{"id":"https://openalex.org/W4307336175","doi":"https://doi.org/10.1162/neco_a_01545","title":"Asymmetric Complexity in a Pupil Control Model With Laterally Imbalanced Neural Activity in the Locus Coeruleus: A Potential Biomarker for Attention-Deficit/Hyperactivity Disorder","display_name":"Asymmetric Complexity in a Pupil Control Model With Laterally Imbalanced Neural Activity in the Locus Coeruleus: A Potential Biomarker for Attention-Deficit/Hyperactivity Disorder","publication_year":2022,"publication_date":"2022-10-25","ids":{"openalex":"https://openalex.org/W4307336175","doi":"https://doi.org/10.1162/neco_a_01545","pmid":"https://pubmed.ncbi.nlm.nih.gov/36283044"},"language":"en","primary_location":{"id":"doi:10.1162/neco_a_01545","doi":"https://doi.org/10.1162/neco_a_01545","is_oa":false,"landing_page_url":"https://doi.org/10.1162/neco_a_01545","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","erih-plus","jufo-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718","https://openalex.org/P4310316440"],"host_organization_lineage_names":["The MIT Press","Massachusetts Institute of Technology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038159573","display_name":"Hiraku Kumano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8488066","display_name":"Chiba Institute of Technology","ror":"https://ror.org/00qwnam72","country_code":"JP","type":"education","lineage":["https://openalex.org/I8488066"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiraku Kumano","raw_affiliation_strings":["Graduate School of Information and Computer Science, Chiba Institute of Technology, Narashino, Chiba 275-0016, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Information and Computer Science, Chiba Institute of Technology, Narashino, Chiba 275-0016, Japan","institution_ids":["https://openalex.org/I8488066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014663937","display_name":"Sou Nobukawa","orcid":"https://orcid.org/0000-0001-7003-6912","observed_orcids":["https://orcid.org/0000-0001-7003-6912"]},"institutions":[{"id":"https://openalex.org/I4210103779","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103779"]},{"id":"https://openalex.org/I4210160792","display_name":"National Institute of Mental Health","ror":"https://ror.org/04t0s7x83","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210103779","https://openalex.org/I4210160792"]},{"id":"https://openalex.org/I8488066","display_name":"Chiba Institute of Technology","ror":"https://ror.org/00qwnam72","country_code":"JP","type":"education","lineage":["https://openalex.org/I8488066"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Sou Nobukawa","raw_affiliation_strings":["Department of Computer Science/Graduate School of Information and Computer Science, Chiba Institute of Technology, Narashino, Chiba 275-0016, Japan","Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan nobukawa@cs.it-chiba.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science/Graduate School of Information and Computer Science, Chiba Institute of Technology, Narashino, Chiba 275-0016, Japan","institution_ids":["https://openalex.org/I8488066"]},{"raw_affiliation_string":"Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan nobukawa@cs.it-chiba.ac.jp","institution_ids":["https://openalex.org/I4210103779","https://openalex.org/I4210160792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024953415","display_name":"Aya Shirama","orcid":"https://orcid.org/0000-0003-4174-5175","observed_orcids":["https://orcid.org/0000-0003-4174-5175"]},"institutions":[{"id":"https://openalex.org/I4210103779","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103779"]},{"id":"https://openalex.org/I4210160792","display_name":"National Institute of Mental Health","ror":"https://ror.org/04t0s7x83","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210103779","https://openalex.org/I4210160792"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Aya Shirama","raw_affiliation_strings":["Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan shirama@ncnp.go.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan shirama@ncnp.go.jp","institution_ids":["https://openalex.org/I4210103779","https://openalex.org/I4210160792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081056035","display_name":"Tetsuya Takahashi","orcid":"https://orcid.org/0000-0002-2917-1810","observed_orcids":["https://orcid.org/0000-0002-2917-1810"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tetsuya Takahashi","raw_affiliation_strings":["Department of Neuropsychiatry, University of Fukui, Fukui 910-1193, Japan","Research Center for Child Mental Development, Kanazawa University, Ishikawa 187-8551, Japan","Uozu Shinkei Sanatorium, Uozu 937-0017, Japan takahash@u-fukui.