{"id":"https://openalex.org/W2137377263","doi":"https://doi.org/10.1186/1471-2105-10-s15-s4","title":"Sub-population analysis based on temporal features of high content images","display_name":"Sub-population analysis based on temporal features of high content images","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2137377263","doi":"https://doi.org/10.1186/1471-2105-10-s15-s4","mag":"2137377263","pmid":"https://pubmed.ncbi.nlm.nih.gov/19958514"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-s15-s4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s15-s4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S15-S4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S15-S4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009753815","display_name":"Merlin Veronika","orcid":null},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4210167254","display_name":"Singapore-MIT Alliance for Research and Technology","ror":"https://ror.org/05yb3w112","country_code":"SG","type":"education","lineage":["https://openalex.org/I4210167254"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Merlin Veronika","raw_affiliation_strings":["Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore. merlin@pmail.ntu.edu.sg","Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore","Bioinformatics Research Centre, Nanyang Technological University, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore. merlin@pmail.ntu.edu.sg","institution_ids":["https://openalex.org/I172675005","https://openalex.org/I4210167254"]},{"raw_affiliation_string":"Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Bioinformatics Research Centre, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James Evans","orcid":null},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Evans","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02139, USA","Whitehead Institute for Biomedical Research, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02139, USA","institution_ids":["https://openalex.org/I4210157710"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084983005","display_name":"Paul Matsudaira","orcid":"https://orcid.org/0000-0002-8399-3276"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Paul Matsudaira","raw_affiliation_strings":["Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore, 637460","Department of Biological Science, National University of Singapore, Singapore, 117543","Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore","Department of Biological Science, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore, 637460","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Department of Biological Science, National University of Singapore, Singapore, 117543","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Department of Biological Science, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081284390","display_name":"Roy E. Welsch","orcid":"https://orcid.org/0000-0002-9038-1622"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Roy Welsch","raw_affiliation_strings":["Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore, 637460","Sloan School of Management, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA","Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore","Sloan School of Management, Massachusetts Institute of Technology, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore, 637460","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Sloan School of Management, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Sloan School of Management, Massachusetts Institute of Technology, Cambridge, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026076885","display_name":"Jagath C. Rajapakse","orcid":"https://orcid.org/0000-0001-7944-1658"},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jagath Rajapakse","raw_affiliation_strings":["Bioinformatics Research Centre, Nanyang Technological University, Singapore, 637553","Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore, 637460","Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore","Bioinformatics Research Centre, Nanyang Technological University, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Research Centre, Nanyang Technological University, Singapore, 637553","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore, 637460","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Computation and Systems Biology, Singapore-MIT Alliance, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Bioinformatics Research Centre, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5009753815"],"corresponding_institution_ids":["https://openalex.org/I172675005","https://openalex.org/I4210167254"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.1348,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.84480059,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"10","issue":"S15","first_page":"S4","last_page":"S4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9623000025749207,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9623000025749207,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6975308656692505},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6968340277671814},{"id":"https://openalex.org/keywords/terabyte","display_name":"Terabyte","score":0.6090081334114075},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5957475304603577},{"id":"https://openalex.org/keywords/high-content-screening","display_name":"High-content screening","score":0.5825670957565308},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5305431485176086},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.467795193195343},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.45101550221443176},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4412318766117096},{"id":"https://openalex.org/keywords/autoregressive-model","display_name":"Autoregressive