{"id":"https://openalex.org/W2116591959","doi":"https://doi.org/10.1186/1471-2105-10-427","title":"In silico method for systematic analysis of feature importance in microRNA-mRNA interactions","display_name":"In silico method for systematic analysis of feature importance in microRNA-mRNA interactions","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2116591959","doi":"https://doi.org/10.1186/1471-2105-10-427","mag":"2116591959","pmid":"https://pubmed.ncbi.nlm.nih.gov/20015389"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-427","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-427","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-427","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-427","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108863928","display_name":"Jiamin Xiao","orcid":null},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiamin Xiao","raw_affiliation_strings":["College of Chemistry, Sichuan University, Chengdu 610064, PR China. xiaojiamin07@126.com","College of Chemistry, Sichuan University, Chengdu, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu 610064, PR China. xiaojiamin07@126.com","institution_ids":["https://openalex.org/I102345215"]},{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, PR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719729","display_name":"Yizhou Li","orcid":"https://orcid.org/0000-0002-0351-1792"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yizhou Li","raw_affiliation_strings":["College of Chemistry, Sichuan University, Chengdu, 610064, PR China","College of Chemistry, Sichuan University, Chengdu, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, 610064, PR China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, PR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035387429","display_name":"Kelong Wang","orcid":"https://orcid.org/0000-0002-5285-3940"},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Kelong Wang","raw_affiliation_strings":["College of Chemistry, Sichuan University, Chengdu, 610064, PR China","Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, 79409-1061, USA","Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, USA","College of Chemistry, Sichuan University, Chengdu, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, 610064, PR China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, 79409-1061, USA","institution_ids":["https://openalex.org/I12315562"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, USA","institution_ids":["https://openalex.org/I12315562"]},{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, PR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007166385","display_name":"Zhining Wen","orcid":"https://orcid.org/0000-0002-0477-4906"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhining Wen","raw_affiliation_strings":["College of Chemistry, Sichuan University, Chengdu, 610064, PR China","College of Chemistry, Sichuan University, Chengdu, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, 610064, PR China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, PR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100703866","display_name":"Menglong Li","orcid":"https://orcid.org/0000-0001-7365-0344"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Menglong Li","raw_affiliation_strings":["College of Chemistry, Sichuan University, Chengdu, 610064, PR China","College of Chemistry, Sichuan University, Chengdu, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, 610064, PR China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, PR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453759","display_name":"Lifang Zhang","orcid":"https://orcid.org/0009-0002-4569-5080"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifang Zhang","raw_affiliation_strings":["College of Chemistry, Sichuan University, Chengdu, 610064, PR China","College of Chemistry, Sichuan University, Chengdu, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, 610064, PR China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, PR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063116361","display_name":"Xuanmin Guang","orcid":"https://orcid.org/0000-0003-3013-634X"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuanmin Guang","raw_affiliation_strings":["College of Chemistry, Sichuan University, Chengdu, 610064, PR China","College of Chemistry, Sichuan University, Chengdu, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, 610064, PR China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"College of Chemistry, Sichuan University, Chengdu, PR China","institution_ids":["https://openalex.org/I24185976"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100703866"],"corresponding_institution_ids":["https://openalex.org/I24185976"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.5036,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.64825479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"427","last_page":"427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.4936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.4936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.36399999260902405,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5868310928344727},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5644368529319763},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5466338992118835},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5085240602493286},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5073928236961365},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.47594285011291504},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.46934235095977783},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.43705233931541443},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.42872804403305054},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.4128657877445221},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3404282331466675},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3317052721977234},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.32069456577301025},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2827499806880951},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15234047174453735},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13027775287628174},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08816832304000854}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5868310928344727},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5644368529319763},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5466338992118835},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5085240602493286},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5073928236961365},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.47594285011291504},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.46934235095977783},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.43705233931541443},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.42872804403305054},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