{"id":"https://openalex.org/W2149044412","doi":"https://doi.org/10.1186/1471-2105-10-379","title":"SitesIdentify: a protein functional site prediction tool","display_name":"SitesIdentify: a protein functional site prediction tool","publication_year":2009,"publication_date":"2009-11-18","ids":{"openalex":"https://openalex.org/W2149044412","doi":"https://doi.org/10.1186/1471-2105-10-379","mag":"2149044412","pmid":"https://pubmed.ncbi.nlm.nih.gov/19922660"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-379","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-379","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-379","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-379","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033508779","display_name":"Tracey Bray","orcid":null},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tracey Bray","raw_affiliation_strings":["Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK. t.bray@postgrad.manchester.ac.uk","Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK. t.bray@postgrad.manchester.ac.uk","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006778304","display_name":"Pedro Chan","orcid":null},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pedro Chan","raw_affiliation_strings":["Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002870745","display_name":"Salim Bougouffa","orcid":"https://orcid.org/0000-0001-9218-6452"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Salim Bougouffa","raw_affiliation_strings":["Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110498085","display_name":"Richard B. Greaves","orcid":null},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Greaves","raw_affiliation_strings":["Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000626384","display_name":"Andrew J. Doig","orcid":"https://orcid.org/0000-0003-0346-2270"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew J Doig","raw_affiliation_strings":["Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012922833","display_name":"Jim Warwicker","orcid":"https://orcid.org/0000-0002-1302-0815"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jim Warwicker","raw_affiliation_strings":["Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012922833"],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.4851,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.81889284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"379","last_page":"379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.816100001335144,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.816100001335144,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.07129999995231628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.03480000048875809,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6120515465736389},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5291137099266052},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5134226083755493},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3518933057785034},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2892191410064697},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17521923780441284},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.0778740644454956},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.06528493762016296}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6120515465736389},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5291137099266052},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5134226083755493},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3518933057785034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2892191410064697},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17521923780441284},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0778740644454956},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.06528493762016296}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-10-379","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-379","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-379","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19922660","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19922660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/5adaf597-b1e7-4746-807f-08f28b1be697","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/5adaf597-b1e7-4746-807f-08f28b1be697","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bray, T, Chan, P, Bougouffa, S, Greaves, R, Doig, A J & Warwicker, J 2009, 'SitesIdentify: A protein functional site prediction tool', BMC Bioinformatics, vol. 10, 379. https://doi.org/10.1186/1471-2105-10-379","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:156ec3fdf080438f89c2b1a46ac0b7a9","is_oa":true,"landing_page_url":"https://doaj.org/article/156ec3fdf080438f89c2b1a46ac0b7a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 379 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2783165","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2783165","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/5adaf597-b1e7-4746-807f-08f28b1be697","is_oa":false,"landing_page_url":"https://www.research.manchester.ac.uk/portal/en/publications/sitesidentify-a-protein-functional-site-prediction-tool(5adaf597-b1e7-4746-807f-08f28b1be697).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-379","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-379","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-379","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2149044412.pdf","grobid_xml":"https://content.openalex.org/works/W2149044412.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1517566065","https://openalex.org/W1585634379","https://openalex.org/W1819481941","https://openalex.org/W1964640688","https://openalex.org/W1967293793","https://openalex.org/W1968733906","https://openalex.org/W1971099088","https://openalex.org/W1986154009","https://openalex.org/W1986969007","https://openalex.org/W1987219907","https://openalex.org/W2003066987","https://openalex.org/W2004360551","https://openalex.org/W2007872355","https://openalex.org/W2013988051","https://openalex.org/W2015341379","https://openalex.org/W2043886357","https://openalex.org/W2045110975","https://openalex.org/W2046407284","https://openalex.org/W2069663555","https://openalex.org/W2079672600","https://openalex.org/W2082972649","https://openalex.org/W2085277871","https://openalex.org/W2089639709","https://openalex.org/W2090699441","https://openalex.org/W2090774487","https://openalex.org/W2092750499","https://openalex.org/W2099182237","https://openalex.org/W2101780178","https://openalex.org/W2104760790","https://openalex.org/W2107327414","https://openalex.org/W2108237355","https://openalex.org/W2108302275","https://openalex.org/W2111105050","https://openalex.org/W2113944588","https://openalex.org/W2114886480","https://openalex.org/W2115410056","https://openalex.org/W2116900051","https://openalex.org/W2116973522","https://openalex.org/W2119498937","https://openalex.org/W2122854841","https://openalex.org/W2124018463","https://openalex.org/W2127866370","https://openalex.org/W2128037544","https://openalex.org/W2128276810","https://openalex.org/W2128402268","https://openalex.org/W2132886170","https://openalex.org/W2133990057","https://openalex.org/W2137503746","https://openalex.org/W2143185848","https://openalex.org/W2146678880","https://openalex.org/W2146939455","https://openalex.org/W2149997286","https://openalex.org/W2153463820","https://openalex.org/W2154333184","https://openalex.org/W2157892451","https://openalex.org/W2158020463","https://openalex.org/W2158714788","https://openalex.org/W2162335096","https://openalex.org/W2172118638","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"rate":[2],"of":[3,35,118,125],"protein":[4,37],"structures":[5,27],"being":[6],"deposited":[7],"in":[8,43,47,115,140,150],"the":[9,14,33,36],"Protein":[10],"Data":[11],"Bank":[12],"surpasses":[13],"capacity":[15],"to":[16,24,40,49,61,109,136,144],"experimentally":[17],"characterise":[18],"them":[19],"and":[20],"therefore":[21],"computational":[22],"methods":[23,120],"analyse":[25],"these":[26],"have":[28,103],"become":[29],"increasingly":[30],"important.":[31],"Identifying":[32],"region":[34],"most":[38],"likely":[39],"be":[41],"involved":[42],"function":[44],"is":[45,96,134,162],"useful":[46],"order":[48],"gain":[50],"information":[51,90],"about":[52],"its":[53,145],"potential":[54],"role.":[55],"There":[56],"are":[57,67],"many":[58,66],"available":[59,70,98,147,163],"approaches":[60],"predict":[62],"functional":[63,80,111,142],"site,":[64],"but":[65,149],"not":[68],"made":[69],"via":[71,99,164],"a":[72,79,100,116,122,165],"publicly-accessible":[73],"application.":[74],"RESULTS:":[75],"Here":[76],"we":[77],"present":[78],"site":[81,112],"prediction":[82,113],"tool":[83],"(SitesIdentify),":[84],"based":[85],"on":[86,121],"combining":[87],"sequence":[88],"conservation":[89],"with":[91,128,157],"geometry-based":[92],"cleft":[93],"identification,":[94],"that":[95,105],"freely":[97],"web-server.":[101],"We":[102],"shown":[104],"SitesIdentify":[106,133,161],"compares":[107],"favourably":[108],"other":[110],"tools":[114],"comparison":[117],"seven":[119],"non-redundant":[123],"set":[124],"237":[126],"enzymes":[127],"annotated":[129],"active":[130],"sites.":[131],"CONCLUSION:":[132],"able":[135],"produce":[137],"comparable":[138],"accuracy":[139,154],"predicting":[141],"sites":[143],"closest":[146],"counterpart,":[148],"addition":[151],"achieves":[152],"improved":[153],"for":[155],"proteins":[156],"few":[158],"characterised":[159],"homologues.":[160],"webserver":[166],"at":[167],"http://www.manchester.ac.uk/bioinformatics/sitesidentify/":[168]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}