{"id":"https://openalex.org/W2086580189","doi":"https://doi.org/10.1186/1471-2105-10-s6-s16","title":"Modeling heterocyst pattern formation in cyanobacteria","display_name":"Modeling heterocyst pattern formation in cyanobacteria","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2086580189","doi":"https://doi.org/10.1186/1471-2105-10-s6-s16","mag":"2086580189","pmid":"https://pubmed.ncbi.nlm.nih.gov/19534741"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-s6-s16","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s6-s16","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S6-S16","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S6-S16","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061528180","display_name":"Ziomara P. Gerdtzen","orcid":"https://orcid.org/0000-0002-7486-8537"},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]},{"id":"https://openalex.org/I4210086090","display_name":"Fraunhofer Chile Research Foundation","ror":"https://ror.org/00h0my365","country_code":"CL","type":"facility","lineage":["https://openalex.org/I4210086090","https://openalex.org/I4923324"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Ziomara P Gerdtzen","raw_affiliation_strings":["Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Av, Beauchef 850, Santiago 837-0448, Chile. zgerdtze@ing.uchile.cl","Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Av, Beauchef 850, Santiago 837-0448, Chile. zgerdtze@ing.uchile.cl","institution_ids":["https://openalex.org/I69737025","https://openalex.org/I4210086090"]},{"raw_affiliation_string":"Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040868192","display_name":"J. Cristian Salgado","orcid":"https://orcid.org/0000-0002-5507-8695"},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"J Cristian Salgado","raw_affiliation_strings":["Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Av. Beauchef 850, Santiago, 837-0448, Chile","Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Av. Beauchef 850, Santiago, 837-0448, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072338061","display_name":"Axel Osses","orcid":"https://orcid.org/0000-0001-6833-4064"},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Axel Osses","raw_affiliation_strings":["Department of Mathematical Engineering, Center for Mathematical Modeling (UMI 2807-CNRS), University of Chile, Casilla 170/3 Correo 3, Santiago, Chile","Department of Mathematical Engineering, Center for Mathematical Modeling (UMI 2807-CNRS), University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Engineering, Center for Mathematical Modeling (UMI 2807-CNRS), University of Chile, Casilla 170/3 Correo 3, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Department of Mathematical Engineering, Center for Mathematical Modeling (UMI 2807-CNRS), University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069731582","display_name":"Juan A. Asenjo","orcid":"https://orcid.org/0000-0002-3475-7664"},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Juan A Asenjo","raw_affiliation_strings":["Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Av. Beauchef 850, Santiago, 837-0448, Chile","Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Av. Beauchef 850, Santiago, 837-0448, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045992675","display_name":"Iv\u00e1n Rapaport","orcid":"https://orcid.org/0000-0002-2969-5083"},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Ivan Rapaport","raw_affiliation_strings":["Department of Mathematical Engineering, Center for Mathematical Modeling (UMI 2807-CNRS), University of Chile, Casilla 170/3 Correo 3, Santiago, Chile","Department of Mathematical Engineering, Center for Mathematical Modeling (UMI 2807-CNRS), University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Engineering, Center for Mathematical Modeling (UMI 2807-CNRS), University of Chile, Casilla 170/3 Correo 3, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Department of Mathematical Engineering, Center for Mathematical Modeling (UMI 2807-CNRS), University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055040873","display_name":"B\u00e1rbara A. Andrews","orcid":"https://orcid.org/0000-0002-1001-2406"},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Barbara A Andrews","raw_affiliation_strings":["Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Av. Beauchef 850, Santiago, 837-0448, Chile","Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Av. Beauchef 850, Santiago, 837-0448, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Centre for Biochemical Engineering and Biotechnology, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5061528180"],"corresponding_institution_ids":["https://openalex.org/I4210086090","https://openalex.org/I69737025"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.6757,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.69639567,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"S6","first_page":"S16","last_page":"S16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.6478000283241272,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.6478000283241272,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.10589999705553055,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heterocyst","display_name":"Heterocyst","score":0.8262882828712463},{"id":"https://openalex.org/keywords/cyanobacteria","display_name":"Cyanobacteria","score":0.7939926385879517},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5218585729598999},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5018062591552734},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.498488187789917},{"id":"https://openalex.org/keywords/anabaena","display_name":"Anabaena","score":0.25319451093673706},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23200806975364685},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.19778788089752197},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11599650979042053},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.11211615800857544}],"concepts":[{"id":"https://openalex.org/C24417256","wikidata":"https://www.wikidata.org/wiki/Q899004","display_name":"Heterocyst","level":5,"score":0.8262882828712463},{"id":"https://openalex.org/C2779669040","wikidata":"https://www.wikidata.org/wiki/Q93315","display_name