{"id":"https://openalex.org/W2064629375","doi":"https://doi.org/10.1186/1471-2105-10-s1-s33","title":"A structural interpretation of the effect of GC-content on efficiency of RNA interference","display_name":"A structural interpretation of the effect of GC-content on efficiency of RNA interference","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2064629375","doi":"https://doi.org/10.1186/1471-2105-10-s1-s33","mag":"2064629375","pmid":"https://pubmed.ncbi.nlm.nih.gov/19208134"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-s1-s33","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s1-s33","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S1-S33","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S1-S33","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111935093","display_name":"Chi Yu Chan","orcid":null},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi Yu Chan","raw_affiliation_strings":["Wadsworth Center, New York State Department of Health, 150 New Scotland Avenue, Albany, NY 12208, USA. c.clarence@yahoo.com","New York State Department of Health, Wadsworth Center, 150 New Scotland Avenue, Albany, NY, 12208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wadsworth Center, New York State Department of Health, 150 New Scotland Avenue, Albany, NY 12208, USA. c.clarence@yahoo.com","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]},{"raw_affiliation_string":"New York State Department of Health, Wadsworth Center, 150 New Scotland Avenue, Albany, NY, 12208, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006661042","display_name":"C. Steven Carmack","orcid":null},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Steven Carmack","raw_affiliation_strings":["New York State Department of Health, Wadsworth Center, 150 New Scotland Avenue, Albany, NY, 12208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York State Department of Health, Wadsworth Center, 150 New Scotland Avenue, Albany, NY, 12208, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058981490","display_name":"Dang Long","orcid":"https://orcid.org/0000-0001-9018-260X"},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dang D Long","raw_affiliation_strings":["New York State Department of Health, Wadsworth Center, 150 New Scotland Avenue, Albany, NY, 12208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York State Department of Health, Wadsworth Center, 150 New Scotland Avenue, Albany, NY, 12208, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067328766","display_name":"Anil Maliyekkel","orcid":null},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210116763","display_name":"Albany Research Institute","ror":"https://ror.org/01hv1yg09","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116763"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Maliyekkel","raw_affiliation_strings":["Cancer Center, Ordway Research Institute, Albany, New York, 12208, USA","Department of Molecular Genetics, University of Illinois at Chicago, Chicago, IL, 60607, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Ordway Research Institute, Albany, New York, 12208, USA","institution_ids":["https://openalex.org/I4210116763"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Illinois at Chicago, Chicago, IL, 60607, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028209679","display_name":"Yu Shao","orcid":"https://orcid.org/0000-0003-3546-2574"},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Shao","raw_affiliation_strings":["New York State Department of Health, Wadsworth Center, 150 New Scotland Avenue, Albany, NY, 12208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York State Department of Health, Wadsworth Center, 150 New Scotland Avenue, Albany, NY, 12208, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006208805","display_name":"Igor B. Roninson","orcid":"https://orcid.org/0000-0002-9211-1327"},"institutions":[{"id":"https://openalex.org/I4210116763","display_name":"Albany Research Institute","ror":"https://ror.org/01hv1yg09","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116763"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor B Roninson","raw_affiliation_strings":["Cancer Center, Ordway Research Institute, Albany, New York, 12208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Ordway Research Institute, Albany, New York, 12208, USA","institution_ids":["https://openalex.org/I4210116763"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101974630","display_name":"Ye Ding","orcid":"https://orcid.org/0000-0003-3460-1122"},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ye Ding","raw_affiliation_strings":["New York State Department of Health, Wadsworth Center, 150 New Scotland Avenue, Albany, NY, 12208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York State Department of Health, Wadsworth Center, 150 New Scotland Avenue, Albany, NY, 