{"id":"https://openalex.org/W2138459937","doi":"https://doi.org/10.1186/1471-2105-10-39","title":"Protein domain organisation: adding order","display_name":"Protein domain organisation: adding order","publication_year":2009,"publication_date":"2009-01-29","ids":{"openalex":"https://openalex.org/W2138459937","doi":"https://doi.org/10.1186/1471-2105-10-39","mag":"2138459937","pmid":"https://pubmed.ncbi.nlm.nih.gov/19178743"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-39","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-39","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-39","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-39","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053299894","display_name":"Sarah Kummerfeld","orcid":"https://orcid.org/0000-0002-0089-2358"},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Sarah K Kummerfeld","raw_affiliation_strings":["Department of Developmental Biology, 279 Campus Dr, Stanford, 94305, CA, USA. sarahkk@gene.com","Department of Developmental Biology, Stanford, USA","MRC Laboratory of Molecular Biology, \u00a0, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, 279 Campus Dr, Stanford, 94305, CA, USA. sarahkk@gene.com","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Developmental Biology, Stanford, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, \u00a0, Cambridge, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028596003","display_name":"Sarah A. Teichmann","orcid":"https://orcid.org/0000-0002-6294-6366"},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah A Teichmann","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Hills Rd, Cambridge, CB2 2QH, UK","MRC Laboratory of Molecular Biology, Cambridge UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Hills Rd, Cambridge, CB2 2QH, UK","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge UK","institution_ids":["https://openalex.org/I170203145"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053299894"],"corresponding_institution_ids":["https://openalex.org/I170203145","https://openalex.org/I97018004"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.5115,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.8188585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"39","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.41920000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.41920000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.10970000177621841,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.08649999648332596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.5756336450576782},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5719043612480164},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5604166388511658},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.517454206943512},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.49224963784217834},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4538808763027191},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"Gene duplication","score":0.4455043375492096},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.445089727640152},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.43525487184524536},{"id":"https://openalex.org/keywords/protein-function-prediction","display_name":"Protein function prediction","score":0.4198019504547119},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.41102245450019836},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3093366026878357},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.21858906745910645},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16562870144844055},{"id":"https://openalex.org/keywords/protein-function","display_name":"Protein function","score":0.12153619527816772}],"concepts":[{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.5756336450576782},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5719043612480164},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5604166388511658},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.517454206943512},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.49224963784217834},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4538808763027191},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.4455043375492096},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.445089727640152},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43525487184524536},{"id":"https://openalex.org/C207060522","wikidata":"https://www.wikidata.org/wiki/Q7251473","display_name":"Protein function prediction","level":4,"score":0.4198019504547119},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.41102245450019836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3093366026878357},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21858906745910645},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16562870144844055},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.12153619527816772},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-10-39","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-39","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-39","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19178743","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19178743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.330.8861","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.330.8861","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.biomedcentral.com/content/pdf/1471-2105-10-39.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:110f59cce2664855bb1266c3a6f251dc","is_oa":true,"landing_page_url":"https://doaj.org/article/110f59cce2664855bb1266c3a6f251dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 39 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2657131","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2657131","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/237638","is_oa":true,"landing_page_url":"http://www.dspace.cam.ac.uk/handle/1810/237638","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-39","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-39","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-39","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138459937.pdf","grobid_xml":"https://content.openalex.org/works/W2138459937.