{"id":"https://openalex.org/W1978645448","doi":"https://doi.org/10.1186/1471-2105-10-308","title":"Detection of recurrent copy number alterations in the genome: taking among-subject heterogeneity seriously","display_name":"Detection of recurrent copy number alterations in the genome: taking among-subject heterogeneity seriously","publication_year":2009,"publication_date":"2009-09-23","ids":{"openalex":"https://openalex.org/W1978645448","doi":"https://doi.org/10.1186/1471-2105-10-308","mag":"1978645448","pmid":"https://pubmed.ncbi.nlm.nih.gov/19775444"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-308","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-308","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-308","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-308","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000532226","display_name":"Oscar M. Rueda","orcid":"https://orcid.org/0000-0003-0008-4884"},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Oscar M Rueda","raw_affiliation_strings":["Structural and Computational Biology Programme, Spanish National Cancer Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, 28029 Madrid, Spain. rueda.om@gmail.com","Structural and Computational Biology Programme, Spanish National Cancer Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, 28029, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural and Computational Biology Programme, Spanish National Cancer Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, 28029 Madrid, Spain. rueda.om@gmail.com","institution_ids":["https://openalex.org/I4210089594"]},{"raw_affiliation_string":"Structural and Computational Biology Programme, Spanish National Cancer Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, 28029, Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080620893","display_name":"Ram\u00f3n D\u00edaz\u2010Uriarte","orcid":"https://orcid.org/0000-0002-6637-9039"},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Ramon Diaz-Uriarte","raw_affiliation_strings":["Structural and Computational Biology Programme, Spanish National Cancer Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, 28029, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural and Computational Biology Programme, Spanish National Cancer Centre (CNIO), Melchor Fern\u00e1ndez Almagro 3, 28029, Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000532226","https://openalex.org/A5080620893"],"corresponding_institution_ids":["https://openalex.org/I4210089594"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.6136,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.84100151,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"10","issue":"1","first_page":"308","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9682000279426575,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9682000279426575,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.779488742351532},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5381677150726318},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.504016101360321},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4872364103794098},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4628865420818329},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"Copy-number variation","score":0.4572640657424927},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4553147256374359},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.382510781288147},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.3799605965614319},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.36607903242111206},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2841915488243103},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.16827580332756042},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14195382595062256}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.779488742351532},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5381677150726318},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.504016101360321},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4872364103794098},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4628865420818329},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.4572640657424927},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4553147256374359},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.382510781288147},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3799605965614319},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36607903242111206},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2841915488243103},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.16827580332756042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14195382595062256},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-10-308","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-308","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-308","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19775444","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19775444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:dnet:biblosearchi::ca08e0fb95c54a2ef855f73c581bcdb8","is_oa":false,"landing_page_url":"http://hdl.handle.net/10486/669893","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2760535","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2760535","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b2078a9526a047e8a9fab9f27a16595c","is_oa":false,"landing_page_url":"https://doaj.org/article/b2078a9526a047e8a9fab9f27a16595c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 308 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-308","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-308","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-308","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3474831318","display_name":null,"funder_award_id":"CSD2007-00050","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":"https://ror.org/034900433"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978645448.pdf","grobid_xml":"https://content.openalex.org/works/W1978645448.