{"id":"https://openalex.org/W2074678993","doi":"https://doi.org/10.1162/neco_a_00196","title":"Estimating Parameters of Generalized Integrate-and-Fire Neurons from the Maximum Likelihood of Spike Trains","display_name":"Estimating Parameters of Generalized Integrate-and-Fire Neurons from the Maximum Likelihood of Spike Trains","publication_year":2011,"publication_date":"2011-08-19","ids":{"openalex":"https://openalex.org/W2074678993","doi":"https://doi.org/10.1162/neco_a_00196","mag":"2074678993","pmid":"https://pubmed.ncbi.nlm.nih.gov/21851282"},"language":"en","primary_location":{"id":"doi:10.1162/neco_a_00196","is_oa":false,"landing_page_url":"https://doi.org/10.1162/neco_a_00196","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3513351","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031658542","display_name":"Yi Dong","orcid":"https://orcid.org/0000-0003-1294-4888"},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210151493","display_name":"Lieber Institute for Brain Development","ror":"https://ror.org/04q36wn27","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210151493"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Dong","raw_affiliation_strings":["Department of Neuroscience and Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, U.S.A","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I1314596251","https://openalex.org/I4210151493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072126704","display_name":"\u015etefan Mihala\u015f","orcid":"https://orcid.org/0000-0002-2629-7100"},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210151493","display_name":"Lieber Institute for Brain Development","ror":"https://ror.org/04q36wn27","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210151493"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Mihalas","raw_affiliation_strings":["Department of Neuroscience and Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, U.S.A","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I1314596251","https://openalex.org/I4210151493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103276239","display_name":"Alexander F. Russell","orcid":"https://orcid.org/0009-0006-2995-9276"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Russell","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, U.S.A","Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, 21218, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, U.S.A","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, 21218, U.S.A","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037936459","display_name":"Ralph Etienne\u2010Cummings","orcid":"https://orcid.org/0000-0003-4445-973X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph Etienne-Cummings","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, U.S.A","Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, 21218, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, U.S.A","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, 21218, U.S.A","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016761623","display_name":"Ernst Niebur","orcid":"https://orcid.org/0000-0002-2815-9262"},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210151493","display_name":"Lieber Institute for Brain Development","ror":"https://ror.org/04q36wn27","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210151493"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernst Niebur","raw_affiliation_strings":["Department of Neuroscience and Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, U.S.A","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I1314596251","https://openalex.org/I4210151493"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9942,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.74945136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"23","issue":"11","first_page":"2833","last_page":"2867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spike","display_name":"Spike (software development)","score":0.7094704508781433},{"id":"https://openalex.org/keywords/spike-train","display_name":"Spike train","score":0.5588391423225403},{"id":"https://openalex.org/keywords/simple","display_name":"Simple (philosophy)","score":0.5352972149848938},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5190446972846985},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5161036252975464},{"id":"https://openalex.org/keywords/likelihood-function","display_name":"Likelihood function","score":0.509465754032135},{"id":"https://openalex.org/keywords/convexity","display_name":"Convexity","score":0.43648552894592285},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.43105271458625793},{"id":"https://openalex.org/keywords/gradient-descent","display_name":"Gradient descent","score":0.42835599184036255},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.38419169187545776},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.28273993730545044},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27496543526649475},{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.17925891280174255}],"concepts":[{"id":"https://openalex.org/C2781390188","wikidata":"https://www.wikidata.org/wiki/Q25203449","display_name":"Spike (software development)","level":2,"score":0.7094704508781433},{"id":"https://openalex.org/C2909946758","wikidata":"https://www.wikidata.org/wiki/Q194277","display_name":"Spike train","level":3,"score":0.5588391423225403},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.5352972149848938},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5190446972846985},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5161036252975464},{"id":"https://openalex.org/C89106044","wikidata":"https://www.wikidata.org/wiki/Q45284","display_name":"Likelihood function","level":3,"score":0.509465754032135},{"id":"https://openalex.org/C72134830","wikidata":"https://www.wikidata.org/wiki/Q5166524","display_name":"Convexity","level":2,"score":0.43648552894592285},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.43105271458625793},{"id":"https://openalex.org/C153258448","wikidata":"https://www.wikidata.org/wiki/Q1199743","display_name":"Gradient