4128657877445221},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3404282331466675},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3317052721977234},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.32069456577301025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2827499806880951},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15234047174453735},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13027775287628174},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08816832304000854},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-10-427","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-427","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-427","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20015389","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20015389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:0d9668deb91c4f16976c3128e733a7a5","is_oa":false,"landing_page_url":"https://doaj.org/article/0d9668deb91c4f16976c3128e733a7a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 427 (2009)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2098568","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3087347","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:ttu-ir.tdl.org:2346/89198","is_oa":true,"landing_page_url":"https://hdl.handle.net/2346/89198","pdf_url":null,"source":{"id":"https://openalex.org/S4306402519","display_name":"ThinkTech (Texas Tech University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I12315562","host_organization_name":"Texas Tech University","host_organization_lineage":["https://openalex.org/I12315562"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-427","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-427","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-427","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7121925639","display_name":"G\u86cb\u767d\u5076\u8054\u53d7\u4f53\u7684\u7ed3\u6784\u4e0e\u529f\u80fd\u7814\u7a76","funder_award_id":"20775052","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2116591959.pdf","grobid_xml":"https://content.openalex.org/works/W2116591959.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W273955616","https://openalex.org/W1583563537","https://openalex.org/W1875061881","https://openalex.org/W1890374229","https://openalex.org/W1920564293","https://openalex.org/W1967543716","https://openalex.org/W1992941735","https://openalex.org/W2017199818","https://openalex.org/W2058059940","https://openalex.org/W2059073003","https://openalex.org/W2060434878","https://openalex.org/W2062290101","https://openalex.org/W2070571588","https://openalex.org/W2075110522","https://openalex.org/W2075996757","https://openalex.org/W2078349873","https://openalex.org/W2082681476","https://openalex.org/W2089142809","https://openalex.org/W2089146881","https://openalex.org/W2090219560","https://openalex.org/W2103760949","https://openalex.org/W2105846417","https://openalex.org/W2109136664","https://openalex.org/W2112326496","https://openalex.org/W2114973325","https://openalex.org/W2120456037","https://openalex.org/W2121936213","https://openalex.org/W2124050695","https://openalex.org/W2124274499","https://openalex.org/W2125818518","https://openalex.org/W2129931962","https://openalex.org/W2130674065","https://openalex.org/W2143481518","https://openalex.org/W2148180921","https://openalex.org/W2149785901","https://openalex.org/W2150597604","https://openalex.org/W2151922790","https://openalex.org/W2153381693","https://openalex.org/W2155318580","https://openalex.org/W2159793493","https://openalex.org/W2160303605","https://openalex.org/W2163199119","https://openalex.org/W2167557255","https://openalex.org/W2170722275","https://openalex.org/W2911964244","https://openalex.org/W4237473415"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2101501829","https://openalex.org/W2985427592","https://openalex.org/W2003194288","https://openalex.org/W2060263731","https://openalex.org/W391093122","https://openalex.org/W4361305867","https://openalex.org/W1521239975","https://openalex.org/W2113159581"],"abstract_inverted_index":{"BACKGROUND:":[0],"MicroRNA":[1],"(miRNA),":[2],"which":[3,190],"is":[4,63,184],"short":[5],"non-coding":[6],"RNA,":[7],"plays":[8],"a":[9,241],"pivotal":[10],"role":[11],"in":[12,113,132,187,196,204,240],"the":[13,21,57,82,135,198],"regulation":[14],"of":[15,25,39,60,84,90,141,151,172,200,218,221],"many":[16],"biological":[17],"processes":[18],"and":[19,93,115,128,144,150,154,169,174,203,228],"affects":[20],"stability":[22],"and/or":[23],"translation":[24],"mRNA.":[26],"Recently,":[27],"machine":[28],"learning":[29],"algorithms":[30],"were":[31,108,120,163,226],"developed":[32,121,164],"to":[33,48,80,193,230,237],"predict":[34],"potential":[35],"miRNA":[36,182],"targets.":[37],"Most":[38],"these":[40,188],"methods":[41],"are":[42,45,191],"robust":[43],"but":[44],"not":[46],"sensitive":[47],"redundant":[49],"or":[50],"irrelevant":[51],"features.":[52,222],"Despite":[53],"their":[54],"good":[55],"performance,":[56],"relative":[58],"importance":[59],"each":[61],"feature":[62,117],"still":[64],"unclear.":[65],"With":[66],"increasing":[67],"experimental":[68],"data":[69,102,148,158,179],"becoming":[70],"available,":[71],"research":[72],"interest":[73],"has":[74],"shifted":[75],"from":[76,110,209],"higher":[77],"prediction":[78],"performance":[79],"uncovering":[81],"mechanism":[83,199],"microRNA-mRNA":[85,201],"interactions.":[86],"RESULTS:":[87],"Systematic":[88],"analysis":[89,217],"sequence,":[91,126],"structural":[92,127],"positional":[94,129],"features":[95,107,112,168,225],"was":[96],"carried":[97],"out":[98],"for":[99,146,156,176],"two":[100,177],"different":[101,178],"sets.":[103,118,180],"The":[104],"dominant":[105],"functional":[106],"distinguished":[109],"uninformative":[111],"single":[114],"hybrid":[116],"Models":[119],"using":[122],"only":[123],"statistically":[124],"significant":[125,224],"features,":[130,189],"resulting":[131],"area":[133],"under":[134],"receiver":[136],"operating":[137],"curves":[138],"(AUC)":[139],"values":[140],"0.919,":[142],"0.927":[143],"0.969":[145],"one":[147],"set":[149],"0.926,":[152],"0.874":[153],"0.954":[155],"another":[157],"set,":[159],"respectively.":[160],"Hybrid":[161],"models":[162,232],"by":[165],"combining":[166],"various":[167],"achieved":[170],"AUC":[171],"0.978":[173],"0.970":[175],"Functional":[181],"information":[183],"well":[185],"reflected":[186],"expected":[192],"be":[194],"valuable":[195],"understanding":[197],"interactions":[202],"designing":[205],"experiments.":[206],"CONCLUSIONS:":[207],"Differing":[208],"previous":[210,238],"approaches,":[211],"this":[212],"study":[213],"focused":[214],"on":[215],"systematic":[216],"all":[219],"types":[220],"Statistically":[223],"identified":[227],"used":[229],"construct":[231],"that":[233],"yield":[234],"similar":[235],"accuracy":[236],"studies":[239],"shorter":[242],"computation":[243],"time.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-07-27T08:26:11.824852","created_date":"2025-10-10T00:00:00"}