{"id":"https://openalex.org/W2464207583","doi":"https://doi.org/10.1162/neco_a_00854","title":"Asymmetry of Neuronal Combinatorial Codes Arises from Minimizing Synaptic Weight Change","display_name":"Asymmetry of Neuronal Combinatorial Codes Arises from Minimizing Synaptic Weight Change","publication_year":2016,"publication_date":"2016-06-27","ids":{"openalex":"https://openalex.org/W2464207583","doi":"https://doi.org/10.1162/neco_a_00854","mag":"2464207583","pmid":"https://pubmed.ncbi.nlm.nih.gov/27348595"},"language":"en","primary_location":{"id":"doi:10.1162/neco_a_00854","is_oa":false,"landing_page_url":"https://doi.org/10.1162/neco_a_00854","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013263880","display_name":"Christian Leibold","orcid":"https://orcid.org/0000-0002-4859-8000"},"institutions":[{"id":"https://openalex.org/I4210134961","display_name":"Bernstein Center for Computational Neuroscience Munich","ror":"https://ror.org/04bz45c46","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210092532","https://openalex.org/I4210134961"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christian Leibold","raw_affiliation_strings":["Department Biology II, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, and Bernstein Center for Computational Neuroscience Munich, 82152 Martisreid, Germany"],"affiliations":[{"raw_affiliation_string":"Department Biology II, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, and Bernstein Center for Computational Neuroscience Munich, 82152 Martisreid, Germany","institution_ids":["https://openalex.org/I4210134961","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003184409","display_name":"Mauro M. Monsalve\u2010Mercado","orcid":"https://orcid.org/0000-0003-2263-4111"},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mauro M. Monsalve-Mercado","raw_affiliation_strings":["Department II Biology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 82152 Martisreid, Germany"],"affiliations":[{"raw_affiliation_string":"Department II Biology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 82152 Martisreid, Germany","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003184409","https://openalex.org/A5013263880"],"corresponding_institution_ids":["https://openalex.org/I4210134961","https://openalex.org/I8204097"],"apc_list":null,"apc_paid":null,"fwci":0.1625,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.53770084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"28","issue":"8","first_page":"1527","last_page":"1552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6899023056030273},{"id":"https://openalex.org/keywords/place-cell","display_name":"Place cell","score":0.4734717905521393},{"id":"https://openalex.org/keywords/memorization","display_name":"Memorization","score":0.468345582485199},{"id":"https://openalex.org/keywords/object","display_name":"Object (grammar)","score":0.4557511508464813},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"Synaptic plasticity","score":0.4515305757522583},{"id":"https://openalex.org/keywords/synaptic-weight","display_name":"Synaptic weight","score":0.435791552066803},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.41277655959129333},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3878753185272217},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.3243083357810974},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.2756393551826477},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1610463559627533},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12199512124061584}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6899023056030273},{"id":"https://openalex.org/C2781369091","wikidata":"https://www.wikidata.org/wiki/Q2303730","display_name":"Place cell","level":3,"score":0.4734717905521393},{"id":"https://openalex.org/C30038468","wikidata":"https://www.wikidata.org/wiki/Q4354775","display_name":"Memorization","level":2,"score":0.468345582485199},{"id":"https://openalex.org/C2781238097","wikidata":"https://www.wikidata.org/wiki/Q175026","display_name":"Object (grammar)","level":2,"score":0.4557511508464813},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.4515305757522583},{"id":"https://openalex.org/C66949984","wikidata":"https://www.wikidata.org/wiki/Q7662043","display_name":"Synaptic weight","level":3,"score":0.435791552066803},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41277655959129333},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3878753185272217},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.3243083357810974},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.2756393551826477},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1610463559627533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12199512124061584},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C145420912","wikidata":"https://www.wikidata.org/wiki/Q853077","display_name":"Mathematics