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, University of Fukui, Fukui 910-1193, Japan","institution_ids":["https://openalex.org/I111966504"]},{"raw_affiliation_string":"Research Center for Child Mental Development, Kanazawa University, Ishikawa 187-8551, Japan","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Uozu Shinkei Sanatorium, Uozu 937-0017, Japan takahash@u-fukui.ac.jp","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075467750","display_name":"Toshinobu Takeda","orcid":"https://orcid.org/0000-0002-6905-5013","observed_orcids":["https://orcid.org/0000-0002-6905-5013"]},"institutions":[{"id":"https://openalex.org/I103390050","display_name":"Ryukoku University","ror":"https://ror.org/012tqgb57","country_code":"JP","type":"education","lineage":["https://openalex.org/I103390050"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshinobu Takeda","raw_affiliation_strings":["Faculty of Letters, Ryukoku University, Kyoto 612-8577, Japan t-tak@umin.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Letters, Ryukoku University, Kyoto 612-8577, Japan t-tak@umin.ac.jp","institution_ids":["https://openalex.org/I103390050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110449332","display_name":"Haruhisa Ohta","orcid":"https://orcid.org/0000-0001-8481-472X","observed_orcids":["https://orcid.org/0000-0001-8481-472X"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Haruhisa Ohta","raw_affiliation_strings":["Medical Institute of Developmental Disabilities Research, Showa University, Tokyo 157-8577, Japan haruhisap@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Institute of Developmental Disabilities Research, Showa University, Tokyo 157-8577, Japan haruhisap@gmail.com","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091199185","display_name":"Mitsuru Kikuchi","orcid":"https://orcid.org/0000-0003-3013-7844","observed_orcids":["https://orcid.org/0000-0003-3013-7844"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mitsuru Kikuchi","raw_affiliation_strings":["Research Center for Child Mental Development and Department of Psychiatry and Behavioral Science, Kanazawa University, Ishikawa 920-8640, Japan mitsuruk@med.kanazawa-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Child Mental Development and Department of Psychiatry and Behavioral Science, Kanazawa University, Ishikawa 920-8640, Japan mitsuruk@med.kanazawa-u.ac.jp","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000497923","display_name":"Akira Iwanami","orcid":"https://orcid.org/0000-0003-4731-4886","observed_orcids":["https://orcid.org/0000-0003-4731-4886"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akira Iwanami","raw_affiliation_strings":["Department of Psychiatry, School of Medicine, Showa University, Tokyo 157-8577, Japan iwanami@med.showa-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, Showa University, Tokyo 157-8577, Japan iwanami@med.showa-u.ac.jp","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109011558","display_name":"Nobumasa Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Nobumasa Kato","raw_affiliation_strings":["Medical Institute of Developmental Disabilities Research, Showa University, Tokyo 157-8577, Japan katon@med.showa-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Institute of Developmental Disabilities Research, Showa University, Tokyo 157-8577, Japan katon@med.showa-u.ac.jp","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109947581","display_name":"Shigenobu Toda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]},{"id":"https://openalex.org/I4387152633","display_name":"SHOWA Medical University East Hospital","ror":"https://ror.org/0145f3g58","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387152633"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shigenobu Toda","raw_affiliation_strings":["Department of Psychiatry and Behavioral Science, Kanazawa University, Ishikawa 920-8640, Japan","Department of Psychiatry, Showa University East Hospital, Showa University, Tokyo 142-0054, Japan todashige@outlook.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Science, Kanazawa University, Ishikawa 920-8640, Japan","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Psychiatry, Showa University East Hospital, Showa University, Tokyo 142-0054, Japan todashige@outlook.jp","institution_ids":["https://openalex.org/I119182057","https://openalex.org/I4387152633"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5000497923","https://openalex.org/A5014663937","https://openalex.org/A5024953415","https://openalex.org/A5075467750","https://openalex.org/A5081056035","https://openalex.org/A5091199185","https://openalex.org/A5109011558","https://openalex.org/A5109947581","https://openalex.org/A5110449332"],"corresponding_institution_ids":["https://openalex.org/I10091056","https://openalex.org/I103390050","https://openalex.org/I111966504","https://openalex.org/I119182057","https://openalex.org/I4210103779","https://openalex.org/I4210160792","https://openalex.org/I4387152633","https://openalex.org/I8488066"],"apc_list":null,"apc_paid":null,"fwci":1.3095,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.79698707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"34","issue":"12","first_page":"2388","last_page":"2407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.9639999866485596},{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"locus