":"Cyanobacteria","level":3,"score":0.7939926385879517},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5218585729598999},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5018062591552734},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.498488187789917},{"id":"https://openalex.org/C2777530773","wikidata":"https://www.wikidata.org/wiki/Q133353","display_name":"Anabaena","level":4,"score":0.25319451093673706},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23200806975364685},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.19778788089752197},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11599650979042053},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11211615800857544}],"mesh":[{"descriptor_ui":"D000458","descriptor_name":"Cyanobacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000458","descriptor_name":"Cyanobacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000458","descriptor_name":"Cyanobacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009586","descriptor_name":"Nitrogen Fixation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009586","descriptor_name":"Nitrogen Fixation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009586","descriptor_name":"Nitrogen Fixation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2105-10-s6-s16","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s6-s16","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S6-S16","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19534741","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19534741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2697639","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2697639","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-s6-s16","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s6-s16","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S6-S16","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2086580189.pdf","grobid_xml":"https://content.openalex.org/works/W2086580189.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W37249727","https://openalex.org/W1485634206","https://openalex.org/W1490400076","https://openalex.org/W1528889918","https://openalex.org/W1529582667","https://openalex.org/W1571843306","https://openalex.org/W1576847343","https://openalex.org/W1893422419","https://openalex.org/W1949328498","https://openalex.org/W1967250666","https://openalex.org/W1980661496","https://openalex.org/W1998466320","https://openalex.org/W2026755920","https://openalex.org/W2030704130","https://openalex.org/W2043318069","https://openalex.org/W2055782318","https://openalex.org/W2071938573","https://openalex.org/W2089840306","https://openalex.org/W2094552408","https://openalex.org/W2096531324","https://openalex.org/W2100761655","https://openalex.org/W2101101406","https://openalex.org/W2101981014","https://openalex.org/W2107743190","https://openalex.org/W2111530758","https://openalex.org/W2137091233","https://openalex.org/W2147262362","https://openalex.org/W2149928591","https://openalex.org/W2154016070","https://openalex.org/W2158332022","https://openalex.org/W2161560166","https://openalex.org/W2171913781","https://openalex.org/W2184926083","https://openalex.org/W2584243144","https://openalex.org/W2911967907","https://openalex.org/W4238917852","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2028665699","https://openalex.org/W2738004495","https://openalex.org/W1994532782","https://openalex.org/W4256008174","https://openalex.org/W2795520785","https://openalex.org/W2022192908","https://openalex.org/W2486987055","https://openalex.org/W2212352283","https://openalex.org/W399554149","https://openalex.org/W2057518669"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"allow":[2,58],"the":[3,6,9,18,33,45,50,53,59,75,78,82,99,126,168,193,205,211,214,220,230],"survival":[4],"of":[5,11,20,47,52,61,77,84,98,125,130,136,158,204,232],"population":[7],"in":[8,44,88,164,197,224],"absence":[10,46],"nitrogen,":[12],"some":[13],"cyanobacteria":[14,37],"strains":[15],"have":[16],"developed":[17],"capability":[19],"differentiating":[21],"into":[22,42],"nitrogen":[23,48,237],"fixing":[24],"cells,":[25],"forming":[26],"a":[27,63,133,143],"characteristic":[28,134],"pattern.":[29],"In":[30,174],"this":[31,89,131],"paper,":[32],"process":[34,91],"by":[35],"which":[36,73],"differentiates":[38],"from":[39,210],"vegetative":[40],"cells":[41,138],"heterocysts":[43,113],"and":[49,81,96,109,156,160,213,241],"elements":[51],"gene":[54,70,194,239],"network":[55,71,195,212],"involved":[56,87,196],"that":[57],"formation":[60],"such":[62,102,235],"pattern":[64,222],"are":[65],"investigated.":[66],"METHODS:":[67],"A":[68,186],"simple":[69,187],"model,":[72],"represents":[74],"complexity":[76],"differentiation":[79,199],"process,":[80],"role":[83],"all":[85,175],"variables":[86],"cellular":[90],"is":[92,120,216],"proposed.":[93,201],"Specific":[94],"characteristics":[95],"details":[97],"system's":[100,152],"behavior":[101,203],"as":[103,227,229,236],"transcript":[104],"profiles":[105],"for":[106],"ntcA,":[107],"hetR":[108,161],"patS":[110,159],"between":[111,139],"consecutive":[112],"were":[114],"studied.":[115],"RESULTS:":[116],"The":[117,151,202],"proposed":[118,169],"model":[119,170,190,215],"able":[121,217],"to":[122,148,154,166,218],"capture":[123,219],"one":[124],"most":[127],"distinctive":[128],"features":[129],"system:":[132],"distance":[135],"10":[137],"two":[140],"heterocysts,":[141],"with":[142,181],"small":[144],"standard":[145],"deviation":[146],"according":[147],"experimental":[149,172,183],"variability.":[150],"response":[153],"knock-out":[155,240],"over-expression":[157,242],"was":[162,200],"simulated":[163],"order":[165],"validate":[167],"against":[171],"observations.":[173],"cases,":[176],"simulations":[177],"show":[178],"good":[179],"agreement":[180],"reported":[182],"results.":[184],"CONCLUSION:":[185],"evolution":[188],"mathematical":[189],"based":[191],"on":[192],"heterocyst":[198,225],"biological":[206],"system":[207],"naturally":[208],"emerges":[209],"spacing":[221],"observed":[223],"differentiation,":[226],"well":[228],"effect":[231],"external":[233],"perturbations":[234],"deprivation,":[238],"without":[243],"specific":[244],"parameter":[245],"fitting.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}