education","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1162/neco_a_00854","is_oa":false,"landing_page_url":"https://doi.org/10.1162/neco_a_00854","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},{"id":"pmid:27348595","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27348595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural computation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1868297237","https://openalex.org/W1896376703","https://openalex.org/W1967324141","https://openalex.org/W1970359800","https://openalex.org/W1970916727","https://openalex.org/W1975705681","https://openalex.org/W1979013024","https://openalex.org/W1980236492","https://openalex.org/W1987727679","https://openalex.org/W1987832351","https://openalex.org/W2001270585","https://openalex.org/W2010690283","https://openalex.org/W2014806995","https://openalex.org/W2017814058","https://openalex.org/W2019633617","https://openalex.org/W2023768217","https://openalex.org/W2027968420","https://openalex.org/W2028978164","https://openalex.org/W2030221612","https://openalex.org/W2035774707","https://openalex.org/W2041099773","https://openalex.org/W2044973682","https://openalex.org/W2048072444","https://openalex.org/W2066796187","https://openalex.org/W2074376560","https://openalex.org/W2086967399","https://openalex.org/W2092150690","https://openalex.org/W2095683621","https://openalex.org/W2098807436","https://openalex.org/W2100985468","https://openalex.org/W2102304321","https://openalex.org/W2120127728","https://openalex.org/W2120601002","https://openalex.org/W2121007598","https://openalex.org/W2121881115","https://openalex.org/W2128084896","https://openalex.org/W2129386380","https://openalex.org/W2131023774","https://openalex.org/W2133639480","https://openalex.org/W2146561158","https://openalex.org/W2158014445","https://openalex.org/W2159367480","https://openalex.org/W2161278885"],"related_works":["https://openalex.org/W4387561393","https://openalex.org/W3163481960","https://openalex.org/W3093895509","https://openalex.org/W2323394100","https://openalex.org/W3019106518","https://openalex.org/W2792724031","https://openalex.org/W2902576472","https://openalex.org/W2732008908","https://openalex.org/W4386158178","https://openalex.org/W2334941166"],"abstract_inverted_index":{"Synaptic":[0],"change":[1,35],"is":[2],"a":[3,12,50,81,123,127,152],"costly":[4],"resource,":[5],"particularly":[6],"for":[7],"brain":[8,179],"structures":[9],"that":[10,98,159,186],"have":[11],"high":[13],"demand":[14],"of":[15,22,28,126,155,162,168],"synaptic":[16,70],"plasticity.":[17],"For":[18],"example,":[19,136],"building":[20],"memories":[21],"object":[23,45,129,146],"positions":[24],"requires":[25],"efficient":[26],"use":[27],"plasticity":[29],"resources":[30],"since":[31],"objects":[32],"can":[33,43],"easily":[34],"their":[36],"location":[37,63],"in":[38,66],"space":[39],"and":[40,64,105,118,145],"yet":[41],"we":[42,137],"memorize":[44],"locations.":[46],"But":[47],"how":[48,85],"should":[49,72,90,102,114],"neural":[51],"circuit":[52],"ideally":[53,91],"be":[54,73,92,103,115,132,175],"set":[55],"up":[56],"to":[57,131,177],"integrate":[58],"two":[59,87],"input":[60,88,192],"streams":[61],"(object":[62],"identity)":[65],"case":[67],"the":[68,86,95,99,109],"overall":[69],"changes":[71,167],"minimized":[74],"during":[75],"ongoing":[76],"learning?":[77],"This":[78],"letter":[79],"provides":[80,151],"theoretical":[82],"framework":[83],"on":[84],"pathways":[89],"specified.":[93],"Generally":[94],"model":[96,149],"predicts":[97],"information-rich":[100],"pathway":[101,110],"plastic":[104],"encoded":[106,116],"sparsely,":[107],"whereas":[108],"conveying":[111],"less":[112],"information":[113],"densely":[117],"undergo":[119],"learning":[120],"only":[121],"if":[122],"neuronal":[124],"representation":[125],"novel":[128],"has":[130],"established.":[133],"As":[134],"an":[135],"consider":[138],"hippocampal":[139,156],"area":[140],"CA1,":[141],"which":[142],"combines":[143],"place":[144,163],"information.":[147],"The":[148],"thereby":[150],"normative":[153],"account":[154],"rate":[157],"remapping,":[158],"is,":[160],"modulations":[161],"field":[164],"activity":[165],"by":[166],"local":[169],"cues.":[170],"It":[171],"may":[172],"as":[173,182],"well":[174],"applicable":[176],"other":[178],"areas":[180],"(such":[181],"neocortical":[183],"layer":[184],"V)":[185],"learn":[187],"combinatorial":[188],"codes":[189],"from":[190],"multiple":[191],"streams.":[193]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}