model","score":0.4219207167625427},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22042390704154968},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.21649369597434998},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.0825623869895935}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6975308656692505},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6968340277671814},{"id":"https://openalex.org/C199683683","wikidata":"https://www.wikidata.org/wiki/Q8799","display_name":"Terabyte","level":2,"score":0.6090081334114075},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5957475304603577},{"id":"https://openalex.org/C157044486","wikidata":"https://www.wikidata.org/wiki/Q5754482","display_name":"High-content screening","level":3,"score":0.5825670957565308},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5305431485176086},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.467795193195343},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.45101550221443176},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4412318766117096},{"id":"https://openalex.org/C159877910","wikidata":"https://www.wikidata.org/wiki/Q2202883","display_name":"Autoregressive model","level":2,"score":0.4219207167625427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22042390704154968},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21649369597434998},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0825623869895935},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-10-s15-s4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s15-s4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S15-S4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19958514","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19958514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/143351","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/143351","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/52543","is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/52543","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioMed Central","raw_type":"http://purl.org/eprint/type/JournalArticle"},{"id":"pmh:oai:europepmc.org:1895178","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2788355","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-s15-s4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s15-s4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S15-S4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309369","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137377263.pdf","grobid_xml":"https://content.openalex.org/works/W2137377263.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1480376833","https://openalex.org/W1535084325","https://openalex.org/W1554944419","https://openalex.org/W1966827520","https://openalex.org/W1967660686","https://openalex.org/W1969754919","https://openalex.org/W1984643873","https://openalex.org/W1993669821","https://openalex.org/W1998202992","https://openalex.org/W2049562411","https://openalex.org/W2075744820","https://openalex.org/W2087042384","https://openalex.org/W2091781764","https://openalex.org/W2104095591","https://openalex.org/W2108303909","https://openalex.org/W2109565498","https://openalex.org/W2114487471","https://openalex.org/W2116040950","https://openalex.org/W2120549843","https://openalex.org/W2124067983","https://openalex.org/W2126191032","https://openalex.org/W2133059825","https://openalex.org/W2144661638","https://openalex.org/W2145735068","https://openalex.org/W2154917588","https://openalex.org/W2167158173","https://openalex.org/W2175885977","https://openalex.org/W2409220685"],"related_works":["https://openalex.org/W2134017072","https://openalex.org/W2915208987","https://openalex.org/W1940452713","https://openalex.org/W2152256925","https://openalex.org/W1994777790","https://openalex.org/W2005567565","https://openalex.org/W2806040249","https://openalex.org/W2098714418","https://openalex.org/W848768768","https://openalex.org/W1538652242"],"abstract_inverted_index":{"BACKGROUND:":[0],"High":[1],"content":[2,149],"screening":[3,150],"techniques":[4],"are":[5],"increasingly":[6],"used":[7,71],"to":[8,88,109,123,153],"understand":[9],"the":[10,31,60,68,82,138,145],"regulation":[11],"and":[12,41,85,100,129,155],"progression":[13],"of":[14,19,25,27,34,45,57,67,78,103,147],"cell":[15,36,83,90],"motility.":[16],"The":[17,92],"demand":[18],"new":[20,154],"platforms,":[21],"coupled":[22],"with":[23],"availability":[24],"terabytes":[26],"data":[28,151],"has":[29],"challenged":[30],"traditional":[32],"technique":[33],"identifying":[35],"populations":[37],"by":[38,63,96],"manual":[39],"methods":[40],"resulted":[42],"in":[43,114],"development":[44],"high-dimensional":[46],"analytical":[47],"methods.":[48],"RESULTS:":[49],"In":[50],"this":[51],"paper,":[52],"we":[53],"present":[54],"sub-populations":[55,93,113,125],"analysis":[56,136,152],"cells":[58],"at":[59,137],"tissue":[61,139],"level":[62],"using":[64,126],"dynamic":[65,99],"features":[66,128,133],"cells.":[69],"We":[70,106,118],"active":[72],"contour":[73],"without":[74],"edges":[75],"for":[76],"segmentation":[77],"cells,":[79],"which":[80],"preserves":[81],"morphology,":[84],"autoregressive":[86],"modeling":[87],"model":[89],"trajectories.":[91],"were":[94,107],"obtained":[95],"clustering":[97],"static,":[98],"a":[101,120],"combination":[102],"both":[104],"features.":[105],"able":[108],"identify":[110,124],"three":[111],"unique":[112],"combined":[115],"clustering.":[116],"CONCLUSION:":[117],"report":[119],"novel":[121],"method":[122],"kinetic":[127],"demonstrate":[130],"that":[131],"these":[132],"improve":[134],"sub-population":[135],"level.":[140],"These":[141],"advances":[142],"will":[143],"facilitate":[144],"application":[146],"high":[148],"complex":[156],"biological":[157],"problems.":[158]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}