{"id":"https://openalex.org/W2158715856","doi":"https://doi.org/10.1186/1471-2105-10-284","title":"CASSIOPE: An expert system for conserved regions searches","display_name":"CASSIOPE: An expert system for conserved regions searches","publication_year":2009,"publication_date":"2009-09-10","ids":{"openalex":"https://openalex.org/W2158715856","doi":"https://doi.org/10.1186/1471-2105-10-284","mag":"2158715856","pmid":"https://pubmed.ncbi.nlm.nih.gov/19740451"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-284","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-284","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-284","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-284","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006507874","display_name":"Virginie Lopez Rascol","orcid":null},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210138206","display_name":"Institut de Math\u00e9matiques de Marseille","ror":"https://ror.org/042h2y225","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210138206","https://openalex.org/I4210141950","https://openalex.org/I4210142724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Virginie Lopez Rascol","raw_affiliation_strings":["EBM UMR 6632 LATP, 3 place V Hugo - 13 331 Marseille cedex 03 France. virginie.lopez-rascol@univ-provence.fr","EBM UMR 6632.LATP, 3 place V. Hugo, 13 331, Marseille, cedex 03, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EBM UMR 6632 LATP, 3 place V Hugo - 13 331 Marseille cedex 03 France. virginie.lopez-rascol@univ-provence.fr","institution_ids":["https://openalex.org/I21491767","https://openalex.org/I4210138206"]},{"raw_affiliation_string":"EBM UMR 6632.LATP, 3 place V. Hugo, 13 331, Marseille, cedex 03, France","institution_ids":["https://openalex.org/I4210138206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024401591","display_name":"Anthony Levasseur","orcid":"https://orcid.org/0000-0003-2989-7539"},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210144005","display_name":"Centre d\u2019Immunologie de Marseille-Luminy","ror":"https://ror.org/03vyjkj45","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210144005"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Anthony Levasseur","raw_affiliation_strings":["UMR-1163, INRA de Biotechnologie des Champignons Filamenteux, IFR86-BAIM. ESIL, 163 avenue de Luminy, CP 925, 13288, Marseille, Cedex 09, France","Universit\u00e9s Aix-Marseille I & II, UMR-1163, case 925, 163 avenue de Luminy, 13288, Marseille, Cedex 09, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR-1163, INRA de Biotechnologie des Champignons Filamenteux, IFR86-BAIM. ESIL, 163 avenue de Luminy, CP 925, 13288, Marseille, Cedex 09, France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9s Aix-Marseille I & II, UMR-1163, case 925, 163 avenue de Luminy, 13288, Marseille, Cedex 09, France","institution_ids":["https://openalex.org/I21491767","https://openalex.org/I4210144005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002190685","display_name":"Olivier Chabrol","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138206","display_name":"Institut de Math\u00e9matiques de Marseille","ror":"https://ror.org/042h2y225","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210138206","https://openalex.org/I4210141950","https://openalex.org/I4210142724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Chabrol","raw_affiliation_strings":["EBM UMR 6632.LATP, 3 place V. Hugo, 13 331, Marseille, cedex 03, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EBM UMR 6632.LATP, 3 place V. Hugo, 13 331, Marseille, cedex 03, France","institution_ids":["https://openalex.org/I4210138206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077564483","display_name":"Simona Grusea","orcid":"https://orcid.org/0000-0003-0391-1080"},"institutions":[{"id":"https://openalex.org/I4210138206","display_name":"Institut de Math\u00e9matiques de Marseille","ror":"https://ror.org/042h2y225","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210138206","https://openalex.org/I4210141950","https://openalex.org/I4210142724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Simona Grusea","raw_affiliation_strings":["EBM UMR 6632.LATP, 3 place V. Hugo, 13 331, Marseille, cedex 03, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EBM UMR 6632.LATP, 3 place V. Hugo, 13 331, Marseille, cedex 03, France","institution_ids":["https://openalex.org/I4210138206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083845543","display_name":"Philippe Gouret","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138206","display_name":"Institut de Math\u00e9matiques de Marseille","ror":"https://ror.org/042h2y225","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210138206","https://openalex.org/I4210141950","https://openalex.org/I4210142724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Gouret","raw_affiliation_strings":["EBM