{"id":"https://openalex.org/W2131164625","doi":"https://doi.org/10.1186/1471-2105-10-89","title":"The PHA Depolymerase Engineering Database: A systematic analysis tool for the diverse family of polyhydroxyalkanoate (PHA) depolymerases","display_name":"The PHA Depolymerase Engineering Database: A systematic analysis tool for the diverse family of polyhydroxyalkanoate (PHA) depolymerases","publication_year":2009,"publication_date":"2009-03-18","ids":{"openalex":"https://openalex.org/W2131164625","doi":"https://doi.org/10.1186/1471-2105-10-89","mag":"2131164625","pmid":"https://pubmed.ncbi.nlm.nih.gov/19296857"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-89","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-89","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-89","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-89","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103556063","display_name":"Michael Knoll","orcid":null},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Knoll","raw_affiliation_strings":["Institute of Technical Biochemistry, University of Stuttgart, Allmandring, Germany. michael.knoll@itb.uni-stuttgart.de","\u2002Institute of Technical Biochemistry, University of Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technical Biochemistry, University of Stuttgart, Allmandring, Germany. michael.knoll@itb.uni-stuttgart.de","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"\u2002Institute of Technical Biochemistry, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081612607","display_name":"Thomas Hamm","orcid":"https://orcid.org/0000-0003-4873-1710"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas M Hamm","raw_affiliation_strings":["Institute of Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany","\u2002Institute of Technical Biochemistry, University of Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"\u2002Institute of Technical Biochemistry, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050390468","display_name":"Florian Wagner","orcid":"https://orcid.org/0000-0001-7639-3486"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Wagner","raw_affiliation_strings":["Institute of Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany","\u2002Institute of Technical Biochemistry, University of Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"\u2002Institute of Technical Biochemistry, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075508499","display_name":"Virginia Mart\u00ednez","orcid":"https://orcid.org/0009-0004-6940-8589"},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210147680","display_name":"Centro de Investigaciones Biol\u00f3gicas Margarita Salas","ror":"https://ror.org/04advdf21","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Virginia Martinez","raw_affiliation_strings":["Department of Molecular Microbiology, Centro de Investigaciones Biologicas, Ramiro de Maeztu, 9, 28040, Madrid, Spain","Department of Molecular Microbiology, Centro de Investigaciones Biologicas, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology, Centro de Investigaciones Biologicas, Ramiro de Maeztu, 9, 28040, Madrid, Spain","institution_ids":["https://openalex.org/I4210147680"]},{"raw_affiliation_string":"Department of Molecular Microbiology, Centro de Investigaciones Biologicas, Madrid, Spain","institution_ids":["https://openalex.org/I134820265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067406221","display_name":"J\u00fcrgen Pleiss","orcid":"https://orcid.org/0000-0003-1045-8202"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J\u00fcrgen Pleiss","raw_affiliation_strings":["Institute of Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany","\u2002Institute of Technical Biochemistry, University of Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"\u2002Institute of Technical Biochemistry, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067406221"],"corresponding_institution_ids":["https://openalex.org/I100066346"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.9235,"has_fulltext":true,"cited_by_count":159,"citation_normalized_percentile":{"value":0.90374194,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"10","issue":"1","first_page":"89","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10753","display_name":"Microplastics and Plastic Pollution","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10389","display_name":"Polymer crystallization and properties","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyhydroxyalkanoates","display_name":"Polyhydroxyalkanoates","score":0.7060633897781372},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5911394953727722},{"id":"https://openalex.org/keywords/sequence-analysis","display_name":"Sequence analysis","score":0.5184404850006104},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5059630274772644},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.4717180132865906},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.45350411534309387},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4374270737171173},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.43379056453704834},{"id":"https://openalex.org/keywords/hydrolase","display_name":"Hydrolase","score":0.43045574426651},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"Protein