{"id":"https://openalex.org/W2103996345","doi":"https://doi.org/10.1186/1471-2105-10-52","title":"Improving the analysis of designed studies by combining statistical modelling with study design information","display_name":"Improving the analysis of designed studies by combining statistical modelling with study design information","publication_year":2009,"publication_date":"2009-02-07","ids":{"openalex":"https://openalex.org/W2103996345","doi":"https://doi.org/10.1186/1471-2105-10-52","mag":"2103996345","pmid":"https://pubmed.ncbi.nlm.nih.gov/19200393"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-52","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-52","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-52","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-52","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020381866","display_name":"Uwe Thissen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109520","display_name":"TiFN","ror":"https://ror.org/0183vre95","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210109520"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Uwe Thissen","raw_affiliation_strings":["Dutch nutrigenomics consortium of the Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands. uwe.thissen@tno.nl","Dutch nutrigenomics consortium of the Top Institute Food and Nutrition (TIFN), PO Box 557, 6700 AN Wageningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dutch nutrigenomics consortium of the Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands. uwe.thissen@tno.nl","institution_ids":["https://openalex.org/I4210109520"]},{"raw_affiliation_string":"Dutch nutrigenomics consortium of the Top Institute Food and Nutrition (TIFN), PO Box 557, 6700 AN Wageningen, The Netherlands","institution_ids":["https://openalex.org/I4210109520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021730809","display_name":"Suzan Wopereis","orcid":"https://orcid.org/0000-0001-9612-657X"},"institutions":[{"id":"https://openalex.org/I4210109520","display_name":"TiFN","ror":"https://ror.org/0183vre95","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210109520"]},{"id":"https://openalex.org/I4210164629","display_name":"Pension Fund for Care and Well-Being","ror":"https://ror.org/05a8epj20","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I4210164629"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Suzan Wopereis","raw_affiliation_strings":["Dutch nutrigenomics consortium of the Top Institute Food and Nutrition (TIFN), PO Box 557, 6700 AN Wageningen, The Netherlands","TNO Quality of Life, PO Box 360, 3700, AJ Zeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dutch nutrigenomics consortium of the Top Institute Food and Nutrition (TIFN), PO Box 557, 6700 AN Wageningen, The Netherlands","institution_ids":["https://openalex.org/I4210109520"]},{"raw_affiliation_string":"TNO Quality of Life, PO Box 360, 3700, AJ Zeist, The Netherlands","institution_ids":["https://openalex.org/I4210164629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110363093","display_name":"S. A. van den Berg","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109520","display_name":"TiFN","ror":"https://ror.org/0183vre95","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210109520"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sjoerd AA van den Berg","raw_affiliation_strings":["Department of Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300, RC Leiden, The Netherlands","Dutch nutrigenomics consortium of the Top Institute Food and Nutrition (TIFN), PO Box 557, 6700 AN Wageningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300, RC Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Dutch nutrigenomics consortium of the Top Institute Food and Nutrition (TIFN), PO Box 557, 6700 AN Wageningen, The Netherlands","institution_ids":["https://openalex.org/I4210109520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042517950","display_name":"I. Bobeldijk","orcid":null},"institutions":[{"id":"https://openalex.org/I4210164629","display_name":"Pension Fund for Care and Well-Being","ror":"https://ror.org/05a8epj20","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I4210164629"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ivana Bobeldijk","raw_affiliation_strings":["TNO Quality of Life, PO Box 360, 3700, AJ Zeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO Quality of Life, PO Box 360, 3700, AJ Zeist, The Netherlands","institution_ids":["https://openalex.org/I4210164629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063674598","display_name":"Robert Kleemann","orcid":"https://orcid.org/0000-0002-1350-0149"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Kleemann","raw_affiliation_strings":["TNO Quality of Life, PO Box 2215, 2301, CE Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO Quality of Life, PO Box 2215, 2301, CE Leiden, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110169024","display_name":"Teake Kooistra","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teake Kooistra","raw_affiliation_strings":["TNO Quality of Life, PO Box 2215, 2301, CE Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO Quality of Life, PO Box 2215, 2301, CE Leiden, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080811781","display_name":"Ko Willems van Dijk","orcid":"https://orcid.org/0000-0002-2172-7394"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ko Willems van Dijk","raw_affiliation_strings":["Department of Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300, RC Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300, RC Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049866928","display_name":"Ben van Ommen","orcid":"https://orcid.org/0000-0002-0124-9428"},"institutions":[{"id":"https://openalex.org/I4210164629","display_name":"Pension Fund for Care and Well-Being","ror":"https://ror.org/05a8epj20","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I4210164629"]},{"id":"https://openalex.org/I4210109520","display_name":"TiFN","ror":"https://ror.org/0183vre95","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210109520"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ben