{"id":"https://openalex.org/W2048862998","doi":"https://doi.org/10.1186/1471-2105-10-203","title":"Integrated analysis of DNA copy number and gene expression microarray data using gene sets","display_name":"Integrated analysis of DNA copy number and gene expression microarray data using gene sets","publication_year":2009,"publication_date":"2009-06-29","ids":{"openalex":"https://openalex.org/W2048862998","doi":"https://doi.org/10.1186/1471-2105-10-203","mag":"2048862998","pmid":"https://pubmed.ncbi.nlm.nih.gov/19563656"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-203","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-203","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-203","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-203","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054621707","display_name":"Ren\u00e9e X. de Menezes","orcid":"https://orcid.org/0000-0002-1378-2721"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ren\u00e9e X Menezes","raw_affiliation_strings":["Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. r.x.menezes@lumc.nl","Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. r.x.menezes@lumc.nl","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063484441","display_name":"Marten Boetzer","orcid":null},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marten Boetzer","raw_affiliation_strings":["Center for Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands","Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066831195","display_name":"Melle Sieswerda","orcid":"https://orcid.org/0000-0003-2025-0771"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Melle Sieswerda","raw_affiliation_strings":["Center for Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands","Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055691889","display_name":"Gert\u2010Jan B. van Ommen","orcid":"https://orcid.org/0000-0002-8603-218X"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I4210092740","display_name":"Centre for Medical Systems Biology","ror":"https://ror.org/00e7dfm13","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210092740"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gert-Jan B van Ommen","raw_affiliation_strings":["Center for Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands","Center for Medical Systems Biology, Leiden, The Netherlands","Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Center for Medical Systems Biology, Leiden, The Netherlands","institution_ids":["https://openalex.org/I4210092740"]},{"raw_affiliation_string":"Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016091450","display_name":"Judith M. Boer","orcid":"https://orcid.org/0000-0003-4848-7789"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I2801582894","display_name":"Netherlands Bioinformatics Centre","ror":"https://ror.org/01r0k6965","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I2801582894"]},{"id":"https://openalex.org/I4210092740","display_name":"Centre for Medical Systems Biology","ror":"https://ror.org/00e7dfm13","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210092740"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Judith M Boer","raw_affiliation_strings":["BioRange, Netherlands Bioinformatics Centre, Nijmegen, The Netherlands","Center for Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands","Center for Medical Systems Biology, Leiden, The Netherlands","Center for Human and Clinical Genetics, Leiden University Medical Center, , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioRange, Netherlands Bioinformatics Centre, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2801582894"]},{"raw_affiliation_string":"Center for Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Center for Medical Systems Biology, Leiden, The Netherlands","institution_ids":["https://openalex.org/I4210092740"]},{"raw_affiliation_string":"Center for Human and Clinical Genetics, Leiden University Medical Center, , The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.8537,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.93729793,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"203","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9424999952316284,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9424999952316284,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.7824834585189819},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5434463620185852},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5281835794448853},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5147397518157959},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4969022572040558},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4908977150917053},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4872263967990875},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"Copy-number variation","score":0.4800349473953247},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.47740212082862854},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.47180572152137756},{"id":"https://openalex.org/keywords/microarray-databases","display_name":"Microarray databases","score":0.46634596586227417},{"id":"https://openalex.org/keywords/gene-dosage","display_name":"Gene dosage","score":0.42709869146347046},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.41985514760017395},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.22996389865875244}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.7824834585189819},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5434463620185852},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5281835794448853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5147397518157959},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4969022572040558},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4908977150917053},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4872263967990875},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.4800349473953247},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.47740212082862854},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.47180572152137756},{"id":"https://openalex.org/C548314002","wikidata":"https://www.wikidata.org/wiki/Q6839218","display_name":"Microarray