{"id":"https://openalex.org/W2129562880","doi":"https://doi.org/10.1186/1471-2105-10-215","title":"Regression based predictor for p53 transactivation","display_name":"Regression based predictor for p53 transactivation","publication_year":2009,"publication_date":"2009-07-14","ids":{"openalex":"https://openalex.org/W2129562880","doi":"https://doi.org/10.1186/1471-2105-10-215","mag":"2129562880","pmid":"https://pubmed.ncbi.nlm.nih.gov/19602281"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-215","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-215","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-215","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-215","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110458542","display_name":"Sivakumar Gowrisankar","orcid":null},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sivakumar Gowrisankar","raw_affiliation_strings":["Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. sgowrisankar@partners.org","Department of Biomedical Engineering, University of Cincinnati, Cincinnati, USA","Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, USA"],"affiliations":[{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. sgowrisankar@partners.org","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Cincinnati, Cincinnati, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061689835","display_name":"Anil G. Jegga","orcid":"https://orcid.org/0000-0002-4881-7752"},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil G Jegga","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA","Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA","institution_ids":["https://openalex.org/I92156820"]},{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, USA","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110458542"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.2953,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.62604499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"10","issue":"1","first_page":"215","last_page":"215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9905999898910522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transactivation","display_name":"Transactivation","score":0.7294906377792358},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5541349649429321},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.47809168696403503},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47036999464035034},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39431142807006836},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39021849632263184},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3506997227668762},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3369288444519043},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3005145788192749},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2714340388774872},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2077045738697052},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17287325859069824},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.1462787389755249},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14442920684814453},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.14140582084655762}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.7294906377792358},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5541349649429321},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.47809168696403503},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47036999464035034},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39431142807006836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39021849632263184},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3506997227668762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3369288444519043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3005145788192749},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2714340388774872},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2077045738697052},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17287325859069824},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1462787389755249},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14442920684814453},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14140582084655762}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-10-215","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-215","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-215","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19602281","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19602281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:b95812da041c4136bced45886c1cd1c9","is_oa":true,"landing_page_url":"https://doaj.org/article/b95812da041c4136bced45886c1cd1c9","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 215 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2719629","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2719629","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-215","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-215","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-215","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308208","display_name":"Ohio Cancer Research Associates","ror":"https://ror.org/00wzt9y79"},{"id":"https://openalex.org/F4320309575","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48"},{"id":"https://openalex.org/F4320310256","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079"},{"id":"https://openalex.org/F4320311893","display_name":"Ohio Cancer Research","ror":"https://ror.org/00wzt9y79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129562880.pdf","grobid_xml":"https://content.openalex.org/works/W2129562880.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W172347017","https://openalex.org/W1536291417","https://openalex.org/W1964719993","https://openalex.org/W1967790134","https://openalex.org/W1980694082","https://openalex.org/W1985999867","https://openalex.org/W1991494214","https://openalex.org/W2017488005","https://openalex.org/W2034059961","https://openalex.org/W2035066592","https://openalex.org/W2035462635","https://openalex.org/W2042075518","https://openalex.org/W2049945082","https://openalex.org/W2056572892","https://openalex.org/W2064194464","https://openalex.org/W2074222004","https://openalex.org/W2085442947","https://openalex.org/W2091041925","https://openalex.org/W2092863749","https://openalex.org/W2111496191","https://openalex.org/W2112287022","https://openalex.org/W2119337308","https://openalex.org/W2130885391","https://openalex.org/W2133373613","https://openalex.org/W2134582937","https://openalex.org/W2140894046","https://openalex.org/W2148613526","https://openalex.org/W2158266834","https://openalex.org/W2161645441","https://openalex.org/W2168783124","https://openalex.org/W2169902960","https://openalex.org/W2171407623","https://openalex.org/W2187031962","https://openalex.org/W2466977433","https://openalex.org/W2740984310","https://openalex.org/W4240861547","https://openalex.org/W4246354968","https://openalex.org/W6730578797"],"related_works":["https://openalex.org/W2044264814","https://openalex.org/W2015076784","https://openalex.org/W2088950084","https://openalex.org/W2035906232","https://openalex.org/W2049911257","https://openalex.org/W2035435589","https://openalex.org/W2315681052","https://openalex.org/W2411581817","https://openalex.org/W1966687443","https://openalex.org/W2042408429"],"abstract_inverted_index":{"Taking":[0],"into":[1],"account":[2],"both":[3],"nucleotide":[4],"interactions":[5],"and":[6,24,30,33],"the":[7,36],"spacer":[8],"length":[9],"of":[10,38],"p53-RE,":[11],"we":[12],"have":[13],"created":[14],"a":[15],"novel":[16,31],"in-silico":[17],"regression-based":[18],"transactivation":[19],"capability":[20],"predictor":[21],"for":[22],"p53-REs":[23,32],"used":[25],"it":[26],"to":[27,34],"analyze":[28],"validated":[29],"predict":[35],"impact":[37],"SNPs":[39],"overlapping":[40],"these":[41],"elements.":[42]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}