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W114380400","https://openalex.org/W1581315874","https://openalex.org/W1656674553","https://openalex.org/W1969460352","https://openalex.org/W1988461381","https://openalex.org/W1989509003","https://openalex.org/W2003788979","https://openalex.org/W2008620264","https://openalex.org/W2031170804","https://openalex.org/W2048324994","https://openalex.org/W2063252182","https://openalex.org/W2085277871","https://openalex.org/W2099946731","https://openalex.org/W2100022666","https://openalex.org/W2102882929","https://openalex.org/W2105869636","https://openalex.org/W2112090702","https://openalex.org/W2112493377","https://openalex.org/W2112792893","https://openalex.org/W2117219281","https://openalex.org/W2118340207","https://openalex.org/W2122281839","https://openalex.org/W2127966416","https://openalex.org/W2145037531","https://openalex.org/W2145080853","https://openalex.org/W2148950394","https://openalex.org/W2159482845","https://openalex.org/W2160008147","https://openalex.org/W2161211166","https://openalex.org/W2163363312","https://openalex.org/W2169015768","https://openalex.org/W2169239268","https://openalex.org/W4231553787","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W1569021382","https://openalex.org/W2111805188","https://openalex.org/W2952660917","https://openalex.org/W2015534509","https://openalex.org/W2346203657","https://openalex.org/W2584692412","https://openalex.org/W2790515430","https://openalex.org/W2901913417","https://openalex.org/W2911363402","https://openalex.org/W33421173"],"abstract_inverted_index":{"BACKGROUND:":[0],"Domains":[1],"are":[2,42,55,138,176,323,354],"the":[3,56,70,84,99,110,114,116,125,156,164,227,269,331,344,367,394],"building":[4],"blocks":[5],"of":[6,35,58,69,75,86,113,119,134,173,203,230,248,271,279,294,375,378,383,396],"proteins.":[7,89],"During":[8],"evolution,":[9],"they":[10,148,189,322],"have":[11,29,78,130,149,182,274,288],"been":[12,65,183],"duplicated,":[13],"fused":[14],"and":[15,23,26,54,101,145,161,205,208,220,238,252,257,262,296,302,353,385,398],"recombined,":[16],"to":[17,50,82,98,154,211,309,347,356,387],"produce":[18],"proteins":[19,233,307,332],"with":[20,312],"novel":[21,277],"structures":[22],"functions.":[24],"Structural":[25],"genome-scale":[27],"studies":[28,74],"shown":[30],"that":[31,63,137,175,188,285],"pairs":[32,256,299],"or":[33],"groups":[34,172],"domains":[36,87,120,160,174,231,345,379],"observed":[37],"together":[38],"in":[39,46,109,140,191,232,300,305,328,350,380],"a":[40,59,235,276,289,376,381],"protein":[41,165,209,281],"almost":[43],"always":[44],"found":[45,284,335],"only":[47],"one":[48],"N":[49],"C":[51],"terminal":[52],"order":[53,108,118,229,270],"result":[57],"single":[60],"recombination":[61],"event":[62],"has":[64,167],"propagated":[66],"by":[67,95],"duplication":[68],"multi-domain":[71],"unit.":[72],"Previous":[73],"domain":[76,135,207,249,255,298,405],"organisation":[77],"used":[79],"graph":[80,127,237,240],"theory":[81],"represent":[83,226],"co-occurrence":[85],"within":[88,339],"We":[90,170,195,243,283],"build":[91],"on":[92,105,404],"this":[93],"approach":[94],"adding":[96],"directionality":[97],"graphs":[100,311],"connecting":[102],"nodes":[103],"based":[104],"their":[106,213,222,259],"relative":[107,308],"protein.":[111],"Most":[112],"time,":[115],"linear":[117,228],"is":[121],"conserved.":[122],"However,":[123],"using":[124],"directed":[126,236],"representation":[128],"we":[129,225,273,334],"identified":[131],"non-linear":[132],"features":[133,219,318],"organization":[136],"over-represented":[139],"genomes.":[141],"Recognising":[142],"these":[143,218,317],"patterns":[144,247],"unravelling":[146],"how":[147,163],"arisen":[150],"may":[151],"allow":[152],"us":[153],"understand":[155,162,212],"functional":[157,214,260,337,397],"relationships":[158,338],"between":[159],"repertoire":[166],"evolved.":[168],"RESULTS:":[169],"identify":[171,217],"not":[177],"linearly":[178],"conserved,":[179],"but":[180],"instead":[181],"shuffled":[184],"during":[185],"evolution":[186],"so":[187],"occur":[190],"multiple":[192],"different":[193,306],"orders.":[194],"consider":[196],"192":[197],"genomes":[198,287],"across":[199],"all":[200,286],"three":[201],"kingdoms":[202],"life":[204],"use":[206,374],"annotation":[210],"significance.":[215],"To":[216],"assess":[221],"statistical":[223],"significance,":[224],"as":[234,358],"apply":[239],"theoretical":[241],"methods.":[242],"describe":[244],"two":[245],"higher-order":[246],"organisation:":[250],"clusters":[251],"bi-directionally":[253],"associated":[254],"explore":[258],"importance":[261,395],"phylogenetic":[263],"conservation.":[264],"CONCLUSION:":[265],"Taking":[266],"into":[267],"account":[268],"domains,":[272],"derived":[275],"picture":[278],"global":[280],"organization.":[282],"higher":[290],"than":[291],"expected":[292],"degree":[293,314],"clustering":[295],"more":[297],"forward":[301],"reverse":[303],"orientation":[304],"random":[310],"identical":[313],"distributions.":[315],"While":[316],"were":[319],"statistically":[320],"over-represented,":[321],"still":[324],"fairly":[325],"rare.":[326],"Looking":[327],"detail":[329],"at":[330],"involved,":[333],"strong":[336],"each":[340],"cluster.":[341],"In":[342],"addition,":[343],"tended":[346],"be":[348],"involved":[349],"protein-protein":[351],"interaction":[352],"able":[355],"function":[357],"independent":[359],"structural":[360,399],"units.":[361],"A":[362],"particularly":[363],"striking":[364],"example":[365],"was":[366],"human":[368],"Jak-STAT":[369],"signalling":[370],"pathway":[371],"which":[372],"makes":[373],"set":[377],"range":[382],"orders":[384],"orientations":[386],"provide":[388],"nuanced":[389],"signaling":[390],"functionality.":[391],"This":[392],"illustrated":[393],"constraints":[400],"(or":[401],"lack":[402],"thereof)":[403],"organisation.":[406]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-25T15:57:00.446498","created_date":"2025-10-10T00:00:00"}
