{"id":"https://openalex.org/W2095425688","doi":"https://doi.org/10.1186/1471-2105-10-88","title":"Analyses of domains and domain fusions in human proto-oncogenes","display_name":"Analyses of domains and domain fusions in human proto-oncogenes","publication_year":2009,"publication_date":"2009-03-17","ids":{"openalex":"https://openalex.org/W2095425688","doi":"https://doi.org/10.1186/1471-2105-10-88","mag":"2095425688","pmid":"https://pubmed.ncbi.nlm.nih.gov/19292927"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-88","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-88","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2105-10-88.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/1471-2105-10-88.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100453224","display_name":"Qi Liu","orcid":"https://orcid.org/0000-0002-7892-5965"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Qi Liu","raw_affiliation_strings":["Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA. qiliu@csbl.bmb.uga.edu","Zhejiang California International Nanosystems Institute, Zhejiang University, Hangzhou, PR China","Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA. qiliu@csbl.bmb.uga.edu","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Zhejiang California International Nanosystems Institute, Zhejiang University, Hangzhou, PR China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009533194","display_name":"Jinling Huang","orcid":"https://orcid.org/0000-0003-4893-4171"},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinling Huang","raw_affiliation_strings":["Department of Biology, East Carolina University, Greenville, NC, 27858, USA","Dept. of Biology, East Carolina University, Greenville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, East Carolina University, Greenville, NC, 27858, USA","institution_ids":["https://openalex.org/I186335123"]},{"raw_affiliation_string":"Dept. of Biology, East Carolina University, Greenville, USA","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100709947","display_name":"Huiqing Liu","orcid":"https://orcid.org/0000-0002-5227-5204"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huiqing Liu","raw_affiliation_strings":["Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA","Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101932818","display_name":"Ping Wan","orcid":"https://orcid.org/0000-0003-1552-0124"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]},{"id":"https://openalex.org/I96852419","display_name":"Capital Normal University","ror":"https://ror.org/005edt527","country_code":"CN","type":"education","lineage":["https://openalex.org/I96852419"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ping Wan","raw_affiliation_strings":["College of Life Science, Capital Normal University, Beijing, 100037, PR China","Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA","College of Life Science, Capital Normal University, Beijing, PR China","Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Capital Normal University, Beijing, 100037, PR China","institution_ids":["https://openalex.org/I96852419"]},{"raw_affiliation_string":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"College of Life Science, Capital Normal University, Beijing, PR China","institution_ids":["https://openalex.org/I96852419"]},{"raw_affiliation_string":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067118299","display_name":"Xiuzi Ye","orcid":null},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiuzi Ye","raw_affiliation_strings":["College of Computer Science, Zhejiang University, Hangzhou, 310027, PR China","College of Computer Science, Zhejiang University, Hangzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science, Zhejiang University, Hangzhou, 310027, PR China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"College of Computer Science, Zhejiang University, Hangzhou, PR China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020171946","display_name":"Ying Xu","orcid":"https://orcid.org/0000-0002-7856-3343"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ying Xu","raw_affiliation_strings":["Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA","Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Computational Systems Biology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, USA","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5020171946","https://openalex.org/A5067118299"],"corresponding_institution_ids":["https://openalex.org/I165733156","https://openalex.org/I76130692"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.5478,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.67365025,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"10","issue":"1","first_page":"88","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.34610000252723694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.34610000252723694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.16509999334812164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.07020000368356705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6005338430404663},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.5604965090751648},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5589811205863953},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5118095278739929},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.439073383808136},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.28455448150634766},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12160015106201172}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6005338430404663},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5604965090751648},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5589811205863953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5118095278739929},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.439073383808136},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28455448150634766},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12160015106201172},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-10-88","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-88","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2105-10-88.