{"id":"https://openalex.org/W1985034644","doi":"https://doi.org/10.1186/1471-2105-10-s12-s6","title":"Clinical bioinformatics for complex disorders: a schizophrenia case study","display_name":"Clinical bioinformatics for complex disorders: a schizophrenia case study","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W1985034644","doi":"https://doi.org/10.1186/1471-2105-10-s12-s6","mag":"1985034644","pmid":"https://pubmed.ncbi.nlm.nih.gov/19828082"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-s12-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s12-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S12-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S12-S6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111739216","display_name":"Emanuel Schwarz","orcid":null},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Emanuel Schwarz","raw_affiliation_strings":["Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, UK. es505@cam.ac.uk","Institute of Biotechnology; University of Cambridge; Cambridge UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, UK. es505@cam.ac.uk","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Institute of Biotechnology; University of Cambridge; Cambridge UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073016358","display_name":"F. Markus Leweke","orcid":"https://orcid.org/0000-0002-8163-195X"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210105615","display_name":"Central Institute of Mental Health","ror":"https://ror.org/01hynnt93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F Markus Leweke","raw_affiliation_strings":["Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany","Department of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany","Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany","institution_ids":["https://openalex.org/I4210105615","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059529807","display_name":"Sabine Bahn","orcid":"https://orcid.org/0000-0003-4690-6302"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sabine Bahn","raw_affiliation_strings":["Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK","Institute of Biotechnology; University of Cambridge; Cambridge UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Institute of Biotechnology; University of Cambridge; Cambridge UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056748708","display_name":"P\u00edetro Li\u00f3","orcid":"https://orcid.org/0000-0002-0540-5053"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pietro Li\u00f2","raw_affiliation_strings":["Computer Laboratory, University of Cambridge, 15 J.J. Thompson Avenue, Cambridge, CB3 0FD, UK","Computer Laboratory, University of Cambridge Cambridge UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Laboratory, University of Cambridge, 15 J.J. Thompson Avenue, Cambridge, CB3 0FD, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Computer Laboratory, University of Cambridge Cambridge UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111739216"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.6717,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.67759843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"S12","first_page":"S6","last_page":"S6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.3100999891757965,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.3100999891757965,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.16500000655651093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.12060000002384186,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.6096058487892151},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"Schizophrenia (object-oriented programming)","score":0.5255314707756042},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.5220346450805664},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5138247609138489},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.46768954396247864},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4548332393169403},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.42100614309310913},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4073426127433777},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3663829565048218},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.29951202869415283},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2637156844139099},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.25805968046188354},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.17115697264671326}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6096058487892151},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5255314707756042},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5220346450805664},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5138247609138489},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.46768954396247864},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4548332393169403},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42100614309310913},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4073426127433777},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3663829565048218},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.29951202869415283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2637156844139099},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.25805968046188354},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17115697264671326},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2105-10-s12-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s12-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S12-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19828082","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19828082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2762071","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2762071","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-s12-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s12-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S12-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6600000262260437,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309530","display_name":"Stanley