UMR 6632.LATP, 3 place V. Hugo, 13 331, Marseille, cedex 03, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EBM UMR 6632.LATP, 3 place V. Hugo, 13 331, Marseille, cedex 03, France","institution_ids":["https://openalex.org/I4210138206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036519584","display_name":"\u00c9tienne Danchin","orcid":"https://orcid.org/0000-0003-4146-5608"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210150884","display_name":"Fondation Sophia Antipolis","ror":"https://ror.org/05nkcfv27","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210150884"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Etienne GJ Danchin","raw_affiliation_strings":["UMR 1301, INRA, F-06903, Sophia-Antipolis, France","UMR 1301, UNSA, F-06903, Sophia-Antipolis, France","UMR 6243, CNRS, F-06903, Sophia-Antipolis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR 1301, INRA, F-06903, Sophia-Antipolis, France","institution_ids":[]},{"raw_affiliation_string":"UMR 1301, UNSA, F-06903, Sophia-Antipolis, France","institution_ids":["https://openalex.org/I4210150884"]},{"raw_affiliation_string":"UMR 6243, CNRS, F-06903, Sophia-Antipolis, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210150884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080177497","display_name":"Pierre Pontarotti","orcid":"https://orcid.org/0000-0001-7202-3648"},"institutions":[{"id":"https://openalex.org/I4210138206","display_name":"Institut de Math\u00e9matiques de Marseille","ror":"https://ror.org/042h2y225","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210138206","https://openalex.org/I4210141950","https://openalex.org/I4210142724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Pontarotti","raw_affiliation_strings":["EBM UMR 6632.LATP, 3 place V. Hugo, 13 331, Marseille, cedex 03, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EBM UMR 6632.LATP, 3 place V. Hugo, 13 331, Marseille, cedex 03, France","institution_ids":["https://openalex.org/I4210138206"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5024401591"],"corresponding_institution_ids":["https://openalex.org/I21491767","https://openalex.org/I4210144005"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":1.2869,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.82716117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"10","issue":"1","first_page":"284","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.9196000099182129,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.9196000099182129,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12090","display_name":"Language and cultural evolution","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/3316","display_name":"Cultural Studies"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6739144921302795},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"Comparative genomics","score":0.6410866975784302},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6389617919921875},{"id":"https://openalex.org/keywords/synteny","display_name":"Synteny","score":0.5767612457275391},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5654948949813843},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.5343823432922363},{"id":"https://openalex.org/keywords/genome-evolution","display_name":"Genome evolution","score":0.4996371269226074},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.46880605816841125},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.4386708438396454},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4292373061180115},{"id":"https://openalex.org/keywords/phylogenetics","display_name":"Phylogenetics","score":0.4236161410808563},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4039952754974365},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3692990839481354}],"concepts":[{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6739144921302795},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.6410866975784302},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6389617919921875},{"id":"https://openalex.org/C53702515","wikidata":"https://www.wikidata.org/wiki/Q971246","display_name":"Synteny","level":4,"score":0.5767612457275391},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5654948949813843},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5343823432922363},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.4996371269226074},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.46880605816841125},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4386708438396454},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4292373061180115},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.4236161410808563},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4039952754974365},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3692990839481354},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-10-284","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-284","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-284","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19740451","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19740451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2756280","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2756280","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5979ffc9245e4e00a39e3ac2cfcaee3b","is_oa":true,"landing_page_url":"https://doaj.org/article/5979ffc9245e4e00a39e3ac2cfcaee3b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 