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19292927","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19292927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.215.2615","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.215.2615","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.biomedcentral.com/content/pdf/1471-2105-10-88.pdf","raw_type":"text"},{"id":"pmh:oai:TheScholarship.intra.ecu.edu:10342/3329","is_oa":false,"landing_page_url":"http://hdl.handle.net/10342/3329","pdf_url":null,"source":{"id":"https://openalex.org/S4306402312","display_name":"The Scholarship East Carolina University's Institutional Repository (East Carolina University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I186335123","host_organization_name":"East Carolina University","host_organization_lineage":["https://openalex.org/I186335123"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:1bd20efd5da340e4b8eeaaf646537ac9","is_oa":false,"landing_page_url":"https://doaj.org/article/1bd20efd5da340e4b8eeaaf646537ac9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 88 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2679021","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2679021","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-88","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-88","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2105-10-88.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2954911513","display_name":null,"funder_award_id":"ITR-IIS-0407204","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3453259917","display_name":null,"funder_award_id":"DBI-0354771","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4786737960","display_name":null,"funder_award_id":"CCF-0621700","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4883808398","display_name":null,"funder_award_id":"DBI-0542119","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5864136272","display_name":"ITR Collaborative Research:  Combinatorial Algorithms for Biological Data Clustering","funder_award_id":"0407204","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7137655021","display_name":"Computational Prediction of Biological Networks in Microbes and Applications to Cyanobacteria","funder_award_id":"0542119","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7168705754","display_name":"A Computational Capability for Fast and Reliable Characterization of Protein Complexes","funder_award_id":"0354771","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7355656958","display_name":"CompBio: A New Paradigm of Protein Threading: simultaneous backbone threading and side-chain packing prediction.","funder_award_id":"0621700","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306352","display_name":"Georgia Cancer Coalition","ror":"https://ror.org/0009gvn90"},{"id":"https://openalex.org/F4320310571","display_name":"East Carolina University","ror":"https://ror.org/01vx35703"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2095425688.pdf","grobid_xml":"https://content.openalex.org/works/W2095425688.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W26755955","https://openalex.org/W654058512","https://openalex.org/W1503558940","https://openalex.org/W1970150587","https://openalex.org/W1971155547","https://openalex.org/W1972192783","https://openalex.org/W1977922844","https://openalex.org/W1979261738","https://openalex.org/W1987003850","https://openalex.org/W2003891151","https://openalex.org/W2025183726","https://openalex.org/W2038535661","https://openalex.org/W2044350730","https://openalex.org/W2057885377","https://openalex.org/W2063252182","https://openalex.org/W2069688179","https://openalex.org/W2077102469","https://openalex.org/W2077199821","https://openalex.org/W2083769210","https://openalex.org/W2087885007","https://openalex.org/W2102140136","https://openalex.org/W2108914190","https://openalex.org/W2109413613","https://openalex.org/W2118340207","https://openalex.org/W2120627772","https://openalex.org/W2122300808","https://openalex.org/W2123501554","https://openalex.org/W2133070552","https://openalex.org/W2136280642","https://openalex.org/W2141515295","https://openalex.org/W2144494426","https://openalex.org/W2148950394","https://openalex.org/W2150125221","https://openalex.org/W2159201869","https://openalex.org/W2161062388","https://openalex.org/W2168752603","https://openalex.org/W2171126418","https://openalex.org/W2181958706","https://openalex.org/W2276344482","https://openalex.org/W2318951087","https://openalex.org/W2415180754","https://openalex.org/W2471713806","https://openalex.org/W2530014580","https://openalex.org/W3216627664","https://openalex.org/W4211083314","https://openalex.org/W4233484287","https://openalex.org/W4240237951","https://openalex.org/W4252706339"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W1971568933","https://openalex.org/W2013243191","https://openalex.org/W2117258802"],"abstract_inverted_index":{"BACKGROUND:":[0],"Understanding":[1],"the":[2,17,20,41,66,76,123,138],"constituent":[3],"domains":[4,35,45,82,103],"of":[5,22,33,36,40,43,55,60,65,78,81,100,122,126,159],"oncogenes,":[6],"their":[7,10,47],"origins":[8,42],"and":[9,19,46,57,83,104,146],"fusions":[11],"may":[12],"shed":[13],"new":[14,58],"light":[15],"about":[16],"initiation":[18],"development":[21],"cancers.":[23],"RESULTS:":[24],"We":[25,135],"have":[26],"developed":[27],"a":[28,79,119],"computational":[29,139],"pipeline":[30,67,140],"for":[31,141,155],"identification":[32,77],"functional":[34],"human":[37,71,95],"genes,":[38],"prediction":[39,149],"these":[44,101],"major":[48],"fusion":[49,148],"events":[50,125],"during":[51,132],"evolution":[52],"through":[53],"integration":[54],"existing":[56],"tools":[59],"our":[61,115],"own.":[62],"An":[63],"application":[64],"to":[68,75,109,152],"124":[69],"well-characterized":[70],"oncogenes":[72,92,127],"has":[73],"led":[74],"collection":[80],"domain":[84,105,142,144,147],"pairs":[85,106],"that":[86,118,137],"occur":[87],"substantially":[88],"more":[89],"frequently":[90],"in":[91,94,130],"than":[93],"genes":[96],"on":[97],"average.":[98],"Most":[99],"enriched":[102],"are":[107],"related":[108],"tyrosine":[110],"kinase":[111],"activities.":[112],"In":[113],"addition,":[114],"analyses":[116],"indicate":[117],"substantial":[120],"portion":[121],"domain-fusion":[124],"took":[128],"place":[129],"metazoans":[131],"evolution.":[133],"CONCLUSION:":[134],"expect":[136],"identification,":[143],"origin":[145],"will":[150],"prove":[151],"be":[153],"useful":[154],"studying":[156],"other":[157],"groups":[158],"genes.":[160]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}