van Ommen","raw_affiliation_strings":["Dutch nutrigenomics consortium of the Top Institute Food and Nutrition (TIFN), PO Box 557, 6700 AN Wageningen, The Netherlands","TNO Quality of Life, PO Box 360, 3700, AJ Zeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dutch nutrigenomics consortium of the Top Institute Food and Nutrition (TIFN), PO Box 557, 6700 AN Wageningen, The Netherlands","institution_ids":["https://openalex.org/I4210109520"]},{"raw_affiliation_string":"TNO Quality of Life, PO Box 360, 3700, AJ Zeist, The Netherlands","institution_ids":["https://openalex.org/I4210164629"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083251527","display_name":"Age K. Smilde","orcid":"https://orcid.org/0000-0002-3052-4644"},"institutions":[{"id":"https://openalex.org/I1295801184","display_name":"Netherlands Institute for Neuroscience","ror":"https://ror.org/05csn2x06","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1295801184","https://openalex.org/I1322597698"]},{"id":"https://openalex.org/I4210164629","display_name":"Pension Fund for Care and Well-Being","ror":"https://ror.org/05a8epj20","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I4210164629"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Age K Smilde","raw_affiliation_strings":["Biosystems Data Analysis, Swammerdam Institute for Life Sciences, Universiteit van Amsterdam, Nieuwe Achtergracht 166, 1018, WV Amsterdam, The Netherlands","TNO Quality of Life, PO Box 360, 3700, AJ Zeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biosystems Data Analysis, Swammerdam Institute for Life Sciences, Universiteit van Amsterdam, Nieuwe Achtergracht 166, 1018, WV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I1295801184"]},{"raw_affiliation_string":"TNO Quality of Life, PO Box 360, 3700, AJ Zeist, The Netherlands","institution_ids":["https://openalex.org/I4210164629"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5020381866"],"corresponding_institution_ids":["https://openalex.org/I4210109520"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.2311,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.78693476,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"52","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.28600001335144043,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.28600001335144043,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.04650000110268593,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/partial-least-squares-regression","display_name":"Partial least squares regression","score":0.705763041973114},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.6331281065940857},{"id":"https://openalex.org/keywords/analysis-of-variance","display_name":"Analysis of variance","score":0.6055496335029602},{"id":"https://openalex.org/keywords/regression-analysis","display_name":"Regression analysis","score":0.5115152597427368},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.490313321352005},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48899686336517334},{"id":"https://openalex.org/keywords/design-of-experiments","display_name":"Design of experiments","score":0.434852659702301},{"id":"https://openalex.org/keywords/statistical-model","display_name":"Statistical model","score":0.4342246651649475},{"id":"https://openalex.org/keywords/linear-regression","display_name":"Linear regression","score":0.4132690131664276},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.4131205677986145},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.37870949506759644},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.33011406660079956},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3273937702178955}],"concepts":[{"id":"https://openalex.org/C22354355","wikidata":"https://www.wikidata.org/wiki/Q422009","display_name":"Partial least squares regression","level":2,"score":0.705763041973114},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.6331281065940857},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.6055496335029602},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.5115152597427368},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.490313321352005},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48899686336517334},{"id":"https://openalex.org/C34559072","wikidata":"https://www.wikidata.org/wiki/Q2334061","display_name":"Design of experiments","level":2,"score":0.434852659702301},{"id":"https://openalex.org/C114289077","wikidata":"https://www.wikidata.org/wiki/Q3284399","display_name":"Statistical model","level":2,"score":0.4342246651649475},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.4132690131664276},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.4131205677986145},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37870949506759644},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.33011406660079956},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3273937702178955}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2105-10-52","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-52","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-52","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19200393","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19200393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:dare.uva.nl:openaire/ae09b2bd-b4e1-4e37-82e3-db42c44da121","is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/improving-the-analysis-of-designed-studies-by-combining-statistical-modelling-with-study-design-information(ae09b2bd-b4e1-4e37-82e3-db42c44da121).