{"id":"https://openalex.org/W2144102924","doi":"https://doi.org/10.1162/neco_a_00644","title":"Fragility in Dynamic Networks: Application to Neural Networks in the Epileptic Cortex","display_name":"Fragility in Dynamic Networks: Application to Neural Networks in the Epileptic Cortex","publication_year":2014,"publication_date":"2014-07-24","ids":{"openalex":"https://openalex.org/W2144102924","doi":"https://doi.org/10.1162/neco_a_00644","mag":"2144102924","pmid":"https://pubmed.ncbi.nlm.nih.gov/25058705"},"language":"en","primary_location":{"id":"doi:10.1162/neco_a_00644","is_oa":false,"landing_page_url":"https://doi.org/10.1162/neco_a_00644","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718","https://openalex.org/P4310316440"],"host_organization_lineage_names":["The MIT Press","Massachusetts Institute of Technology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056164433","display_name":"Duluxan Sritharan","orcid":"https://orcid.org/0000-0002-7858-0979"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duluxan Sritharan","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, U.S.A","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088809750","display_name":"Sridevi V. Sarma","orcid":"https://orcid.org/0000-0002-4817-6625"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sridevi V. Sarma","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, U.S.A","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8394,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.71330632,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"26","issue":"10","first_page":"2294","last_page":"2327"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7231529355049133},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.5654529333114624},{"id":"https://openalex.org/keywords/network-dynamics","display_name":"Network dynamics","score":0.5625607371330261},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5260229706764221},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.49784016609191895},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.4654563069343567},{"id":"https://openalex.org/keywords/network-model","display_name":"Network model","score":0.43774157762527466},{"id":"https://openalex.org/keywords/biological-neural-network","display_name":"Biological neural network","score":0.433794766664505},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.43128007650375366},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39834198355674744},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3284621238708496},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3099316358566284},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21408170461654663},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.19040009379386902},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.151179701089859}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7231529355049133},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.5654529333114624},{"id":"https://openalex.org/C123757187","wikidata":"https://www.wikidata.org/wiki/Q9195957","display_name":"Network dynamics","level":2,"score":0.5625607371330261},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5260229706764221},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.49784016609191895},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.4654563069343567},{"id":"https://openalex.org/C104122410","wikidata":"https://www.wikidata.org/wiki/Q1416406","display_name":"Network model","level":2,"score":0.43774157762527466},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.433794766664505},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.43128007650375366},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39834198355674744},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3284621238708496},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3099316358566284},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21408170461654663},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.19040009379386902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.151179701089859},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1162/neco_a_00644","is_oa":false,"landing_page_url":"https://doi.org/10.1162/neco_a_00644","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718","https://openalex.org/P4310316440"],"host_organization_lineage_names":["The MIT Press","Massachusetts Institute of Technology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},{"id":"pmid:25058705","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25058705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural computation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1542136448","https://openalex.org/W1548862642","https://openalex.org/W1876456565","https://openalex.org/W1964434285","https://openalex.org/W1967074888","https://openalex.org/W1967106410","https://openalex.org/W1974631391","https://openalex.org/W1976787490","https://openalex.org/W1994222599","https://openalex.org/W2001090930","https://openalex.org/W2005732580","https://openalex.org/W2010124835","https://openalex.org/W2010866903","https://openalex.org/W2015090542","https://openalex.org/W2015701831","https://openalex.org/W2035372517","https://openalex.org/W2045747994","https://openalex.org/W2049594669","https://openalex.org/W2053168002","https://openalex.org/W2067367785","https://openalex.org/W2073937499","https://openalex.org/W2079207152","https://openalex.org/W2087568562","https://openalex.org/W2090063036","https://openalex.org/W2091159354","https://openalex.org/W2107081989","https://openalex.org/W2109870708","https://openalex.org/W2120719475","https://openalex.org/W2124587559","https://openalex.org/W2125273690","https://openalex.org/W2127888717","https://openalex.org/W2139755184","https://openalex.org/W2145384179","https://openalex.org/W2146467321","https://openalex.org/W2155418451","https://openalex.org/W2157586156","https://openalex.org/W2316463358","https://openalex.org/W2321068138","https://openalex.org/W3104859924"],"related_works":["https://openalex.org/W2123745704","https://openalex.org/W2016445007","https://openalex.org/W2890407759","https://openalex.org/W2056683768","https://openalex.org/W2652635008","https://openalex.org/W4281298443","https://openalex.org/W2408257548","https://openalex.org/W2047439469","https://openalex.org/W2018672271","https://openalex.org/W2767044922"],"abstract_inverted_index":{"Epilepsy":[0],"is":[1,31,40,46,49,90,117,141,158,228],"a":[2,34,98,107,114,155,209,271],"network":[3,102,140,167,195,252,280,293],"phenomenon":[4],"characterized":[5],"by":[6],"atypical":[7],"activity":[8,185],"at":[9,106],"the":[10,66,73,78,120,122,138,143,161,165,170,177,192,202,225,231,239,244,251,257,268,279,292],"neuronal":[11,184,217],"and":[12,25,179,235,261,283],"population":[13,219],"levels":[14],"during":[15,221],"seizures,":[16],"including":[17,201],"tonic":[18],"spiking,":[19],"increased":[20],"heterogeneity":[21],"in":[22,58,72,187,194,238],"spiking":[23],"rates,":[24],"synchronization.":[26],"The":[27],"etiology":[28],"of":[29,125,176,204,216,233,264,270],"epilepsy":[30,52,188],"unclear,":[32],"but":[33,60,130],"common":[35],"theme":[36],"among":[37],"proposed":[38],"mechanisms":[39],"that":[41,51,104,168,191,275],"structural":[42,63,162],"connectivity":[43,84],"between":[44],"neurons":[45,71],"altered.":[47],"It":[48],"hypothesized":[50],"arises":[53],"not":[54],"from":[55,61],"random":[56],"changes":[57,64,193,237],"connectivity,":[59],"specific":[62],"to":[65,86,97,119,133,147,164,198,253,290,295],"most":[67,245],"fragile":[68,246],"nodes":[69],"or":[70,149,152,208,218],"network.":[74],"In":[75],"this":[76],"letter,":[77],"minimum":[79],"energy":[80],"perturbation":[81,172],"on":[82,230],"functional":[83,171],"required":[85],"destabilize":[87,250],"linear":[88,286],"networks":[89,181,266],"derived.":[91,174],"Perturbation":[92],"results":[93],"are":[94,173],"then":[95,284],"applied":[96,118],"probabilistic":[99],"nonlinear":[100],"neural":[101,166],"model":[103],"operates":[105],"stable":[108,210,297],"fixed":[109],"point.":[110],"That":[111,223],"is,":[112,224],"if":[113],"small":[115,156],"stimulus":[116,157],"network,":[121],"activation":[123,144],"probabilities":[124,145],"each":[126],"neuron":[127],"respond":[128],"transiently":[129],"eventually":[131],"recover":[132],"their":[134],"baseline":[135],"values.":[136],"When":[137],"perturbed":[139,180],"destabilized,":[142],"shift":[146],"larger":[148],"smaller":[150],"values":[151],"oscillate":[153],"when":[154,278],"applied.":[159],"Finally,":[160,256],"modifications":[163],"achieve":[169],"Simulations":[175],"unperturbed":[178],"qualitatively":[182],"reflect":[183],"observed":[186],"patients,":[189],"suggesting":[190],"dynamics":[196,220],"due":[197],"destabilizing":[199],"perturbations,":[200],"emergence":[203],"an":[205],"unstable":[206],"manifold":[207],"limit":[211],"cycle,":[212],"may":[213],"be":[214],"indicative":[215],"seizure.":[222],"epileptic":[226,265],"cortex":[227],"always":[229],"brink":[232],"instability":[234],"minute":[236],"synaptic":[240],"weights":[241],"associated":[242],"with":[243],"node":[247],"can":[248],"suddenly":[249],"cause":[254],"seizures.":[255],"theory":[258],"developed":[259],"here":[260],"its":[262,296],"interpretation":[263],"enables":[267],"design":[269],"straightforward":[272],"feedback":[273,288],"controller":[274],"first":[276],"detects":[277],"has":[281],"destabilized":[282],"applies":[285],"state":[287],"control":[289],"steer":[291],"back":[294],"state.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-08-15T07:11:24.734988","created_date":"2025-10-10T00:00:00"}