12208, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101974630"],"corresponding_institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.7637,"has_fulltext":true,"cited_by_count":128,"citation_normalized_percentile":{"value":0.8408087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"10","issue":"S1","first_page":"S33","last_page":"S33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.8670250177383423},{"id":"https://openalex.org/keywords/gc-content","display_name":"GC-content","score":0.7105735540390015},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"Gene knockdown","score":0.6612037420272827},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.5868276357650757},{"id":"https://openalex.org/keywords/small-interfering-rna","display_name":"Small interfering RNA","score":0.5532045364379883},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5296086072921753},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.48667484521865845},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4818609654903412},{"id":"https://openalex.org/keywords/nucleic-acid-secondary-structure","display_name":"Nucleic acid secondary structure","score":0.4562495946884155},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"Protein secondary structure","score":0.4502975344657898},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35065633058547974},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.32044678926467896},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.16333109140396118}],"concepts":[{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.8670250177383423},{"id":"https://openalex.org/C42251679","wikidata":"https://www.wikidata.org/wiki/Q933491","display_name":"GC-content","level":4,"score":0.7105735540390015},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6612037420272827},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5868276357650757},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.5532045364379883},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5296086072921753},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48667484521865845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4818609654903412},{"id":"https://openalex.org/C85468374","wikidata":"https://www.wikidata.org/wiki/Q6589957","display_name":"Nucleic acid secondary structure","level":4,"score":0.4562495946884155},{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.4502975344657898},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35065633058547974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32044678926467896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16333109140396118},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001482","descriptor_name":"Base Composition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001482","descriptor_name":"Base Composition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001482","descriptor_name":"Base Composition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-10-s1-s33","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s1-s33","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S1-S33","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19208134","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19208134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:scholarcommons.sc.edu:phar_facpub-1069","is_oa":true,"landing_page_url":"https://scholarcommons.sc.edu/phar_facpub/69","pdf_url":null,"source":{"id":"https://openalex.org/S4306401386","display_name":"Scholar Commons (University of South Carolina)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I155781252","host_organization_name":"University of South Carolina","host_organization_lineage":["https://openalex.org/I155781252"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.215.3601","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.215.3601","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.biomedcentral.com/content/pdf/1471-2105-10-S1-S33.pdf","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2648742","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2648742","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-s1-s33","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-s1-s33","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-S1-S33","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4280941732","display_name":"Statistical Tools for RNA Folding Prediction and Antisense and Ribozyme Design for High Throughput Functional Genomics","funder_award_id":"0200970","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G555071554","display_name":"Regulatory Targets of Nematode MicroRNAs","funder_award_id":"0650991","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6136770641","display_name":null,"funder_award_id":"R01 AG 17921","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G679127712","display_name":null,"funder_award_id":"R33 CA095996","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7139284795","display_name":null,"funder_award_id":"R01 AG017921","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7219621645","display_name":null,"funder_award_id":"R01 GM068726","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7713005854","display_name":null,"funder_award_id":"R33 CA95996","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G910587638","display_name":null,"funder_award_id":"R01CA62099","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2064629375.pdf","grobid_xml":"https://content.openalex.org/works/W2064629375.