284 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-284","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-284","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-284","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5199999809265137,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2158715856.pdf","grobid_xml":"https://content.openalex.org/works/W2158715856.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1530319591","https://openalex.org/W1537213512","https://openalex.org/W1971926406","https://openalex.org/W1991330646","https://openalex.org/W2001109271","https://openalex.org/W2027655271","https://openalex.org/W2053587723","https://openalex.org/W2055043387","https://openalex.org/W2064912476","https://openalex.org/W2092269086","https://openalex.org/W2144866873","https://openalex.org/W2155421451","https://openalex.org/W4210430020"],"related_works":["https://openalex.org/W2626545547","https://openalex.org/W2571897395","https://openalex.org/W4375955900","https://openalex.org/W2952105401","https://openalex.org/W2566862871","https://openalex.org/W2097001759","https://openalex.org/W4254915624","https://openalex.org/W2088015737","https://openalex.org/W2145673003","https://openalex.org/W2332110477"],"abstract_inverted_index":{"BACKGROUND:":[0],"Understanding":[1],"genome":[2,28,52,77],"evolution":[3,29,53],"provides":[4],"insight":[5],"into":[6],"biological":[7,37],"mechanisms.":[8],"For":[9],"many":[10],"years":[11],"comparative":[12],"genomics":[13],"and":[14,30,65,70,105,110,143,162,173,193,222,231],"analysis":[15],"of":[16,36,40,72,92,102,107,112,119,237],"conserved":[17,41,73,121,153,214,225,239],"chromosomal":[18],"regions":[19,42,74,154,166,215],"have":[20],"helped":[21],"to":[22,59,94,115,186,212,223],"unravel":[23],"the":[24,34,103,117,183,235],"mechanisms":[25],"involved":[26],"in":[27,146,170],"their":[31],"implications":[32],"for":[33,140,169],"study":[35,213],"systems.":[38],"Detection":[39],"(descending":[43],"from":[44,216],"a":[45,76,127,132,217],"common":[46],"ancestor)":[47],"not":[48],"only":[49],"helps":[50],"clarify":[51],"but":[54],"also":[55],"makes":[56,209],"it":[57,210],"possible":[58,211],"identify":[60,95],"quantitative":[61],"trait":[62],"loci":[63],"(QTLs)":[64],"investigate":[66],"gene":[67,122,226],"function.The":[68],"identification":[69],"comparison":[71],"on":[75,131,159,229],"scale":[78],"is":[79,182,242],"computationally":[80],"intensive,":[81],"making":[82],"process":[83],"automation":[84],"essential.":[85],"Three":[86],"key":[87,197],"requirements":[88,198],"are":[89,203],"necessary:":[90],"consideration":[91],"phylogeny":[93],"orthologs":[96],"between":[97,155],"multiple":[98,156],"species,":[99],"frequent":[100],"updating":[101],"annotation":[104],"panel":[106],"compared":[108],"genomes":[109,157],"computation":[111],"statistical":[113,163,232],"tests":[114,233],"assess":[116],"significance":[118,236],"identified":[120],"clusters.":[123],"RESULTS:":[124],"We":[125],"developed":[126],"modular":[128],"system":[129,185],"superimposed":[130],"multi-agent":[133],"framework,":[134],"called":[135],"CASSIOPE":[136,148,181,208],"(Clever":[137],"Agent":[138],"System":[139],"Synteny":[141],"Inheritance":[142],"Other":[144],"Phenomena":[145],"Evolution).":[147],"automatically":[149],"identifies":[150],"statistically":[151],"significant":[152],"based":[158,228],"automated":[160],"phylogenies":[161,230],"testing.":[164],"Conserved":[165],"were":[167,176],"searched":[168],"19":[171],"species":[172],"1,561":[174],"hits":[175],"found.":[177],"To":[178],"our":[179],"knowledge,":[180],"first":[184],"date":[187],"that":[188],"integrates":[189],"evolutionary":[190],"biology-based":[191],"concepts":[192],"fulfills":[194],"all":[195],"three":[196],"stated":[199],"above.":[200],"All":[201],"results":[202],"available":[204],"at":[205],"http://194.57.197.245/cassiopeWeb/displayCluster?clusterId=1":[206],"CONCLUSION:":[207],"chosen":[218],"query":[219],"genetic":[220],"region":[221],"infer":[224],"clusters":[227],"assessing":[234],"these":[238],"regions.Source":[240],"code":[241],"freely":[243],"available,":[244],"please":[245],"contact:":[246],"Pierre.pontarotti@univ-provence.fr.":[247]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-29T07:29:34.045763","created_date":"2025-10-10T00:00:00"}