":[20,30],"methods":[21,210,230],"focus":[22],"on":[23,180],"clustering":[25],"differential":[28],"genes":[32,65,99,112,166],"and":[33,97,118,176,187,203,223,245],"do":[34],"not":[35,232],"integrate":[36],"functional":[37,43,61,76,116,135,178,246],"information.":[38],"The":[39,229],"assessment":[40,77],"aspects":[44,216],"time-course":[46,79],"transcriptomics":[47],"data":[48,205],"requires":[49],"use":[51],"approaches":[53],"that":[54,207,225],"exploit":[55],"activation":[57],"dynamics":[58],"categories":[62,121],"to":[63,92,139,153,164,168,171,190,198,213],"where":[64],"are":[66,147,211,226],"annotated.":[67],"METHODS:":[68],"We":[69,184],"present":[70],"three":[71],"novel":[72,193],"methodologies":[73],"for":[74,109,150],"data.":[81],"i)":[82],"maSigFun":[83,104],"derives":[84],"from":[85],"maSigPro":[87],"method,":[88],"a":[89,106,115,124,130,154,181],"regression-based":[90],"strategy":[91],"model":[93,108,132,163],"time-dependent":[94,155],"patterns":[96,142,175],"identify":[98],"with":[100],"differences":[101],"series.":[103],"fits":[105,129],"regression":[107,156],"groups":[110],"labeled":[113],"by":[114],"class":[117],"selects":[119],"those":[120],"which":[122,146],"have":[123],"significant":[125],"model.":[126,157],"ii)":[127],"PCA-maSigFun":[128],"PCA":[131],"each":[134],"class-defined":[136],"matrix":[138],"extract":[140],"orthogonal":[141],"change,":[145],"then":[148],"assessed":[149],"their":[151,169],"fit":[152],"iii)":[158],"ASCA-functional":[159],"uses":[160],"ASCA":[162],"rank":[165],"according":[167],"correlation":[170],"principal":[172],"assess":[177],"enrichment":[179],"GSA":[182],"fashion.":[183],"used":[185],"simulated":[186],"datasets":[189],"these":[192],"approaches.":[194],"Results":[195],"were":[196],"compared":[197],"alternative":[199],"methodologies.":[200],"RESULTS:":[201],"Synthetic":[202],"showed":[206],"different":[209,215,240],"able":[212],"capture":[214],"relationship":[219],"between":[220],"genes,":[221],"functions":[222],"co-expression":[224],"biologically":[227],"meaningful.":[228],"should":[231],"be":[233],"considered":[234],"as":[235],"competitive":[236],"but":[237],"they":[238],"provide":[239],"insights":[241],"into":[242],"molecular":[244],"dynamic":[247],"events":[248],"taking":[249],"place":[250],"within":[251],"biological":[253],"system":[254],"under":[255],"study.":[256]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
