{"id":"https://openalex.org/W2083505311","doi":"https://doi.org/10.1186/1471-2105-10-s1-s52","title":"Mutual information estimation reveals global associations between stimuli and biological processes","display_name":"Mutual information estimation reveals global associations between stimuli and biological processes","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2083505311","doi":"https://doi.org/10.1186/1471-2105-10-s1-s52","mag":"2083505311","pmid":"https://pubmed.ncbi.nlm.nih.gov/19208155"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-s1-s52","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s1-s52","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S1-S52","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S1-S52","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078812767","display_name":"Taiji Suzuki","orcid":"https://orcid.org/0000-0003-3459-1016"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taiji Suzuki","raw_affiliation_strings":["Department of Mathematical Informatics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. s-taiji@stat.t.u-tokyo.ac.jp","Department of Mathematical Informatics, The University of Tokyo, Bunkyo-ku, Tokyo, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Informatics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. s-taiji@stat.t.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Mathematical Informatics, The University of Tokyo, Bunkyo-ku, Tokyo, Japan;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072744508","display_name":"Masashi Sugiyama","orcid":"https://orcid.org/0000-0001-6658-6743"},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Sugiyama","raw_affiliation_strings":["Department of Computer Science, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8552, Japan","Department of Computer Science, Tokyo Institute of Technology, Meguro-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8552, Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"Department of Computer Science, Tokyo Institute of Technology, Meguro-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I114531698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088569462","display_name":"Takafumi Kanamori","orcid":"https://orcid.org/0000-0001-6878-5850"},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Kanamori","raw_affiliation_strings":["Department of Computer Science and Mathematical Informatics, Nagoya University, Furocho, Chikusaku, Nagoya, 464-8603, Japan","Department of Computer Science and Mathematical Informatics, Nagoya University, Furocho, Chikusaku, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Mathematical Informatics, Nagoya University, Furocho, Chikusaku, Nagoya, 464-8603, Japan","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Department of Computer Science and Mathematical Informatics, Nagoya University, Furocho, Chikusaku, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022912020","display_name":"Jun Sese","orcid":"https://orcid.org/0000-0003-3495-4382"},"institutions":[{"id":"https://openalex.org/I26120043","display_name":"Ochanomizu University","ror":"https://ror.org/03599d813","country_code":"JP","type":"education","lineage":["https://openalex.org/I26120043"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Jun Sese","raw_affiliation_strings":["Department of Information Science, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo, 112-8610, Japan","Department of Information Science, Ochanomizu University, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Science, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo, 112-8610, Japan","institution_ids":["https://openalex.org/I26120043"]},{"raw_affiliation_string":"Department of Information Science, Ochanomizu University, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I26120043"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5022912020"],"corresponding_institution_ids":["https://openalex.org/I26120043"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":4.7877,"has_fulltext":true,"cited_by_count":119,"citation_normalized_percentile":{"value":0.96000205,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"10","issue":"S1","first_page":"S52","last_page":"S52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8138999938964844,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8138999938964844,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.1348000019788742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5321580171585083},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5158578753471375},{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.5008540153503418},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.49443697929382324},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.45640432834625244},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4489065706729889},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42326804995536804},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3283599019050598},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27531689405441284},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23613688349723816},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.11683019995689392},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10188770294189453},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10124048590660095}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5321580171585083},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5158578753471375},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.5008540153503418},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.49443697929382324},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.45640432834625244},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4489065706729889},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42326804995536804},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3283599019050598},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27531689405441284},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23613688349723816},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11683019995689392},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10188770294189453},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10124048590660095