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W31653604","https://openalex.org/W1523783156","https://openalex.org/W1539673959","https://openalex.org/W1544851750","https://openalex.org/W1883186006","https://openalex.org/W1966321968","https://openalex.org/W1966938977","https://openalex.org/W1974107857","https://openalex.org/W1977690962","https://openalex.org/W1983781571","https://openalex.org/W1991157854","https://openalex.org/W1999674531","https://openalex.org/W2013643561","https://openalex.org/W2015009944","https://openalex.org/W2015631955","https://openalex.org/W2016299037","https://openalex.org/W2022385074","https://openalex.org/W2030051325","https://openalex.org/W2032247293","https://openalex.org/W2035593347","https://openalex.org/W2046247026","https://openalex.org/W2047432537","https://openalex.org/W2048253203","https://openalex.org/W2056937433","https://openalex.org/W2058121710","https://openalex.org/W2062994827","https://openalex.org/W2084591827","https://openalex.org/W2088131236","https://openalex.org/W2089467606","https://openalex.org/W2090713802","https://openalex.org/W2092343534","https://openalex.org/W2093889847","https://openalex.org/W2096318664","https://openalex.org/W2097361093","https://openalex.org/W2099512426","https://openalex.org/W2104224322","https://openalex.org/W2106483643","https://openalex.org/W2110012127","https://openalex.org/W2110065044","https://openalex.org/W2115480698","https://openalex.org/W2116530373","https://openalex.org/W2118184985","https://openalex.org/W2122769974","https://openalex.org/W2124277850","https://openalex.org/W2124435172","https://openalex.org/W2125471214","https://openalex.org/W2125838338","https://openalex.org/W2127710810","https://openalex.org/W2129359631","https://openalex.org/W2133174470","https://openalex.org/W2134034024","https://openalex.org/W2136119414","https://openalex.org/W2140869203","https://openalex.org/W2140968934","https://openalex.org/W2148133654","https://openalex.org/W2149681218","https://openalex.org/W2150703778","https://openalex.org/W2151652863","https://openalex.org/W2154361640","https://openalex.org/W2155707112","https://openalex.org/W2159595235","https://openalex.org/W2159805523","https://openalex.org/W2163177727","https://openalex.org/W2171844034","https://openalex.org/W4238448376","https://openalex.org/W4241876622","https://openalex.org/W4244244707","https://openalex.org/W4250389103"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W4390569940","https://openalex.org/W2888392564","https://openalex.org/W4361193272","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W2806259446","https://openalex.org/W2963326959","https://openalex.org/W4247136043","https://openalex.org/W4312407344"],"abstract_inverted_index":{"BACKGROUND:":[0],"Alterations":[1],"in":[2,209,247],"the":[3,38,60,65,106,121,154,158,210,217,229,240,248],"number":[4,30],"of":[5,7,41,59,64,109,120,134,141,157,190,212,219,224,231,237],"copies":[6],"genomic":[8,251],"DNA":[9],"that":[10,45,54,113,125,173,178,183],"are":[11,18,93,114],"common":[12,26,49,115,144],"or":[13,27,50],"recurrent":[14,28,51,85,213],"among":[15],"diseased":[16],"individuals":[17],"likely":[19],"to":[20,83,117,149,197,235],"contain":[21],"disease-critical":[22,254],"genes.":[23,255],"Unfortunately,":[24],"defining":[25],"copy":[29],"alteration":[31,135],"(CNA)":[32],"regions":[33,53,66,87,103,252],"remains":[34],"a":[35,143,206],"challenge.":[36],"Moreover,":[37],"heterogeneous":[39],"nature":[40],"many":[42],"diseases":[43],"requires":[44],"we":[46,171,174],"search":[47,249],"for":[48,222,250],"CNA":[52,86,214],"affect":[55],"only":[56,116],"some":[57,118],"subsets":[58,68,119],"samples":[61,122,232],"(without":[62],"knowledge":[63],"and":[67,95,111,138,182,193,226],"affected),":[69],"but":[70],"this":[71],"is":[72],"neglected":[73],"by":[74],"most":[75],"methods.":[76],"RESULTS:":[77],"We":[78],"have":[79,160],"developed":[80,242],"two":[81,155],"methods":[82,92,159,180,204,241],"define":[84],"from":[88,98,168],"aCGH":[89],"data.":[90],"Our":[91],"unique":[94],"qualitatively":[96],"different":[97],"existing":[99],"approaches:":[100],"they":[101,131],"detect":[102,176],"over":[104],"both":[105],"complete":[107],"set":[108],"arrays":[110],"alterations":[112,124],"(i.e.,":[123],"might":[126],"characterize":[127],"previously":[128],"unknown":[129],"groups);":[130],"use":[132],"probabilities":[133,140],"as":[136,152,187],"input":[137],"return":[139],"being":[142],"region,":[145],"thus":[146],"allowing":[147],"researchers":[148,184],"modify":[150],"thresholds":[151,189],"needed;":[153],"parameters":[156],"an":[161],"immediate,":[162],"straightforward,":[163],"biological":[164],"interpretation.":[165],"Using":[166],"data":[167],"previous":[169],"studies,":[170],"show":[172],"can":[175,185,227,243],"patterns":[177,236],"other":[179],"miss":[181],"modify,":[186],"needed,":[188],"immediate":[191],"interpretability":[192],"develop":[194],"custom":[195],"statistics":[196],"answer":[198],"specific":[199],"research":[200],"questions.":[201],"CONCLUSION:":[202],"These":[203],"represent":[205],"qualitative":[207],"advance":[208],"location":[211],"regions,":[215],"highlight":[216],"relevance":[218],"population":[220],"heterogeneity":[221],"definitions":[223],"recurrence,":[225],"facilitate":[228],"clustering":[230],"with":[233],"respect":[234],"CNA.":[238],"Ultimately,":[239],"become":[244],"important":[245],"tools":[246],"harboring":[253]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}