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thissen, U, Wopereis, S, van Berg, S A A, Bobeldijk, I, Kleemann, R, Kooistra, T, van Dijk, K W, van Ommen, B & Smilde, A K 2009, 'Improving the analysis of designed studies by combining statistical modelling with study design information', BMC Bioinformatics, vol. 10, pp. 52. https://doi.org/10.1186/1471-2105-10-52","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/ae09b2bd-b4e1-4e37-82e3-db42c44da121","is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/improving-the-analysis-of-designed-studies-by-combining-statistical-modelling-with-study-design-information(ae09b2bd-b4e1-4e37-82e3-db42c44da121).html","pdf_url":"https://dare.uva.nl/personal/pure/en/publications/improving-the-analysis-of-designed-studies-by-combining-statistical-modelling-with-study-design-information(ae09b2bd-b4e1-4e37-82e3-db42c44da121).html","source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 10. BioMed Central","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:994d7a4c734e4fda87f527624b05684d","is_oa":true,"landing_page_url":"https://doaj.org/article/994d7a4c734e4fda87f527624b05684d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 52 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2657790","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2657790","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:tudelft.nl:uuid:f316944e-2dde-4d1b-8570-2d524f6a3ccb","is_oa":false,"landing_page_url":"http://resolver.tudelft.nl/uuid:f316944e-2dde-4d1b-8570-2d524f6a3ccb","pdf_url":null,"source":{"id":"https://openalex.org/S4306402238","display_name":"Repository hosted by TU Delft Library (TU Delft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 10","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-52","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-52","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-52","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.6000000238418579,"display_name":"Zero hunger"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334952","display_name":"Wageningen University and Research","ror":"https://ror.org/04qw24q55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103996345.pdf","grobid_xml":"https://content.openalex.org/works/W2103996345.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1489637972","https://openalex.org/W1565311713","https://openalex.org/W1595316354","https://openalex.org/W1973778137","https://openalex.org/W1984048213","https://openalex.org/W1992483596","https://openalex.org/W1995843625","https://openalex.org/W2004104751","https://openalex.org/W2006147493","https://openalex.org/W2029223623","https://openalex.org/W2040805429","https://openalex.org/W2044758663","https://openalex.org/W2046173425","https://openalex.org/W2057235898","https://openalex.org/W2062551369","https://openalex.org/W2069005369","https://openalex.org/W2081285461","https://openalex.org/W2082676707","https://openalex.org/W2097057782","https://openalex.org/W2098562143","https://openalex.org/W2101163066","https://openalex.org/W2102667102","https://openalex.org/W2112081648","https://openalex.org/W2124911115","https://openalex.org/W2125555008","https://openalex.org/W2142746589","https://openalex.org/W2152820192","https://openalex.org/W2158985195","https://openalex.org/W2161027523","https://openalex.org/W2171741046","https://openalex.org/W2503993098","https://openalex.org/W2525207921","https://openalex.org/W2798510847","https://openalex.org/W3197494818","https://openalex.org/W4231439430"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W4361193272","https://openalex.org/W4310278675","https://openalex.org/W2806259446","https://openalex.org/W2963326959","https://openalex.org/W4311431240","https://openalex.org/W4312407344","https://openalex.org/W4384115502","https://openalex.org/W4226258012","https://openalex.org/W4383681494"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"the":[2,40,48,123,145,151,154,196],"fields":[3],"of":[4,76,81,103,153,200,233],"life":[5],"sciences,":[6],"so-called":[7],"designed":[8],"studies":[9,22],"are":[10,55,71],"used":[11,45,114],"for":[12,225],"studying":[13],"complex":[14],"biological":[15,188],"systems.":[16],"The":[17,79,136,198],"data":[18,50,52,98,147,202],"derived":[19,194],"from":[20,100,195],"these":[21,70],"comply":[23],"with":[24,57,86,97,148,204],"a":[25,107,109,129,169,186,205],"study":[26,41,112,122],"design":[27,42],"aimed":[28],"at":[29],"generating":[30],"relevant":[31,191],"information":[32],"while":[33],"diminishing":[34],"unwanted":[35],"variation":[36],"(noise).":[37],"Knowledge":[38],"about":[39],"can":[43,63,222],"be":[44,64,223],"to":[46,121,141,150,168,181,216],"decompose":[47],"total":[49],"into":[51],"blocks":[53],"that":[54,89,165,173],"associated":[56],"specific":[58],"effects.":[59,77],"Subsequent":[60],"statistical":[61,171,207,227],"analysis":[62,88],"improved":[65],"by":[66],"this":[67,82],"decomposition":[68,99],"if":[69],"applied":[72,224],"on":[73,115,144],"selected":[74],"combinations":[75],"RESULTS:":[78],"benefit":[80],"approach":[83],"was":[84,139,163],"demonstrated":[85],"an":[87],"combines":[90],"multivariate":[91],"PLS":[92,142,183,217],"(Partial":[93],"Least":[94],"Squares)":[95],"regression":[96,143,218],"ANOVA":[101],"(Analysis":[102],"Variance):":[104],"ANOVA-PLS.":[105],"As":[106],"case,":[108],"nutritional":[110],"intervention":[111],"is":[113,174,212],"Apoliprotein":[116],"E3-Leiden":[117],"(APOE3Leiden)":[118],"transgenic":[119],"mice":[120],"relation":[124],"between":[125],"liver":[126],"lipidomics":[127],"and":[128,159,177,229],"plasma":[130],"inflammation":[131],"marker,":[132],"Serum":[133],"Amyloid":[134],"A.":[135],"ANOVA-PLS":[137,166],"performance":[138],"compared":[140,180],"non-decomposed":[146],"respect":[149],"quality":[152],"modelled":[155],"relation,":[156],"model":[157,172],"reliability,":[158],"interpretability.":[160],"CONCLUSION:":[161],"It":[162],"shown":[164],"leads":[167],"better":[170,178],"more":[175,190],"reliable":[176],"interpretable":[179],"standard":[182],"analysis.":[184],"From":[185],"following":[187],"interpretation,":[189],"metabolites":[192],"were":[193],"model.":[197],"concept":[199],"combining":[201],"composition":[203],"subsequent":[206],"analysis,":[208],"as":[209],"in":[210,219],"ANOVA-PLS,":[211],"however":[213],"not":[214],"limited":[215],"metabolomics":[220],"but":[221],"many":[226,230],"methods":[228],"different":[231],"types":[232],"data.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}