Medical Research Institute","ror":"https://ror.org/01pj5nn22"},{"id":"https://openalex.org/F4320311440","display_name":"National Alliance for Research on Schizophrenia and Depression","ror":"https://ror.org/03a63f080"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1985034644.pdf","grobid_xml":"https://content.openalex.org/works/W1985034644.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W163215356","https://openalex.org/W1481699594","https://openalex.org/W1492162700","https://openalex.org/W1548536793","https://openalex.org/W1588496946","https://openalex.org/W1596515083","https://openalex.org/W1967752035","https://openalex.org/W1976065879","https://openalex.org/W1997578267","https://openalex.org/W2002446886","https://openalex.org/W2013268532","https://openalex.org/W2032273054","https://openalex.org/W2032529228","https://openalex.org/W2038538527","https://openalex.org/W2052794650","https://openalex.org/W2057251357","https://openalex.org/W2083045667","https://openalex.org/W2095293504","https://openalex.org/W2110065044","https://openalex.org/W2110464963","https://openalex.org/W2111642621","https://openalex.org/W2119043225","https://openalex.org/W2120372853","https://openalex.org/W2121564430","https://openalex.org/W2128366083","https://openalex.org/W2130338776","https://openalex.org/W2164706093","https://openalex.org/W2168301815","https://openalex.org/W2561675875","https://openalex.org/W2569586013","https://openalex.org/W2737661290","https://openalex.org/W3021971632","https://openalex.org/W4248346244","https://openalex.org/W4285719527","https://openalex.org/W4293747882"],"related_works":["https://openalex.org/W2161444195","https://openalex.org/W2589019771","https://openalex.org/W2985540061","https://openalex.org/W2185012154","https://openalex.org/W2804364458","https://openalex.org/W4287867321","https://openalex.org/W2911183501","https://openalex.org/W2104014222","https://openalex.org/W3006062179","https://openalex.org/W4298130764"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"the":[2,23,26,40,53,67,98,101,106,112,117,133,136,160,182,201,205,208,228,241],"diagnosis":[3],"of":[4,13,28,42,49,55,108,116,132,135,138,144,152,162,204,207,230,243],"complex":[5,68,74,244],"diseases":[6,76],"such":[7],"as":[8,77,196],"neurological":[9],"pathologies,":[10],"a":[11,43,142,150],"wealth":[12],"clinical":[14],"and":[15,35,104,124,140,172,176,247,255],"molecular":[16,164],"information":[17,29,57],"is":[18,237],"often":[19],"available":[20],"to":[21,39,65,83,221,239],"help":[22,226],"interpretation.":[24],"Yet,":[25],"pieces":[27],"are":[30],"usually":[31],"considered":[32],"in":[33,52,94,149,166,181,227],"isolation":[34],"rarely":[36],"integrated":[37],"due":[38],"lack":[41,48],"sound":[44],"statistical":[45],"framework.":[46],"This":[47],"integration":[50],"results":[51],"loss":[54],"valuable":[56],"about":[58],"how":[59],"disease":[60,212],"associated":[61],"factors":[62,103],"act":[63],"synergistically":[64],"cause":[66],"phenotype.":[69],"RESULTS:":[70],"Here,":[71],"we":[72],"investigated":[73,218],"psychiatric":[75,245],"networks.":[78,197],"The":[79,91,114,198,210,234],"networks":[80,96],"were":[81],"used":[82],"integrate":[84],"data":[85],"originating":[86],"from":[87],"different":[88,193],"profiling":[89,194],"platforms.":[90],"weighted":[92],"links":[93],"these":[95],"capture":[97],"association":[99],"between":[100,170,189],"analyzed":[102,121],"allow":[105],"quantification":[107],"their":[109,222],"relevance":[110],"for":[111],"pathology.":[113],"heterogeneity":[115,134],"patient":[118],"population":[119,137],"was":[120],"by":[122],"clustering":[123],"graph":[125],"theoretical":[126],"procedures.":[127],"We":[128,158,185],"provided":[129],"an":[130,167],"estimate":[131],"schizophrenia":[139,171],"detected":[141],"subgroup":[143],"patients":[145,175],"featuring":[146],"remarkable":[147],"abnormalities":[148],"network":[151,165],"serum":[153],"primary":[154],"fatty":[155],"acid":[156],"amides.":[157],"compared":[159],"stability":[161],"this":[163],"extended":[168],"dataset":[169],"affective":[173],"disorder":[174],"found":[177],"more":[178],"stable":[179],"structures":[180],"latter.":[183],"CONCLUSION:":[184],"quantified":[186],"robust":[187],"associations":[188],"analytes":[190],"measured":[191],"with":[192,219],"platforms":[195],"methodology":[199],"allows":[200],"quantitative":[202],"evaluation":[203],"complexity":[206],"disease.":[209],"identified":[211],"patterns":[213],"can":[214],"then":[215],"be":[216],"further":[217],"regards":[220],"diagnostic":[223],"utility":[224],"or":[225],"prediction":[229],"novel":[231,250],"therapeutic":[232],"targets.":[233],"applied":[235],"framework":[236],"able":[238],"enhance":[240],"understanding":[242],"diseases,":[246],"may":[248],"give":[249],"insights":[251],"into":[252],"drug":[253],"development":[254],"personalized":[256],"medicine":[257],"approaches.":[258]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}