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1611419331","https://openalex.org/W1647075334","https://openalex.org/W1906483060","https://openalex.org/W1965077482","https://openalex.org/W1975806245","https://openalex.org/W1977522713","https://openalex.org/W1984006325","https://openalex.org/W1984675364","https://openalex.org/W1994958179","https://openalex.org/W1995808959","https://openalex.org/W2011879414","https://openalex.org/W2012188597","https://openalex.org/W2014946489","https://openalex.org/W2026978183","https://openalex.org/W2038783205","https://openalex.org/W2041074982","https://openalex.org/W2068205681","https://openalex.org/W2069160702","https://openalex.org/W2069608350","https://openalex.org/W2070571588","https://openalex.org/W2070999095","https://openalex.org/W2071596792","https://openalex.org/W2082213106","https://openalex.org/W2099915551","https://openalex.org/W2114110579","https://openalex.org/W2119340328","https://openalex.org/W2124756133","https://openalex.org/W2133876293","https://openalex.org/W2134653938","https://openalex.org/W2136361016","https://openalex.org/W2141157874","https://openalex.org/W2153140501","https://openalex.org/W2153747430","https://openalex.org/W2155318580","https://openalex.org/W2160923685","https://openalex.org/W2165639228","https://openalex.org/W2166802510","https://openalex.org/W2169440322","https://openalex.org/W2169940012","https://openalex.org/W2318935314"],"related_works":["https://openalex.org/W2024030923","https://openalex.org/W2047147668","https://openalex.org/W2130501958","https://openalex.org/W1975806245","https://openalex.org/W2558432341","https://openalex.org/W3047450301","https://openalex.org/W2345156963","https://openalex.org/W1971402940","https://openalex.org/W2919479895","https://openalex.org/W2131054067"],"abstract_inverted_index":{"BACKGROUND:":[0],"RNA":[1,60],"interference":[2],"(RNAi)":[3],"mediated":[4],"by":[5,50,206],"small":[6],"interfering":[7],"RNAs":[8,13],"(siRNAs)":[9],"or":[10,134],"short":[11],"hairpin":[12],"(shRNAs)":[14],"has":[15],"become":[16],"a":[17,38,70,123,150,160,188,191,230],"powerful":[18],"technique":[19],"for":[20,55,96,112,171,183,187,212,236],"eukaryotic":[21],"gene":[22],"knockdown.":[23],"siRNA":[24,64,118],"GC-content":[25,95,107,213,240],"negatively":[26],"correlates":[27],"with":[28,193],"RNAi":[29,109,128,242],"efficiency,":[30],"and":[31,62,108,130,157,233],"it":[32],"is":[33,91,101,122,149,174,197,214,224],"of":[34,42,75,116,125,137,144,162,169,181,221,239],"interest":[35],"to":[36,79,199],"have":[37,200],"convincing":[39],"mechanistic":[40,234],"interpretation":[41,232],"this":[43,48],"observation.":[44],"We":[45],"here":[46],"examine":[47],"issue":[49],"considering":[51],"the":[52,57,63,113,117,132,135,145,166,178,210,219,237],"secondary":[53,203],"structures":[54],"both":[56],"target":[58,88,154,222],"messenger":[59],"(mRNA)":[61],"guide":[65,119],"strand.":[66],"RESULTS:":[67],"By":[68],"analyzing":[69],"unique":[71],"homogeneous":[72],"data":[73],"set":[74,161],"101":[76],"shRNAs":[77],"targeted":[78],"100":[80],"endogenous":[81],"human":[82],"genes,":[83],"we":[84],"find":[85],"that:":[86],"1)":[87],"site":[89,155],"accessibility":[90,156,223],"more":[92,201],"important":[93],"than":[94,177],"efficient":[97],"RNAi;":[98],"2)":[99],"there":[100,121,148],"an":[102,142],"appreciable":[103],"negative":[104],"correlation":[105,126,152,208,211],"between":[106,127,153],"activity;":[110],"3)":[111],"predicted":[114],"structure":[115],"strand,":[120],"lack":[124],"activity":[129],"either":[131],"stability":[133],"number":[136],"free":[138],"dangling":[139],"nucleotides":[140],"at":[141],"end":[143],"structure;":[146],"4)":[147],"high":[151],"GC-content.":[158],"For":[159],"representative":[163],"structural":[164],"RNAs,":[165],"GC":[167,179,195],"content":[168,180,196],"62.6%":[170],"paired":[172],"bases":[173],"significantly":[175],"higher":[176,194],"38.7%":[182],"unpaired":[184],"bases.":[185],"Thus,":[186],"structured":[189],"RNA,":[190],"region":[192],"likely":[198],"stable":[202],"structure.":[204],"Furthermore,":[205],"partial":[207],"analysis,":[209],"almost":[215],"completely":[216],"diminished,":[217],"when":[218],"effect":[220,238],"controlled.":[225],"CONCLUSION:":[226],"These":[227],"findings":[228],"provide":[229],"target-structure-based":[231],"insight":[235],"on":[241],"efficiency.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}
