{"id":"https://openalex.org/W2007979569","doi":"https://doi.org/10.1186/1471-2105-10-190","title":"Modeling the role of p53 pulses in DNA damage- induced cell death decision","display_name":"Modeling the role of p53 pulses in DNA damage- induced cell death decision","publication_year":2009,"publication_date":"2009-06-22","ids":{"openalex":"https://openalex.org/W2007979569","doi":"https://doi.org/10.1186/1471-2105-10-190","mag":"2007979569","pmid":"https://pubmed.ncbi.nlm.nih.gov/19545411"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-190","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-190","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-190","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-190","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042419809","display_name":"Tingzhe Sun","orcid":"https://orcid.org/0000-0002-9575-4993"},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingzhe Sun","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, PR China. confucian007@126.com","State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, PR China. confucian007@126.com","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054661471","display_name":"Chun Chen","orcid":"https://orcid.org/0000-0002-3608-6972"},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun Chen","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, PR China","State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, PR China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051147169","display_name":"Yuanyuan Wu","orcid":"https://orcid.org/0000-0001-6231-2315"},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Wu","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, PR China","State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, PR China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100328870","display_name":"Shuai Zhang","orcid":"https://orcid.org/0000-0002-2916-3394"},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Zhang","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, PR China","State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, PR China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022770208","display_name":"Jun Cui","orcid":"https://orcid.org/0000-0002-8000-3708"},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Cui","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, PR China","State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, PR China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018224315","display_name":"Pingping Shen","orcid":"https://orcid.org/0000-0002-1072-784X"},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pingping Shen","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, PR China","State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, PR China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.6687,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.83837987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"190","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.7609000205993652,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.7609000205993652,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.07840000092983246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.04309999942779541,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/puma","display_name":"Puma","score":0.8715275526046753},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8378031253814697},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.533645510673523},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.5313207507133484},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"Programmed cell death","score":0.5246548652648926},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5209566354751587},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.5130547285079956},{"id":"https://openalex.org/keywords/suppressor","display_name":"Suppressor","score":0.45875027775764465},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.40912511944770813},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20997768640518188},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.16184785962104797}],"concepts":[{"id":"https://openalex.org/C2777417711","wikidata":"https://www.wikidata.org/wiki/Q270748","display_name":"Puma","level":3,"score":0.8715275526046753},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.8378031253814697},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.533645510673523},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5313207507133484},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5246548652648926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5209566354751587},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5130547285079956},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.45875027775764465},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.40912511944770813},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20997768640518188},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16184785962104797}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-10-190","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-190","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-190","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19545411","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19545411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:4413a61342c84affad50a653ce6a3aad","is_oa":true,"landing_page_url":"https://doaj.org/article/4413a61342c84affad50a653ce6a3aad","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 190 (2009)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1865381","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713228","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-190","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-190","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-190","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2687046332","display_name":null,"funder_award_id":"NCET-06","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7324830102","display_name":null,"funder_award_id":"NCET-06-0445","funder_id":"https://openalex.org/F4320334924","funder_display_name":"Program for New Century Excellent Talents in University"},{"id":"https://openalex.org/G8995973182","display_name":null,"funder_award_id":"30821006","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334924","display_name":"Program for New Century Excellent Talents in University","ror":"https://ror.org/01mv9t934"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007979569.pdf","grobid_xml":"https://content.openalex.org/works/W2007979569.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W122083802","https://openalex.org/W1745634660","https://openalex.org/W1923756169","https://openalex.org/W1937607074","https://openalex.org/W1965512256","https://openalex.org/W1971212979","https://openalex.org/W1978259246","https://openalex.org/W1979634817","https://openalex.org/W1992989336","https://openalex.org/W2000383933","https://openalex.org/W2001824068","https://openalex.org/W2007665513","https://openalex.org/W2008376982","https://openalex.org/W2008887283","https://openalex.org/W2010114834","https://openalex.org/W2010990642","https://openalex.org/W2013493332","https://openalex.org/W2018116689","https://openalex.org/W2019072372","https://openalex.org/W2019379230","https://openalex.org/W2021029116","https://openalex.org/W2022811243","https://openalex.org/W2031117844","https://openalex.org/W2032603938","https://openalex.org/W2033194496","https://openalex.org/W2033889343","https://openalex.org/W2036270526","https://openalex.org/W2037086486","https://openalex.org/W2043004358","https://openalex.org/W2045164156","https://openalex.org/W2046083330","https://openalex.org/W2066440682","https://openalex.org/W2069500900","https://openalex.org/W2071128676","https://openalex.org/W2072159031","https://openalex.org/W2074545297","https://openalex.org/W2079933835","https://openalex.org/W2082185914","https://openalex.org/W2084089807","https://openalex.org/W2085418817","https://openalex.org/W2087764283","https://openalex.org/W2089442061","https://openalex.org/W2091818021","https://openalex.org/W2097651998","https://openalex.org/W2099251756","https://openalex.org/W2105073777","https://openalex.org/W2113126782","https://openalex.org/W2116929481","https://openalex.org/W2118001641","https://openalex.org/W2128252882","https://openalex.org/W2141997480","https://openalex.org/W2142676005","https://openalex.org/W2150424120","https://openalex.org/W2152456839","https://openalex.org/W2152585118","https://openalex.org/W2152750766","https://openalex.org/W2153442184","https://openalex.org/W2162048408","https://openalex.org/W2164234304","https://openalex.org/W2164489545","https://openalex.org/W2167184679","https://openalex.org/W2169895124","https://openalex.org/W2313997600","https://openalex.org/W2321119724"],"related_works":["https://openalex.org/W3029624080","https://openalex.org/W2383247791","https://openalex.org/W2383847661","https://openalex.org/W2977641071","https://openalex.org/W2112968535","https://openalex.org/W2255064539","https://openalex.org/W2347355260","https://openalex.org/W1967092074","https://openalex.org/W2433485935","https://openalex.org/W25001789"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,134],"tumor":[2,103,151],"suppressor":[3],"p53":[4,14,22,51,72,99,125,148,160,183],"plays":[5],"pivotal":[6,121],"roles":[7,27,122],"in":[8,28,44,84,102,149],"tumorigenesis":[9],"suppression.":[10],"Although":[11],"oscillations":[12],"of":[13,21,71,76,137,147],"have":[15],"been":[16],"extensively":[17],"studied,":[18],"the":[19,60,74,114,130,150,154,187],"mechanism":[20,176],"pulses":[23,100,126,146,161,184],"and":[24,50,113,127,165,181,191],"their":[25],"physiological":[26],"DNA":[29,80,91,139],"damage":[30,92,140],"response":[31,75],"remain":[32],"unclear.":[33],"RESULTS:":[34],"To":[35],"address":[36],"these":[37],"questions":[38],"we":[39],"presented":[40],"an":[41],"integrated":[42],"model":[43],"which":[45],"Ataxia-Telangiectasia":[46],"Mutated":[47],"(ATM)":[48],"activation":[49,117,156],"oscillation":[52,70],"were":[53],"incorporated":[54],"with":[55],"downstream":[56],"apoptotic":[57],"events,":[58],"particularly":[59],"interplays":[61],"between":[62,189],"Bcl-2":[63],"family":[64],"proteins.":[65],"We":[66],"first":[67],"reproduced":[68],"digital":[69],"as":[73],"normal":[77],"cells":[78,86,179],"to":[79,123,185],"damage.":[81],"Subsequent":[82],"modeling":[83,172],"mutant":[85],"showed":[87],"that":[88,109],"high":[89,135],"basal":[90,138],"is":[93],"a":[94,174],"plausible":[95,175],"cause":[96],"for":[97,143],"sustained":[98,145],"observed":[101],"cells.":[104,152],"Further":[105],"computational":[106],"analyses":[107],"indicated":[108],"p53-dependent":[110],"PUMA":[111,163],"accumulation":[112,164],"PUMA-controlled":[115],"Bax":[116,155],"switch":[118,157],"might":[119],"play":[120],"count":[124,159],"thus":[128],"decide":[129],"cell":[131],"fate.":[132],"CONCLUSION:":[133],"levels":[136],"are":[141],"responsible":[142],"generating":[144],"Meanwhile,":[153],"can":[158],"through":[162],"transfer":[166],"it":[167],"into":[168],"death":[169],"signal.":[170],"Our":[171],"provides":[173],"about":[177],"how":[178],"generate":[180],"orchestrate":[182],"tip":[186],"balance":[188],"survival":[190],"death.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}