{"id":"https://openalex.org/W2118359303","doi":"https://doi.org/10.1186/1471-2105-10-402","title":"A close examination of double filtering with fold change and t test in microarray analysis","display_name":"A close examination of double filtering with fold change and t test in microarray analysis","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2118359303","doi":"https://doi.org/10.1186/1471-2105-10-402","mag":"2118359303","pmid":"https://pubmed.ncbi.nlm.nih.gov/19995439"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-402","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-402","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-402","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-402","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100366550","display_name":"Song Zhang","orcid":"https://orcid.org/0000-0002-9364-4053"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]},{"id":"https://openalex.org/I4210096815","display_name":"Southwestern Medical Center","ror":"https://ror.org/00t9vx427","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096815"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Song Zhang","raw_affiliation_strings":["Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA. song.zhang@utsouthwestern.edu","Department of Clinical Sciences University of Texas Southwestern Medical Center Dallas Texas USA"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA. song.zhang@utsouthwestern.edu","institution_ids":["https://openalex.org/I4210096815","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Clinical Sciences University of Texas Southwestern Medical Center Dallas Texas USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040628748","display_name":"Jing Cao","orcid":"https://orcid.org/0000-0003-3978-911X"},"institutions":[{"id":"https://openalex.org/I178169726","display_name":"Southern Methodist University","ror":"https://ror.org/042tdr378","country_code":"US","type":"education","lineage":["https://openalex.org/I178169726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Cao","raw_affiliation_strings":["Department of Statistical Science, Southern Methodist University, Dallas, Texas, USA","Southern Methodist University **"],"affiliations":[{"raw_affiliation_string":"Department of Statistical Science, Southern Methodist University, Dallas, Texas, USA","institution_ids":["https://openalex.org/I178169726"]},{"raw_affiliation_string":"Southern Methodist University **","institution_ids":["https://openalex.org/I178169726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100366550"],"corresponding_institution_ids":["https://openalex.org/I4210096815","https://openalex.org/I867280407"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.4828,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.81710825,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"402","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5208709239959717},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5005404949188232},{"id":"https://openalex.org/keywords/fold","display_name":"Fold (higher-order function)","score":0.4823998212814331},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48115789890289307},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4326782822608948},{"id":"https://openalex.org/keywords/fold-change","display_name":"Fold change","score":0.42444926500320435},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38417792320251465},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37296587228775024},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20276165008544922},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.13832730054855347},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12455832958221436},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.12301164865493774}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5208709239959717},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5005404949188232},{"id":"https://openalex.org/C53942344","wikidata":"https://www.wikidata.org/wiki/Q951651","display_name":"Fold (higher-order function)","level":2,"score":0.4823998212814331},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48115789890289307},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4326782822608948},{"id":"https://openalex.org/C2779018089","wikidata":"https://www.wikidata.org/wiki/Q17014303","display_name":"Fold change","level":4,"score":0.42444926500320435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38417792320251465},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37296587228775024},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20276165008544922},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13832730054855347},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12455832958221436},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.12301164865493774}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-10-402","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-402","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-402","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19995439","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19995439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:a65f13047fd74078905f0b63e5e4756a","is_oa":true,"landing_page_url":"https://doaj.org/article/a65f13047fd74078905f0b63e5e4756a","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 402 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2801685","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2801685","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-402","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-402","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-402","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G390237042","display_name":null,"funder_award_id":"UL1 RR024982","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7565613713","display_name":null,"funder_award_id":"RR024982","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118359303.pdf","grobid_xml":"https://content.openalex.org/works/W2118359303.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1896700803","https://openalex.org/W1964895626","https://openalex.org/W1970191962","https://openalex.org/W1984401569","https://openalex.org/W2008233728","https://openalex.org/W2027422071","https://openalex.org/W2038723975","https://openalex.org/W2076889248","https://openalex.org/W2083875149","https://openalex.org/W2100185080","https://openalex.org/W2105793531","https://openalex.org/W2107261481","https://openalex.org/W2109453886","https://openalex.org/W2110891968","https://openalex.org/W2117742873","https://openalex.org/W2132324858","https://openalex.org/W2139290043","https://openalex.org/W2144227498","https://openalex.org/W2157795344","https://openalex.org/W2163738067","https://openalex.org/W2170264612","https://openalex.org/W4231517135","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2041540252","https://openalex.org/W2796636403","https://openalex.org/W170658859","https://openalex.org/W1483316219","https://openalex.org/W4310366902","https://openalex.org/W3023720143","https://openalex.org/W2767847608","https://openalex.org/W2223549427","https://openalex.org/W1972696957","https://openalex.org/W2160802685"],"abstract_inverted_index":{"We":[0],"demonstrate":[1],"through":[2],"hypothesis":[3],"testing":[4,16],"theory,":[5],"simulation":[6],"studies":[7],"and":[8],"real":[9],"data":[10],"examples,":[11],"that":[12],"well":[13],"constructed":[14],"shrinkage":[15],"methods,":[17],"which":[18],"can":[19,28],"be":[20],"united":[21],"under":[22],"the":[23,31],"mixture":[24],"gene":[25],"variance":[26],"assumption,":[27],"considerably":[29],"outperform":[30],"double":[32],"filtering":[33],"procedure.":[34]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}