},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001686","descriptor_name":"Biological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001686","descriptor_name":"Biological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001686","descriptor_name":"Biological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-10-s1-s52","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s1-s52","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S1-S52","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19208155","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19208155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.453.4277","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.453.4277","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://sugiyama-www.cs.titech.ac.jp/~sugi/2009/APBC2009.pdf","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2648797","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2648797","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:t2r2.star.titech.ac.jp:50056833","is_oa":false,"landing_page_url":"http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100572022","pdf_url":null,"source":{"id":"https://openalex.org/S4377196385","display_name":"Tokyo Tech Research Repository (Tokyo Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I114531698","host_organization_name":"Tokyo Institute of Technology","host_organization_lineage":["https://openalex.org/I114531698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Paper"},{"id":"pmh:oai:t2r2.star.titech.ac.jp:50060484","is_oa":false,"landing_page_url":"http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100574740","pdf_url":null,"source":{"id":"https://openalex.org/S4377196385","display_name":"Tokyo Tech Research Repository (Tokyo Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I114531698","host_organization_name":"Tokyo Institute of Technology","host_organization_lineage":["https://openalex.org/I114531698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-s1-s52","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s1-s52","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S1-S52","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2083505311.pdf","grobid_xml":"https://content.openalex.org/works/W2083505311.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W638544165","https://openalex.org/W1509689762","https://openalex.org/W1969705577","https://openalex.org/W1987782593","https://openalex.org/W1989851442","https://openalex.org/W2010353172","https://openalex.org/W2040704490","https://openalex.org/W2058766645","https://openalex.org/W2089075540","https://openalex.org/W2090804142","https://openalex.org/W2092939357","https://openalex.org/W2099111195","https://openalex.org/W2099741732","https://openalex.org/W2103017472","https://openalex.org/W2116801843","https://openalex.org/W2119387367","https://openalex.org/W2119479037","https://openalex.org/W2127053639","https://openalex.org/W2129905273","https://openalex.org/W2130410032","https://openalex.org/W2137683543","https://openalex.org/W2141652941","https://openalex.org/W2146264532","https://openalex.org/W2159058260","https://openalex.org/W2166574880","https://openalex.org/W2742264950","https://openalex.org/W3119651796","https://openalex.org/W4233014035","https://openalex.org/W4251171122","https://openalex.org/W4285719527","https://openalex.org/W4388317518"],"related_works":["https://openalex.org/W2466816617","https://openalex.org/W1970834875","https://openalex.org/W3174028392","https://openalex.org/W842936808","https://openalex.org/W2000517284","https://openalex.org/W2136503713","https://openalex.org/W2365318811","https://openalex.org/W2375330620","https://openalex.org/W2913710507","https://openalex.org/W2363755581"],"abstract_inverted_index":{"BACKGROUND:":[0],"Although":[1],"microarray":[2,122,195],"gene":[3,65,68,163],"expression":[4,66],"analysis":[5],"has":[6],"become":[7],"popular,":[8],"it":[9],"remains":[10],"difficult":[11],"to":[12,120,138,155,183,202],"interpret":[13],"the":[14,73,106,118,156,185,204],"biological":[15,32,130,146,192],"changes":[16,44,56],"caused":[17],"by":[18,60],"stimuli":[19,127],"or":[20],"variation":[21],"of":[22,25,64,108,117,158,189,207],"conditions.":[23],"Clustering":[24],"genes":[26],"and":[27,94,167,180,191],"associating":[28,61],"each":[29],"group":[30],"with":[31,67,112],"functions":[33],"are":[34,134],"often":[35],"used":[36],"methods.":[37,114],"However,":[38],"such":[39],"methods":[40],"only":[41],"detect":[42,98],"partial":[43],"within":[45,57,101],"cell":[46,59,140],"processes.":[47,141],"Herein,":[48],"we":[49,75,143],"propose":[50],"a":[51,58,77,102,173],"method":[52,81,177],"for":[53],"discovering":[54],"global":[55,205],"observed":[62],"conditions":[63,188],"functions.":[69],"RESULTS:":[70],"To":[71],"elucidate":[72,203],"association,":[74],"introduce":[76],"novel":[78,174],"feature":[79,175],"selection":[80,176],"called":[82,178],"Least-Squares":[83],"Mutual":[84],"Information":[85],"(LSMI),":[86],"which":[87],"computes":[88],"mutual":[89],"information":[90],"without":[91],"density":[92],"estimaion,":[93],"therefore":[95],"LSMI":[96,109,182,199],"can":[97,148],"nonlinear":[99],"associations":[100],"cell.":[103],"We":[104,171],"demonstrate":[105],"effectiveness":[107],"through":[110,194],"comparison":[111],"existing":[113],"The":[115],"results":[116],"application":[119],"yeast":[121,190],"datasets":[123],"reveal":[124],"that":[125,145],"non-natural":[126],"affect":[128],"various":[129,159],"processes,":[131],"whereas":[132],"others":[133],"no":[135],"significant":[136],"relation":[137],"specific":[139],"Furthermore,":[142],"discover":[144],"processes":[147,193],"be":[149],"categorized":[150],"into":[151],"four":[152],"types":[153],"according":[154],"responses":[157],"stimuli:":[160],"DNA/RNA":[161],"metabolism,":[162,166],"expression,":[164],"protein":[165,168],"localization.":[169],"CONCLUSION:":[170],"proposed":[172],"LSMI,":[179],"applied":[181],"mining":[184],"association":[186],"between":[187],"datasets.":[196],"In":[197],"fact,":[198],"allows":[200],"us":[201],"organization":[206],"cellular":[208],"process":[209],"control.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":12}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}