coeruleus","score":0.8899999856948853},{"id":"https://openalex.org/keywords/pupil-size","display_name":"pupil size","score":0.8709999918937683},{"id":"https://openalex.org/keywords/lateralization","display_name":"laterality","score":0.5519999861717224},{"id":"https://openalex.org/keywords/edinger-westphal-nucleus","display_name":"Edinger-Westphal nucleus","score":0.9570000171661377},{"id":"https://openalex.org/keywords/contralateral-projections","display_name":"contralateral projections","score":0.7379999756813049},{"id":"https://openalex.org/keywords/temporal-complexity","display_name":"temporal complexity","score":0.4390000104904175},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6620000004768372},{"id":"https://openalex.org/keywords/inattention","display_name":"inattention","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2777394604","wikidata":"https://www.wikidata.org/wiki/Q173318","display_name":"Pupil","level":2,"score":0.8336434364318848},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.678527295589447},{"id":"https://openalex.org/C2778468602","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus coeruleus","level":3,"score":0.609937846660614},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5670597553253174},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.5259866118431091},{"id":"https://openalex.org/C2780319597","wikidata":"https://www.wikidata.org/wiki/Q1549918","display_name":"Impulsivity","level":2,"score":0.467768132686615},{"id":"https://openalex.org/C2778711042","wikidata":"https://www.wikidata.org/wiki/Q3410891","display_name":"Pupillometry","level":3,"score":0.45405393838882446},{"id":"https://openalex.org/C149288182","wikidata":"https://www.wikidata.org/wiki/Q7260673","display_name":"Pupillary response","level":3,"score":0.4488810896873474},{"id":"https://openalex.org/C36951298","wikidata":"https://www.wikidata.org/wiki/Q379784","display_name":"Arousal","level":2,"score":0.44272589683532715},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.33910590410232544},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.23617959022521973},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.14315974712371826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12235644459724426},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10316851735115051}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008125","descriptor_name":"Locus Coeruleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008125","descriptor_name":"Locus Coeruleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008125","descriptor_name":"Locus Coeruleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011680","descriptor_name":"Pupil","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011680","descriptor_name":"Pupil","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011680","descriptor_name":"Pupil","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1162/neco_a_01545","doi":"https://doi.org/10.1162/neco_a_01545","is_oa":false,"landing_page_url":"https://doi.org/10.1162/neco_a_01545","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","erih-plus","jufo-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718","https://openalex.org/P4310316440"],"host_organization_lineage_names":["The MIT Press","Massachusetts Institute of Technology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},{"id":"pmid:36283044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36283044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural computation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1341267965","display_name":"Reconsideration of the diagnostic system for neurodevelopmental disorders with a focus on functional impairment","funder_award_id":"22H00492","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3394649258","display_name":"Investigation of Global Neural Network Dynamics Dysfunction for the Early Diagnosis of Schizophrenia","funder_award_id":"22K12183","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5994748455","display_name":"Estimating the activities in the three neurotransmission systems for clarifying the mechanisms of cognitive dysfunction in