{"id":"https://openalex.org/W2087527688","doi":"https://doi.org/10.1162/089892905775008661","title":"An Effect of Dopamine Depletion on Decision-making: The Temporal Coupling of Deliberation and Execution","display_name":"An Effect of Dopamine Depletion on Decision-making: The Temporal Coupling of Deliberation and Execution","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W2087527688","doi":"https://doi.org/10.1162/089892905775008661","mag":"2087527688","pmid":"https://pubmed.ncbi.nlm.nih.gov/16356326"},"language":"en","primary_location":{"id":"doi:10.1162/089892905775008661","is_oa":false,"landing_page_url":"https://doi.org/10.1162/089892905775008661","pdf_url":null,"source":{"id":"https://openalex.org/S123144817","display_name":"Journal of Cognitive Neuroscience","issn_l":"0898-929X","issn":["0898-929X","1530-8898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cognitive Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059791481","display_name":"Mathias Pessiglione","orcid":"https://orcid.org/0000-0002-6992-3677"},"institutions":[{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Mathias Pessiglione","raw_affiliation_strings":["H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France"],"affiliations":[{"raw_affiliation_string":"H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France","institution_ids":["https://openalex.org/I4210121705","https://openalex.org/I39804081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048881016","display_name":"Virginie Czernecki","orcid":"https://orcid.org/0000-0002-0139-7957"},"institutions":[{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Virginie Czernecki","raw_affiliation_strings":["H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France"],"affiliations":[{"raw_affiliation_string":"H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France","institution_ids":["https://openalex.org/I4210121705","https://openalex.org/I39804081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022599796","display_name":"B. Pillon","orcid":null},"institutions":[{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Pillon","raw_affiliation_strings":["H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France"],"affiliations":[{"raw_affiliation_string":"H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France","institution_ids":["https://openalex.org/I4210121705","https://openalex.org/I39804081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109893858","display_name":"Bruno Dubois","orcid":null},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Dubois","raw_affiliation_strings":["H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France"],"affiliations":[{"raw_affiliation_string":"H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France","institution_ids":["https://openalex.org/I4210121705","https://openalex.org/I39804081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014613164","display_name":"Micha\u00ebl Sch\u00fcpbach","orcid":"https://orcid.org/0000-0003-1382-3359"},"institutions":[{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michael Sch\u00fcpbach","raw_affiliation_strings":["H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France"],"affiliations":[{"raw_affiliation_string":"H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France","institution_ids":["https://openalex.org/I4210121705","https://openalex.org/I39804081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111717236","display_name":"Yves Agid","orcid":null},"institutions":[{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yves Agid","raw_affiliation_strings":["H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France"],"affiliations":[{"raw_affiliation_string":"H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France","institution_ids":["https://openalex.org/I4210121705","https://openalex.org/I39804081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021466238","display_name":"L\u00e9on Tremblay","orcid":"https://orcid.org/0000-0001-8370-6903"},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L\u00e9on Tremblay","raw_affiliation_strings":["H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France"],"affiliations":[{"raw_affiliation_string":"H\u00f4pital de la Salp\u00eatri\u00e9re, Paris, France","institution_ids":["https://openalex.org/I4210121705","https://openalex.org/I39804081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5059791481"],"corresponding_institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210121705"],"apc_list":null,"apc_paid":null,"fwci":0.9964,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.7708246,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"12","first_page":"1886","last_page":"1896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deliberation","display_name":"Deliberation","score":0.7808172702789307},{"id":"https://openalex.org/keywords/dopaminergic","display_name":"Dopaminergic","score":0.7540876865386963},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.7450202703475952},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6327352523803711},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.6013761758804321},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"Basal