engineering","score":0.423200786113739},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.34507209062576294},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33170086145401},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.31952786445617676},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3035612106323242},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.3007556200027466},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11117255687713623},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.08989936113357544}],"concepts":[{"id":"https://openalex.org/C73447357","wikidata":"https://www.wikidata.org/wiki/Q425079","display_name":"Polyhydroxyalkanoates","level":3,"score":0.7060633897781372},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5911394953727722},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.5184404850006104},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5059630274772644},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.4717180132865906},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.45350411534309387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4374270737171173},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.43379056453704834},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.43045574426651},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.423200786113739},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34507209062576294},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33170086145401},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.31952786445617676},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3035612106323242},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3007556200027466},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11117255687713623},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.08989936113357544}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-10-89","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-89","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-89","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19296857","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19296857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:digital.csic.es:10261/53556","is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/53556","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:e245c5aeb33643239341d70ca318b5ea","is_oa":false,"landing_page_url":"https://doaj.org/article/e245c5aeb33643239341d70ca318b5ea","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 89 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2666664","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2666664","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-89","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-89","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-89","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7287250431","display_name":null,"funder_award_id":"BIOPRODUCTION/NMP-2-CT-2007-026515","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7608388151","display_name":null,"funder_award_id":"NMP-2-CT-2007-026515","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2131164625.pdf","grobid_xml":"https://content.openalex.org/works/W2131164625.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W14219724","https://openalex.org/W172569458","https://openalex.org/W1480526287","https://openalex.org/W1517697544","https://openalex.org/W1549091021","https://openalex.org/W1678180139","https://openalex.org/W1783521931","https://openalex.org/W1817751452","https://openalex.org/W1937279395","https://openalex.org/W1967707279","https://openalex.org/W1968259784","https://openalex.org/W1973514124","https://openalex.org/W1975206385","https://openalex.org/W1977316482","https://openalex.org/W1985260357","https://openalex.org/W1987736126","https://openalex.org/W1996423252","https://openalex.org/W2008708467","https://openalex.org/W2020858541","https://openalex.org/W2023631098","https://openalex.org/W2032234148","https://openalex.org/W2056256968","https://openalex.org/W2062530010","https://openalex.org/W2068129643","https://openalex.org/W2070412603","https://openalex.org/W2077037429","https://openalex.org/W2081277585","https://openalex.org/W2085670938","https://openalex.org/W2101869224","https://openalex.org/W2106882534","https://openalex.org/W2112426955","https://openalex.org/W2113849438","https://openalex.org/W2114968093","https://openalex.org/W2116459264","https://openalex.org/W2120707072","https://openalex.org/W2122623413","https://openalex.org/W2130479394","https://openalex.org/W2141885858","https://openalex.org/W2146325576","https://openalex.org/W2150080705","https://openalex.org/W2157203962","https://openalex.org/W2158714788","https://openalex.org/W2164479864","https://openalex.org/W2170826134","https://openalex.org/W2246220490","https://openalex.org/W4245145908","https://openalex.org/W6681765588"],"related_works":["https://openalex.org/W4285502871","https://openalex.org/W3025473131","https://openalex.org/W4280525985","https://openalex.org/W1483564904","https://openalex.org/W2063576191","https://openalex.org/W2161526358","https://openalex.org/W2003031489","https://openalex.org/W1525517788","https://openalex.org/W3119443523","https://openalex.org/W2353952613"],"abstract_inverted_index":{"BACKGROUND:":[0],"Polyhydroxyalkanoates":[1],"(PHAs)":[2],"can":[3,114],"be":[4,115],"degraded":[5],"by":[6],"many":[7],"microorganisms":[8],"using":[9],"intra-":[10],"or":[11],"extracellular":[12],"PHA":[13,15,44,70,120,130],"depolymerases.":[14],"depolymerases":[16],"are":[17,98,104],"very":[18],"diverse":[19],"in":[20,39,126],"sequence":[21,66,85,91],"and":[22,31,78,93,100,137],"substrate":[23],"specificity,":[24],"but":[25],"share":[26],"a":[27,32,54,110],"common":[28],"alpha/beta-hydrolase":[29],"fold":[30],"catalytic":[33],"triad,":[34],"which":[35,72,113],"is":[36,109],"also":[37],"found":[38],"other":[40],"alpha/beta-hydrolases.":[41],"RESULTS:":[42],"The":[43,63,107],"Depolymerase":[45],"Engineering":[46],"Database":[47],"(DED,":[48],"http://www.ded.uni-stuttgart.de)":[49],"has":[50],"been":[51],"established":[52],"as":[53],"tool":[55,112],"for":[56],"systematic":[57],"analysis":[58],"of":[59,68],"this":[60],"enzyme":[61,140],"family.":[62],"DED":[64,108],"contains":[65],"entries":[67],"587":[69],"depolymerases,":[71,131],"were":[73],"assigned":[74],"to":[75,117,128,132,138],"8":[76],"superfamilies":[77],"38":[79],"homologous":[80],"families":[81],"based":[82],"on":[83],"their":[84,134],"similarity.":[86],"For":[87],"each":[88],"family,":[89],"multiple":[90],"alignments":[92],"profile":[94],"hidden":[95],"Markov":[96],"models":[97],"provided,":[99],"functionally":[101],"relevant":[102],"residues":[103],"annotated.":[105],"CONCLUSION:":[106],"valuable":[111],"applied":[116],"identify":[118],"new":[119],"depolymerase":[121],"sequences":[122],"from":[123],"complete":[124],"genomes":[125],"silico,":[127],"classify":[129],"predict":[133],"biochemical":[135],"properties,":[136],"design":[139],"variants":[141],"with":[142],"improved":[143],"properties.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}