schizophrenia","funder_award_id":"20K03490","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W629283852","https://openalex.org/W1559113205","https://openalex.org/W1969237892","https://openalex.org/W1975955945","https://openalex.org/W1978683658","https://openalex.org/W1986839164","https://openalex.org/W2017108196","https://openalex.org/W2017766355","https://openalex.org/W2026689686","https://openalex.org/W2030325164","https://openalex.org/W2047928528","https://openalex.org/W2059040925","https://openalex.org/W2062206551","https://openalex.org/W2065885559","https://openalex.org/W2068779946","https://openalex.org/W2077149536","https://openalex.org/W2077820567","https://openalex.org/W2080843822","https://openalex.org/W2093266575","https://openalex.org/W2096005240","https://openalex.org/W2115095583","https://openalex.org/W2117272607","https://openalex.org/W2137706707","https://openalex.org/W2154555775","https://openalex.org/W2162800060","https://openalex.org/W2210396547","https://openalex.org/W2355762936","https://openalex.org/W2399153035","https://openalex.org/W2555957564","https://openalex.org/W2566679941","https://openalex.org/W2569104003","https://openalex.org/W2595385735","https://openalex.org/W2743854648","https://openalex.org/W2746340968","https://openalex.org/W2758014172","https://openalex.org/W2792056998","https://openalex.org/W2884365002","https://openalex.org/W2909988577","https://openalex.org/W2916744134","https://openalex.org/W2942622378","https://openalex.org/W2963647538","https://openalex.org/W3087194547","https://openalex.org/W3116955806","https://openalex.org/W3127957429","https://openalex.org/W3154568285","https://openalex.org/W4247665917","https://openalex.org/W4294214781","https://openalex.org/W6633740387","https://openalex.org/W6642529289","https://openalex.org/W6779496368","https://openalex.org/W6804947796"],"related_works":["https://openalex.org/W1932385070","https://openalex.org/W3116955806","https://openalex.org/W4281489062","https://openalex.org/W4293072759","https://openalex.org/W3106499489","https://openalex.org/W2743854648","https://openalex.org/W2604427212","https://openalex.org/W2083153865","https://openalex.org/W2916722057","https://openalex.org/W2013313898"],"abstract_inverted_index":{"Locus":[0],"coeruleus":[1],"(LC)":[2],"overactivity,":[3],"especially":[4],"in":[5,75,84,148,164,178,214,234,253,275],"the":[6,27,30,49,52,55,68,98,104,107,115,159,179,188,194,197,205,219,225,235,248,261,269,281],"right":[7,180],"hemisphere,":[8],"is":[9],"a":[10,81,90,138,170,184,232],"recognized":[11],"pathophysiology":[12],"of":[13,29,51,54,58,70,93,119,141,161,196,200,222,224,238,247,271,273,283,288],"attention-deficit/hyperactivity":[14],"disorder":[15],"(ADHD)":[16],"and":[17,33,44,73,129,151,192,245],"may":[18,157],"be":[19,78],"related":[20,37],"to":[21,38,80,106,190,260],"inattention.":[22],"LC":[23,85,105,127,149,176,189,242],"activity":[24,36,150,244],"synchronizes":[25],"with":[26,67,209,217],"kinetics":[28],"pupil":[31,59,63,94,120,133,142,162,171,201,212,276],"diameter":[32,95,143,172,202,277],"reflects":[34],"neural":[35,139,226],"cognitive":[39],"functions":[40],"such":[41],"as":[42],"attention":[43],"arousal.":[45],"Recent":[46],"studies":[47],"highlight":[48],"importance":[50],"complexity":[53,195,239,274],"temporal":[56,117,198],"patterns":[57,118,199],"diameter.":[60,134],"Moreover,":[61],"asymmetrical":[62],"diameter,":[64],"which":[65,111,230,258],"correlates":[66],"severity":[69],"inattention,":[71],"impulsivity,":[72],"hyperactivity":[74],"ADHD,":[76,218],"might":[77],"attributed":[79],"left-right":[82,146],"imbalance":[83],"activity.":[86],"We":[87,135,266],"recently":[88],"constructed":[89],"computational":[91],"model":[92,140,174,227],"based":[96],"on":[97],"newly":[99],"discovered":[100],"contralateral":[101,185],"projection":[102,186],"from":[103,187],"Edinger-Westphal":[108],"nucleus":[109],"(EWN),":[110],"demonstrated":[112],"mechanisms":[113],"for":[114,285],"complex":[116],"kinetics;":[121],"however,":[122],"it":[123],"remains":[124],"unclear":[125],"how":[126],"overactivity":[128,177],"its":[130],"asymmetry":[131],"affect":[132],"hypothesized":[136],"that":[137,246,268],"control":[144,173],"featuring":[145],"differences":[147],"projections":[152],"onto":[153],"two":[154],"opponent":[155],"sides":[156],"clarify":[158],"role":[160],"behavior":[163],"ADHD":[165],"studies.":[166],"Therefore,":[167],"we":[168],"developed":[169],"reflecting":[175],"hemisphere":[181],"by":[182,204],"incorporating":[183],"EWN":[191],"evaluated":[193],"generated":[203],"model.":[206],"Upon":[207],"comparisons":[208],"experimentally":[210],"measured":[211],"diameters":[213],"adult":[215],"patients":[216],"parameter":[220],"region":[221,233,251],"interest":[223],"was":[228,231,264],"estimated,":[229],"two-dimensional":[236],"plot":[237],"versus":[240],"left-side":[241],"baseline":[243],"right.":[249],"A":[250],"resulting":[252],"relatively":[254],"high":[255],"right-side":[256],"complexity,":[257],"corresponded":[259],"pathophysiological":[262],"indexes,":[263],"identified.":[265],"anticipate":[267],"discovery":[270],"lateralization":[272],"fluctuations":[278],"will":[279],"facilitate":[280],"development":[282],"biomarkers":[284],"accurate":[286],"diagnosis":[287],"ADHD.":[289]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-10-10T00:00:00"}