descent","level":3,"score":0.42835599184036255},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.38419169187545776},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.28273993730545044},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27496543526649475},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.17925891280174255},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1162/neco_a_00196","is_oa":false,"landing_page_url":"https://doi.org/10.1162/neco_a_00196","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},{"id":"pmid:21851282","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21851282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural computation","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3513351","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3513351","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neural Comput","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3513351","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3513351","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neural Comput","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3008130261","display_name":null,"funder_award_id":"5R01NS40596","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6552890975","display_name":null,"funder_award_id":"R01 EY016281","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G848483116","display_name":null,"funder_award_id":"R01 NS040596","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G883445469","display_name":null,"funder_award_id":"R01EY016281","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1843946745","https://openalex.org/W1974479903","https://openalex.org/W1981999543","https://openalex.org/W1990849091","https://openalex.org/W1995341919","https://openalex.org/W1995597837","https://openalex.org/W1996196738","https://openalex.org/W2001719329","https://openalex.org/W2015263936","https://openalex.org/W2018916444","https://openalex.org/W2048756013","https://openalex.org/W2063027609","https://openalex.org/W2071080637","https://openalex.org/W2072600732","https://openalex.org/W2081411433","https://openalex.org/W2091201506","https://openalex.org/W2098472054","https://openalex.org/W2103891020","https://openalex.org/W2109596721","https://openalex.org/W2110011089","https://openalex.org/W2111562869","https://openalex.org/W2111701494","https://openalex.org/W2112246597","https://openalex.org/W2116531552","https://openalex.org/W2122717530","https://openalex.org/W2125454504","https://openalex.org/W2128949090","https://openalex.org/W2135736527","https://openalex.org/W2146655366","https://openalex.org/W2150447451","https://openalex.org/W2150694008","https://openalex.org/W2151109698","https://openalex.org/W2164653071","https://openalex.org/W2183588210","https://openalex.org/W2495317841","https://openalex.org/W3103996772","https://openalex.org/W3217350819","https://openalex.org/W4211021241","https://openalex.org/W4211092921","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2383615955","https://openalex.org/W2329992713","https://openalex.org/W2062974934","https://openalex.org/W2187212244","https://openalex.org/W1558157446","https://openalex.org/W2173049006","https://openalex.org/W4281636778","https://openalex.org/W2950605049","https://openalex.org/W2014837149","https://openalex.org/W3091858974"],"abstract_inverted_index":{"When":[0],"a":[1,116,127,134,153,189,246,262,269],"neuronal":[2],"spike":[3,62],"train":[4],"is":[5,29,65,88,160,169,185,201,234,259],"observed,":[6],"what":[7],"can":[8,100,123],"we":[9,174,224,266],"deduce":[10],"from":[11],"it":[12,204],"about":[13,34],"the":[14,17,35,49,60,66,71,161,166,206,209,230,240,250,256,280],"properties":[15],"of":[16,37,119,147,152,163,187,192,208,229,242],"neuron":[18,72],"that":[19,54,83,156,226,268],"generated":[20],"it?":[21],"A":[22],"natural":[23],"way":[24],"to":[25,30,58,114,218],"answer":[26],"this":[27,44,222,238,243],"question":[28],"make":[31],"an":[32,40,138,144,150,176],"assumption":[33],"type":[36],"neuron,":[38],"select":[39],"appropriate":[41],"model":[42,50,135,178,251],"for":[43,237,249],"type,":[45],"and":[46,79,90,212],"then":[47],"choose":[48],"parameters":[51],"as":[52,261],"those":[53],"are":[55],"most":[56],"likely":[57],"generate":[59,115],"observed":[61],"train.":[63],"This":[64],"maximum":[67,215],"likelihood":[68,216],"method.":[69],"If":[70],"obeys":[73],"simple":[74,128],"integrate-and-fire":[75,129],"dynamics,":[76],"Paninski,":[77],"Pillow,":[78],"Simoncelli":[80],"(2004)":[81],"showed":[82],"its":[84,96,148],"negative":[85,231],"log-likelihood":[86,232],"function":[87,233,244,271],"convex":[89],"that,":[91],"at":[92],"least":[93],"in":[94,126,253],"principle,":[95],"unique":[97],"global":[98,281],"minimum":[99,241],"thus":[101],"be":[102,124,158,219],"found":[103],"by":[104],"gradient":[105],"descent":[106],"techniques.":[107],"Many":[108],"biological":[109],"neurons":[110],"are,":[111],"however,":[112],"known":[113],"richer":[117],"repertoire":[118],"spiking":[120],"behaviors":[121],"than":[122],"explained":[125,159],"model.":[130],"For":[131],"instance,":[132],"such":[133],"retains":[136],"only":[137],"implicit":[139],"(through":[140],"spike-induced":[141],"currents),":[142],"not":[143,235],"explicit,":[145],"memory":[146],"input;":[149],"example":[151],"physiological":[154],"situation":[155],"cannot":[157],"absence":[162],"firing":[164,194],"if":[165,255],"input":[167],"current":[168],"increased":[170],"very":[171],"slowly.":[172],"Therefore,":[173],"use":[175],"expanded":[177],"(Mihalas":[179],"&":[180],"Niebur,":[181],"2009":[182],"),":[183],"which":[184],"capable":[186],"generating":[188],"large":[190],"number":[191],"complex":[193],"patterns":[195],"while":[196],"still":[197,213],"being":[198],"linear.":[199],"Linearity":[200],"important":[202],"because":[203],"maintains":[205],"distribution":[207],"random":[210],"variables":[211],"allows":[214],"methods":[217],"used.":[220],"In":[221],"study,":[223],"show":[225,267],"although":[227],"convexity":[228],"guaranteed":[236],"model,":[239],"yields":[245],"good":[247],"estimate":[248],"parameters,":[252],"particular":[254],"noise":[257],"level":[258],"treated":[260],"free":[263],"parameter.":[264],"Furthermore,":[265],"nonlinear":[270],"minimization":[272],"method":[273],"(r-algorithm":[274],"with":[275],"space":[276],"dilation)":[277],"usually":[278],"reaches":[279],"minimum.":[282]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2016-06-24T00:00:00"}