{"id":"https://openalex.org/W1993093505","doi":"https://doi.org/10.1186/1471-2105-10-141","title":"Robust MS quantification method for phospho-peptides using 18O/16O labeling","display_name":"Robust MS quantification method for phospho-peptides using 18O/16O labeling","publication_year":2009,"publication_date":"2009-05-11","ids":{"openalex":"https://openalex.org/W1993093505","doi":"https://doi.org/10.1186/1471-2105-10-141","mag":"1993093505","pmid":"https://pubmed.ncbi.nlm.nih.gov/19432989"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-10-141","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-141","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-141","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-141","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101570764","display_name":"Claus A. Andersen","orcid":"https://orcid.org/0000-0003-3450-7777"},"institutions":[{"id":"https://openalex.org/I4210117667","display_name":"Siena Biotech (Italy)","ror":"https://ror.org/02ka1d450","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210117667"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Claus A Andersen","raw_affiliation_strings":["Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100 Siena, Italy. candersen@sienabiotech.it","Siena Biotech SpA, Discovery Research, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100 Siena, Italy. candersen@sienabiotech.it","institution_ids":["https://openalex.org/I4210117667"]},{"raw_affiliation_string":"Siena Biotech SpA, Discovery Research, Siena, Italy","institution_ids":["https://openalex.org/I4210117667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057732876","display_name":"Stefano Gotta","orcid":null},"institutions":[{"id":"https://openalex.org/I4210117667","display_name":"Siena Biotech (Italy)","ror":"https://ror.org/02ka1d450","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210117667"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Gotta","raw_affiliation_strings":["Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100, Siena, Italy","Siena Biotech SpA, Discovery Research, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100, Siena, Italy","institution_ids":["https://openalex.org/I4210117667"]},{"raw_affiliation_string":"Siena Biotech SpA, Discovery Research, Siena, Italy","institution_ids":["https://openalex.org/I4210117667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033613886","display_name":"Letizia Magnoni","orcid":"https://orcid.org/0000-0001-8525-033X"},"institutions":[{"id":"https://openalex.org/I4210117667","display_name":"Siena Biotech (Italy)","ror":"https://ror.org/02ka1d450","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210117667"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Letizia Magnoni","raw_affiliation_strings":["Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100, Siena, Italy","Siena Biotech SpA, Discovery Research, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100, Siena, Italy","institution_ids":["https://openalex.org/I4210117667"]},{"raw_affiliation_string":"Siena Biotech SpA, Discovery Research, Siena, Italy","institution_ids":["https://openalex.org/I4210117667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001257940","display_name":"Roberto Raggiaschi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210117667","display_name":"Siena Biotech (Italy)","ror":"https://ror.org/02ka1d450","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210117667"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Raggiaschi","raw_affiliation_strings":["Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100, Siena, Italy","Siena Biotech SpA, Discovery Research, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100, Siena, Italy","institution_ids":["https://openalex.org/I4210117667"]},{"raw_affiliation_string":"Siena Biotech SpA, Discovery Research, Siena, Italy","institution_ids":["https://openalex.org/I4210117667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026135229","display_name":"Andreas Kremer","orcid":"https://orcid.org/0000-0003-1466-0600"},"institutions":[{"id":"https://openalex.org/I4210117667","display_name":"Siena Biotech (Italy)","ror":"https://ror.org/02ka1d450","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210117667"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andreas Kremer","raw_affiliation_strings":["Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100, Siena, Italy","Siena Biotech SpA, Discovery Research, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100, Siena, Italy","institution_ids":["https://openalex.org/I4210117667"]},{"raw_affiliation_string":"Siena Biotech SpA, Discovery Research, Siena, Italy","institution_ids":["https://openalex.org/I4210117667"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017478342","display_name":"Georg C. Terstappen","orcid":"https://orcid.org/0000-0003-3669-0421"},"institutions":[{"id":"https://openalex.org/I4210117667","display_name":"Siena Biotech (Italy)","ror":"https://ror.org/02ka1d450","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210117667"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Georg C Terstappen","raw_affiliation_strings":["Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100, Siena, Italy","Siena Biotech SpA, Discovery Research, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100, Siena, Italy","institution_ids":["https://openalex.org/I4210117667"]},{"raw_affiliation_string":"Siena Biotech SpA, Discovery Research, Siena, Italy","institution_ids":["https://openalex.org/I4210117667"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5101570764"],"corresponding_institution_ids":["https://openalex.org/I4210117667"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.5005,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.6292378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"10","issue":"1","first_page":"141","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.030700000002980232,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5546174645423889},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.48250865936279297},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4217906594276428},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4092182517051697},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.39004945755004883},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2734116315841675},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17610913515090942},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07689511775970459},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.07351037859916687}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5546174645423889},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.48250865936279297},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4217906594276428},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4092182517051697},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.39004945755004883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2734116315841675},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17610913515090942},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07689511775970459},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07351037859916687}],"mesh":[{"descriptor_ui":"D010103","descriptor_name":"Oxygen Isotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010103","descriptor_name":"Oxygen Isotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010103","descriptor_name":"Oxygen Isotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010748","descriptor_name":"Phosphopeptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010748","descriptor_name":"Phosphopeptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010748","descriptor_name":"Phosphopeptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010748","descriptor_name":"Phosphopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010748","descriptor_name":"Phosphopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010748","descriptor_name":"Phosphopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-10-141","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-141","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-141","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19432989","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19432989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:eur:oai:pure.eur.nl:publications/4b92a546-9297-49df-a05d-3fae0b572a94","is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/4b92a546-9297-49df-a05d-3fae0b572a94","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 10. BioMed Central Ltd.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e0907b28dc9c4dfa92cebb30922ddd4c","is_oa":true,"landing_page_url":"https://doaj.org/article/e0907b28dc9c4dfa92cebb30922ddd4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 10, Iss 1, p 141 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2693437","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693437","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-10-141","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-10-141","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-10-141","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1993093505.pdf","grobid_xml":"https://content.openalex.org/works/W1993093505.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1519955500","https://openalex.org/W1653222112","https://openalex.org/W1841303832","https://openalex.org/W1977994906","https://openalex.org/W1981715798","https://openalex.org/W1995945562","https://openalex.org/W2007843519","https://openalex.org/W2020630954","https://openalex.org/W2069862631","https://openalex.org/W2072554198","https://openalex.org/W2084270048","https://openalex.org/W2086502504","https://openalex.org/W2089444196","https://openalex.org/W2091101858","https://openalex.org/W2106306343","https://openalex.org/W2112023359","https://openalex.org/W2119699023","https://openalex.org/W2122545105","https://openalex.org/W2126946948","https://openalex.org/W2155553629","https://openalex.org/W2171479873","https://openalex.org/W2797563284","https://openalex.org/W3190730724"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W2062208111","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"BACKGROUND:":[0],"Quantitative":[1],"measurements":[2],"of":[3,24,56,84,86,98,115,140,161,169,256,262,281],"specific":[4,87],"protein":[5],"phosphorylation":[6,85,141],"sites,":[7],"as":[8,59,264],"presented":[9,28,75],"here,":[10],"can":[11,272],"be":[12,274],"used":[13,58,275],"to":[14,48,66,157,190,229,239,249],"investigate":[15],"signal":[16,278],"transduction":[17],"pathways,":[18],"which":[19,149],"is":[20,70,175],"an":[21,221],"important":[22],"aspect":[23],"cell":[25,80,104,283],"dynamics.":[26],"The":[27,74,96,113,206],"method":[29,76,170,271],"quantitatively":[30],"compares":[31],"peptide":[32,88],"abundances":[33],"from":[34,40,90,102,108],"experiments":[35],"using":[36,93,144,172],"18O/16O":[37,94],"labeling":[38,117,131,203,225],"starting":[39],"elaborated":[41],"MS":[42,91],"spectra.":[43,164,237],"It":[44],"was":[45,106,119,133,150,188,214,247],"originally":[46],"developed":[47],"study":[49],"signaling":[50],"cascades":[51],"activated":[52],"by":[53,121,266],"amyloid-beta":[54],"treatment":[55],"neurons":[57],"a":[60,123,153,166,182,243,259,286],"cellular":[61],"model":[62,251],"system":[63],"with":[64,152,196,201,220,258],"relevance":[65],"Alzheimer's":[67],"disease,":[68],"but":[69],"generally":[71],"applicable.":[72],"RESULTS:":[73],"assesses,":[77],"in":[78,181,233,285],"complete":[79],"lysates,":[81],"the":[82,130,145,159,162,192,230,234,250],"degree":[83,261],"residues":[89],"spectra":[92,242],"labeling.":[95],"abundance":[97],"each":[99],"observed":[100,236,241],"phospho-peptide":[101],"two":[103],"states":[105],"estimated":[107],"three":[109],"overlapping":[110],"isotope":[111],"contours.":[112],"influence":[114],"peptide-specific":[116],"efficiency":[118,132,226],"removed":[120],"performing":[122],"label":[124,136],"swapped":[125],"experiment":[126],"and":[127,200,224],"assuming":[128],"that":[129],"unchanged":[134],"upon":[135],"swapping.":[137],"Different":[138],"degrees":[139],"were":[142],"reported":[143],"fold":[146,207],"change":[147,208],"measure":[148],"extended":[151],"confidence":[154],"interval":[155],"found":[156,232,248],"reflect":[158],"quality":[160],"underlying":[163],"Furthermore":[165],"new":[167,270],"way":[168],"assessment":[171],"simulated":[173,178,212],"data":[174,179,186,213,267],"presented.":[176],"Using":[177],"generated":[180],"manner":[183],"mimicking":[184],"real":[185],"it":[187],"possible":[189],"show":[191],"method's":[193],"robustness":[194],"both":[195],"increasing":[197],"noise":[198],"levels":[199],"decreasing":[202],"efficiency.":[204],"CONCLUSION:":[205],"error":[209,253],"assessable":[210],"on":[211,215],"average":[216],"0.16":[217],"(median":[218],"0.10)":[219],"error-to-signal":[222],"ratio":[223],"distributions":[227],"similar":[228],"ones":[231],"experimentally":[235,240],"Applied":[238],"very":[244],"good":[245],"match":[246],"(<10%":[252],"for":[254,276],"85%":[255],"spectra)":[257],"high":[260,287],"robustness,":[263],"assessed":[265],"removal.":[268],"This":[269],"thus":[273],"quantitative":[277],"cascade":[279],"analysis":[280],"total":[282],"extracts":[284],"throughput":[288],"mode.":[289]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}