databases","level":5,"score":0.46634596586227417},{"id":"https://openalex.org/C55548728","wikidata":"https://www.wikidata.org/wiki/Q1465102","display_name":"Gene dosage","level":4,"score":0.42709869146347046},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.41985514760017395},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.22996389865875244}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-10-203","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-203","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-203","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19563656","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19563656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:eur:oai:repub.eur.nl:24937","is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/24937","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B M C Bioinformatics, 10","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e3ea0dc72f8f4d6eb5b441910abd062d","is_oa":true,"landing_page_url":"https://doaj.org/article/e3ea0dc72f8f4d6eb5b441910abd062d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 203 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2753845","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2753845","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:repub.eur.nl:24937","is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/24937","pdf_url":null,"source":{"id":"https://openalex.org/S4306400997","display_name":"RePub (Erasmus University, Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B M C Bioinformatics vol. 10","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-203","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-203","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-203","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6399999856948853}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320328608","display_name":"Centre for Medical Systems Biology","ror":"https://ror.org/00e7dfm13"},{"id":"https://openalex.org/F4320328786","display_name":"Norwegian Biodiversity Information Centre","ror":"https://ror.org/04jnzhb65"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2048862998.pdf","grobid_xml":"https://content.openalex.org/works/W2048862998.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1484187172","https://openalex.org/W1596515083","https://openalex.org/W2005145657","https://openalex.org/W2011912935","https://openalex.org/W2014606320","https://openalex.org/W2015009944","https://openalex.org/W2016299037","https://openalex.org/W2031288274","https://openalex.org/W2041236924","https://openalex.org/W2060084956","https://openalex.org/W2076356585","https://openalex.org/W2094628672","https://openalex.org/W2097255042","https://openalex.org/W2103659026","https://openalex.org/W2106483643","https://openalex.org/W2109363337","https://openalex.org/W2112877739","https://openalex.org/W2118069309","https://openalex.org/W2123106337","https://openalex.org/W2124277850","https://openalex.org/W2127053639","https://openalex.org/W2128985829","https://openalex.org/W2131057697","https://openalex.org/W2131994307","https://openalex.org/W2132800834","https://openalex.org/W2135185276","https://openalex.org/W2145897029","https://openalex.org/W2146531100","https://openalex.org/W2147246240","https://openalex.org/W2152147560","https://openalex.org/W2154361640","https://openalex.org/W2156138784","https://openalex.org/W2159805523","https://openalex.org/W2159929448","https://openalex.org/W2163402891","https://openalex.org/W2164147743","https://openalex.org/W2170828133","https://openalex.org/W2582743722"],"related_works":["https://openalex.org/W2131096798","https://openalex.org/W1978543818","https://openalex.org/W2982435583","https://openalex.org/W2943416042","https://openalex.org/W1544923801","https://openalex.org/W2490137852","https://openalex.org/W2056932428","https://openalex.org/W3023720143","https://openalex.org/W1483316219","https://openalex.org/W2412120523"],"abstract_inverted_index":{"BACKGROUND:":[0],"Genes":[1],"that":[2],"play":[3],"an":[4],"important":[5],"role":[6],"in":[7,108],"tumorigenesis":[8],"are":[9],"expected":[10],"to":[11,23,60,122,128,192],"show":[12,118],"association":[13,100],"between":[14,101,152],"DNA":[15],"copy":[16,33,41,62,134,153,185],"number":[17,34,42,63,135,154,186],"and":[18,35,64,80,104,147,155,163,173],"RNA":[19],"expression.":[20],"Optimal":[21],"power":[22],"find":[24],"such":[25],"associations":[26,130],"can":[27],"only":[28],"be":[29],"achieved":[30],"if":[31],"analysing":[32],"gene":[36,69,102,105],"expression":[37,51,65,106,156,181],"jointly.":[38],"Furthermore,":[39],"some":[40],"changes":[43],"extend":[44],"over":[45],"larger":[46],"chromosomal":[47],"regions":[48],"affecting":[49],"the":[50,176],"levels":[52],"of":[53,99,110,125,168,178],"multiple":[54,169],"resident":[55],"genes.":[56,74],"RESULTS:":[57],"We":[58,82,159],"propose":[59],"analyse":[61],"array":[66],"data":[67,171],"using":[68,123,143],"sets,":[70,172],"rather":[71],"than":[72],"individual":[73],"The":[75],"proposed":[76],"model":[77,140],"is":[78,182],"robust":[79],"sensitive.":[81],"re-analysed":[83],"two":[84,91],"publicly":[85],"available":[86],"datasets":[87,95],"as":[88],"illustration.":[89],"These":[90],"independent":[92],"breast":[93],"cancer":[94],"yielded":[96],"similar":[97],"patterns":[98],"dosage":[103],"levels,":[107],"spite":[109],"different":[111],"platforms":[112],"having":[113],"been":[114],"used.":[115],"Our":[116],"comparisons":[117],"a":[119,161,189],"clear":[120],"advantage":[121],"sets":[124],"genes'":[126],"expressions":[127],"detect":[129],"with":[131],"long-spanning,":[132],"low-amplitude":[133],"aberrations.":[136],"In":[137],"addition,":[138],"our":[139],"allows":[141],"for":[142,166,196],"additional":[144],"explanatory":[145],"variables":[146],"does":[148],"not":[149],"require":[150],"mapping":[151],"probes.":[157],"CONCLUSION:":[158],"developed":[160],"general":[162],"flexible":[164],"tool":[165],"integration":[167],"microarray":[170],"showed":[174],"how":[175],"identification":[177],"genes":[179],"whose":[180],"affected":[183],"by":[184],"aberrations":[187],"provides":[188],"powerful":[190],"approach":[191],"prioritize":[193],"putative":[194],"targets":[195],"functional":[197],"validation.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2016-06-24T00:00:00"}