ganglia","score":0.5711075067520142},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.56635582447052},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.5028218626976013},{"id":"https://openalex.org/keywords/dopaminergic-pathways","display_name":"Dopaminergic pathways","score":0.4431866705417633},{"id":"https://openalex.org/keywords/cognitive-psychology","display_name":"Cognitive psychology","score":0.43280303478240967},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.2098182737827301},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.136711984872818},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12591999769210815},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1006237268447876}],"concepts":[{"id":"https://openalex.org/C2776946740","wikidata":"https://www.wikidata.org/wiki/Q358652","display_name":"Deliberation","level":3,"score":0.7808172702789307},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7540876865386963},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.7450202703475952},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6327352523803711},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6013761758804321},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.5711075067520142},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.56635582447052},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.5028218626976013},{"id":"https://openalex.org/C2776286997","wikidata":"https://www.wikidata.org/wiki/Q2880966","display_name":"Dopaminergic pathways","level":4,"score":0.4431866705417633},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.43280303478240967},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.2098182737827301},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.136711984872818},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12591999769210815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1006237268447876},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003657","descriptor_name":"Decision Making","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003657","descriptor_name":"Decision Making","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003657","descriptor_name":"Decision Making","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004295","descriptor_name":"Dihydroxyphenylalanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004295","descriptor_name":"Dihydroxyphenylalanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004295","descriptor_name":"Dihydroxyphenylalanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004567","descriptor_name":"Electrodes, Implanted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004567","descriptor_name":"Electrodes, Implanted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004567","descriptor_name":"Electrodes, Implanted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1162/089892905775008661","is_oa":false,"landing_page_url":"https://doi.org/10.1162/089892905775008661","pdf_url":null,"source":{"id":"https://openalex.org/S123144817","display_name":"Journal of Cognitive Neuroscience","issn_l":"0898-929X","issn":["0898-929X","1530-8898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cognitive Neuroscience","raw_type":"journal-article"},{"id":"pmid:16356326","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16356326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cognitive neuroscience","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","score":0.8199999928474426,"display_name":"Peace, Justice and strong institutions"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1481125086","https://openalex.org/W1562703792","https://openalex.org/W1597262397","https://openalex.org/W1598742496","https://openalex.org/W1806855318","https://openalex.org/W1832682301","https://openalex.org/W1841405833","https://openalex.org/W1859758524","https://openalex.org/W1969316685","https://openalex.org/W1971078086","https://openalex.org/W1971933252","https://openalex.org/W1972418461","https://openalex.org/W1979455727","https://openalex.org/W1980046851","https://openalex.org/W1981037418","https://openalex.org/W1981583264","https://openalex.org/W1985174354","https://openalex.org/W1987971960","https://openalex.org/W1989605251","https://openalex.org/W1994180654","https://openalex.org/W1997392514","https://openalex.org/W2001041331","https://openalex.org/W2002314838","https://openalex.org/W2003435725","https://openalex.org/W2005590459","https://openalex.org/W2009021103","https://openalex.org/W2010478807","https://openalex.org/W2014089188","https://openalex.org/W2018091645","https://openalex.org/W2025534723","https://openalex.org/W2028116697","https://openalex.org/W2038805077","https://openalex.org/W2047205872","https://openalex.org/W2048941040","https://openalex.org/W2049885903","https://openalex.org/W2054520155","https://openalex.org/W2058801186","https://openalex.org/W2061644128","https://openalex.org/W2063293639","https://openalex.org/W2063976700","https://openalex.org/W2066989680","https://openalex.org/W2068697146","https://openalex.org/W2080530802","https://openalex.org/W2082809746","https://openalex.org/W2099652807","https://openalex.org/W2101036582","https://openalex.org/W2103315959","https://openalex.org/W2108340920","https://openalex.org/W2116496076","https://openalex.org/W2117726420","https://openalex.org/W2122602553","https://openalex.org/W2123208606","https://openalex.org/W2126873017","https://openalex.org/W2131402502","https://openalex.org/W2141405085","https://openalex.org/W2142625367","https://openalex.org/W2145665803","https://openalex.org/W2150594880","https://openalex.org/W2150857753","https://openalex.org/W2153638564","https://openalex.org/W2158325962","https://openalex.org/W2158620349","https://openalex.org/W2168122820","https://openalex.org/W2186321983","https://openalex.org/W2276751657","https://openalex.org/W2305277766","https://openalex.org/W2328435466","https://openalex.org/W2421622941","https://openalex.org/W2435058420","https://openalex.org/W4293082841"],"related_works":["https://openalex.org/W1936532143","https://openalex.org/W2414914326","https://openalex.org/W2345504199","https://openalex.org/W2052924733","https://openalex.org/W2329350644","https://openalex.org/W3210516368","https://openalex.org/W2943709574","https://openalex.org/W2461275624","https://openalex.org/W2416250553","https://openalex.org/W2804278889"],"abstract_inverted_index":{"When":[0],"a":[1,75,106,207],"decision":[2,39,46],"between":[3,80,86,175,229],"alternative":[4],"actions":[5],"has":[6],"to":[7,15,37,49,120,129,222],"be":[8,121,220],"made,":[9],"the":[10,38,41,45,55,59,87,100,118,140,157,167,201,223],"primate":[11],"brain":[12,144,193],"is":[13],"able":[14],"uncouple":[16],"motor":[17,42],"execution":[18,43,90,178],"from":[19],"mental":[20,34],"deliberation,":[21],"providing":[22],"time":[23,159,169],"for":[24],"higher":[25],"cognitive":[26],"processes":[27],"such":[28,217],"as":[29],"remembering":[30],"and":[31,40,58,63,89,139,177,212],"reasoning.":[32],"The":[33],"deliberation":[35,88,176,211],"leading":[36],"applying":[44],"are":[47],"likely":[48],"involve":[50],"different":[51,234],"neuronal":[52],"circuits":[53,232],"linking":[54],"basal":[56,230],"ganglia":[57,231],"frontal":[60],"cortex.":[61],"Behavioral":[62],"physiological":[64],"studies":[65],"in":[66,74,84,96,105,200],"monkeys":[67],"indicate":[68],"that":[69,216],"dopamine":[70],"depletion":[71],"may":[72,219],"result":[73],"loss":[76,224],"of":[77,102,111,115,125,203,210,225,236],"functional":[78,227],"segregation":[79,228],"these":[81],"circuits,":[82],"hence,":[83],"interference":[85,174,181],"processes.":[91,179],"To":[92],"test":[93],"this":[94],"hypothesis":[95],"humans,":[97],"we":[98],"analyzed":[99],"movements":[101,202],"parkinsonian":[103],"patients":[104,126],"go/no-go":[107],"task,":[108],"contrasting":[109],"periods":[110,114],"uncertainty":[112],"with":[113,136,142,171,185,191],"knowledge":[116],"about":[117],"rule":[119],"applied.":[122],"Two":[123],"groups":[124,147],"were":[127,148,198],"compared":[128],"healthy":[130,155],"subjects:":[131],"one":[132],"group":[133],"was":[134,160,182,189],"treated":[135],"dopaminergic":[137,186],"medication":[138,187],"other":[141],"deep":[143,192],"stimulation;":[145],"both":[146],"also":[149],"tested":[150],"without":[151],"any":[152],"treatment.":[153],"In":[154,164],"subjects,":[156],"movement":[158,168],"unaffected":[161],"by":[162],"uncertainty.":[163],"untreated":[165],"patients,":[166,205],"increased":[170],"uncertainty,":[172],"reflecting":[173],"This":[180],"fully":[183],"corrected":[184],"but":[188],"unchanged":[190],"stimulation.":[194],"Moreover,":[195],"decision-related":[196],"hesitations":[197],"detectable":[199],"dopamine-depleted":[204],"revealing":[206],"temporal":[208],"coupling":[209,218],"execution.":[213],"We":[214],"suggest":[215],"related":[221],"dopamine-mediated":[226],"processing":[233],"stages":[235],"goal-directed":[237],"behavior.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}